{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:35:21Z","timestamp":1769744121290,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["113112"],"award-info":[{"award-number":["113112"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["213548"],"award-info":[{"award-number":["213548"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["216231"],"award-info":[{"award-number":["216231"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["25\/627\/2006"],"award-info":[{"award-number":["25\/627\/2006"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["61\/627\/2005"],"award-info":[{"award-number":["61\/627\/2005"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001829","name":"Universiteit Utrecht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001280","name":"Horserace Betting Levy Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.bone.2008.07.254","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T07:23:39Z","timestamp":1218698619000},"page":"1108-1114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Changes in subchondral bone mineral density and collagen matrix organization in growing horses"],"prefix":"10.1016","volume":"43","author":[{"given":"Jaakko T.","family":"Holopainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.J.","family":"Brama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa","family":"Halmesm\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terhi","family":"Harjula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Tuukkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Ren\u00e9","family":"van Weeren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki J.","family":"Helminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika M.","family":"Hyttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.07.254_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bone.2008.07.254_bib2","first-page":"9","article-title":"The development of articular cartilage: The spatial and temporal patterns of collagen types","volume":"189","author":"Morrison","year":"1996","journal-title":"J. Anat."},{"key":"10.1016\/j.bone.2008.07.254_bib3","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1359\/jbmr.2000.15.9.1776","article-title":"Collagen structure regulates fibril mineralization in osteogenesis as revealed by cross-link patterns in calcifying callus","volume":"15","author":"Wassen","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2746\/042516401776767377","article-title":"Contact areas and pressure distribution on the proximal articular surface of the proximal phalanx under sagittal plane loading","volume":"33","author":"Brama","year":"2001","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.2042-3306.2001.tb00599.x","article-title":"Intra-articular pressure profiles of the cadaveric equine fetlock joint in motion","volume":"33","author":"da Gracca Macoris","year":"2001","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jor.1100060205","article-title":"Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs","volume":"6","author":"Kiviranta","year":"1988","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib7","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/art.1780361018","article-title":"Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joints of beagle dogs","volume":"36","author":"Arokoski","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2008.07.254_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00003086-199905000-00031","article-title":"Remobilization does not fully restore immobilization induced articular cartilage atrophy","volume":"362","author":"Haapala","year":"1999","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.2042-3306.1999.tb05314.x","article-title":"Influence of different exercise levels and age on the biochemical characteristics of immature equine articular cartilage","volume":"31","author":"Brama","year":"1999","journal-title":"Equine Vet. J. Suppl."},{"key":"10.1016\/j.bone.2008.07.254_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2746\/042516400777584613","article-title":"The influence of strenuous exercise on collagen characteristics of articular cartilage in Thoroughbreds age 2 years","volume":"32","author":"Brama","year":"2000","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2746\/042516402776186146","article-title":"Development of biochemical heterogeneity of articular cartilage: influences of age and exercise","volume":"34","author":"Brama","year":"2002","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2746\/042516408X253091","article-title":"Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse","volume":"40","author":"Van Weeren","year":"2008","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0736-0266(02)00093-1","article-title":"MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens","volume":"21","author":"Patel","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1054\/JHSB.2001.0714","article-title":"Subchondral bone mineral density patterns representing the loading history of the wrist joint","volume":"27","author":"Hoogbergen","year":"2002","journal-title":"J. Hand Surg. [Br]."},{"key":"10.1016\/j.bone.2008.07.254_bib15","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.joca.2006.04.010","article-title":"The ratio of medial to lateral tibial plateau bone mineral density and compartment-specific tibiofemoral osteoarthritis","volume":"14","author":"Lo","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2008.07.254_bib16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/jbmr.5650110903","article-title":"Implications of increased bone density in osteoarthritis","volume":"11","author":"Hamerman","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/joca.2002.0525","article-title":"Subchondral bone of the human knee joint in aging and osteoarthritis","volume":"10","author":"Yamada","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2008.07.254_bib18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0889-857X(03)00061-9","article-title":"Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?","volume":"29","author":"Burr","year":"2003","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.bone.2008.07.254_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jor.1100160311","article-title":"Blunt impact causes changes in bone and cartilage in a regularly exercised animal model","volume":"16","author":"Newberry","year":"1998","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S8756-3282(97)00253-6","article-title":"Subchondral bone failure in an equine model of overload arthrosis","volume":"22","author":"Norrdin","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.07.254_bib21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/000164701317323444","article-title":"Bone density does not reflect mechanical properties in early-stage arthrosis","volume":"72","author":"Ding","year":"2001","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.bone.2008.07.254_bib22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s001980050179","article-title":"Fractal analysis of proximal femur radiographs: correlation with biomechanical properties and bone mineral density","volume":"9","author":"Lin","year":"1999","journal-title":"Osteoporos. Int."},{"issue":"Suppl 1","key":"10.1016\/j.bone.2008.07.254_bib23","first-page":"S127,32","article-title":"Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone","volume":"53","author":"Goldstein","year":"1993","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2008.07.254_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2106\/00004623-199703000-00016","article-title":"Age-related changes in the compressive strength of cancellous bone. The relative importance of changes in density and trabecular architecture","volume":"79","author":"McCalden","year":"1997","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2008.07.254_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1469-7580.2003.00193.x","article-title":"Nanomechanical properties and mineral concentration in articular calcified cartilage and subchondral bone","volume":"203","author":"Ferguson","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.bone.2008.07.254_bib26","first-page":"349","article-title":"Biochemical and mechanical properties of subchondral bone in osteoarthritis","volume":"41","author":"Bailey","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.bone.2008.07.254_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0021-9290(98)00176-6","article-title":"Accuracy of cancellous bone volume fraction measured by micro-CT scanning","volume":"32","author":"Ding","year":"1999","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2008.07.254_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S8756-3282(97)00007-0","article-title":"Three-dimensional methods for quantification of cancellous bone architecture","volume":"20","author":"Odgaard","year":"1997","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.07.254_bib29","first-page":"29","article-title":"Exercise at young age may influence the final quality of the equine musculoskeletal system","volume":"46","author":"van Weeren","year":"2000","journal-title":"AAEP Proceedings"},{"key":"10.1016\/j.bone.2008.07.254_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/tvjl.2001.0570","article-title":"Training affects the collagen framework of subchondral bone in foals","volume":"162","author":"Brama","year":"2001","journal-title":"Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2746\/042516402776767150","article-title":"Biochemical development of subchondral bone from birth until age eleven months and the influence of physical activity","volume":"34","author":"Brama","year":"2002","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2746\/0425164054530678","article-title":"Study of cartilage and bone layers of the bearing surface of the equine metacarpophalangeal joint relative to different timescales of maturation","volume":"37","author":"van der Harst","year":"2005","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib33","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.joca.2004.05.004","article-title":"An integral biochemical analysis of the main constituents of articular cartilage, subchondral and trabecular bone","volume":"12","author":"van der Harst","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2008.07.254_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.2042-3306.1999.tb05318.x","article-title":"Influence of exercise on bone mineral density of immature cortical and trabecular bone of the equine metacarpus and proximal sesamoid bone","volume":"31","author":"Cornelissen","year":"1999","journal-title":"Equine Vet. J. Suppl."},{"key":"10.1016\/j.bone.2008.07.254_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.2042-3306.1999.tb05317.x","article-title":"Effect of age, exercise and growth rate on bone mineral density (BMD) in third carpal bone and distal radius of Dutch Warmblood foals with osteochondrosis","volume":"31","author":"Firth","year":"1999","journal-title":"Equine Vet. J. Suppl."},{"key":"10.1016\/j.bone.2008.07.254_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/PL00010638","article-title":"Regular joint loading in youth assists in the establishing and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis","volume":"18","author":"Helminen","year":"2000","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2008.07.254_bib37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.2042-3306.1999.tb05307.x","article-title":"Study design to evaluate the influence of exercise on the development of the musculoskeletal system of foals up to age 11 months","volume":"31","author":"Van Weeren","year":"1999","journal-title":"Equine Vet. J. Suppl."},{"key":"10.1016\/j.bone.2008.07.254_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2746\/042516408X268923","article-title":"Evaluation of a new strategy to modulate skeletal development in the equine athlete by imposing track-based exercise during growth","volume":"40","author":"Rogers","year":"2008","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib39","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2460\/ajvr.67.7.1212","article-title":"Quantification of spontaneous locomotion activity in Warmblood foals kept in pastures under various management conditions","volume":"67","author":"Kurvers","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/ard.55.4.253","article-title":"Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy","volume":"55","author":"Arokoski","year":"1996","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2008.07.254_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/A:1020802631968","article-title":"Specimen preparation and quantification of collagen birefringence in unstained sections of articular cartilage using image analysis and polarizing light microscopy","volume":"29","author":"Kiraly","year":"1997","journal-title":"Histochem. J."},{"key":"10.1016\/j.bone.2008.07.254_bib42","article-title":"Practical considerations in the use of polarized light microscopy in the analysis of the collagen network in articular cartilage","author":"Rieppo","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bone.2008.07.254_bib43","series-title":"Polarized light: Fundamentals and Applications","first-page":"1","author":"Collet","year":"1992"},{"key":"10.1016\/j.bone.2008.07.254_bib44","series-title":"Polarized Light in Optics and Spectroscopy","first-page":"1","author":"Kliger","year":"1950"},{"key":"10.1016\/j.bone.2008.07.254_bib45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2746\/042516400776563626","article-title":"Functional adaptation of equine articular cartilage: the formation of regional biochemical characteristics up to age one year","volume":"32","author":"Brama","year":"2000","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib46","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2746\/0425164054223769","article-title":"Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis","volume":"37","author":"Brommer","year":"2005","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib47","first-page":"145","article-title":"Subchondral bone and articular cartilage responses to long distance running training (40\u00a0km per day) in the beagle knee joint","volume":"1","author":"Oettmeier","year":"1992","journal-title":"Eur. J. Exp. Musculoskel. Res."},{"key":"10.1016\/j.bone.2008.07.254_bib48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.2042-3306.1992.tb02813.x","article-title":"Ultrasound speed in the metacarpal cortex\u2014a survey of 347 thoroughbreds in training","volume":"24","author":"Buckingham","year":"1992","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0007-1935(17)43651-7","article-title":"A review of studies on the growth rate of the horse","volume":"117","author":"Green","year":"1961","journal-title":"Br. Vet. J."},{"key":"10.1016\/j.bone.2008.07.254_bib50","series-title":"Osteoarthritis. A companion to rheumatology","first-page":"15","article-title":"The role of subchondral bone in osteoarthritis","author":"Martel-Pelletier","year":"2007"},{"key":"10.1016\/j.bone.2008.07.254_bib51","first-page":"183","article-title":"The influence of exercise on the composition of developing equine joints","volume":"39","author":"van de Lest","year":"2002","journal-title":"Biorheology"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208005966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208005966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:36:39Z","timestamp":1762659399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328208005966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S8756328208005966"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.07.254","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in subchondral bone mineral density and collagen matrix organization in growing horses","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2008.07.254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}