{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:20:16Z","timestamp":1791040816148,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.bone.2008.11.004","type":"journal-article","created":{"date-parts":[[2008,11,22]],"date-time":"2008-11-22T10:47:57Z","timestamp":1227350877000},"page":"413-417","source":"Crossref","is-referenced-by-count":41,"title":["Vertebral fractures are associated with increased cortical porosity in iliac crest bone biopsy of men with idiopathic osteoporosis"],"prefix":"10.1016","volume":"44","author":[{"given":"Agn\u00e8s","family":"Ostertag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Cohen-Solal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Audran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Legrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Marty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chappard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"de Vernejoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.11.004_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2008.11.004_bib2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/jbmr.2002.17.6.1051","article-title":"The incidence of vertebral fractures in men and women: the Rotterdam Study","volume":"17","author":"Van der Klift","year":"2002","journal-title":"J. Bone. Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/jbmr.5650110719","article-title":"The prevalence of vertebral deformity in European men and women: the European Vertebral Osteoporosis Study","volume":"11","author":"O'Neill","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib4","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s00198-005-1970-9","article-title":"Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study","volume":"16","author":"Szulc","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2008.11.004_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bone.2003.10.001","article-title":"Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study","volume":"34","author":"Schuit","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.berh.2005.07.004","article-title":"Determinants of skeletal fragility","volume":"19","author":"Bouxsein","year":"2005","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bone.2008.11.004_bib7","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","article-title":"Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss","volume":"72","author":"Parfitt","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2008.11.004_bib8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00003086-198702000-00038","article-title":"The microanatomy of trabecular bone loss in normal aging men and women","volume":"215","author":"Aaron","year":"1987","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1359\/JBMR.050916","article-title":"Effects of sex and age on bone microstructure at the ultradistal radius: a population-based non invasive in vivo assessment","volume":"21","author":"Khosla","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib10","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1359\/jbmr.2001.16.12.2276","article-title":"The biomechanical basis of vertebral body fragility in men and women","volume":"16","author":"Duan","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0169-6009(90)90061-J","article-title":"A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects","volume":"11","author":"Kimmel","year":"1990","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1359\/jbmr.061206","article-title":"Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study","volume":"23","author":"Sornay-Rendu","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1359\/jbmr.2000.15.1.13","article-title":"Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis","volume":"15","author":"Legrand","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib14","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1359\/jbmr.2000.15.7.1368","article-title":"Bone structure in patients with low bone mineral density with or without vertebral fractures","volume":"15","author":"Oleksik","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib15","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1359\/jbmr.060801","article-title":"Independent and combined contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women","volume":"21","author":"Qiu","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib16","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1210\/jc.84.10.3431","article-title":"Osteoporosis in men","volume":"84","author":"Bilezikian","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2008.11.004_bib17","first-page":"281","article-title":"Bone mastocytosis. A report of nine cases with a bone histomorphometric study","volume":"279","author":"de Gennes","year":"1992","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib18","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S8756-3282(02)00875-X","article-title":"A potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men","volume":"31","author":"Brumsen","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/8756-3282(90)90208-G","article-title":"Star volume of marrow space and trabeculae in iliac crest: sampling procedure and correlation to star volume of first lumbar vertebra","volume":"11","author":"Vesterby","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/8756-3282(93)90092-O","article-title":"Age- and sex-related changes in iliac cortical bone mass and remodeling","volume":"14","author":"Brockstedt","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib22","series-title":"Generalized linear models","author":"McCullagh","year":"1989"},{"key":"10.1016\/j.bone.2008.11.004_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF01623379","article-title":"Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine","volume":"3","author":"Dempster","year":"1993","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2008.11.004_bib24","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S8756-3282(01)00702-5","article-title":"Predicting human vertebral bone strength by vertebral static histomorphometry","volume":"30","author":"Thomsen","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib25","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1359\/jbmr.1998.13.8.1213","article-title":"A structural approach to renal bone disease","volume":"13","author":"Parfitt","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/jbmr.5650110516","article-title":"Altered trabecular architecture induced by corticosteroids: a bone histomorphometric study","volume":"11","author":"Chappard","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jemt.20501","article-title":"Trabecular bone microarchitecture is related to the number of risk factors and etiology in osteoporotic men","volume":"70","author":"Legrand","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bone.2008.11.004_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S8756-3282(99)00117-9","article-title":"The structural basis of bone fragility in men","volume":"25","author":"Seeman","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00198-006-0254-3","article-title":"Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study","volume":"18","author":"Szulc","year":"2007","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2008.11.004_bib30","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1359\/jbmr.040916","article-title":"Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites","volume":"19","author":"Riggs","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1359\/jbmr.2006.21.2.307","article-title":"Cortical and trabecular load sharing in the human vertebral body","volume":"21","author":"Eswaran","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0021-9290(88)90186-8","article-title":"Stiffness of compact bone: effects of porosity and density","volume":"21","author":"Schaffler","year":"1988","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2008.11.004_bib33","first-page":"193","article-title":"Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure","volume":"751","author":"McCalden","year":"1993","journal-title":"J. Bone. Joint. Surg. Am."},{"key":"10.1016\/j.bone.2008.11.004_bib34","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2008.11.004_bib35","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1359\/jbmr.2001.16.7.1308","article-title":"Distribution of intracortical porosity in human midfemoral cortex by age and gender","volume":"16","author":"Bousson","year":"2001","journal-title":"J. Bone. Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1469-7580.2006.00589.x","article-title":"Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone","volume":"209","author":"Thomas","year":"2006","journal-title":"J. Anat."},{"key":"10.1016\/j.bone.2008.11.004_bib37","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1359\/jbmr.040124","article-title":"Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiation","volume":"19","author":"Bousson","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.11.004_bib38","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.bone.2006.11.011","article-title":"Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft","volume":"40","author":"Cooper","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.11.004_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S8756-3282(98)00143-4","article-title":"Regional differences in cortical porosity in the fractured femoral neck","volume":"24","author":"Bell","year":"1999","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208009010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208009010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T08:08:38Z","timestamp":1684656518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328208009010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S8756328208009010"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.11.004","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}