{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:12:06Z","timestamp":1791072726721,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.bone.2008.12.011","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T05:41:37Z","timestamp":1230183697000},"page":"936-941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia: A novel role of oxidative stress and therapeutic implications"],"prefix":"10.1016","volume":"44","author":[{"given":"Yasuhiro","family":"Hamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Yodoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.12.011_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02556109","article-title":"Diabetic bone disease","volume":"49","author":"Bouillon","year":"1991","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2008.12.011_bib2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s001250051248","article-title":"Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey","volume":"42","author":"Forsen","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.bone.2008.12.011_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00003086-197201000-00017","article-title":"Does diabetes delay fracture healing?","volume":"82","author":"Cozen","year":"1972","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2008.12.011_bib4","first-page":"63","article-title":"Diabetes mellitus and healing of closed fractures","volume":"18","author":"Herskind","year":"1992","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.bone.2008.12.011_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diab.44.7.775","article-title":"Bone loss and bone turnover in diabetes","volume":"44","author":"Krakauer","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2008.12.011_bib6","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2337\/diabetes.54.10.2875","article-title":"Bone formation is impaired in a model of type 1 diabetes","volume":"54","author":"Thrailkill","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2008.12.011_bib7","first-page":"1194","article-title":"Influence of age, sex, and insulin on osteoblast function: osteoblast dysfunction in diabetes mellitus","volume":"80","author":"Bouillon","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2008.12.011_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.med.46.1.223","article-title":"Advanced protein glycosylation in diabetes and aging","volume":"46","author":"Brownlee","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bone.2008.12.011_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1523-1755.2001.00788.x","article-title":"Aldose reductase expression is induced by hyperglycemia in diabetic nephropathy","volume":"60","author":"Hodgkinson","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2008.12.011_bib10","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2337\/diabetes.49.11.1939","article-title":"High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells","volume":"49","author":"Inoguchi","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2008.12.011_bib11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bone.2008.12.011_bib12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bone.2008.12.011_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0891-5849(01)00610-4","article-title":"Oxidative stress modulates osteoblastic differentiation of vascular and bone cells","volume":"31","author":"Mody","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bone.2008.12.011_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2008.12.011_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1196\/annals.1338.038","article-title":"2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation","volume":"1042","author":"Chen","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bone.2008.12.011_bib16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bone.2006.02.062","article-title":"Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: the effects of glutamate and protection by purines","volume":"39","author":"Fatokun","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.12.011_bib17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bone.2006.12.057","article-title":"Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress","volume":"40","author":"Hamada","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.12.011_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bone.2007.10.007","article-title":"Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats","volume":"42","author":"Fujii","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.12.011_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.immunol.15.1.351","article-title":"Redox regulation of cellular activation","volume":"15","author":"Nakamura","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bone.2008.12.011_bib20","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1073\/pnas.96.7.4131","article-title":"Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage","volume":"96","author":"Takagi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2008.12.011_bib21","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1046\/j.1523-1755.2003.00224.x","article-title":"Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia\/reperfusion injury","volume":"64","author":"Kasuno","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2008.12.011_bib22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/01.CIR.0000027817.55925.B4","article-title":"Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity","volume":"106","author":"Shioji","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2008.12.011_bib23","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/ndt\/gfm099","article-title":"Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy","volume":"22","author":"Hamada","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2008.12.011_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.12.011_bib25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1172\/JCI114485","article-title":"Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo","volume":"85","author":"Garrett","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2008.12.011_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/8756-3282(96)00177-9","article-title":"Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae","volume":"19","author":"Fraser","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.12.011_bib27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0304-4165(93)90116-P","article-title":"Participation of oxidative stress in the process of osteoclast differentiation","volume":"1157","author":"Suda","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bone.2008.12.011_bib28","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/(SICI)1097-4652(199809)176:3<574::AID-JCP14>3.0.CO;2-#","article-title":"Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells","volume":"176","author":"Steinbeck","year":"1998","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2008.12.011_bib29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbrc.2004.07.035","article-title":"Thioredoxin-1 mediates osteoclast stimulation by reactive oxygen species","volume":"321","author":"Lean","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2008.12.011_bib30","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1359\/jbmr.040913","article-title":"Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling","volume":"19","author":"Aitken","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2008.12.011_bib31","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","article-title":"Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2008.12.011_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00774-006-0719-7","article-title":"The kidney and bone metabolism: Nephrologists' point of view","volume":"24","author":"Fukagawa","year":"2006","journal-title":"J. Bone Miner. Metab."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208009496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208009496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:33:48Z","timestamp":1757612028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328208009496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S8756328208009496"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.12.011","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia: A novel role of oxidative stress and therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2008.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}