{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:05:57Z","timestamp":1791248757893,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["11557202"],"award-info":[{"award-number":["11557202"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["19790585"],"award-info":[{"award-number":["19790585"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.bone.2009.02.003","type":"journal-article","created":{"date-parts":[[2009,2,14]],"date-time":"2009-02-14T10:11:32Z","timestamp":1234606292000},"page":"S2-S7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"S1","title":["The roles of Na\/Pi-II transporters in phosphate metabolism"],"prefix":"10.1016","volume":"45","author":[{"given":"Hiroko","family":"Segawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumito","family":"Aranami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tomoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2009.02.003_bib1","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","author":"Beck","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2009.02.003_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1086\/499409","article-title":"SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis","volume":"78","author":"Bergwitz","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2009.02.003_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00232-005-0738-7","article-title":"Protein\/protein interactions (PDZ) in proximal tubules","volume":"203","author":"Biber","year":"2005","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bone.2009.02.003_bib4","unstructured":"Biber J, Hernando N, Forster I, Murer H. Regulation of phosphate transport in proximal tubules. Pflugers Arch, in press. DOI 10.1007\/s00424-008-0580-8."},{"key":"10.1016\/j.bone.2009.02.003_bib5","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1073\/pnas.91.17.8205","article-title":"Electrophysiological analysis of Na+\/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes","volume":"91","author":"Busch","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2009.02.003_bib6","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1681\/ASN.2005060663","article-title":"Control of hyperphosphatemia among patients with ESRD","volume":"2","author":"Coladonato","year":"2005","journal-title":"J. Am. Soc. Nephrol. Suppl."},{"key":"10.1016\/j.bone.2009.02.003_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00424-003-1088-x","article-title":"The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors","volume":"447","author":"Collins","year":"2004","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib8","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ng1905","article-title":"Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism","volume":"38","author":"Feng","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2009.02.003_bib9","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1074\/jbc.M008745200","article-title":"Interaction of the type IIa Na\/Pi cotransporter with PDZ proteins","volume":"276","author":"Gisler","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2009.02.003_bib10","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1210\/jc.2005-2840","article-title":"Intronic deletions in the SLC34A3 gene cause hereditary hypophosphatemic rickets with hypercalciuria","volume":"91","author":"Ichikawa","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2009.02.003_bib11","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj20031223","article-title":"Interaction of a farnesylated protein with renal type IIa Na\/Pi co-transporter in response to parathyroid hormone and dietary phosphate","volume":"377","author":"Ito","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2009.02.003_bib12","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1152\/ajprenal.00090.2008","article-title":"A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc","volume":"295","author":"Jaureguiberry","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1681\/ASN.V123507","article-title":"Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na\/Pi cotransporter NPT2 gene","volume":"12","author":"Jones","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2009.02.003_bib14","doi-asserted-by":"crossref","first-page":"27930","DOI":"10.1074\/jbc.M303210200","article-title":"Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule","volume":"278","author":"Jutabha","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2009.02.003_bib15","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJMoa0802836","article-title":"NHERF1 mutations and responsiveness of renal parathyroid hormone","volume":"359","author":"Karim","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2009.02.003_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/oxfordjournals.jbchem.a021569","article-title":"Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter (NaP(i)-2) in rat kidney","volume":"121","author":"Katai","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.bone.2009.02.003_bib17","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1073\/pnas.91.15.7071","article-title":"Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters","volume":"91","author":"Kavanaugh","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2009.02.003_bib18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1046\/j.1523-1755.1998.00115.x","article-title":"Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na\/Pi-cotransporter type II","volume":"54","author":"Keusch","year":"1998","journal-title":"Kidney. Int."},{"key":"10.1016\/j.bone.2009.02.003_bib19","doi-asserted-by":"crossref","unstructured":"Kremke B, Bergwitz C, Ahrens W, Sch\u00fctt S, Schumacher M, Wagner V, Holterhus PM, J\u00fcppner H, Hiort O. Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3\/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications. Exp Clin Endocrinol Diabetes 2008; 117:49--56.","DOI":"10.1055\/s-2008-1076716"},{"key":"10.1016\/j.bone.2009.02.003_bib20","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/ng1868","article-title":"DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis","volume":"38","author":"Lorenz-Depiereux","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2009.02.003_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1086\/499410","article-title":"Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3","volume":"78","author":"Lorenz-Depiereux","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2009.02.003_bib22","first-page":"402","article-title":"Segment-specific expression of sodium-phosphate cotransporters NaPi-IIa and -IIc and interacting proteins in mouse renal proximal tubules","volume":"448","author":"Madjdpour","year":"2004","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib23","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1073\/pnas.90.13.5979","article-title":"Expression cloning of human and rat renal cortex Na\/Pi cotransport","volume":"90","author":"Magagnin","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2009.02.003_bib24","doi-asserted-by":"crossref","first-page":"C1042","DOI":"10.1152\/ajpcell.00568.2004","article-title":"Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells","volume":"289","author":"McWilliams","year":"2005","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000107069","article-title":"New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter","volume":"27","author":"Miyamoto","year":"2007","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.bone.2009.02.003_bib26","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/physrev.2000.80.4.1373","article-title":"Proximal tubular phosphate reabsorption: molecular mechanisms","volume":"80","author":"Murer","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2009.02.003_bib27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00424-003-1072-5","article-title":"The sodium phosphate cotransporter family SLC34","volume":"447","author":"Murer","year":"2004","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib28","first-page":"119","article-title":"Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus","volume":"1","author":"O'Hara","year":"1990","journal-title":"Cell. Growth. Differ."},{"key":"10.1016\/j.bone.2009.02.003_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00424-003-1010-6","article-title":"Cloning, gene structure and dietary regulation of the type-IIc Na\/Pi cotransporter in the mouse kidney","volume":"446","author":"Ohkido","year":"2003","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib30","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1210\/en.2005-0777","article-title":"Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice","volume":"146","author":"Perwad","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2009.02.003_bib31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJMoa020028","article-title":"Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter","volume":"347","author":"Prie","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2009.02.003_bib32","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1074\/jbc.M200943200","article-title":"Growth-related renal type II Na\/Pi cotransporter","volume":"277","author":"Segawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2009.02.003_bib33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00424-003-1084-1","article-title":"Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na\/Pi transporter","volume":"446","author":"Segawa","year":"2003","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib34","doi-asserted-by":"crossref","first-page":"F587","DOI":"10.1152\/ajprenal.00097.2004","article-title":"Internalization of renal type IIc Na-Pi cotransporter in response to a high-phosphate diet","volume":"288","author":"Segawa","year":"2005","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib35","doi-asserted-by":"crossref","first-page":"F395","DOI":"10.1152\/ajprenal.00100.2006","article-title":"Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter","volume":"292","author":"Segawa","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib36","doi-asserted-by":"crossref","unstructured":"Segawa Hiroko, Onitsuka Akemi, Kuwahata Masashi, Hanabusa Etsuyo, Furutani Junya, Kaneko Ichiro, Matsumoto Natsuki, Ito Mikiko, Matsumoto Mitsuru, Li Minqi, Amizuka Norio, Miyamoto Ken-ichi. Type IIc sodium-dependent phosphate transporter regulates calcium metabolism. J Am Soc Nephrol 2008;20:104\u2013113.","DOI":"10.1681\/ASN.2008020177"},{"key":"10.1016\/j.bone.2009.02.003_bib37","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1210\/endo.139.4.5925","article-title":"Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands","volume":"139","author":"Tatsumi","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2009.02.003_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.nutr.25.050304.092642","article-title":"Regulation of phosphorus homeostasis by the type iia na\/phosphate cotransporter","volume":"25","author":"Tenenhouse","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bone.2009.02.003_bib39","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00424-002-0865-2","article-title":"Na\/P(i) cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2","volume":"444","author":"Tenenhouse","year":"2002","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.bone.2009.02.003_bib40","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jsbmb.2006.12.090","article-title":"Phosphate transport: molecular basis, regulation and pathophysiology","volume":"103","author":"Tenenhouse","year":"2007","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2009.02.003_bib41","doi-asserted-by":"crossref","first-page":"F148","DOI":"10.1152\/ajprenal.2000.278.1.F148","article-title":"Internalization of proximal tubular type II Na-P(i) cotransporter by PTH: immunogold electron microscopy","volume":"278","author":"Traebert","year":"2000","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib42","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/bbrc.2000.2407","article-title":"p-Aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1","volume":"270","author":"Uchino","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2009.02.003_bib43","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1128\/AAC.44.3.574-577.2000","article-title":"Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1","volume":"44","author":"Uchino","year":"2000","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.bone.2009.02.003_bib44","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/sj.ki.5002703","article-title":"Interactions of the growth-related, type IIc renal sodium\/phosphate cotransporter with PDZ proteins","volume":"73","author":"Villa-Bellosta","year":"2008","journal-title":"Kidney. Int."},{"key":"10.1016\/j.bone.2009.02.003_bib45","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1359\/jbmr.2003.18.12.2135","article-title":"Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa","volume":"18","author":"Virkki","year":"2003","journal-title":"J. Bone. Miner. Res."},{"key":"10.1016\/j.bone.2009.02.003_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1113\/jphysiol.2005.086777","article-title":"The role of NHERF-1 in the regulation of renal proximal tubule sodium\u2013hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a","volume":"567","author":"Weinman","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.bone.2009.02.003_bib47","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0022-3565(24)37735-3","article-title":"Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1","volume":"286","author":"Yabuuchi","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bone.2009.02.003_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00774-007-0776-6","article-title":"Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function","volume":"25","author":"Yamamoto","year":"2007","journal-title":"J. Bone. Miner. Metab."},{"key":"10.1016\/j.bone.2009.02.003_bib49","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1210\/endo.141.6.7484","article-title":"Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport","volume":"141","author":"Zhao","year":"2000","journal-title":"Endocrinology"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820900444X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820900444X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:34:18Z","timestamp":1757612058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632820900444X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":49,"alternative-id":["S875632820900444X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2009.02.003","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The roles of Na\/Pi-II transporters in phosphate metabolism","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2009.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}