{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:54:36Z","timestamp":1791258876338,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.bone.2009.05.017","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T17:42:47Z","timestamp":1243618967000},"page":"414-422","source":"Crossref","is-referenced-by-count":36,"title":["Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints"],"prefix":"10.1016","volume":"45","author":[{"given":"Kathryn S.","family":"Stok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadi","family":"Pelled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Zilberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Kallai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Goldhahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2009.05.017_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0049-0172(90)90081-P","article-title":"Osteoarthritis research: animal models","volume":"19","author":"Altman","year":"1990","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bone.2009.05.017_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0140-6736(97)07226-7","article-title":"Osteoarthritis","volume":"350","author":"Creamer","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2009.05.017_bib3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1056\/NEJMcp051726","article-title":"Clinical practice. Osteoarthritis of the knee","volume":"354","author":"Felson","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2009.05.017_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/bmj.332.7542.639","article-title":"Osteoarthritis","volume":"332","author":"Hunter","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.bone.2009.05.017_bib5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/art.1780380706","article-title":"Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group","volume":"38","author":"Nevitt","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2009.05.017_bib6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S8756-3282(02)00982-1","article-title":"Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans","volume":"32","author":"Bobinac","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.05.017_bib7","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1249\/00005768-199412000-00003","article-title":"Pathomechanics of knee osteoarthritis","volume":"26","author":"Martin","year":"1994","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2009.05.017_bib8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1063-4584(97)80034-9","article-title":"Chondrocyte cytokine and growth factor expression in murine osteoarthritis","volume":"5","author":"Chambers","year":"1997","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/joca.2001.0481","article-title":"Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints","volume":"10","author":"Chambers","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib10","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1053\/joca.2002.0818","article-title":"Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR\/ort model of osteoarthritis","volume":"10","author":"Flannelly","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1063-4584(97)80018-0","article-title":"Elevated aggrecan mRNA in early murine osteoarthritis","volume":"5","author":"Gaffen","year":"1997","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib12","first-page":"49","article-title":"IL-18 drives cartilage destruction in murine osteoarthritis","author":"Joosten","year":"2003","journal-title":"Trans. Orthop. Res. Soc."},{"key":"10.1016\/j.bone.2009.05.017_bib13","first-page":"118","article-title":"Natural history of degenerative joint disease in small laboratory animals. I. Pathological anatomy of degenerative joint disease in mice","volume":"62","author":"Sokoloff","year":"1956","journal-title":"AMA. Arch. Pathol."},{"key":"10.1016\/j.bone.2009.05.017_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/path.1711230206","article-title":"Degenerative joint disease in the mouse knee; radiological and morphological observations","volume":"123","author":"Walton","year":"1977","journal-title":"J. Pathol."},{"key":"10.1016\/j.bone.2009.05.017_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/joca.2001.0500","article-title":"Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR\/ort model of osteoarthritis and in collagen-induced arthritis","volume":"10","author":"Price","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1063-4584(05)80042-1","article-title":"Articular cartilage proteoglycans in osteoarthritic STR\/Ort mice","volume":"3","author":"Gaffen","year":"1995","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.joca.2003.10.006","article-title":"Chondrocyte death during murine osteoarthritis","volume":"12","author":"Mistry","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/joca.2000.0363","article-title":"The STR\/ort mouse and its use as a model of osteoarthritis","volume":"9","author":"Mason","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.10066","article-title":"Formalization of the MESF unit of fluorescence intensity","volume":"57B","author":"Schwartz","year":"2004","journal-title":"Cytom. Part. B-Clin. Cy."},{"key":"10.1016\/j.bone.2009.05.017_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bone.2007.05.018","article-title":"Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models","volume":"41","author":"Kohler","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.05.017_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1109\/TSMC.1979.4310204","article-title":"Picture thresholding using an iterative selection method \u2014 comments","volume":"9","author":"Trussell","year":"1979","journal-title":"IEEE. T. Syst. Man. Cyb."},{"key":"10.1016\/j.bone.2009.05.017_bib22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2009.05.017_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00223-005-0039-2","article-title":"Compartmental bone morphometry in the mouse femur: reproducibility and resolution dependence of microtomographic measurements","volume":"77","author":"Kohler","year":"2005","journal-title":"Calcif. Tissue. Int."},{"key":"10.1016\/j.bone.2009.05.017_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/jemt.20713","article-title":"Morphometric characterisation of murine articular cartilage \u2014 novel application of confocal laser scanning microscopy","author":"Stok","year":"2009","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bone.2009.05.017_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1063-4584(05)80061-5","article-title":"Chondro-osseous metaplasia, bone density and patellar cartilage proteoglycan content in the osteoarthritis of STR\/ORT mice","volume":"2","author":"Collins","year":"1994","journal-title":"Osteoarthr. Cartil"},{"key":"10.1016\/j.bone.2009.05.017_bib26","series-title":"Design and analysis of experiments","author":"Montgomery","year":"1997"},{"key":"10.1016\/j.bone.2009.05.017_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s11926-001-0065-7","article-title":"Joint structure modification in osteoarthritis: development of SMOAD drugs","volume":"3","author":"Beary","year":"2001","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bone.2009.05.017_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/joca.2002.0861","article-title":"Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies","volume":"11","author":"Nalbant","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1359\/jbmr.2002.17.4.687","article-title":"Mechanical and architectural bone adaptation in early stage experimental osteoarthritis","volume":"17","author":"Boyd","year":"2002","journal-title":"J. Bone. Miner. Res."},{"key":"10.1016\/j.bone.2009.05.017_bib30","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/art.22797","article-title":"The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model","volume":"56","author":"Sondergaard","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2009.05.017_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2008.06.001","article-title":"The disease modifying osteoarthritis drug (DMOAD): is it in the horizon?","volume":"58","author":"Qvist","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bone.2009.05.017_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.joca.2008.01.014","article-title":"Should subchondral bone turnover be targeted when treating osteoarthritis?","volume":"16","author":"Karsdal","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2009.05.017_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0736-0266(02)00093-1","article-title":"MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens","volume":"21","author":"Patel","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2009.05.017_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.joca.2003.10.009","article-title":"Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee","volume":"12","author":"Lindsey","year":"2004","journal-title":"Osteoarthr. Cartil."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209016160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209016160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T07:57:44Z","timestamp":1545206264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328209016160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S8756328209016160"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2009.05.017","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}