{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:34:45Z","timestamp":1791023685168,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.bone.2009.09.028","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T08:21:04Z","timestamp":1254039664000},"page":"534-542","source":"Crossref","is-referenced-by-count":63,"title":["An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation"],"prefix":"10.1016","volume":"46","author":[{"given":"Sanjay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Matheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Marquis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice A.","family":"Vasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Stroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernal R.","family":"Vaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyking","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"DelMar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo M.","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Gowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingming","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore M.","family":"Danoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine A.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2009.09.028_bb0005","first-page":"7","article-title":"Incidence of fragility fractures","volume":"19","author":"Tarantino","year":"2007","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.bone.2009.09.028_bb0010","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1001\/archinte.163.18.2237","article-title":"Aging bone and osteoporosis: strategies for preventing fractures in the elderly","volume":"163","author":"Ettinger","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bone.2009.09.028_bb0015","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2009.09.028_bb0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bone.2007.08.043","article-title":"Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro","volume":"42","author":"Bonnelye","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.09.028_bb0025","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1365-2265.2008.03342.x","article-title":"No difference between strontium ranelate (SR) and calcium\/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial","volume":"70","author":"Anastasilakis","year":"2009","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.bone.2009.09.028_bb0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semarthrit.2006.04.001","article-title":"The effects of antifracture therapies on the components of bone strength: assessment of fracture risk today and in the future","volume":"36","author":"Davison","year":"2006","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bone.2009.09.028_bb0035","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.bone.2009.09.028_bb0040","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/jbmr.5650050911","article-title":"Human parathyroid hormone-(1\u201334) prevents bone loss and augments bone formation in sexually mature ovariectomized rats","volume":"5","author":"Liu","year":"1990","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2009.09.028_bb0045","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1210\/jc.2007-2781","article-title":"Randomized trial of once-weekly PTH(1\u201384) on bone mineral density and remodeling","volume":"93","author":"Black","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2009.09.028_bb0050","first-page":"659","article-title":"Effect of intermittent injection of recombinant human parathyroid hormone on bone histomorphometry of ovariectomized rats","volume":"23","author":"Zhang","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bone.2009.09.028_bb0055","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/endo-110-2-506","article-title":"Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration","volume":"110","author":"Tam","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2009.09.028_bb0060","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/bmj.280.6228.1340","article-title":"Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial","volume":"280","author":"Reeve","year":"1980","journal-title":"Br. Med. J."},{"key":"10.1016\/j.bone.2009.09.028_bb0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2165\/00002512-199915020-00005","article-title":"The bone-building action of the parathyroid hormone: implications for the treatment of osteoporosis","volume":"15","author":"Whitfield","year":"1999","journal-title":"Drugs Aging"},{"key":"10.1016\/j.bone.2009.09.028_bb0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1385\/ENDO:17:1:29","article-title":"Differential effects of intermittent and continuous administration of parathyroid hormone on bone histomorphometry and gene expression","volume":"17","author":"Lotinun","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.bone.2009.09.028_bb0075","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0002-9343(98)00418-5","article-title":"Physiology and pathophysiology of the extracellular calcium-sensing receptor","volume":"106","author":"Brown","year":"1999","journal-title":"Amer. J. Med."},{"key":"10.1016\/j.bone.2009.09.028_bb0080","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1172\/JCI9038","article-title":"Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats","volume":"105","author":"Gowen","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2009.09.028_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1677\/jme.0.0290015","article-title":"The search for calcium receptor antagonists (calcilytics)","volume":"29","author":"Nemeth","year":"2002","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bone.2009.09.028_bb0090","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.2174\/1381612023393387","article-title":"Pharmacological regulation of parathyroid hormone secretion","volume":"8","author":"Nemeth","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bone.2009.09.028_bb0095","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-3565(24)29333-2","article-title":"Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone","volume":"299","author":"Nemeth","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bone.2009.09.028_bb0100","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry nomenclature, symbols and units: report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2009.09.028_bb0105","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00774-004-0520-4","article-title":"Human parathyroid hormone (1\u201334) increases mass and structure of the cortical shell, with resultant increase in lumbar bone strength, in ovariectomized rats","volume":"22","author":"Arita","year":"2004","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2009.09.028_bb0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S8756-3282(00)00316-1","article-title":"Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1\u201334) therapy in women with severe osteoporosis","volume":"27","author":"Hodsman","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.09.028_bb0115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2007.08.041","article-title":"Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats","volume":"42","author":"Nozaka","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.09.028_bb0120","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S8756-3282(00)00350-1","article-title":"Daily transient decreases in plasma parathyroid hormone levels induced by the calcimimetic NPS R-568 slows the rate of bone loss but does not increase bone mass in ovariectomized rats","volume":"27","author":"Miller","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.09.028_bb0125","first-page":"S292","article-title":"Dose-dependent PTH effects in young, intact, female rats after 9\u00a0months of treatment","volume":"16","author":"Sato","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2009.09.028_bb0130","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1210\/endo.138.10.5440","article-title":"Biosynthetic human parathyroid hormone (1\u201334) effects on bone quality in aged ovariectomized rats","volume":"138","author":"Sato","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2009.09.028_bb0135","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI118224","article-title":"Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D","volume":"96","author":"Naveh-Many","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2009.09.028_bb0140","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1699-0463.1991.tb01306.x","article-title":"Parathyroid cell number and size in hypocalcemic young rats","volume":"99","author":"Wernerson","year":"1991","journal-title":"APMIS"},{"key":"10.1016\/j.bone.2009.09.028_bb0145","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00774-005-0656-x","article-title":"Secondary hyperparathyroidism as a palpable intrathyroid parathyroid gland in a patient with hypophosphatemic osteomalacia","volume":"24","author":"Su","year":"2006","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2009.09.028_bb0150","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archsurg.139.2.218","article-title":"Parathyroidectomy for tertiary hyperparathyroidism associated with X-linked dominant hypophosphatemic rickets","volume":"139","author":"Savio","year":"2004","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bone.2009.09.028_bb0155","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S8756-3282(03)00202-3","article-title":"Anabolic and catabolic bone effects of human parathyroid hormone (1\u201334) are predicted by duration of hormone exposure","volume":"33","author":"Frolik","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.09.028_bb0160","series-title":"Principles of bone biology","first-page":"1305","article-title":"Parathyroid hormone","author":"Hodsman","year":"2002"},{"key":"10.1016\/j.bone.2009.09.028_bb0165","first-page":"66","article-title":"[Parathyroid disorders and bone metabolism]","volume":"15","author":"Okazaki","year":"2005","journal-title":"Clin. Calcium"},{"key":"10.1016\/j.bone.2009.09.028_bb0170","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1345\/aph.1D353","article-title":"Teriparatide for severe osteoporosis","volume":"38","author":"Cappuzzo","year":"2004","journal-title":"Ann. Pharmacother."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209019371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209019371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:14:32Z","timestamp":1739358872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328209019371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S8756328209019371"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2009.09.028","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}