{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:09:26Z","timestamp":1773745766483,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01EB006834"],"award-info":[{"award-number":["R01EB006834"]}]},{"name":"NIH","award":["R01AR056246-01A1"],"award-info":[{"award-number":["R01AR056246-01A1"]}]},{"name":"Orthopaedic Research and Educational Foundation (OREF) Career Development Award","award":["04-023"],"award-info":[{"award-number":["04-023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bone.2009.10.032","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T07:14:47Z","timestamp":1257491687000},"page":"695-702","source":"Crossref","is-referenced-by-count":34,"title":["Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis"],"prefix":"10.1016","volume":"46","author":[{"given":"Sung Wook","family":"Seo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Minematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham D.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel K.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2009.10.032_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bone.2009.10.032_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003086-199203000-00003","article-title":"Mechanism and clinical significance of wear debris-induced osteolysis","volume":"276","author":"Amstutz","year":"1992","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2009.10.032_bib3","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: mechanisms and misconceptions","volume":"64","author":"Nair","year":"1996","journal-title":"Infect. Immun."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2009.10.032_bib4","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2009.10.032_bib5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2106\/00004623-199604000-00002","article-title":"Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages","volume":"78","author":"Hicks","year":"1996","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2009.10.032_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bone.2009.10.032_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bone.2009.10.032_bib8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/jbmr.5650060912","article-title":"Role of colony-stimulating factors in osteoclast development","volume":"6","author":"Takahashi","year":"1991","journal-title":"J. Bone Miner Res."},{"key":"10.1016\/j.bone.2009.10.032_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coi.2005.11.006","article-title":"Colony-stimulating factor-1 in immunity and inflammation","volume":"18","author":"Chitu","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bone.2009.10.032_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/cyto.1997.0249","article-title":"M-CSF: haematopoietic growth factor or inflammatory cytokine?","volume":"10","author":"Fixe","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.bone.2009.10.032_bib11","doi-asserted-by":"crossref","first-page":"C1686","DOI":"10.1152\/ajpcell.1998.274.6.C1686","article-title":"Inflammatory cytokines (IL-1alpha, TNF-alpha) and LPS modulate the Ca2+ signaling pathway in osteoblasts","volume":"274","author":"Tam","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bone.2009.10.032_bib12","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI11176","article-title":"TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2009.10.032_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL\u2013RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2009.10.032_bib14","first-page":"201","article-title":"The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts","volume":"83-A","author":"Vermes","year":"2000","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2009.10.032_bib15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bone.2003.10.006","article-title":"Metabolic activity of osteoblasts retrieved from osteoarthritic patients after stimulation with mediators involved in periprosthetic loosening","volume":"34","author":"Lavigne","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.10.032_bib16","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.lfs.2005.08.017","article-title":"Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts","volume":"78","author":"Tanaka","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.bone.2009.10.032_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/08916930701694717","article-title":"Review: immune cells and mediators of inflammatory arthritis","volume":"41","author":"Schett","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.bone.2009.10.032_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/ar1857","article-title":"Osteoclasts; culprits in inflammatory osteolysis","volume":"8","author":"Teitelbaum","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2009.10.032_bib19","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.4049\/jimmunol.166.5.3574","article-title":"Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors","volume":"166","author":"Kikuchi","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.bone.2009.10.032_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2006.10.010","article-title":"GATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae","volume":"4","author":"Elefteriou","year":"2006","journal-title":"Cell. Metab."},{"key":"10.1016\/j.bone.2009.10.032_bib21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","article-title":"Activated T lymphocytes support osteoclast formation in vitro","volume":"265","author":"Horwood","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2009.10.032_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat. Rev., Immunol."},{"key":"10.1016\/j.bone.2009.10.032_bib23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7150\/ijbs.5.182","article-title":"Association between apoptosis and CD4(+)\/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacement","volume":"5","author":"Landgraeber","year":"2009","journal-title":"Int. J. Biol. Sci."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209020006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209020006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T12:37:45Z","timestamp":1685191065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328209020006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S8756328209020006"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2009.10.032","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}