{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:43:52Z","timestamp":1789447432341,"version":"build-2803163510"},"reference-count":13,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Isaac & Rose Nassau Professorship of Orthopaedic Molecular Medicine","award":["R01-AR46831"],"award-info":[{"award-number":["R01-AR46831"]}]},{"name":"Isaac & Rose Nassau Professorship of Orthopaedic Molecular Medicine","award":["R01-AR41916"],"award-info":[{"award-number":["R01-AR41916"]}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bone.2009.11.001","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:38:58Z","timestamp":1257986338000},"page":"868-872","source":"Crossref","is-referenced-by-count":27,"title":["GNAS-associated disorders of cutaneous ossification: Two different clinical presentations"],"prefix":"10.1016","volume":"46","author":[{"given":"R.J.","family":"Schimmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.M.A.","family":"Pasmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.E.","family":"Stadhouders-Keet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Shore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.S.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2009.11.001_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2106\/00004623-199403000-00013","article-title":"Progressive osseous heteroplasia: a distinct developmental disorder of hetertopic ossification","volume":"76","author":"Kaplan","year":"1994","journal-title":"J. Bone Joint. Surg. Am."},{"key":"10.1016\/j.bone.2009.11.001_bib2","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1359\/jbmr.2000.15.11.2084","article-title":"Progressive osseous heteroplasia","volume":"15","author":"Kaplan","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2009.11.001_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bone.2008.05.013","article-title":"Insights form a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP)","volume":"43","author":"Shore","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2009.11.001_bib4","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/ajmg.a.32346","article-title":"Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification","volume":"146A","author":"Adegbite","year":"2008","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bone.2009.11.001_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJMoa011262","article-title":"Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia","volume":"346","author":"Shore","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2009.11.001_bib6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1302\/0301-620X.80B5.8626","article-title":"Progressive osseous heteroplasia: report of a family","volume":"80","author":"Urtizberea","year":"1998","journal-title":"J. Bone Joint. Surg. Br."},{"key":"10.1016\/j.bone.2009.11.001_bib7","first-page":"339","article-title":"Progressive osseous heteroplasia: a case report and review of the literature","volume":"B11","author":"Aynaci","year":"2002","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.bone.2009.11.001_bib8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/ajmg.a.31200","article-title":"Progressive osseous heteroplasia controlled by intravenous administration of Pamidronate","volume":"140A","author":"Hou","year":"2006","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bone.2009.11.001_bib9","article-title":"Madelung deformity: overview","author":"Lamberti","year":"2008","journal-title":"Emedicine"},{"key":"10.1016\/j.bone.2009.11.001_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1542\/peds.111.3.573","article-title":"Intravenous bisphosphonate therapy in children with osteogenesis imperfecta","volume":"11","author":"Falk","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.bone.2009.11.001_bib11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.sc.3101761","article-title":"Amino-bisphosphonates in heterotopic ossification: first experience in five consecutive cases","volume":"43","author":"Schuetz","year":"2005","journal-title":"Spinal Cord"},{"key":"10.1016\/j.bone.2009.11.001_bib12","first-page":"149","article-title":"Long-lasting effect of pamidronate on bone metabolism in osteoporosis after stopping therapy","volume":"1","author":"Devogelaer","year":"2000","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"1","key":"10.1016\/j.bone.2009.11.001_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.berh.2007.11.007","article-title":"Fibrodysplasia ossificans progressiva","volume":"22","author":"Kaplan","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209020134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328209020134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T07:29:43Z","timestamp":1544858983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328209020134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S8756328209020134"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2009.11.001","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}