{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:41:12Z","timestamp":1792712472739,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.bone.2010.05.023","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T08:18:19Z","timestamp":1274775499000},"page":"197-204","source":"Crossref","is-referenced-by-count":30,"title":["Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model"],"prefix":"10.1016","volume":"47","author":[{"given":"Haixiang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Shimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Balian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis H.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2010.05.023_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.spinee.2006.04.013","article-title":"Osteoporotic compression fractures of the spine; current options and considerations for treatment","volume":"6","author":"Kim","year":"2006","journal-title":"Spine J."},{"key":"10.1016\/j.bone.2010.05.023_bib2","article-title":"Long bone defect models for tissue engineering applications: criteria for choice","author":"Horner","year":"2009","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bone.2010.05.023_bib3","article-title":"Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate","author":"Shirasu","year":"2009","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bone.2010.05.023_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1600-0501.2008.01659.x","article-title":"Bone repair and augmentation using block of sintered bovine-derived anorganic bone graft in cranial bone defect model","volume":"20","author":"Cestari","year":"2009","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2010.05.023_bib5","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.biomaterials.2008.12.050","article-title":"The challenge of establishing preclinical models for segmental bone defect research","volume":"30","author":"Reichert","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2010.05.023_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.spinee.2006.01.014","article-title":"In vivo BMP-7 (OP-1) enhancement of osteoporotic vertebral bodies in an ovine model","volume":"6","author":"Phillips","year":"2006","journal-title":"Spine J."},{"key":"10.1016\/j.bone.2010.05.023_bib7","article-title":"Long-term evaluation of a calcium phosphate bone cement with carboxymethyl cellulose in a vertebral defect model","author":"Kobayashi","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bone.2010.05.023_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jbm.a.31056","article-title":"Histological evaluation of an impacted bone graft substitute composed of a combination of mineralized and demineralized allograft in a sheep vertebral bone defect","volume":"82","author":"Fujishiro","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bone.2010.05.023_bib9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.spinee.2006.12.007","article-title":"Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model","volume":"8","author":"Turner","year":"2008","journal-title":"Spine J."},{"key":"10.1016\/j.bone.2010.05.023_bib10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1148\/radiol.2472070808","article-title":"Heat distribution in the spinal canal during radiofrequency ablation for vertebral lesions: study in swine","volume":"247","author":"Adachi","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2010.05.023_bib11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1302\/0301-620X.80B5.8830","article-title":"Changes in the disc space after fractures of the thoracolumbar spine","volume":"80","author":"Oner","year":"1998","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.bone.2010.05.023_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s002560050542","article-title":"MRI findings of thoracolumbar spine fractures: a categorisation based on MRI examinations of 100 fractures","volume":"28","author":"Oner","year":"1999","journal-title":"Skeletal Radiol."},{"key":"10.1016\/j.bone.2010.05.023_bib13","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1016\/S0142-9612(03)00337-5","article-title":"Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein","volume":"24","author":"Yamamoto","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2010.05.023_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1163\/156856298X00550","article-title":"Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein","volume":"9","author":"Yamamoto","year":"1998","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.bone.2010.05.023_bib15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpharm.2004.01.040","article-title":"Controlled release of rhBMP-2 from collagen minipellet and the relationship between release profile and ectopic bone formation","volume":"275","author":"Maeda","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bone.2010.05.023_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1010-5182(98)80050-4","article-title":"Osteoinduction capability of recombinant human bone morphogenetic protein-2 in intramuscular and subcutaneous sites: an experimental study","volume":"26","author":"Yoshida","year":"1998","journal-title":"J. Craniomaxillofac. Surg."},{"key":"10.1016\/j.bone.2010.05.023_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1517\/14712598.4.5.741","article-title":"The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications","volume":"4","author":"Khan","year":"2004","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.bone.2010.05.023_bib18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00264-007-0418-6","article-title":"A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft)","volume":"31","author":"McKay","year":"2007","journal-title":"Int. Orthop."},{"key":"10.1016\/j.bone.2010.05.023_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1115\/1.429662","article-title":"Biological activity of rhBMP-2 released from PLGA microspheres","volume":"122","author":"Oldham","year":"2000","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.bone.2010.05.023_bib20","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1016\/j.biomaterials.2009.02.004","article-title":"The bioactivity of rhBMP-2 immobilized poly(lactide-co-glycolide) scaffolds","volume":"30","author":"Shen","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2010.05.023_bib21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00007632-199502001-00003","article-title":"An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics","volume":"20","author":"Boden","year":"1995","journal-title":"Spine"},{"key":"10.1016\/j.bone.2010.05.023_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jor.20024","article-title":"Modulation of endochondral development of the distal femoral condyle by mechanical loading","volume":"24","author":"Sundaramurthy","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2010.05.023_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/8756-3282(92)90364-3","article-title":"Characterization of cells with osteogenic potential from human marrow","volume":"13","author":"Haynesworth","year":"1992","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.05.023_bib24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00006534-199803000-00001","article-title":"Tissue engineered bone repair of calvarial defects using cultured periosteal cells","volume":"101","author":"Breitbart","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bone.2010.05.023_bib25","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.153.5.1133","article-title":"Circulating skeletal stem cells","volume":"153","author":"Kuznetsov","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2010.05.023_bib26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.orthres.2003.08.010","article-title":"Endochondral ossification in fracture callus during long bone repair: the localisation of 'cavity-lining cells' within the cartilage","volume":"22","author":"Ford","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2010.05.023_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jbm.10201","article-title":"The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies","volume":"61","author":"Borden","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bone.2010.05.023_bib28","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1302\/0301-620X.86B8.14267","article-title":"Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix","volume":"86","author":"Borden","year":"2004","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.bone.2010.05.023_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0142-9612(02)00374-5","article-title":"Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair","volume":"24","author":"Borden","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2010.05.023_bib30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.spinee.2006.03.006","article-title":"Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix","volume":"6","author":"Shen","year":"2006","journal-title":"Spine J."},{"key":"10.1016\/j.bone.2010.05.023_bib31","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/j.biomaterials.2008.04.031","article-title":"Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering","volume":"29","author":"Kempen","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2010.05.023_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2007.05.029","article-title":"Enhanced bone regeneration with BMP-2 loaded functional nanoparticle\u2013hydrogel complex","volume":"121","author":"Chung","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bone.2010.05.023_bib33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1163\/156856298X00307","article-title":"Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution","volume":"9","author":"Hong","year":"1998","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.bone.2010.05.023_bib34","first-page":"396","article-title":"Possibilities in the reconstruction of bone defects","volume":"23","author":"Baumgart","year":"1994","journal-title":"Orthopade"},{"key":"10.1016\/j.bone.2010.05.023_bib35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1210\/en.139.2.663","article-title":"Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research","volume":"139","author":"Aerssens","year":"1998","journal-title":"Endocrinology"},{"issue":"Suppl 2","key":"10.1016\/j.bone.2010.05.023_bib36","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1007\/s00198-005-1859-7","article-title":"Animal models for fracture treatment in osteoporosis","volume":"16","author":"Egermann","year":"2005","journal-title":"Osteoporos. Int."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210012561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210012561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T22:50:50Z","timestamp":1544482250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328210012561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S8756328210012561"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2010.05.023","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}