{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:19:56Z","timestamp":1778149196346,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.bone.2010.10.169","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T04:37:58Z","timestamp":1288327078000},"page":"496-506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats"],"prefix":"10.1016","volume":"48","author":[{"given":"Thomas","family":"Lind","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Monica","family":"Lind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annica","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Sundqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Risteli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Africa","family":"Yebra-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rodriguez-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Melhus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2010.10.169_bb0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1753-4887.2000.tb01848.x","article-title":"Hypervitaminosis A and bone","volume":"58","author":"Binkley","year":"2000","journal-title":"Nutr Rev"},{"key":"10.1016\/j.bone.2010.10.169_bb0010","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/neu.20242","article-title":"Overview of retinoid metabolism and function","volume":"66","author":"Blomhoff","year":"2006","journal-title":"J Neurobiol"},{"key":"10.1016\/j.bone.2010.10.169_bb0015","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.cell.2009.04.043","article-title":"Genomic antagonism between retinoic acid and estrogen signaling in breast cancer","volume":"137","author":"Hua","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bone.2010.10.169_bb0020","series-title":"Global prevalence of vitamin A deficiency in populations at risk 1995\u20132005","author":"WHO","year":"2009"},{"key":"10.1016\/j.bone.2010.10.169_bb0025","doi-asserted-by":"crossref","first-page":"770","DOI":"10.7326\/0003-4819-129-10-199811150-00003","article-title":"Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture","volume":"129","author":"Melhus","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bone.2010.10.169_bb0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1056\/NEJMoa021171","article-title":"Serum retinol levels and the risk of fracture","volume":"348","author":"Micha\u00eblsson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2010.10.169_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1753-4887.2007.tb00268.x","article-title":"Vitamin A: is it a risk factor for osteoporosis and bone fracture?","volume":"65","author":"Ribaya-Mercado","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1016\/j.bone.2010.10.169_bb0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1042\/bj0390222","article-title":"Hypervitaminosis A","volume":"39","author":"Moore","year":"1945","journal-title":"Biochem J"},{"key":"10.1016\/j.bone.2010.10.169_bb0045","first-page":"171","article-title":"Vitamin-A deficiency and excess in relation to skeletal growth","volume":"29","author":"Wolbach","year":"1947","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.bone.2010.10.169_bb0050","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0021-9258(18)91422-5","article-title":"Effects of hypervitaminosis A and D on skeletal metabolism","volume":"239","author":"Clark","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2010.10.169_bb0055","series-title":"Nutritional aspects of bone health, The Royal Society of Chemistry","first-page":"368","article-title":"Vitamin A and fracture risk","author":"Melhus","year":"2003"},{"key":"10.1016\/j.bone.2010.10.169_bb0060","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bone.2004.11.006","article-title":"Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents","volume":"36","author":"Kneissel","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.10.169_bb0065","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S8756-3282(02)00910-9","article-title":"Subclinical hypervitaminosis A causes fragile bones in rats","volume":"31","author":"Johansson","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.10.169_bb0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cbi.2005.10.104","article-title":"Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes","volume":"159","author":"Lind","year":"2006","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bone.2010.10.169_bb0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S8756-3282(98)00092-1","article-title":"Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin","volume":"23","author":"Boskey","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.10.169_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(00)00262-6","article-title":"Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3, 3\u2032, 4, 4\u2032, 5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C","volume":"151","author":"Lind","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.bone.2010.10.169_bb0085","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/clinchem\/39.4.635","article-title":"Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation","volume":"39","author":"Risteli","year":"1993","journal-title":"Clin Chem"},{"key":"10.1016\/j.bone.2010.10.169_bb0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/excr.2002.5612","article-title":"Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport","volume":"279","author":"Hollberg","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.bone.2010.10.169_bb0095","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bone.2008.01.019","article-title":"Osteoclast polarization is not required for degradation of bone matrix in rachitic FGF23 transgenic mice","volume":"42","author":"Hollberg","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.10.169_bb0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/bbrc.1995.1633","article-title":"Epitope mapping of a monoclonal antibody that blocks the binding of retinol-binding protein to its receptor","volume":"210","author":"Melhus","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2010.10.169_bb0105","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1074\/jbc.M700030200","article-title":"Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT\/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma","volume":"282","author":"Kang","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2010.10.169_bb0110","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1021\/es060769x","article-title":"Effect of in ovo exposure to PCBs and Hg on Clapper Rail bone mineral chemistry from a contaminated salt marsh in coastal Georgia","volume":"40","author":"Rodriguez-Navarro","year":"2006","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.bone.2010.10.169_bb0115","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1210\/endo-122-6-2933","article-title":"Effects of hypervitaminosis A on the bone and mineral metabolism of the rat","volume":"122","author":"Hough","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2010.10.169_bb0120","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2741\/1270","article-title":"Endothelial microparticles as markers of endothelial dysfunction","volume":"9","author":"Horstman","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.bone.2010.10.169_bb0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00774-007-0764-x","article-title":"A histological assessment on the distribution of the osteocytic lacunar canalicular system using silver staining","volume":"25","author":"Hirose","year":"2007","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bone.2010.10.169_bb0130","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1172\/JCI113257","article-title":"Hypercalcemia induced with an arotinoid in thyroparathyroidectomized rats. New model to study bone resorption in vivo","volume":"80","author":"Trechsel","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2010.10.169_bb0135","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-007-9091-4","article-title":"Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model","volume":"82","author":"Rissanen","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.10.169_bb0140","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00223-007-9101-6","article-title":"Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model","volume":"82","author":"Rissanen","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.10.169_bb0145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1358\/dot.2003.39.2.740211","article-title":"Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors","volume":"39","author":"Singer","year":"2003","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.bone.2010.10.169_bb0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1096\/fj.08-118976","article-title":"Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism","volume":"23","author":"Yakar","year":"2009","journal-title":"Faseb J"},{"key":"10.1016\/j.bone.2010.10.169_bb0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1359\/jbmr.090813","article-title":"Short term exposure to low-carbohydrate\/high fat diets induces low bone mineral density and reduces bone formation in rats","volume":"25","author":"Bielohuby","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2010.10.169_bb0160","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1042\/bj0630344","article-title":"Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats","volume":"63","author":"Nerurkar","year":"1956","journal-title":"Biochem J"},{"key":"10.1016\/j.bone.2010.10.169_bb0165","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1096\/fj.09-132548","article-title":"Retinoids inhibit differentiation of hematopoietic osteoclast progenitors","volume":"23","author":"Conaway","year":"2009","journal-title":"Faseb J"},{"key":"10.1016\/j.bone.2010.10.169_bb0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.200806139","article-title":"Identification of cell cycle-arrested quiescent osteoclast precursors in vivo","volume":"184","author":"Mizoguchi","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bone.2010.10.169_bb0175","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00310266","article-title":"Inhibitory effects of 9-cis and all-trans retinoic acid on 1,25 (OH)2 vitamin D3-induced bone resorption","volume":"57","author":"Kindmark","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.10.169_bb0180","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1113\/jphysiol.1952.sp004708","article-title":"The effect of hypervitaminosis A on embryonic limb bones cultivated in vitro","volume":"116","author":"Fell","year":"1952","journal-title":"J Physiol"},{"key":"10.1016\/j.bone.2010.10.169_bb0185","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1521-6926(03)00043-4","article-title":"Retinoic acid syndrome: manifestations, pathogenesis, and treatment","volume":"16","author":"Larson","year":"2003","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.bone.2010.10.169_bb0190","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1182\/blood.V99.6.2017","article-title":"Infant hypervitaminosis A causes severe anemia and thrombocytopenia: evidence of a retinol-dependent bone marrow cell growth inhibition","volume":"99","author":"Perrotta","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bone.2010.10.169_bb0195","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0925-5710(96)00578-6","article-title":"Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management","volume":"66","author":"Hatake","year":"1997","journal-title":"Int J Hematol"},{"key":"10.1016\/j.bone.2010.10.169_bb0200","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1182\/blood.V97.12.3919","article-title":"Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid","volume":"97","author":"Kini","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bone.2010.10.169_bb0205","first-page":"90","article-title":"Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome","volume":"95","author":"Tallman","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bone.2010.10.169_bb0210","first-page":"44","article-title":"Inhibition of angiogenesis through modulation of collagen metabolism","volume":"59","author":"Ingber","year":"1988","journal-title":"Lab Invest"},{"key":"10.1016\/j.bone.2010.10.169_bb0215","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bone.2010.10.169_bb0220","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1182\/blood-2003-09-3293","article-title":"Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells","volume":"104","author":"Suzuki","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bone.2010.10.169_bb0225","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrg2665","article-title":"Generating specificity and diversity in the transcriptional response to hypoxia","volume":"10","author":"Lendahl","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bone.2010.10.169_bb0230","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1172\/JCI31581","article-title":"The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development","volume":"117","author":"Wang","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2010.10.169_bb0235","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/jcp.s3-11.1.78","article-title":"Ischaemia of bone","volume":"11","author":"Catto","year":"1977","journal-title":"J Clin Pathol Suppl R Coll Pathol"},{"key":"10.1016\/j.bone.2010.10.169_bb0240","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00003086-200203000-00036","article-title":"Decreases in bone blood flow and bone material properties in aging Fischer-344 rats","volume":"396","author":"Bloomfield","year":"2002","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.bone.2010.10.169_bb0245","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00003086-199711000-00033","article-title":"Dysbaric osteonecrosis in divers and caisson workers. An animal model","volume":"344","author":"Lehner","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.bone.2010.10.169_bb0250","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/modpathol.3800747","article-title":"Cellular and molecular mechanisms of abnormal calcification following ischemia\u2013reperfusion injury in human liver transplantation","volume":"20","author":"Kalantari","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1016\/j.bone.2010.10.169_bb0255","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00223-002-0006-0","article-title":"Accuracy of peripheral quantitative computed tomography (pQCT) for assessing area and density of mouse cortical bone","volume":"73","author":"Brodt","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.10.169_bb0260","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/path.2534","article-title":"Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis","volume":"218","author":"Knowles","year":"2009","journal-title":"J Pathol"},{"key":"10.1016\/j.bone.2010.10.169_bb0265","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1074\/jbc.272.30.18538","article-title":"cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450","volume":"272","author":"White","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2010.10.169_bb0270","doi-asserted-by":"crossref","first-page":"7854","DOI":"10.1073\/pnas.92.17.7854","article-title":"Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types","volume":"92","author":"Taneja","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bone.2010.10.169_bb0275","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jcp.21973","article-title":"Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: involvement of MAPKs, NF-kappaB, and HIF-1alpha","volume":"222","author":"Lee","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bone.2010.10.169_bb0280","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-2275(20)36724-9","article-title":"Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat","volume":"16","author":"Mallia","year":"1975","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bone.2010.10.169_bb0285","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1056\/NEJM197604082941503","article-title":"Vitamin A transport in human vitamin A toxicity","volume":"294","author":"Smith","year":"1976","journal-title":"N Engl J Med"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210019873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210019873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:36:28Z","timestamp":1757612188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328210019873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S8756328210019873"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2010.10.169","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2010.10.169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}