{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:02Z","timestamp":1790934362883,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.bone.2010.12.020","type":"journal-article","created":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T09:45:37Z","timestamp":1293183937000},"page":"720-725","source":"Crossref","is-referenced-by-count":108,"title":["Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes"],"prefix":"10.1016","volume":"48","author":[{"given":"Ippei","family":"Kanazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitsugu","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2010.12.020_bb0005","first-page":"5","article-title":"Insulin and bone, clinical and scientific view","volume":"4","author":"Thomas","year":"1997","journal-title":"Endocrinol Metab North Am"},{"key":"10.1016\/j.bone.2010.12.020_bb0010","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1172\/JCI9017","article-title":"Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover","volume":"105","author":"Ogata","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2010.12.020_bb0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.200204046","article-title":"Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts","volume":"159","author":"Akune","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bone.2010.12.020_bb0020","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1210\/jc.2008-2187","article-title":"Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus","volume":"94","author":"Kanazawa","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/EJE-08-0642","article-title":"Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus","volume":"160","author":"Kanazawa","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bone.2010.12.020_bb0030","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1210\/jc.2006-2097","article-title":"Serum adiponectin and bone mineral density in women","volume":"92","author":"Richards","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2121-8-51","article-title":"Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells","volume":"8","author":"Kanazawa","year":"2007","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.bone.2010.12.020_bb0040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bone.2010.12.020_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/jc.2008-1455","article-title":"Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus","volume":"94","author":"Kanazawa","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00198-010-1184-7","article-title":"Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus","volume":"22","author":"Kanazawa","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2010.12.020_bb0055","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/jc.2008-0270","article-title":"The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training","volume":"94","author":"Fernandez-Real","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0060","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/dmrr.1045","article-title":"The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced \u03b2-cell function in middle-aged male subjects","volume":"25","author":"Hwang","year":"2009","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.bone.2010.12.020_bb0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2008-1422","article-title":"Association between serum osteocalcin and markers of metabolic phenotype","volume":"94","author":"Pittas","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2337\/dc09-1237","article-title":"Osteocalcin is related to enhanced insulin secretion in gestational diabetes mellitus","volume":"33","author":"Winhofer","year":"2010","journal-title":"Diab Care"},{"key":"10.1016\/j.bone.2010.12.020_bb0075","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1359\/jbmr.081234","article-title":"Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men","volume":"24","author":"Kindblom","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2010.12.020_bb0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2008.07.001","article-title":"Relationship between osteocalcin and glucose metabolism in postmenopausal women","volume":"396","author":"Im","year":"2008","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.bone.2010.12.020_bb0085","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3945\/ajcn.2009.28151","article-title":"\u03b3-Carboxylation of osteocalcin and insulin resistance in older men and women","volume":"90","author":"Shea","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.bone.2010.12.020_bb0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1530\/EJE-09-0585","article-title":"Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals","volume":"161","author":"Zhou","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bone.2010.12.020_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-002-1009-0","article-title":"The relative contributions of insuloin resistance and beta-cell dysfunction to the pathophysiology of type II diabetes","volume":"46","author":"Kahn","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.bone.2010.12.020_bb0100","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2337\/diacare.27.2.314","article-title":"Indexes of insulin resistance and secretion in obese children and adolescents: validation study","volume":"27","author":"Conwell","year":"2004","journal-title":"Diab Care"},{"key":"10.1016\/j.bone.2010.12.020_bb0105","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJMoa012578","article-title":"Prevalence of impaired glucose tolerance among children and adolescents with marked obesity","volume":"346","author":"Sinha","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2010.12.020_bb0110","first-page":"385","article-title":"Report of the Committee of Japan Diabetes Society on the classification and diagnostic criteria of diabetes mellitus","volume":"42","year":"1999","journal-title":"J Japan Diab Soc"},{"key":"10.1016\/j.bone.2010.12.020_bb0115","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bone.2010.12.020_bb0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2265.2005.02312.x","article-title":"The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men","volume":"63","author":"Oh","year":"2005","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.bone.2010.12.020_bb0125","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1074\/jbc.M311113200","article-title":"Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity","volume":"279","author":"Pajvani","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2010.12.020_bb0130","doi-asserted-by":"crossref","first-page":"40352","DOI":"10.1074\/jbc.M300365200","article-title":"Impaired multimerization of human adiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin","volume":"278","author":"Waki","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2010.12.020_bb0135","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2337\/diabetes.51.9.2734","article-title":"Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein","volume":"51","author":"Nishizawa","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2010.12.020_bb0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bone.2009.05.003","article-title":"Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes","volume":"45","author":"Yamaguchi","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2010.12.020_bb0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00223-010-9398-4","article-title":"Relationship between visceral adiposity and bone mineral density in Korean adults","volume":"87","author":"Choi","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.12.020_bb0150","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1002\/dme.1996.13.s6.7","article-title":"Overview of non-insulin-dependent diabetes mellitus (NIDDM) in different population groups","volume":"13","author":"Fujimoto","year":"1996","journal-title":"Diabet Med"},{"key":"10.1016\/j.bone.2010.12.020_bb0155","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2337\/diacare.27.2.354","article-title":"Ethnic differences in insulin sensitivity and beta-cell function in premenopaulsa or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN)","volume":"27","author":"Torrens","year":"2004","journal-title":"Diab Care"},{"key":"10.1016\/j.bone.2010.12.020_bb0160","first-page":"A29","article-title":"Osteocalcin is not just for bones: effects on adipocytes and role in human metabolism","volume":"57","author":"Vestri","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2010.12.020_bb0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2337\/dc09-1837","article-title":"Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children","volume":"33","author":"Prats-Puig","year":"2010","journal-title":"Diab Care"},{"key":"10.1016\/j.bone.2010.12.020_bb0170","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2006.10.008","article-title":"Convergence between bone and energy homeostases: leptin regulation of bone mass","volume":"4","author":"Karsenty","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.bone.2010.12.020_bb0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.exger.2010.09.014","article-title":"Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice","volume":"46","author":"Halade","year":"2011","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.bone.2010.12.020_bb0180","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00223-006-0155-7","article-title":"Insulin-like effects of visfatin on human osteoblasts","volume":"80","author":"Xie","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2010.12.020_bb0185","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcb.20915","article-title":"Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism","volume":"99","author":"Thommesen","year":"2006","journal-title":"J Cell Biochem"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210021174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328210021174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T08:56:57Z","timestamp":1559897817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328210021174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S8756328210021174"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2010.12.020","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}