{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:09:42Z","timestamp":1790978982285,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.bone.2011.03.720","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T03:44:13Z","timestamp":1300938253000},"page":"1388-1400","source":"Crossref","is-referenced-by-count":177,"title":["Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model"],"prefix":"10.1016","volume":"48","author":[{"given":"Yi-Xin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-zhen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wai","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong-Man","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leung-Kim","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Sui","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2011.03.720_bb0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0925-4773(99)00142-2","article-title":"Does adult fracture repair recapitulate embryonic skeletal formation?","volume":"87","author":"Ferguson","year":"1999","journal-title":"Mech Dev"},{"key":"10.1016\/j.bone.2011.03.720_bb0010","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"Einhorn","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0015","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1359\/jbmr.2003.18.9.1584","article-title":"Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption","volume":"18","author":"Gerstenfeld","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0020","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/00005131-200511101-00002","article-title":"The science of fracture healing","volume":"19","author":"Einhorn","year":"2005","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.bone.2011.03.720_bb0025","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1359\/jbmr.2001.16.6.1004","article-title":"Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing","volume":"16","author":"Kon","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0030","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bone.2007.07.022","article-title":"Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice","volume":"41","author":"Yang","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0035","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1242\/dev.00559","article-title":"Altered fracture repair in the absence of MMP9","volume":"130","author":"Colnot","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bone.2011.03.720_bb0040","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1359\/jbmr.2002.17.3.513","article-title":"Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing","volume":"17","author":"Cho","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0045","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.bbrc.2006.12.234","article-title":"Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice","volume":"354","author":"Kosaki","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2011.03.720_bb0050","doi-asserted-by":"crossref","first-page":"e1150","DOI":"10.1371\/journal.pone.0001150","article-title":"Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration","volume":"2","author":"Behonick","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bone.2011.03.720_bb0055","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bone.2007.06.006","article-title":"Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats","volume":"41","author":"Hao","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0060","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jor.20505","article-title":"Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model","volume":"26","author":"McCann","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0065","first-page":"108","article-title":"Effects of ovariectomy on fracture healing in female rats","volume":"36","author":"Qiao","year":"2005","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.bone.2011.03.720_bb0070","first-page":"111","article-title":"Osteoporosis influences the middle and late periods of fracture healing in a rat osteoporotic model","volume":"8","author":"Wang","year":"2005","journal-title":"Chin J Traumatol"},{"key":"10.1016\/j.bone.2011.03.720_bb0075","first-page":"1205","article-title":"Osteoporosis impairs fracture healing of tibia in a rat osteoporotic model","volume":"84","author":"Xu","year":"2004","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.bone.2011.03.720_bb0080","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0736-0266(02)00266-8","article-title":"Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis","volume":"21","author":"Lill","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0085","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S8756-3282(00)00414-2","article-title":"Osteoporosis influences the early period of fracture healing in a rat osteoporotic model","volume":"28","author":"Namkung-Matthai","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0090","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s002640100287","article-title":"Failure of intertrochanteric fracture fixation with a dynamic hip screw in relation to pre-operative fracture stability and osteoporosis","volume":"25","author":"Kim","year":"2001","journal-title":"Int Orthop"},{"key":"10.1016\/j.bone.2011.03.720_bb0095","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0736-0266(00)90034-2","article-title":"Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats","volume":"19","author":"Meyer","year":"2001","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0100","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00005131-199310000-00006","article-title":"Healing complications after internal fixation of trochanteric hip fractures: the prognostic value of osteoporosis","volume":"7","author":"Barrios","year":"1993","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.bone.2011.03.720_bb0105","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00005373-199211000-00016","article-title":"Mechanical failures of internal fixation in T and Y fractures of the distal humerus","volume":"33","author":"Sodergard","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.bone.2011.03.720_bb0110","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/00007632-199106000-00009","article-title":"Importance of bone mineral density in instrumented spine fusions","volume":"16","author":"Wittenberg","year":"1991","journal-title":"Spine"},{"key":"10.1016\/j.bone.2011.03.720_bb0115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.regpep.2009.11.004","article-title":"Changes of substance P during fracture healing in ovariectomized mice","volume":"159","author":"Ding","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.bone.2011.03.720_bb0120","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/jor.21041","article-title":"Influence of defective bone marrow osteogenesis on fracture repair in an experimental model of senile osteoporosis","volume":"28","author":"Egermann","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.injury.2003.08.019","article-title":"Fracture fixation problems in osteoporosis","volume":"35","author":"Stromsoe","year":"2004","journal-title":"Injury"},{"key":"10.1016\/j.bone.2011.03.720_bb0130","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00223-009-9314-y","article-title":"Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration","volume":"86","author":"Monfoulet","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2011.03.720_bb0135","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.2106\/JBJS.G.01580","article-title":"Variability in the assessment of fracture-healing in orthopaedic trauma studies","volume":"90","author":"Corrales","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.bone.2011.03.720_bb0140","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S8756-3282(01)00406-9","article-title":"A metaphyseal defect model of the femur for studies of murine bone healing","volume":"28","author":"Uusitalo","year":"2001","journal-title":"Bone"},{"issue":"Suppl 3","key":"10.1016\/j.bone.2011.03.720_bb0145","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2106\/JBJS.F.00891","article-title":"Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study","volume":"88","author":"Cui","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.bone.2011.03.720_bb0150","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.bone.2004.11.013","article-title":"Bisphosphonate (YM529) delays the repair of cortical bone defect after drill-hole injury by reducing terminal differentiation of osteoblasts in the mouse femur","volume":"36","author":"Nagashima","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00223-002-2120-4","article-title":"Establishment of a model of cortical bone repair in mice","volume":"73","author":"Campbell","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2011.03.720_bb0160","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bone.2009.05.022","article-title":"Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone","volume":"45","author":"Songlin","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0165","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bone.2005.11.019","article-title":"Flavonoids derived from herbal Epimedium brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption","volume":"38","author":"Zhang","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0170","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1002\/art.24847","article-title":"Continuous occurrence of both insufficient neovascularization and elevated vascular permeability in rabbit proximal femur during inadequate repair of steroid-associated osteonecrotic lesions","volume":"60","author":"Zhang","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.03.720_bb0175","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1359\/jbmr.061103","article-title":"Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice","volume":"22","author":"Duvall","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0180","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.joca.2008.09.015","article-title":"Female hormone receptors are differentially expressed in mouse fibrocartilages","volume":"17","author":"Wang","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.03.720_bb0185","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1073\/pnas.0306948101","article-title":"Mitochondrial localization of estrogen receptor beta","volume":"101","author":"Yang","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bone.2011.03.720_bb0190","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3899\/jrheum.080475","article-title":"The HLA-B27 transgenic rat, a model of spondyloarthritis, has decreased bone mineral density and increased RANKL to osteoprotegerin mRNA ratio","volume":"36","author":"Rauner","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.bone.2011.03.720_bb0195","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF01774016","article-title":"Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques","volume":"5","author":"Gluer","year":"1995","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2011.03.720_bb0200","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol Bull"},{"key":"10.1016\/j.bone.2011.03.720_bb0205","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: the cellular picture","volume":"19","author":"Schindeler","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.bone.2011.03.720_bb0210","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1210\/en.2008-0814","article-title":"Longitudinal in vivo analysis of the region-specific efficacy of parathyroid hormone in a rat cortical defect model","volume":"150","author":"Komatsu","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2011.03.720_bb0215","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bone.2009.09.007","article-title":"Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing","volume":"46","author":"Monfoulet","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0220","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bone.2008.09.010","article-title":"Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair","volume":"44","author":"Wohl","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.03.720_bb0225","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1359\/jbmr.080103","article-title":"Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling","volume":"23","author":"Jacobsen","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0230","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00223-006-0275-0","article-title":"Influence of estradiol on vascular endothelial growth factor expression in bone: a study in Gottingen miniature pigs and human osteoblasts","volume":"80","author":"Pufe","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2011.03.720_bb0235","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1359\/jbmr.2003.18.9.1622","article-title":"Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography","volume":"18","author":"David","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0240","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1359\/jbmr.080808","article-title":"Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice","volume":"23","author":"Buie","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0245","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1359\/jbmr.060504","article-title":"Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen","volume":"21","author":"Zaman","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0250","first-page":"289","article-title":"The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism","volume":"39","author":"Hou","year":"2006","journal-title":"Fen Zi Xi Bao Sheng Wu Xue Bao"},{"key":"10.1016\/j.bone.2011.03.720_bb0255","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcb.1096","article-title":"Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice","volume":"Suppl. 36","author":"Zhou","year":"2001","journal-title":"J Cell Biochem Suppl"},{"key":"10.1016\/j.bone.2011.03.720_bb0260","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00223-004-0119-8","article-title":"Effects of sex steroid receptor specificity in the regulation of skeletal metabolism","volume":"75","author":"Tozum","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2011.03.720_bb0265","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1359\/jbmr.0301203","article-title":"Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice","volume":"19","author":"Chagin","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.03.720_bb0270","doi-asserted-by":"crossref","first-page":"11207","DOI":"10.1158\/0008-5472.CAN-06-0017","article-title":"Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts","volume":"66","author":"Hartman","year":"2006","journal-title":"Cancer Res"},{"issue":"Suppl","key":"10.1016\/j.bone.2011.03.720_bb0275","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF03026330","article-title":"In vivo characterization of skeletal phenotype of genetically modified mice","volume":"23","author":"Ke","year":"2005","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bone.2011.03.720_bb0280","first-page":"479","article-title":"The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice","volume":"2","author":"Ke","year":"2002","journal-title":"J Musculoskelet Neuronal Interact"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328211008283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328211008283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:15:26Z","timestamp":1712315726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328211008283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S8756328211008283"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2011.03.720","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}