{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:56:24Z","timestamp":1792158984221,"version":"4.4.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.bone.2011.10.010","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T06:10:46Z","timestamp":1318918246000},"page":"204-211","source":"Crossref","is-referenced-by-count":289,"title":["Osteochondral alterations in osteoarthritis"],"prefix":"10.1016","volume":"51","author":[{"given":"Sunita","family":"Suri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2011.10.010_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.joca.2005.08.006","article-title":"Magnetic resonance imaging characterization of osteochondral defect repair in a goat model at 8 T","volume":"14","author":"Kangarlu","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0010","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/acr.20068","article-title":"Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis","volume":"62","author":"Kothari","year":"2010","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joca.2006.03.015","article-title":"The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis","volume":"14","author":"Torres","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/art.20051","article-title":"Osteoarthritis: is it a disease of cartilage or of bone?","volume":"50","author":"Felson","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/art.20136","article-title":"Is osteoarthritis a systemic disorder of bone?","volume":"50","author":"Rogers","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0030","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/ard.2006.058347","article-title":"Yet more evidence that osteoarthritis is not a cartilage disease","volume":"65","author":"Brandt","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone-cartilage unit in osteoarthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.bone.2011.10.010_bb0040","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1136\/ard.2005.050112","article-title":"Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis","volume":"65","author":"Tan","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0045","series-title":"Kelley's Textbook of Rheumatology","first-page":"1","article-title":"Biology of the normal joint","author":"Sledge","year":"2001"},{"key":"10.1016\/j.bone.2011.10.010_bb0050","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1053\/joca.2002.0814","article-title":"Quantitative structural organization of normal adult human articular cartilage","volume":"10","author":"Hunziker","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0055","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2474-7-52","article-title":"The normal human chondro-osseous junctional region: evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces","volume":"7","author":"Lyons","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.bone.2011.10.010_bb0405","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0891-8422(23)01166-7","article-title":"Articular cartilage. Anatomy, injury, and repair","volume":"18","author":"Hayes","year":"2001","journal-title":"Clin Podiatr Med Surg"},{"key":"10.1016\/j.bone.2011.10.010_bb0065","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","article-title":"Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis","volume":"15","author":"Walsh","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0410","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2006.063354","article-title":"Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis","volume":"66","author":"Suri","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0075","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/stem.534","article-title":"Stem cells and cartilage development: complexities of a simple tissue","volume":"28","author":"Hollander","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2011.10.010_bb0080","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.joca.2009.11.015","article-title":"Osteochondral angiogenesis and increased protease inhibitor expression in OA","volume":"18","author":"Franses","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0085","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1302\/0301-620X.72B5.2211774","article-title":"The structure of the human subchondral plate","volume":"72","author":"Clark","year":"1990","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.bone.2011.10.010_bb0090","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/107110078600700103","article-title":"Subchondral pathways to the superior surface of the human talus","volume":"7","author":"Berry","year":"1986","journal-title":"Foot Ankle"},{"key":"10.1016\/j.bone.2011.10.010_bb0415","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2106\/00004623-198769080-00015","article-title":"The tibial subchondral plate. A scanning electron microscopic study","volume":"69","author":"Duncan","year":"1987","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.bone.2011.10.010_bb0100","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","article-title":"Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis","volume":"49","author":"Walsh","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2011.10.010_bb0420","series-title":"Osteoarthritic cartilage loses its ability to remain avascular","author":"Fenwick","year":"1999"},{"key":"10.1016\/j.bone.2011.10.010_bb0110","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/ard.59.6.448","article-title":"Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage","volume":"59","author":"Pfander","year":"2000","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0115","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1073\/pnas.96.6.2645","article-title":"Troponin I is present in human cartilage and inhibits angiogenesis","volume":"96","author":"Moses","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bone.2011.10.010_bb0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/joca.1998.0238","article-title":"Osteoarthritic cartilage loses its ability to remain avascular","volume":"7","author":"Fenwick","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00774-007-0753-0","article-title":"Expression of bone resorption genes in osteoarthritis and in osteoporosis","volume":"25","author":"Logar","year":"2007","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bone.2011.10.010_bb0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/rvsc.2001.0522","article-title":"Localisation and activity of cathepsins K and B in equine osteoclasts","volume":"72","author":"Gray","year":"2002","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.bone.2011.10.010_bb0135","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/ard.44.10.676","article-title":"Bidirectional erosion of cartilage in the rheumatoid knee joint","volume":"44","author":"Bromley","year":"1985","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0425","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.joca.2010.06.007","article-title":"Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease","volume":"18","author":"Strassle","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joca.2007.05.017","article-title":"Angiogenesis in two animal models of osteoarthritis","volume":"16","author":"Mapp","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0150","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/art.27462","article-title":"Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis","volume":"62","author":"Ashraf","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.bone.2011.10.010_bb0160","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0945-053X(01)00132-9","article-title":"Role of the subchondral vascular system in endochondral ossification: endothelial cell-derived proteinases derepress late cartilage differentiation in vitro","volume":"20","author":"Babarina","year":"2001","journal-title":"Matrix Biol"},{"key":"10.1016\/j.bone.2011.10.010_bb0165","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/1529-0131(200105)44:5<1082::AID-ANR188>3.0.CO;2-X","article-title":"The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage","volume":"44","author":"Pufe","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0170","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/ard.60.11.1070","article-title":"Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints","volume":"60","author":"Pfander","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0175","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/excr.1997.3849","article-title":"Role of the subchondral vascular system in endochondral ossification: endothelial cells specifically derepress late differentiation in resting chondrocytesin vitro","volume":"238","author":"Bittner","year":"1998","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/01926230600611836","article-title":"Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate","volume":"34","author":"Hall","year":"2006","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.bone.2011.10.010_bb0185","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/joca.2001.0505","article-title":"Development and regulation of osteophyte formation during experimental osteoarthritis","volume":"10","author":"Hashimoto","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0190","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/03635465980260060601","article-title":"Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia","volume":"26","author":"Dye","year":"1998","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.bone.2011.10.010_bb0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mvr.2007.07.004","article-title":"Nerve growth factor as an angiogenic factor","volume":"75","author":"Nico","year":"2008","journal-title":"Microvasc Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0200","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1359\/jbmr.2003.18.6.1073","article-title":"Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HGF: potential implication of osteoblasts on the presence of HGF in cartilage","volume":"18","author":"Gu\u00e9vremont","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0205","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jbspin.2010.07.001","article-title":"Osteochondral plate angiogenesis: a new treatment target in osteoarthritis","volume":"78","author":"Pesesse","year":"2011","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.bone.2011.10.010_bb0210","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.joca.2008.09.005","article-title":"On new bone formation in the pre-osteoarthritic joint","volume":"17","author":"Thambyah","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0430","doi-asserted-by":"crossref","unstructured":"Nakamura T, Mizuno S. The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. Proc Jpn Acad Ser B Phys Biol Sci 86: 588\u2013610.","DOI":"10.2183\/pjab.86.588"},{"key":"10.1016\/j.bone.2011.10.010_bb0220","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/joca.1999.0259","article-title":"Hepatocyte growth factor in human osteoarthritic cartilage","volume":"7","author":"Pfander","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0225","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joca.2005.03.008","article-title":"Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1\u03b2 and oncostatin M pre-treated non-sclerotic osteoblasts","volume":"13","author":"Sanchez","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2302\/kjm.58.29","article-title":"New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?","volume":"58","author":"Tat","year":"2009","journal-title":"Keio J Med"},{"key":"10.1016\/j.bone.2011.10.010_bb0235","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1002\/art.22174","article-title":"Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis","volume":"54","author":"Aigner","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0240","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.orthres.2004.12.016","article-title":"Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype","volume":"23","author":"Yagi","year":"2005","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/ard.2008.097139","article-title":"Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy","volume":"69","author":"Brew","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0250","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1002\/art.22968","article-title":"Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis","volume":"56","author":"Appleton","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/labinvest.2009.111","article-title":"Rho\/ROCK and MEK\/ERK activation by transforming growth factor-alpha induces articular cartilage degradation","volume":"90","author":"Appleton","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.bone.2011.10.010_bb0260","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/art.24247","article-title":"Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1","volume":"60","author":"Blom","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0435","doi-asserted-by":"crossref","unstructured":"Blom AB, van Lent PL, van der Kraan PM, van den Berg WB. To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy. Curr Drug Targets 11: 620\u2013629.","DOI":"10.2174\/138945010791011901"},{"key":"10.1016\/j.bone.2011.10.010_bb0270","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.joca.2011.04.014","article-title":"Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis","volume":"19","author":"Chan","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0275","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/0022034510376401","article-title":"The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration","volume":"89","author":"Zhang","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0280","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","article-title":"Bisphosphonates: the first 40 years","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2011.10.010_bb0285","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ejphar.2010.10.058","article-title":"Alendronate and raloxifene affect the osteoprotegerin\/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis","volume":"650","author":"Giner","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bone.2011.10.010_bb0290","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2460\/ajvr.2005.66.1487","article-title":"Effects of zoledronate on markers of bone metabolism and subchondral bone mineral density in dogs with experimentally induced cruciate-deficient osteoarthritis","volume":"66","author":"Agnello","year":"2005","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.bone.2011.10.010_bb0295","first-page":"1972","article-title":"Partial chondroprotective effect of zoledronate in a rabbit model of inflammatory arthritis","volume":"26","author":"Podworny","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.bone.2011.10.010_bb0300","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1002\/art.20627","article-title":"The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis","volume":"50","author":"Carbone","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0305","doi-asserted-by":"crossref","first-page":"R625","DOI":"10.1186\/ar1716","article-title":"Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]","volume":"7","author":"Spector","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.bone.2011.10.010_bb0310","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/art.22160","volume":"54","author":"Bingham","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0315","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.joca.2007.10.002","article-title":"Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial","volume":"16","author":"Garnero","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0320","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00774-007-0813-5","article-title":"Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial","volume":"26","author":"Kawasaki","year":"2008","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bone.2011.10.010_bb0325","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1136\/ard.2007.085563","article-title":"The effect of alendronate on progression of spinal osteophytes and disc-space narrowing","volume":"67","author":"Neogi","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 3","key":"10.1016\/j.bone.2011.10.010_bb0440","article-title":"Zoledronic acid reduces bone marrow lesions and knee pain over one year","volume":"70","author":"Laslett","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2011.10.010_bb0335","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1582-4934.2005.tb00355.x","article-title":"Matrix metalloproteinases and angiogenesis","volume":"9","author":"Rundhaug","year":"2005","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bone.2011.10.010_bb0340","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/art.11030","article-title":"Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats","volume":"48","author":"Renkiewicz","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0345","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","article-title":"Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage","volume":"97","author":"Mitchell","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2011.10.010_bb0350","doi-asserted-by":"crossref","first-page":"27781","DOI":"10.1074\/jbc.M703286200","article-title":"Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects","volume":"282","author":"Johnson","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2011.10.010_bb0355","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/art.24629","article-title":"A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models","volume":"60","author":"Baragi","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0360","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/art.27596","volume":"62","author":"Settle","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0445","doi-asserted-by":"crossref","unstructured":"Tat SK, Pelletier JP, Mineau F, Caron J, Martel-Pelletier J. Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts. Bone 49: 559\u2013567.","DOI":"10.1016\/j.bone.2011.06.005"},{"key":"10.1016\/j.bone.2011.10.010_bb0370","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.joca.2009.12.006","article-title":"Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis","volume":"18","author":"Mapp","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0375","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0140-6736(97)02135-1","article-title":"Nerve ingrowth into diseased intervertebral disc in chronic back pain","volume":"350","author":"Freemont","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2011.10.010_bb0450","doi-asserted-by":"crossref","DOI":"10.1002\/art.30422","article-title":"Contributions of angiogenesis to inflammation, joint damage and pain in a rat model of osteoarthritis","author":"Ashraf","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2011.10.010_bb0385","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1110\/ps.035402.108","article-title":"Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors","volume":"17","author":"Abdiche","year":"2008","journal-title":"Protein Sci"},{"key":"10.1016\/j.bone.2011.10.010_bb0390","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","article-title":"Tanezumab for the treatment of pain from osteoarthritis of the knee","volume":"363","author":"Lane","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2011.10.010_bb0395","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.joca.2011.01.009","article-title":"Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain","volume":"19","author":"Schnitzer","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bone.2011.10.010_bb0400","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jor.21134","article-title":"Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis","volume":"28","author":"Hsieh","year":"2010","journal-title":"J Orthop Res"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328211012907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328211012907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T20:37:14Z","timestamp":1713040634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328211012907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S8756328211012907"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2011.10.010","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}