{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:11:54Z","timestamp":1791425514487,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.bone.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T17:30:53Z","timestamp":1350149453000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Vitamin D signaling in osteocytes: Effects on bone and mineral homeostasis"],"prefix":"10.1016","volume":"54","author":[{"given":"Liesbet","family":"Lieben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2012.10.007_bb0005","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.beem.2011.05.008","article-title":"Calcemic actions of vitamin D: effects on the intestine, kidney and bone","volume":"25","author":"Lieben","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2012.10.007_bb0010","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1210\/mend.16.7.0866","article-title":"Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D","volume":"16","author":"Erben","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2012.10.007_bb0015","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2012.10.007_bb0020","doi-asserted-by":"crossref","first-page":"13324","DOI":"10.1073\/pnas.231474698","article-title":"Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects","volume":"98","author":"Van Cromphaut","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2012.10.007_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.bone.2012.10.007_bb0030","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1053\/j.gastro.2008.12.051","article-title":"Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice","volume":"136","author":"Xue","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bone.2012.10.007_bb0035","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","article-title":"Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses","volume":"140","author":"Amling","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0040","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1210\/endo.139.10.6262","article-title":"Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice","volume":"139","author":"Li","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0045","series-title":"15th Vitamin D Workshop","article-title":"Vitamin D receptor in osteoblasts is a negative regulator of bone mass control","author":"Kato","year":"2012"},{"key":"10.1016\/j.bone.2012.10.007_bb0050","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1096\/fj.99-1075com","article-title":"Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage","volume":"14","author":"Gardiner","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.bone.2012.10.007_bb0055","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2012.10.007_bb0060","doi-asserted-by":"crossref","first-page":"F1192","DOI":"10.1152\/ajprenal.00360.2009","article-title":"Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology","volume":"297","author":"Meir","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.bone.2012.10.007_bb0065","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.111.032680","article-title":"Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy","volume":"124","author":"Chen","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2012.10.007_bb0070","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/154405910708600404","article-title":"DMP1-targeted Cre expression in odontoblasts and osteocytes","volume":"86","author":"Lu","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.bone.2012.10.007_bb0075","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI45890","article-title":"Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization","volume":"122","author":"Lieben","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2012.10.007_bb0080","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.bone.2012.10.007_bb0085","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"Quarles","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.bone.2012.10.007_bb0090","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jbmr.1567","article-title":"Demonstration of osteocytic perilacunar\/canalicular remodeling in mice during lactation","volume":"27","author":"Qing","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2012.10.007_bb0095","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.bbagen.2009.09.006","article-title":"Role of matrix vesicles in biomineralization","volume":"1790","author":"Golub","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bone.2012.10.007_bb0100","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1182\/blood-2011-01-315069","article-title":"Bone and the hematopoietic niche: a tale of two stem cells","volume":"117","author":"Bianco","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bone.2012.10.007_bb0105","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1359\/jbmr.060714","article-title":"Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast","volume":"21","author":"Baldock","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2012.10.007_bb0110","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1128\/MCB.00353-06","article-title":"Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers","volume":"26","author":"Kim","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bone.2012.10.007_bb0115","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1210\/endo.140.2.6673","article-title":"Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice","volume":"140","author":"Takeda","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0120","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.bone.2012.10.007_bb0125","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Ben Dov","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2012.10.007_bb0130","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1074\/jbc.M207872200","article-title":"Human fibroblast growth factor-23 mutants suppress Na+\u2212dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production","volume":"278","author":"Saito","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2012.10.007_bb0135","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2005111185","article-title":"Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D","volume":"17","author":"Liu","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.bone.2012.10.007_bb0140","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.00474.2004","article-title":"Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism","volume":"289","author":"Shimada","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.bone.2012.10.007_bb0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00002.2011","article-title":"Regulation and function of the FGF23\/klotho endocrine pathways","volume":"92","author":"Martin","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bone.2012.10.007_bb0150","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1210\/en.2008-1410","article-title":"Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development","volume":"150","author":"Naja","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0155","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2012.10.007_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.matbio.2006.10.003","article-title":"Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice","volume":"26","author":"Hesse","year":"2007","journal-title":"Matrix Biol"},{"key":"10.1016\/j.bone.2012.10.007_bb0165","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1210\/en.2003-1768","article-title":"Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis","volume":"145","author":"Larsson","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0170","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1210\/en.2004-0233","article-title":"Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders","volume":"145","author":"Bai","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2012.10.007_bb0175","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1182\/blood-2010-04-279216","article-title":"Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche","volume":"116","author":"Kawamori","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bone.2012.10.007_bb0180","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1182\/blood-2010-04-280552","article-title":"Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen","volume":"116","author":"Jeanson","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bone.2012.10.007_bb0185","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.steroids.2011.10.015","article-title":"VDR dependent and independent effects of 1,25-dihydroxyvitamin D3 on nitric oxide production by osteoblasts","volume":"77","author":"Willems","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.bone.2012.10.007_bb0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.abb.2008.03.038","article-title":"The direct role of vitamin D on bone homeostasis","volume":"473","author":"St Arnaud","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bone.2012.10.007_bb0195","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/kem240","article-title":"Effect of annual intramuscular vitamin D on fracture risk in elderly men and women\u2013a population-based, randomized, double-blind, placebo-controlled trial","volume":"46","author":"Smith","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2012.10.007_bb0200","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328212013154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328212013154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T13:23:48Z","timestamp":1562246628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328212013154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S8756328212013154"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2012.10.007","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D signaling in osteocytes: Effects on bone and mineral homeostasis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2012.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}