{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:45:36Z","timestamp":1762659936063,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bone.2013.02.020","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T20:39:29Z","timestamp":1362429569000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells"],"prefix":"10.1016","volume":"55","author":[{"given":"Isabella W.Y.","family":"Mak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Turcotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ghert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2013.02.020_bb0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ocl.2005.08.005","article-title":"Giant cell tumor of bone","volume":"37","author":"Turcotte","year":"2006","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.bone.2013.02.020_bb0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00432-008-0427-x","article-title":"Treatment options for recurrent giant cell tumors of bone","volume":"135","author":"Balke","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.bone.2013.02.020_bb0015","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2106\/JBJS.D.02771","article-title":"Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy","volume":"90","author":"Becker","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.bone.2013.02.020_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/BLO.0b013e31804856a1","article-title":"Properties of the stromal cell in giant cell tumor of bone","volume":"459","author":"Ghert","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.bone.2013.02.020_bb0025","first-page":"297","article-title":"The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts","volume":"16","author":"Zheng","year":"2001","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.bone.2013.02.020_bb0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bone.2009.04.253","article-title":"Upregulation of MMP-13 via Runx2 in the stromal cell of giant cell tumor of bone","volume":"45","author":"Mak","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2013.02.020_bb0035","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/jcb.23149","article-title":"The role of TWIST as a regulator in giant cell tumor of bone","volume":"112","author":"Singh","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.bone.2013.02.020_bb0040","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.humpath.2010.03.001","article-title":"Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone","volume":"41","author":"Mak","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.bone.2013.02.020_bb0045","doi-asserted-by":"crossref","first-page":"164197","DOI":"10.1155\/2011\/164197","article-title":"AP-1 as a regulator of MMP-13 in the stromal cell of giant cell tumor of bone","volume":"2011","author":"Mak","year":"2011","journal-title":"Biochem Res Int"},{"key":"10.1016\/j.bone.2013.02.020_bb0050","doi-asserted-by":"crossref","first-page":"e19975","DOI":"10.1371\/journal.pone.0019975","article-title":"PTHrP induces autocrine\/paracrine proliferation of bone tumor cells through inhibition of apoptosis","volume":"6","author":"Mak","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2013.02.020_bb0055","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/jbmr.1638","article-title":"Transcriptomic and proteomic analyses in bone tumor cells: deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis","volume":"27","author":"Mak","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2013.02.020_bb0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1402.046","article-title":"PTHrP and tumorigenesis: is there a role in prognosis?","volume":"1117","author":"Nishihara","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bone.2013.02.020_bb0065","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bone.2013.02.020_bb0070","first-page":"981","article-title":"Parathyroid hormone-related protein as a common target molecule in specific immunotherapy for a wide variety of tumor types","volume":"27","author":"Arima","year":"2005","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bone.2013.02.020_bb0075","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/sj.onc.1202587","article-title":"Signal transduction pathways that regulate cell survival and cell death","volume":"17","author":"Dragovich","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2013.02.020_bb0080","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0955-0674(00)00251-9","article-title":"Anoikis mechanisms","volume":"13","author":"Frisch","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.bone.2013.02.020_bb0085","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","article-title":"Integrins and anoikis","volume":"9","author":"Frisch","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.bone.2013.02.020_bb0090","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/clinchem\/38.11.2171","article-title":"Parathyroid hormone-related protein: structure, function, and measurement","volume":"38","author":"Burtis","year":"1992","journal-title":"Clin Chem"},{"key":"10.1016\/j.bone.2013.02.020_bb0095","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/bioinformatics\/btp656","article-title":"EGAN: exploratory gene association networks","volume":"26","author":"Paquette","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bone.2013.02.020_bb0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes","volume":"115","author":"Boyden","year":"1962","journal-title":"J Exp Med"},{"key":"10.1016\/j.bone.2013.02.020_bb0105","first-page":"163","article-title":"Signalling via integrins: implications for cell survival and anticancer strategies","volume":"1775","author":"Hehlgans","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bone.2013.02.020_bb0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10555-006-9033-z","article-title":"Skeletal metastasis: established and emerging roles of parathyroid hormone related protein (PTHrP)","volume":"25","author":"Liao","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.bone.2013.02.020_bb0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.regpep.2006.12.017","article-title":"Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines","volume":"141","author":"Shen","year":"2007","journal-title":"Regul Pept"},{"key":"10.1016\/j.bone.2013.02.020_bb0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0167-0115(02)00293-8","article-title":"Parathyroid hormone-related protein upregulates integrin expression via an intracrine pathway in PC-3 prostate cancer cells","volume":"113","author":"Shen","year":"2003","journal-title":"Regul Pept"},{"key":"10.1016\/j.bone.2013.02.020_bb0125","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yexcr.2003.11.028","article-title":"PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration, and invasion via an intracrine pathway","volume":"294","author":"Shen","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.bone.2013.02.020_bb0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1530\/ERC-11-0278","article-title":"Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells","volume":"19","author":"Park","year":"2012","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.bone.2013.02.020_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.acthis.2008.11.022","article-title":"Molecular interactions in cancer cell metastasis","volume":"112","author":"Brooks","year":"2010","journal-title":"Acta Histochem"},{"key":"10.1016\/j.bone.2013.02.020_bb0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.regpep.2004.07.025","article-title":"PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression","volume":"125","author":"Shen","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.bone.2013.02.020_bb0145","first-page":"124","article-title":"The promise of integrins as effective targets for anticancer agents","volume":"2","author":"Rust","year":"2002","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.bone.2013.02.020_bb0150","doi-asserted-by":"crossref","first-page":"M33","DOI":"10.1016\/S0962-8924(99)01667-0","article-title":"Cell adhesion: old and new questions","volume":"9","author":"Hynes","year":"1999","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.bone.2013.02.020_bb0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cellsig.2011.10.005","article-title":"Cell surface adhesion molecules and adhesion-initiated signaling: understanding of anoikis resistance mechanisms and therapeutic opportunities","volume":"24","author":"Zhong","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.bone.2013.02.020_bb0160","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1242\/jcs.072165","article-title":"Overcoming anoikis \u2014 pathways to anchorage-independent growth in cancer","volume":"124","author":"Guadamillas","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bone.2013.02.020_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-207-6_1","article-title":"Cell migration: an overview","volume":"769","author":"Vicente-Manzanares","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.bone.2013.02.020_bb0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mrrev.2011.05.002","article-title":"Initial steps of metastasis: cell invasion and endothelial transmigration","volume":"728","author":"van Zijl","year":"2011","journal-title":"Mutat Res"},{"key":"10.1016\/j.bone.2013.02.020_bb0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2010.06.009","article-title":"PTHrP promotes colon cancer cell migration and invasion in an integrin alpha6beta4-dependent manner through activation of Rac1","volume":"298","author":"Mula","year":"2010","journal-title":"Cancer Lett"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328213000926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328213000926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:37:56Z","timestamp":1762659476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328213000926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S8756328213000926"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2013.02.020","relation":{},"ISSN":["8756-3282"],"issn-type":[{"type":"print","value":"8756-3282"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2013.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}