{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:58:49Z","timestamp":1790513929424,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bone.2013.12.002","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T13:45:17Z","timestamp":1386596717000},"page":"162-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"special_numbering":"C","title":["A myostatin and activin decoy receptor enhances bone formation in mice"],"prefix":"10.1016","volume":"60","author":[{"given":"P.","family":"Bialek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Parkington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Root","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Seeherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Yaworsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6628","key":"10.1016\/j.bone.2013.12.002_bb0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bone.2013.12.002_bb0010","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2527\/2002.8071879x","article-title":"Gene expression in sexually dimorphic muscles in sheep","volume":"80","author":"Mateescu","year":"2002","journal-title":"J Anim Sci"},{"issue":"23","key":"10.1016\/j.bone.2013.12.002_bb0015","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.94.23.12457","article-title":"Double muscling in cattle due to mutations in the myostatin gene","volume":"94","author":"McPherron","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.bone.2013.12.002_bb0020","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s003359900557","article-title":"Myostatin maps to the interval containing the bovine mh locus","volume":"8","author":"Smith","year":"1997","journal-title":"Mamm Genome"},{"issue":"9","key":"10.1016\/j.bone.2013.12.002_bb0025","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1101\/gr.7.9.910","article-title":"Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle","volume":"7","author":"Kambadur","year":"1997","journal-title":"Genome Res"},{"issue":"Pt 22","key":"10.1016\/j.bone.2013.12.002_bb0030","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1242\/jeb.00635","article-title":"Analysis of myostatin gene structure, expression and function in zebrafish","volume":"206","author":"Xu","year":"2003","journal-title":"J Exp Biol"},{"issue":"4","key":"10.1016\/j.bone.2013.12.002_bb0035","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbiotec.2005.04.023","article-title":"Myostatin gene silenced by RNAi show a zebrafish giant phenotype","volume":"119","author":"Acosta","year":"2005","journal-title":"J Biotechnol"},{"issue":"9\u201310","key":"10.1016\/j.bone.2013.12.002_bb0040","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.nmd.2007.06.008","article-title":"Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene","volume":"17","author":"Shelton","year":"2007","journal-title":"Neuromuscul Disord"},{"issue":"5","key":"10.1016\/j.bone.2013.12.002_bb0045","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1371\/journal.pgen.0030079","article-title":"A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs","volume":"3","author":"Mosher","year":"2007","journal-title":"PLoS Genet"},{"issue":"26","key":"10.1016\/j.bone.2013.12.002_bb0050","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1056\/NEJMoa040933","article-title":"Myostatin mutation associated with gross muscle hypertrophy in a child","volume":"350","author":"Schuelke","year":"2004","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.bone.2013.12.002_bb0055","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s00018-008-8077-3","article-title":"Myostatin as a therapeutic target for musculoskeletal disease","volume":"65","author":"Bradley","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0060","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/mus.23539","article-title":"A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers","volume":"47","author":"Attie","year":"2012","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/JES.0b013e318201f601","article-title":"A role for myokines in muscle\u2013bone interactions","volume":"39","author":"Hamrick","year":"2011","journal-title":"Exerc Sport Sci Rev"},{"issue":"6","key":"10.1016\/j.bone.2013.12.002_bb0070","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/MCO.0b013e32833e341d","article-title":"Adipocyte\u2013myocyte crosstalk in skeletal muscle insulin resistance; is there a role for thyroid hormone?","volume":"13","author":"Havekes","year":"2010","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"42","key":"10.1016\/j.bone.2013.12.002_bb0075","doi-asserted-by":"crossref","first-page":"15675","DOI":"10.1073\/pnas.0607501103","article-title":"Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects","volume":"103","author":"Feldman","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4652(199907)180:1<1::AID-JCP1>3.0.CO;2-V","article-title":"Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct","volume":"180","author":"Sharma","year":"1999","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.domaniend.2005.12.001","article-title":"Myostatin inhibits differentiation of bovine preadipocyte","volume":"32","author":"Hirai","year":"2007","journal-title":"Domest Anim Endocrinol"},{"issue":"7381","key":"10.1016\/j.bone.2013.12.002_bb0090","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature10763","article-title":"The contribution of bone to whole-organism physiology","volume":"481","author":"Karsenty","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0095","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIR.0b013e3181d0ba8b","article-title":"Myostatin: regulator of muscle wasting in heart failure and treatment target for cardiac cachexia","volume":"121","author":"Springer","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ar.a.10044","article-title":"Increased bone mineral density in the femora of GDF8 knockout mice","volume":"272","author":"Hamrick","year":"2003","journal-title":"Anat Rec A: Discov Mol Cell Evol Biol"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00223-001-1109-8","article-title":"Bone mineral content and density in the humerus of adult myostatin-deficient mice","volume":"71","author":"Hamrick","year":"2002","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0110","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S8756-3282(00)00339-2","article-title":"Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice","volume":"27","author":"Hamrick","year":"2000","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2013.12.002_bb0115","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0736-0266(03)00105-0","article-title":"Bone architecture and disc degeneration in he lumbar spine of mice lacking GDF-8 (myostatin)","volume":"21","author":"Hamrick","year":"2003","journal-title":"J Orthop Res"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.archoralbio.2005.05.008","article-title":"Biomineralization and adaptive plasticity of the temporomandibular joint in myostatin knockout mice","volume":"51","author":"Nicholson","year":"2006","journal-title":"Arch Oral Biol"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0125","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1359\/jbmr.2002.17.3.513","article-title":"Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing","volume":"17","author":"Cho","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bone.2008.08.126","article-title":"Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume","volume":"44","author":"Kellum","year":"2009","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.bone.2013.12.002_bb0135","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/1521-1878(200011)22:11<970::AID-BIES3>3.0.CO;2-L","article-title":"A neuro (endo)crine regulation of bone remodeling","volume":"22","author":"Amling","year":"2000","journal-title":"Bioessays"},{"issue":"12","key":"10.1016\/j.bone.2013.12.002_bb0140","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1210\/me.2008-0290","article-title":"Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators","volume":"22","author":"Souza","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2003.10.004","article-title":"The transforming growth factor-beta superfamily of receptors","volume":"15","author":"de Caestecker","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"issue":"20","key":"10.1016\/j.bone.2013.12.002_bb0150","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1128\/MCB.23.20.7230-7242.2003","article-title":"Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis","volume":"23","author":"Rebbapragada","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"19","key":"10.1016\/j.bone.2013.12.002_bb0155","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1073\/pnas.0711263105","article-title":"A soluble activin type IIA receptor induces bone formation and improves skeletal integrity","volume":"105","author":"Pearsall","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"50","key":"10.1016\/j.bone.2013.12.002_bb0160","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0505996102","article-title":"Regulation of muscle growth by multiple ligands signaling through activin type II receptors","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1359\/jbmr.1997.12.3.403","article-title":"Osteoblasts express types I and II activin receptors during early intramembranous and endochondral bone formation","volume":"12","author":"Shuto","year":"1997","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.bone.2013.12.002_bb0170","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bone.2007.02.012","article-title":"Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading","volume":"40","author":"Hamrick","year":"2007","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2013.12.002_bb0175","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7150\/ijbs.2929","article-title":"TGF-beta and BMP signaling in osteoblast differentiation and bone formation","volume":"8","author":"Chen","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"2 Pt 1","key":"10.1016\/j.bone.2013.12.002_bb0180","first-page":"145","article-title":"Central control of bone formation","volume":"63","author":"Karsenty","year":"2002","journal-title":"Ann Endocrinol (Paris)"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/83810","article-title":"Bone morphogenetic protein-3 is a negative regulator of bone density","volume":"27","author":"Daluiski","year":"2001","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.bone.2013.12.002_bb0190","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1002\/dvdy.22048","article-title":"Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures","volume":"238","author":"Gamer","year":"2009","journal-title":"Dev Dyn"},{"issue":"43","key":"10.1016\/j.bone.2013.12.002_bb0195","doi-asserted-by":"crossref","first-page":"40735","DOI":"10.1074\/jbc.M206379200","article-title":"The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum","volume":"277","author":"Hill","year":"2002","journal-title":"J Biol Chem"},{"issue":"6914","key":"10.1016\/j.bone.2013.12.002_bb0200","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nature01154","article-title":"Functional improvement of dystrophic muscle by myostatin blockade","volume":"420","author":"Bogdanovich","year":"2002","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bone.2013.12.002_bb0205","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1359\/jbmr.070507","article-title":"Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice","volume":"22","author":"Glatt","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.bone.2013.12.002_bb0210","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2106\/00004623-200409000-00015","article-title":"Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model","volume":"86-A","author":"Seeherman","year":"2004","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"10.1016\/j.bone.2013.12.002_bb0235","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1152\/japplphysiol.90780.2008","article-title":"Effects of spaceflight on murine skeletal muscle gene expression","volume":"106","author":"Allen","year":"2009","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.bone.2013.12.002_bb0240","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1677\/joe.0.1670417","article-title":"Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight","volume":"167","author":"Lalani","year":"2000","journal-title":"J Endocrinol"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0245","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1152\/ajpendo.00275.2002","article-title":"Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension","volume":"285","author":"McMahon","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.bone.2013.12.002_bb0250","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1023\/A:1016366409691","article-title":"Content and localization of myostatin in mouse skeletal muscles during aging, mechanical unloading and reloading","volume":"22","author":"Kawada","year":"2001","journal-title":"J Muscle Res Cell Motil"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0255","doi-asserted-by":"crossref","first-page":"e53813","DOI":"10.1371\/journal.pone.0053813","article-title":"Load regulates bone formation and sclerostin expression through a TGFbeta-dependent mechanism","volume":"8","author":"Nguyen","year":"2013","journal-title":"PLoS One"},{"issue":"26","key":"10.1016\/j.bone.2013.12.002_bb0260","doi-asserted-by":"crossref","first-page":"15842","DOI":"10.1073\/pnas.2534946100","article-title":"Activation of latent myostatin by the BMP-1\/tolloid family of metalloproteinases","volume":"100","author":"Wolfman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"33","key":"10.1016\/j.bone.2013.12.002_bb0265","doi-asserted-by":"crossref","first-page":"27313","DOI":"10.1074\/jbc.M112.377960","article-title":"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex","volume":"287","author":"Townson","year":"2012","journal-title":"J Biol Chem"},{"issue":"27","key":"10.1016\/j.bone.2013.12.002_bb0270","doi-asserted-by":"crossref","first-page":"21037","DOI":"10.1074\/jbc.M110.114959","article-title":"Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb","volume":"285","author":"Sako","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0275","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bone.2009.09.018","article-title":"Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)","volume":"46","author":"Fajardo","year":"2010","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2013.12.002_bb0280","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.bone.2010.01.370","article-title":"A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys","volume":"46","author":"Lotinun","year":"2010","journal-title":"Bone"},{"issue":"20","key":"10.1016\/j.bone.2013.12.002_bb0285","doi-asserted-by":"crossref","first-page":"14233","DOI":"10.1016\/S0021-9258(19)49702-0","article-title":"Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation","volume":"267","author":"Ogawa","year":"1992","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0290","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/bbrc.2000.2075","article-title":"Activin A is an essential cofactor for osteoclast induction","volume":"268","author":"Fuller","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0295","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/bbrc.1993.2006","article-title":"Activin enhances osteoclast-like cell formation in vitro","volume":"195","author":"Sakai","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.bone.2013.12.002_bb0300","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S8756-3282(99)00152-0","article-title":"Local administration of activin promotes fracture healing in the rat fibula fracture model","volume":"25","author":"Sakai","year":"1999","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0305","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S8756-3282(00)00307-0","article-title":"Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats","volume":"27","author":"Sakai","year":"2000","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2013.12.002_bb0310","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1210\/en.2006-0848","article-title":"Inhibin A is an endocrine stimulator of bone mass and strength","volume":"148","author":"Perrien","year":"2007","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.bone.2013.12.002_bb0315","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.bcp.2013.03.002","article-title":"Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies","volume":"85","author":"Esbrit","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.bone.2013.12.002_bb0320","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/gerona\/glt030","article-title":"Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents","volume":"68","author":"Chiu","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2013.12.002_bb0325","doi-asserted-by":"crossref","first-page":"i119","DOI":"10.1136\/ard.2010.141150","article-title":"Targeting sclerostin as potential treatment of osteoporosis","volume":"70","author":"Papapoulos","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"41","key":"10.1016\/j.bone.2013.12.002_bb0330","doi-asserted-by":"crossref","first-page":"29809","DOI":"10.1074\/jbc.M113.485938","article-title":"Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes","volume":"288","author":"Rhee","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bone.2013.12.002_bb0335","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Badhi","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"5","key":"10.1016\/j.bone.2013.12.002_bb0340","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/BF03346385","article-title":"Effects of raloxifene therapy on circulating osteoprotegerin and RANK ligand levels in post-menopausal osteoporosis","volume":"31","author":"Fernandez-Garcia","year":"2008","journal-title":"J Endocrinol Invest"},{"issue":"8","key":"10.1016\/j.bone.2013.12.002_bb0345","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med"},{"issue":"9886","key":"10.1016\/j.bone.2013.12.002_bb0350","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0140-6736(13)60856-9","article-title":"Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial","volume":"382","author":"Tsai","year":"2013","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.bone.2013.12.002_bb0355","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1210\/jc.2013-2020","article-title":"Effects of odanacatib on BMD and safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate: a randomized placebo-controlled trial","author":"Bonnick","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.bone.2013.12.002_bb0360","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.bone.2008.01.010","article-title":"Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice","volume":"42","author":"Liu","year":"2008","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328213004900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328213004900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T09:11:18Z","timestamp":1647681078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328213004900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":68,"alternative-id":["S8756328213004900"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2013.12.002","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A myostatin and activin decoy receptor enhances bone formation in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2013.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}