{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:43:08Z","timestamp":1780569788555,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.bone.2014.04.015","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T03:20:39Z","timestamp":1398309639000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women"],"prefix":"10.1016","volume":"64","author":[{"given":"Markus R.","family":"John","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evita","family":"Harfst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Belleli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.M.","family":"Bruin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd B.","family":"Klickstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mindeholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Widler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kneissel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2014.04.015_bb0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11926-005-0007-x","article-title":"Quality-of-life issues in osteoporosis","volume":"7","author":"Silverman","year":"2005","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.bone.2014.04.015_bb0010","first-page":"435","article-title":"Osteoporosis \u2014 a current view of pharmacological prevention and treatment","volume":"7","author":"Das","year":"2013","journal-title":"Drug Des Devel Ther"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives","volume":"97","author":"Baron","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"7968","key":"10.1016\/j.bone.2014.04.015_bb0020","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0140-6736(76)92216-9","article-title":"Anabolic effect of low doses of a fragment of human parathyroid hormone on the skeleton in postmenopausal osteoporosis","volume":"1","author":"Reeve","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2014.04.015_bb0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-94-007-2888-2_5","article-title":"Signaling through the extracellular calcium-sensing receptor (CaSR)","volume":"740","author":"Chakravarti","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"19","key":"10.1016\/j.bone.2014.04.015_bb0030","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.bone.2014.04.015_bb0035","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.bone.2009.07.091","article-title":"Rapid and robust response of biochemical markers of bone formation to teriparatide therapy","volume":"45","author":"Glover","year":"2009","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2014.04.015_bb0040","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0009-9236(97)90169-7","article-title":"Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1\u201384)] in healthy postmenopausal volunteers","volume":"61","author":"Schwietert","year":"1997","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.bone.2014.04.015_bb0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4155\/fmc.11.17","article-title":"Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis","volume":"3","author":"Widler","year":"2011","journal-title":"Future Med Chem"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bone.2011.04.007","article-title":"ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans","volume":"49","author":"John","year":"2011","journal-title":"Bone"},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2014.04.015_bb0055","first-page":"S1173","article-title":"A novel calcium-sensing receptor antagonist leads to dose-dependent transient release of parathyroid hormone after oral administration to healthy volunteers \u2014 an initial proof-of-concept for a potential new class of anabolic osteoporosis therapeutics","author":"Widler","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2014.04.015_bb0060","first-page":"SU0372","article-title":"A 4-week study of AXT914, a novel calcilytic compound for oral bone anabolic osteoporosis therapy in postmenopausal women","author":"John","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0065","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bone.2009.09.028","article-title":"An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation","volume":"46","author":"Kumar","year":"2010","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2014.04.015_bb0070","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1210\/jc.2010-2855","article-title":"The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density","volume":"96","author":"Fitzpatrick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0075","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2217\/17455057.3.2.243","article-title":"Anabolic therapy for osteoporosis","volume":"3","author":"Bilezikian","year":"2007","journal-title":"Womens Health (Lond Engl)"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/jbmr.554","article-title":"Ronacaleret, a calcium-sensing receptor antagonist, increases trabecular but not cortical bone in postmenopausal women","volume":"27","author":"Fitzpatrick","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.bone.2014.04.015_bb0085","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bone.2011.06.017","article-title":"Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: results of a randomized, double-blinded, placebo-controlled phase II clinical trial","volume":"49","author":"Fitzpatrick","year":"2011","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.bone.2014.04.015_bb0090","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jcem.84.11.6236","article-title":"A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure","volume":"84","author":"John","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.bone.2014.04.015_bb0095","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bone.2013.05.021","article-title":"Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women","volume":"56","author":"Caltabiano","year":"2013","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2014.04.015_bb0100","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1172\/JCI57407","article-title":"PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor","volume":"122","author":"Loupy","year":"2012","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.bone.2014.04.015_bb0105","first-page":"233","article-title":"Electrolyte disorders and arrhythmogenesis","volume":"18","author":"El-Sherif","year":"2011","journal-title":"Cardiol J"},{"issue":"5","key":"10.1016\/j.bone.2014.04.015_bb0110","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/cen.12056","article-title":"Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914","volume":"78","author":"Park","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"10.1016\/j.bone.2014.04.015_bb0115","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.clinbiochem.2012.03.034","article-title":"The role of the calcium-sensing receptor in human disease","volume":"45","author":"Ward","year":"2012","journal-title":"Clin Biochem"},{"issue":"2","key":"10.1016\/j.bone.2014.04.015_bb0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2174\/1874467211205020182","article-title":"Antagonizing the calcium-sensing receptor: towards new bone anabolics?","volume":"5","author":"Riccardi","year":"2012","journal-title":"Curr Mol Pharmacol"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214001501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214001501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T18:26:44Z","timestamp":1538677604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328214001501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":24,"alternative-id":["S8756328214001501"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2014.04.015","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2014.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}