{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:13:36Z","timestamp":1792113216694,"version":"4.4.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bone.2014.05.014","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T09:14:10Z","timestamp":1401700450000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Anorexia nervosa and bone metabolism"],"prefix":"10.1016","volume":"66","author":[{"given":"Pouneh K.","family":"Fazeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Klibanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2014.05.014_bb0590","series-title":"Diagnostic and statistical manual of mental disorders (DSM-IV)","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.bone.2014.05.014_bb0010","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1176\/ajp.148.7.917","article-title":"50-year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study","volume":"148","author":"Lucas","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bone.2014.05.014_bb0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/(SICI)1098-108X(199912)26:4<397::AID-EAT5>3.0.CO;2-0","article-title":"The ups and downs of anorexia nervosa","volume":"26","author":"Lucas","year":"1999","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.bone.2014.05.014_bb0020","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1176\/appi.ajp.2007.06081388","article-title":"Epidemiology and course of anorexia nervosa in the community","volume":"164","author":"Keski-Rahkonen","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bone.2014.05.014_bb0025","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1017\/S003329170100407X","article-title":"Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study","volume":"31","author":"Lowe","year":"2001","journal-title":"Psychol Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0595","author":"Trickey"},{"key":"10.1016\/j.bone.2014.05.014_bb0035","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1054-139X(03)00060-0","article-title":"Eating disorders in adolescent boys: a review of the adolescent and young adult literature","volume":"33","author":"Muise","year":"2003","journal-title":"J Adolesc Health"},{"key":"10.1016\/j.bone.2014.05.014_bb0040","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archinte.165.5.561","article-title":"Medical findings in outpatients with anorexia nervosa","volume":"165","author":"Miller","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0045","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","article-title":"Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa","volume":"133","author":"Grinspoon","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0050","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1001\/jama.1991.03460090081037","article-title":"The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass","volume":"265","author":"Rigotti","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2014.05.014_bb0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0025-6196(11)63994-3","article-title":"Long-term fracture risk among women with anorexia nervosa: a population-based cohort study","volume":"74","author":"Lucas","year":"1999","journal-title":"Mayo Clin Proc"},{"issue":"Pt 6","key":"10.1016\/j.bone.2014.05.014_bb0060","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1177\/000456329803500602","article-title":"Dissociation of bone turnover in anorexia nervosa","volume":"35","author":"Stefanis","year":"1998","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.bone.2014.05.014_bb0065","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1210\/jc.2005-2818","article-title":"Determinants of skeletal loss and recovery in anorexia nervosa","volume":"91","author":"Miller","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0070","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/ajcn\/84.4.698","article-title":"Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents","volume":"84","author":"Misra","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.bone.2014.05.014_bb0075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00198-007-0476-z","article-title":"Low prevalence of vitamin D deficiency among adolescents with anorexia nervosa","volume":"19","author":"Haagensen","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2014.05.014_bb0080","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0028-1097104","article-title":"Effects of LH\u2013RH on plasma levels of LH and FSH in anorexia nervosa","volume":"4","author":"Wiegelmann","year":"1972","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.bone.2014.05.014_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00005792-197403000-00003","article-title":"Hypothalamic dysfunction in patients with anorexia nervosa","volume":"53","author":"Mecklenburg","year":"1974","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bone.2014.05.014_bb0090","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1530\/acta.0.0810252","article-title":"Some aspects of hypothalamic\u2013pituitary function in patients with anorexia nervosa","volume":"81","author":"Travaglini","year":"1976","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10.1016\/j.bone.2014.05.014_bb0095","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0002-9378(75)90349-X","article-title":"Successful induction of follicular maturation and ovulation by prolonged treatment with LH-releasing hormone in women with anorexia nervosa","volume":"122","author":"Nillius","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bone.2014.05.014_bb0100","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM197410242911701","article-title":"Anorexia nervosa. Immaturity of the 24-hour luteinizing hormone secretory pattern","volume":"291","author":"Boyar","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0105","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF02555743","article-title":"The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis","volume":"38","author":"Riis","year":"1986","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2014.05.014_bb0110","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/jcem-68-3-548","article-title":"Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa","volume":"68","author":"Biller","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0115","first-page":"898","article-title":"The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa","volume":"80","author":"Klibanski","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0120","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1210\/jcem.87.6.8574","article-title":"Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa","volume":"87","author":"Grinspoon","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0125","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/jbmr.447","article-title":"Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa","volume":"26","author":"Misra","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.05.014_bb0130","first-page":"4489","article-title":"The effects of anorexia nervosa on bone metabolism in female adolescents","volume":"84","author":"Soyka","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0135","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1210\/jcem-71-3-705","article-title":"A comparative and longitudinal study on endocrine changes related to ovarian function in patients with anorexia nervosa","volume":"71","author":"van Binsbergen","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0140","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1210\/jc.2006-2501","article-title":"Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea","volume":"92","author":"Miller","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0145","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1210\/jc.2011-0380","article-title":"Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study","volume":"96","author":"Miller","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0150","first-page":"3861","article-title":"Serum leptin levels in women with anorexia nervosa","volume":"81","author":"Grinspoon","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0155","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1152\/ajpendo.00041.2005","article-title":"Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents","volume":"289","author":"Misra","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0160","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1210\/jc.2004-0720","article-title":"Preservation of neuroendocrine control of reproductive function despite severe undernutrition","volume":"89","author":"Miller","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0165","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00198-009-1120-x","article-title":"Anorexia nervosa, osteoporosis and circulating leptin: the missing link","volume":"21","author":"Legroux-Gerot","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2014.05.014_bb0170","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bone.2009.09.005","article-title":"Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa","volume":"46","author":"Lawson","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0175","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa040388","article-title":"Recombinant human leptin in women with hypothalamic amenorrhea","volume":"351","author":"Welt","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0180","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/archpsyc.1975.01760240067005","article-title":"Hypothalamic\u2013pituitary function in anorexia nervosa","volume":"32","author":"Garfinkel","year":"1975","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bone.2014.05.014_bb0185","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1210\/jcem.82.10.4275","article-title":"Spontaneous nocturnal growth hormone secretion in anorexia nervosa","volume":"82","author":"Scacchi","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0190","first-page":"2056","article-title":"Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis","volume":"84","author":"Stoving","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0195","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1210\/jc.2003-030532","article-title":"Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism","volume":"88","author":"Misra","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0200","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1172\/JCI118137","article-title":"Effects of rhIGF-I administration on bone turnover during short-term fasting","volume":"96","author":"Grinspoon","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2014.05.014_bb0205","first-page":"762","article-title":"The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins","volume":"75","author":"Counts","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0210","first-page":"200","article-title":"The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa","volume":"85","author":"Hotta","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0215","first-page":"2805","article-title":"Effects of recombinant human insulin-like growth factor I administration on spontaneous and growth hormone (GH)-releasing hormone-stimulated GH secretion in anorexia nervosa","volume":"85","author":"Gianotti","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0220","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-1450669","article-title":"Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa","volume":"145","author":"Otto","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bone.2014.05.014_bb0225","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1210\/jc.2003-031861","article-title":"Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls","volume":"89","author":"Misra","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0230","doi-asserted-by":"crossref","first-page":"E347","DOI":"10.1152\/ajpendo.00615.2004","article-title":"Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents","volume":"289","author":"Misra","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0235","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.1002271107","article-title":"Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2014.05.014_bb0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1210\/en.2012-1849","article-title":"The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice","volume":"154","author":"Gahete","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0245","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bone.2008.07.241","article-title":"IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts","volume":"43","author":"Nakasaki","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0250","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1172\/JCI109908","article-title":"Effect of insulin-like growth factor I on DNA and protein synthesis in cultured rat calvaria","volume":"66","author":"Canalis","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2014.05.014_bb0255","first-page":"2049","article-title":"Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea","volume":"84","author":"Grinspoon","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0260","first-page":"3864","article-title":"Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa","volume":"81","author":"Grinspoon","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0265","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bone.2009.06.002","article-title":"Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa","volume":"45","author":"Misra","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0270","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-4781(00)00067-1","article-title":"Identification of a novel FGF, FGF-21, preferentially expressed in the liver","volume":"1492","author":"Nishimura","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bone.2014.05.014_bb0275","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2014.05.014_bb0280","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2014.05.014_bb0285","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0290","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cmet.2008.05.006","article-title":"Inhibition of growth hormone signaling by the fasting-induced hormone FGF21","volume":"8","author":"Inagaki","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0295","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/jc.2009-1730","article-title":"Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa","volume":"95","author":"Fazeli","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0300","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.1200797109","article-title":"Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma","volume":"109","author":"Wei","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2014.05.014_bb0305","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/jc.2008-2532","article-title":"Increased bone marrow fat in anorexia nervosa","volume":"94","author":"Bredella","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0600","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2010.09.005","article-title":"Sirtuin-1 regulation of mammalian metabolism","volume":"17","author":"Gillum","year":"2010","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0315","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1073\/pnas.1220606110","article-title":"SIRT1 regulates adaptive response of the growth hormone-insulin-like growth factor-I axis under fasting conditions in liver","volume":"110","author":"Yamamoto","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2014.05.014_bb0320","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1359\/JBMR.041237","article-title":"Ghrelin directly regulates bone formation","volume":"20","author":"Fukushima","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.05.014_bb0325","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1210\/jc.2005-0512","article-title":"Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents","volume":"90","author":"Misra","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0330","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1210\/jc.2007-2419","article-title":"Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II","volume":"93","author":"Misra","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0335","first-page":"4712","article-title":"Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation","volume":"85","author":"Leung","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0340","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0006-291X(78)90177-8","article-title":"Regulation of hepatic growth hormone receptors by insulin","volume":"84","author":"Baxter","year":"1978","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2014.05.014_bb0345","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/jcem-56-4-668","article-title":"Subnormal plasma dehydroisoandrosterone to cortisol ratio in anorexia nervosa: a second hormonal parameter of ontogenic regression","volume":"56","author":"Zumoff","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0350","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1067\/mpd.2002.125003","article-title":"Physiologic regulators of bone turnover in young women with anorexia nervosa","volume":"141","author":"Gordon","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.bone.2014.05.014_bb0355","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1210\/jc.2002-020545","article-title":"Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial","volume":"87","author":"Gordon","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0360","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.metabol.2011.11.016","article-title":"The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa","volume":"61","author":"Divasta","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.bone.2014.05.014_bb0365","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1056\/NEJM197701272960403","article-title":"Cortisol secretion and metabolism in anorexia nervosa","volume":"296","author":"Boyar","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0370","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1210\/jc.2004-0723","article-title":"Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism","volume":"89","author":"Misra","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0375","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1210\/jc.2009-1046","article-title":"Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa","volume":"94","author":"Lawson","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0380","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000323771","article-title":"The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism","volume":"93","author":"Misra","year":"2011","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0385","first-page":"3441","article-title":"Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis","volume":"81","author":"Canalis","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0390","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2010.05.005","article-title":"Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor","volume":"11","author":"Rauch","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0395","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1210\/endo-126-3-1569","article-title":"Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells","volume":"126","author":"McCarthy","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0400","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1210\/endo-112-5-1782","article-title":"Cortisol inhibits and adrenocorticotropin has no effect on luteinizing hormone-releasing hormone-induced release of luteinizing hormone from bovine pituitary cells in vitro","volume":"112","author":"Padmanabhan","year":"1983","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0405","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1210\/endo.134.1.8275958","article-title":"Regulation of parathyroid hormone (PTH)\/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17\/2.8 and OK cells","volume":"134","author":"Urena","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0410","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/jcem-40-3-470","article-title":"Low serum triiodothyronine in patients with anorexia nervosa","volume":"40","author":"Moshang","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0415","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1210\/jcem-40-2-334","article-title":"Serum thyroid hormones and thyrotropin in anorexia nervosa","volume":"40","author":"Miyai","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0420","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/jcem-44-1-167","article-title":"Low serum triiodothyronine (T3) and hypothyroidism in anorexia nervosa","volume":"44","author":"Croxson","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0425","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/bmj.2.6136.526","article-title":"Hypothalamo\u2013pituitary\u2013thyroid function in anorexia nervosa: influence of weight gain","volume":"2","author":"Leslie","year":"1978","journal-title":"Br Med J"},{"key":"10.1016\/j.bone.2014.05.014_bb0430","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0306-4530(82)90055-5","article-title":"Delayed TSH release in anorexia nervosa following injection of thyrotropin-releasing hormone (TRH)","volume":"7","author":"Casper","year":"1982","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bone.2014.05.014_bb0435","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2265.1979.tb02100.x","article-title":"Serum T3 and T4 levels in patients with anorexia nervosa showing transient hyperthyroidism during weight gain","volume":"10","author":"Moore","year":"1979","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bone.2014.05.014_bb0440","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/eje.1.01850","article-title":"L-tri-iodothyronine is a major determinant of resting energy expenditure in underweight patients with anorexia nervosa and during weight gain","volume":"152","author":"Onur","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bone.2014.05.014_bb0445","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0140-6736(71)91383-3","article-title":"Osteoporosis and fractures following thyrotoxicosis","volume":"1","author":"Fraser","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2014.05.014_bb0450","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S8756-3282(97)00097-5","article-title":"The expression of thyroid hormone receptors in human bone","volume":"21","author":"Abu","year":"1997","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0455","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bone.2005.01.017","article-title":"Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors","volume":"36","author":"Kindblom","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0460","first-page":"950","article-title":"Effects of hypothyroidism and hyperthyroidism on insulin-like growth factors (IGFs) and growth hormone- and IGF-binding proteins","volume":"76","author":"Miell","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0465","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jc.2005-1878","article-title":"Elevated peptide YY levels in adolescent girls with anorexia nervosa","volume":"91","author":"Misra","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0470","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bone.2008.03.007","article-title":"Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa","volume":"43","author":"Utz","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0475","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI0214588","article-title":"Hypothalamic Y2 receptors regulate bone formation","volume":"109","author":"Baldock","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2014.05.014_bb0480","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1210\/jc.2006-2855","article-title":"Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa","volume":"92","author":"Misra","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0485","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/jc.2003-031260","article-title":"Adiponectin in anorexia nervosa and bulimia nervosa","volume":"89","author":"Tagami","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0490","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/jc.2004-1364","article-title":"Serum adiponectin and resistin concentrations in patients with restrictive and binge\/purge form of anorexia nervosa and bulimia nervosa","volume":"90","author":"Housova","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0495","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.nut.2012.07.011","article-title":"The role of adiponectin multimers in anorexia nervosa","volume":"29","author":"Amitani","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.bone.2014.05.014_bb0500","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3181\/0806-RM-192","article-title":"Adiponectin is a negative regulator of bone mineral and bone strength in growing mice","volume":"233","author":"Ealey","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.bone.2014.05.014_bb0505","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0196-9781(89)90082-X","article-title":"Influence of oxytocin on feeding behavior in the rat","volume":"10","author":"Arletti","year":"1989","journal-title":"Peptides"},{"key":"10.1016\/j.bone.2014.05.014_bb0510","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0031-9384(95)02179-5","article-title":"Central oxytocin increases food intake and daily weight gain in rats","volume":"59","author":"Bjorkstrand","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bone.2014.05.014_bb0515","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jne.12120","article-title":"The oxytocin-bone axis","volume":"26","author":"Colaianni","year":"2014","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.bone.2014.05.014_bb0520","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1073\/pnas.0901890106","article-title":"Oxytocin is an anabolic bone hormone","volume":"106","author":"Tamma","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2014.05.014_bb0525","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1634\/stemcells.2008-0127","article-title":"Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis","volume":"26","author":"Elabd","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2014.05.014_bb0530","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.4088\/JCP.10m06617","article-title":"Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass","volume":"72","author":"Lawson","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.bone.2014.05.014_bb0535","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/jbmr.182","article-title":"Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats","volume":"25","author":"Li","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.05.014_bb0540","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2014.05.014_bb0605","first-page":"jc20132565","article-title":"Role of sclerostin and dickkopf-1 in the dramatic alteration in bone mass acquisition in adolescents and young women with recent anorexia nervosa","author":"Maimoun","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0550","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bone.2012.06.006","article-title":"Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls","volume":"51","author":"Faje","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.05.014_bb0610","first-page":"jc20134105","article-title":"Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa","author":"Fazeli","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0560","first-page":"1620","article-title":"Potential value of vertebral proton MR spectroscopy in determining bone weakness","volume":"22","author":"Schellinger","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bone.2014.05.014_bb0565","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00198-006-0285-9","article-title":"MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women","volume":"18","author":"Shen","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2014.05.014_bb0570","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1210\/jc.2011-2605","article-title":"Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study","volume":"97","author":"Shen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0575","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1210\/jc.2007-2691","article-title":"Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults","volume":"93","author":"Di Iorgi","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0580","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1210\/jc.2010-1922","article-title":"Bone marrow fat is inversely related to cortical bone in young and old subjects","volume":"96","author":"Wren","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.05.014_bb0585","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00002030-200206140-00009","article-title":"Reduced intravertebral bone marrow fat in HIV-infected men","volume":"16","author":"Huang","year":"2002","journal-title":"AIDS"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214001896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214001896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T05:31:01Z","timestamp":1565501461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328214001896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":117,"alternative-id":["S8756328214001896"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2014.05.014","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anorexia nervosa and bone metabolism","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2014.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}