{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:39:24Z","timestamp":1791189564365,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Odense University Hospital, Denmark"},{"name":"King Abdullah City for Science and Technology (KACST), KSA","award":["10-BIO1308-02"],"award-info":[{"award-number":["10-BIO1308-02"]}]},{"name":"University of New South Wales (UNSW) IPRS"},{"name":"UNSW Visiting Fellow Scheme"},{"name":"Australian Government EIF Super Science Scheme"},{"name":"New South Wales State Government Science Leveraging Fund"}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bone.2014.06.027","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T19:16:13Z","timestamp":1403982973000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype"],"prefix":"10.1016","volume":"67","author":[{"given":"Natalie A.","family":"Twine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi N.","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustapha","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2014.06.027_bb0005","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bone.2014.06.027_bb0010","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1359\/jbmr.2001.16.9.1575","article-title":"Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers","volume":"16","author":"Hauge","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"5","key":"10.1016\/j.bone.2014.06.027_bb0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02557826","article-title":"Human bone cells in vitro","volume":"37","author":"Robey","year":"1985","journal-title":"Calcif Tissue Int"},{"issue":"12","key":"10.1016\/j.bone.2014.06.027_bb0020","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/jbmr.5650081207","article-title":"1,25-Dihydroxyvitamin D3 potentiates fluoride-stimulated collagen type I production in cultures of human bone marrow stromal osteoblast-like cells","volume":"8","author":"Kassem","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.bone.2014.06.027_bb0025","first-page":"85","article-title":"Gene expression in osteoblastic cells","volume":"1","author":"Rodan","year":"1991","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"3","key":"10.1016\/j.bone.2014.06.027_bb0030","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jcp.1041430304","article-title":"Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix","volume":"143","author":"Owen","year":"1990","journal-title":"J Cell Physiol"},{"issue":"Pt 9","key":"10.1016\/j.bone.2014.06.027_bb0035","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1242\/jcs.00376","article-title":"Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation","volume":"116","author":"Liu","year":"2003","journal-title":"J Cell Sci"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bone.2008.03.011","article-title":"Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells","volume":"43","author":"Post","year":"2008","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2014.06.027_bb0045","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1359\/jbmr.1997.12.9.1335","article-title":"Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo","volume":"12","author":"Kuznetsov","year":"1997","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.bone.2014.06.027_bb0050","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1359\/jbmr.091018","article-title":"Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity","volume":"25","author":"Larsen","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.06.027_bb0055","series-title":"Bone, the osteoblast and osteocyte","first-page":"351","article-title":"Bone forming cells in clinical conditions","author":"AM","year":"1991"},{"issue":"3","key":"10.1016\/j.bone.2014.06.027_bb0065","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jbmr.5650100319","article-title":"Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis","volume":"10","author":"Parfitt","year":"1995","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.bone.2014.06.027_bb0070","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1359\/jbmr.2001.16.6.1120","article-title":"Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis","volume":"16","author":"Stenderup","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0075","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5144\/0256-4947.2012.68","article-title":"Human stromal (mesenchymal) stem cells: basic biology and current clinical use for tissue regeneration","volume":"32","author":"Aldahmash","year":"2012","journal-title":"Ann Saudi Med"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0080","doi-asserted-by":"crossref","first-page":"e16266","DOI":"10.1371\/journal.pone.0016266","article-title":"Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease","volume":"6","author":"Twine","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2014.06.027_bb0085","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/bib\/bbr004","article-title":"Design and validation issues in RNA-seq experiments","volume":"12","author":"Fang","year":"2011","journal-title":"Brief Bioinform"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0090","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12015-012-9365-8","article-title":"Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential","volume":"9","author":"Al-Nbaheen","year":"2013","journal-title":"Stem Cell Rev"},{"issue":"6","key":"10.1016\/j.bone.2014.06.027_bb0095","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nbt0602-592","article-title":"Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells","volume":"20","author":"Simonsen","year":"2002","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.bone.2014.06.027_bb0100","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol"},{"issue":"5","key":"10.1016\/j.bone.2014.06.027_bb0105","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"10","key":"10.1016\/j.bone.2014.06.027_bb0110","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bone.2014.06.027_bb0120","series-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2013"},{"issue":"11","key":"10.1016\/j.bone.2014.06.027_bb0125","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1359\/jbmr.2000.15.11.2095","article-title":"A skeletal gene database","volume":"15","author":"Ho","year":"2000","journal-title":"J Bone Miner Res"},{"issue":"Database issue","key":"10.1016\/j.bone.2014.06.027_bb0130","first-page":"D43","article-title":"Update on activities at the Universal Protein Resource (UniProt) in 2013","volume":"41","author":"UniProt","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.bone.2014.06.027_bb0135","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nmeth1102","article-title":"A gene expression bar code for microarray data","volume":"4","author":"Zilliox","year":"2007","journal-title":"Nat Methods"},{"issue":"Database issue","key":"10.1016\/j.bone.2014.06.027_bb0140","doi-asserted-by":"crossref","first-page":"D1011","DOI":"10.1093\/nar\/gkq1259","article-title":"The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes","volume":"39","author":"McCall","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.bone.2014.06.027_bb0145","doi-asserted-by":"crossref","first-page":"e45142","DOI":"10.1371\/journal.pone.0045142","article-title":"The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors","volume":"7","author":"Benisch","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2014.06.027_bb0150","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/ten.tec.2009.0405","article-title":"Gene expression patterns related to osteogenic differentiation of bone marrow-derived mesenchymal stem cells during ex vivo expansion","volume":"16","author":"Granchi","year":"2010","journal-title":"Tissue Eng Part C Methods"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0155","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"44","key":"10.1016\/j.bone.2014.06.027_bb0160","doi-asserted-by":"crossref","first-page":"18587","DOI":"10.1073\/pnas.0812334106","article-title":"Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis","volume":"106","author":"Hamidouche","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bone.2014.06.027_bb0165","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jcb.20462","article-title":"Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation","volume":"95","author":"Mayer","year":"2005","journal-title":"J Cell Biochem"},{"issue":"12","key":"10.1016\/j.bone.2014.06.027_bb0170","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1359\/jbmr.2002.17.12.2106","article-title":"Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development","volume":"17","author":"Vaes","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.bone.2014.06.027_bb0175","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1359\/JBMR.040216","article-title":"Identification of novel regulators associated with early-phase osteoblast differentiation","volume":"19","author":"de Jong","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"7","key":"10.1016\/j.bone.2014.06.027_bb0180","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/1529-0131(200107)44:7<1608::AID-ART284>3.0.CO;2-T","article-title":"Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo","volume":"44","author":"Dell'Accio","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0185","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/art.23143","article-title":"A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells","volume":"58","author":"De Bari","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.bone.2014.06.027_bb0190","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1023\/B:JMSM.0000046394.53153.21","article-title":"Relation between in vitro and in vivo osteogenic potential of cultured human bone marrow stromal cells","volume":"15","author":"Mendes","year":"2004","journal-title":"J Mater Sci Mater Med"},{"issue":"7","key":"10.1016\/j.bone.2014.06.027_bb0195","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1089\/ten.tea.2009.0735","article-title":"Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential","volume":"16","author":"Burns","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"3","key":"10.1016\/j.bone.2014.06.027_bb0200","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bone.2009.11.007","article-title":"Eight genes are highly associated with BMD variation in postmenopausal Caucasian women","volume":"46","author":"Reppe","year":"2010","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2014.06.027_bb0205","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.396","article-title":"Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype","volume":"26","author":"Jemtland","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.bone.2014.06.027_bb0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yexmp.2010.10.011","article-title":"Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing","volume":"90","author":"Kawakatsu","year":"2011","journal-title":"Exp Mol Pathol"},{"issue":"6","key":"10.1016\/j.bone.2014.06.027_bb0215","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.yexcr.2010.12.015","article-title":"Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations","volume":"317","author":"Taipaleenmaki","year":"2011","journal-title":"Exp Cell Res"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214002361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214002361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T23:29:45Z","timestamp":1716852585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328214002361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":42,"alternative-id":["S8756328214002361"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2014.06.027","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2014.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}