{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:17:16Z","timestamp":1791328636266,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24229009"],"award-info":[{"award-number":["24229009"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["26861553"],"award-info":[{"award-number":["26861553"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24592805"],"award-info":[{"award-number":["24592805"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Uehara Memorial Science Foundation"},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shimabara Science Foundation"},{"name":"The Ichiro Kanehara Foundation"},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.bone.2014.09.006","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:39:56Z","timestamp":1410838796000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion"],"prefix":"10.1016","volume":"69","author":[{"given":"Akiko","family":"Mizokami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yasutake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Kawakubo-Yasukochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Chishaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2014.09.006_bb0005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bone.2014.09.006_bb0010","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bone.2014.09.006_bb0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2010.06.002","article-title":"Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition","volume":"142","author":"Fulzele","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bone.2014.09.006_bb0020","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.cell.2011.02.004","article-title":"Endocrine regulation of male fertility by the skeleton","volume":"144","author":"Oury","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bone.2014.09.006_bb0025","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2013.08.042","article-title":"Maternal and offspring pools of osteocalcin influence brain development and functions","volume":"155","author":"Oury","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bone.2014.09.006_bb0030","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.molmet.2013.08.004","article-title":"In vivo analysis of the contribution of bone resorption to the control of glucose metabolism","volume":"2","author":"Lacombe","year":"2013","journal-title":"Mol Metab"},{"key":"10.1016\/j.bone.2014.09.006_bb0035","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jbmr.390","article-title":"Gprc6a mediates responses to osteocalcin in \u03b2-cells in vitro and pancreas in vivo","volume":"26","author":"Pi","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.09.006_bb0040","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1083\/jcb.200809113","article-title":"The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity","volume":"183","author":"Hinoi","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bone.2014.09.006_bb0045","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates \u03b2 cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2014.09.006_bb0050","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bone.2011.04.017","article-title":"Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice","volume":"50","author":"Ferron","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.09.006_bb0055","doi-asserted-by":"crossref","first-page":"e57375","DOI":"10.1371\/journal.pone.0057375","article-title":"Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice","volume":"8","author":"Mizokami","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2014.09.006_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.bone.2014.09.006_bb0065","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/jdi.12065","article-title":"Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas","volume":"4","author":"Seino","year":"2013","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.bone.2014.09.006_bb0070","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1210\/endo.136.8.7628397","article-title":"Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV","volume":"136","author":"Kieffer","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.09.006_bb0075","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2010.11.002","article-title":"Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications","volume":"12","author":"Nauck","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.bone.2014.09.006_bb0080","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2337\/db11-0739","article-title":"Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides","volume":"61","author":"Watanabe","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2014.09.006_bb0085","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S8756-3282(01)00581-6","article-title":"Circadian and longitudinal variation of serum C-telopeptide, osteocalcin, and skeletal alkaline phosphatase in C3H\/HeJ mice","volume":"29","author":"Srivastava","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2014.09.006_bb0090","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.2337\/db08-0307","article-title":"Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion","volume":"57","author":"Edfalk","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2014.09.006_bb0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.bone.2014.09.006_bb0100","doi-asserted-by":"crossref","first-page":"40201","DOI":"10.1074\/jbc.M505186200","article-title":"Identification of novel extracellular cation-sensing G-protein coupled receptor","volume":"280","author":"Pi","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2014.09.006_bb0105","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1124\/mol.104.007559","article-title":"Deorphanization of GPRC6A: a promiscuous L-\u03b1-amino acid receptor with preference for basic amino acids","volume":"67","author":"Wellendorph","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bone.2014.09.006_bb0110","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1210\/en.2012-1301","article-title":"GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets","volume":"153","author":"Pi","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2014.09.006_bb0115","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1074\/jbc.M112.402677","article-title":"The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells","volume":"288","author":"Oya","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2014.09.006_bb0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1471-4159.2005.03025.x","article-title":"Cloning and characterization of a family C orphan G-protein coupled receptor","volume":"93","author":"Kuang","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.bone.2014.09.006_bb0125","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/sj.bjp.0707121","article-title":"Pharmacological characterization of mouse GPRC6A, an L-\u03b1-amino acid receptor with ability to sense divalent cations","volume":"150","author":"Christiansen","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bone.2014.09.006_bb0130","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/bph.12365","article-title":"The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function","volume":"171","author":"Clemmensen","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bone.2014.09.006_bb0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.gene.2007.03.008","article-title":"The rat GPRC6A: cloning and characterization","volume":"396","author":"Wellendorph","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.bone.2014.09.006_bb0140","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00726-009-0334-8","article-title":"L-arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells","volume":"38","author":"Tan","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.bone.2014.09.006_bb0145","doi-asserted-by":"crossref","first-page":"G271","DOI":"10.1152\/ajpgi.00074.2012","article-title":"Sensing of amino acids by the gut-expressed taste receptor T1R1\u2013T1R3 stimulates CCK secretion","volume":"304","author":"Daly","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.bone.2014.09.006_bb0150","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.clnu.2011.01.007","article-title":"The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)","volume":"30","author":"Steinet","year":"2011","journal-title":"Clin Nutr"},{"key":"10.1016\/j.bone.2014.09.006_bb0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1677\/joe.1.05876","article-title":"Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob\/ob mice","volume":"185","author":"Green","year":"2005","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bone.2014.09.006_bb0160","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/nm1196-1254","article-title":"Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene","volume":"2","author":"Scrocchi","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.bone.2014.09.006_bb0165","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2337\/diabetes.47.7.1046","article-title":"Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor \u2212\/\u2212 mice","volume":"47","author":"Pederson","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2014.09.006_bb0170","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2337\/diabetes.47.4.632","article-title":"Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling","volume":"47","author":"Scrocchi","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2014.09.006_bb0175","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1074\/jbc.M209423200","article-title":"Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214003366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328214003366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T21:16:51Z","timestamp":1565817411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328214003366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":35,"alternative-id":["S8756328214003366"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2014.09.006","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2014.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}