{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:58:18Z","timestamp":1780700298412,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.bone.2014.12.006","type":"journal-article","created":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T02:34:17Z","timestamp":1418438057000},"page":"176-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Areal bone mineral density in children and adolescents with Marfan syndrome: Evidence of an evolving problem"],"prefix":"10.1016","volume":"73","author":[{"given":"Giuliana","family":"Trifir\u00f2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Viecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2014.12.006_bb0005","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2014.12.006_bb0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/adc.76.1.41","article-title":"Evolving phenotype of Marfan's syndrome","volume":"76","author":"Lipscomb","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.bone.2014.12.006_bb0015","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1111\/apa.12072","article-title":"The kid-short Marfan score (Kid-SMS) \u2014 an easy executable risk score for suspected paediatric patients with Marfan syndrome","volume":"102","author":"Mueller","year":"2013","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.bone.2014.12.006_bb0020","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"De Paepe","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.bone.2014.12.006_bb0025","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.bone.2014.12.006_bb0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ymgme.2012.07.023","article-title":"Structure and function of the mammalian fibrillin gene family: implications for human connective tissue diseases","volume":"107","author":"Davis","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.bone.2014.12.006_bb0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1749-6632.2009.05350.x","article-title":"Extracellular regulation of transforming growth factor \u03b2 and bone morphogenetic protein signaling in bone","volume":"1192","author":"Nistala","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bone.2014.12.006_bb0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of TGF-\u03b2 activation contributes to pathogenesis in Marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.bone.2014.12.006_bb0045","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/0002-9343(93)90351-O","article-title":"Bone mineral status of women with Marfan syndrome","volume":"95","author":"Kohlmeier","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/j.bone.2014.12.006_bb0050","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/jbmr.5650101017","article-title":"The bone mineral status of patients with Marfan syndrome","volume":"10","author":"Kohlmeier","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2014.12.006_bb0055","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/rheumatology\/39.3.307","article-title":"Bone mineral density in adults with Marfan syndrome","volume":"39","author":"Carter","year":"2000","journal-title":"Rheumatology"},{"key":"10.1016\/j.bone.2014.12.006_bb0060","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jbspin.2006.01.026","article-title":"Bone mineral density in Marfan syndrome","volume":"73","author":"Moura","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.bone.2014.12.006_bb0065","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00198-003-1433-0","article-title":"Assessment of bone mineral density in adults and children with Marfan syndrome","volume":"14","author":"Giampietro","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2014.12.006_bb0070","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/ajmg.a.35540","article-title":"Assessment of bone mineral status in children with Marfan syndrome","volume":"158A","author":"Grover","year":"2012","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.bone.2014.12.006_bb0075","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF03344156","article-title":"Italian cross-sectional growth charts for height, weight and BMI (2 to 20yr)","volume":"29","author":"Cacciari","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.bone.2014.12.006_bb0080","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00198-008-0689-9","article-title":"Special report on the 2007 adult and pediatric Position Development Conferences of the International Society for Clinical Densitometry","volume":"19","author":"Lewiecki","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bone.2014.12.006_bb0085","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1210\/jc.2009-2057","article-title":"Height adjustment in assessing dual energy X-ray absorptiometry measurements of bone mass and density in children","volume":"95","author":"Zemel","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.12.006_bb0090","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/17446651.1.2.297","article-title":"Monitoring bone mass, bone density and bone geometry in children and adolescents","volume":"1","author":"Mora","year":"2006","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.bone.2014.12.006_bb0095","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1074\/jbc.M209256200","article-title":"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein","volume":"278","author":"Isogai","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2014.12.006_bb0100","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/01.CIR.103.6.789","article-title":"Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy","volume":"103","author":"Lim","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2014.12.006_bb0105","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1097\/01.hjh.0000182521.44440.c5","article-title":"Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats","volume":"23","author":"Lavoie","year":"2005","journal-title":"J Hypertens"},{"key":"10.1016\/j.bone.2014.12.006_bb0110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bone.2014.12.006_bb0115","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1093\/hmg\/ddq409","article-title":"Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome","volume":"19","author":"Nistala","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bone.2014.12.006_bb0120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2010.12.070","article-title":"The Ghent Marfan Trial\u2014a randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with \u03b2-blockers","volume":"157","author":"M\u00f6berg","year":"2012","journal-title":"Int J Cardiol"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821400458X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821400458X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T01:21:43Z","timestamp":1538011303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632821400458X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":24,"alternative-id":["S875632821400458X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2014.12.006","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Areal bone mineral density in children and adolescents with Marfan syndrome: Evidence of an evolving problem","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2014.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}