{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:37:45Z","timestamp":1791279465269,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270011"],"award-info":[{"award-number":["81270011"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101372"],"award-info":[{"award-number":["81101372"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thebonejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.bone.2015.02.017","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T21:16:46Z","timestamp":1424467006000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-\u03baB and PI3K\/Akt signaling pathways"],"prefix":"10.1016","volume":"75","author":[{"given":"Feng-Lai","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Sheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Long","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2015.02.017_bb0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2225-4110.110407","article-title":"Herbal treatment for osteoporosis: a current review","volume":"3","author":"Leung","year":"2013","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.bone.2015.02.017_bb0010","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jbmr.242","article-title":"Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways","volume":"26","author":"Li","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2015.02.017_bb0015","doi-asserted-by":"crossref","first-page":"356260","DOI":"10.1155\/2013\/356260","article-title":"Chinese herbal medicine for osteoporosis: a systematic review of randomized controlled trails","volume":"2013","author":"Wang","year":"2013","journal-title":"Evid Based Complement Altern Med"},{"key":"10.1016\/j.bone.2015.02.017_bb0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ptr.2291","article-title":"Dosing effects of an antiosteoporosis herbal formula\u2014a preclinical investigation using a rat model","volume":"22","author":"Sun","year":"2008","journal-title":"Phytother Res"},{"key":"10.1016\/j.bone.2015.02.017_bb0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2012.03.008","article-title":"Estrogen and the skeleton","volume":"23","author":"Khosla","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bone.2015.02.017_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejogrb.2013.02.022","article-title":"Effect of leonurine hydrochloride on endothelin and the endothelin receptor-mediated signal pathway in medically-induced incomplete abortion in rats","volume":"169","author":"Li","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bone.2015.02.017_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejogrb.2011.09.006","article-title":"Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats","volume":"159","author":"Li","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bone.2015.02.017_bb0040","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1359\/jbmr.070709","article-title":"Regulation of osteoclast differentiation and function by phosphate: potential role of osteoclasts in the skeletal abnormalities in hypophosphatemic conditions","volume":"22","author":"Hayashibara","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2015.02.017_bb0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/0470846658.ch16","article-title":"The molecular basis of osteoclast differentiation and activation","volume":"232","author":"Suda","year":"2001","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.bone.2015.02.017_bb0050","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature02444","article-title":"Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis","volume":"428","author":"Koga","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bone.2015.02.017_bb0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1196\/annals.1443.016","article-title":"RANK\/RANKL: regulators of immune responses and bone physiology","volume":"1143","author":"Leibbrandt","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bone.2015.02.017_bb0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2015.02.017_bb0065","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1210\/en.2009-0026","article-title":"Phosphatidylinositol 3 kinase\/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation","volume":"150","author":"Mandal","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2015.02.017_bb0070","first-page":"2088","article-title":"RelA\/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice","volume":"118","author":"Vaira","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2015.02.017_bb0075","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI200419657","article-title":"Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation","volume":"114","author":"Ikeda","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2015.02.017_bb0080","doi-asserted-by":"crossref","first-page":"e80873","DOI":"10.1371\/journal.pone.0080873","article-title":"Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2015.02.017_bb0085","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.0105-2896.2005.00332.x","article-title":"Fos\/AP-1 proteins in bone and the immune system","volume":"208","author":"Wagner","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bone.2015.02.017_bb0090","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.2741\/2252","article-title":"Osteoclast differentiation and gene regulation","volume":"12","author":"Zhao","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.bone.2015.02.017_bb0095","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1016\/j.febslet.2013.08.017","article-title":"Acid-sensing ion channel 1a is involved in acid-induced osteoclastogenesis by regulating activation of the transcription factor NFATc1","volume":"587","author":"Li","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bone.2015.02.017_bb0100","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.biocel.2012.04.003","article-title":"Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo","volume":"44","author":"Zhu","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bone.2015.02.017_bb0105","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1038\/sj.onc.1206310","article-title":"PSK-mediated NF-kappaB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1","volume":"22","author":"Zhang","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2015.02.017_bb0110","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1128\/MCB.24.17.7806-7819.2004","article-title":"NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity","volume":"24","author":"Fujioka","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bone.2015.02.017_bb0115","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2015.02.017_bb0120","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI200316069","article-title":"Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis","volume":"111","author":"Ritchlin","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2015.02.017_bb0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","article-title":"RANKL-RANK signaling in osteoclastogenesis and bone disease","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bone.2015.02.017_bb0130","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/978-0-387-89520-8_9","article-title":"RANK(L) as a key target for controlling bone loss","volume":"647","author":"Leibbrandt","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bone.2015.02.017_bb0135","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.190.12.1741","article-title":"Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors","volume":"190","author":"Arai","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.bone.2015.02.017_bb0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/08916930701694543","article-title":"Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss","volume":"41","author":"Abu-Amer","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.bone.2015.02.017_bb0145","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1210\/endo.142.9.8402","article-title":"Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor","volume":"142","author":"Huber","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2015.02.017_bb0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.1101254","article-title":"Akt induces osteoclast differentiation through regulating the GSK3beta\/NFATc1 signaling cascade","volume":"188","author":"Moon","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.bone.2015.02.017_bb0155","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1096\/fj.11-194399","article-title":"Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1","volume":"26","author":"Hwang","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.bone.2015.02.017_bb0160","first-page":"141","article-title":"Further study on the effects of motherwort (Leonurus sibiricus L.) on preneoplastic and neoplastic mammary gland growth in multiparous GR\/A mice","volume":"12","author":"Nagasawa","year":"1992","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bone.2015.02.017_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jep.2013.12.052","article-title":"Leonurus japonicus Houtt.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"152","author":"Shang","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bone.2015.02.017_bb0170","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bone.2015.02.017_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/bonekey.2012.59","article-title":"Osteoimmunology: the expanding role of immunoreceptors in osteoclasts and bone remodeling","volume":"1","author":"Long","year":"2012","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.bone.2015.02.017_bb0180","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.bone.2015.02.017_bb0185","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/360741a0","article-title":"Bone and haematopoietic defects in mice lacking c-fos","volume":"360","author":"Wang","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bone.2015.02.017_bb0190","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.274.19.13613","article-title":"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival","volume":"274","author":"Lum","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2015.02.017_bb0195","doi-asserted-by":"crossref","first-page":"412768","DOI":"10.1155\/2013\/412768","article-title":"RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease","volume":"2013","author":"Lo Iacono","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.bone.2015.02.017_bb0200","doi-asserted-by":"crossref","first-page":"451","DOI":"10.5483\/BMBRep.2014.47.8.206","article-title":"Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability during RANKL-mediated osteoclastogenesis","volume":"47","author":"Kim","year":"2014","journal-title":"BMB Rep"},{"key":"10.1016\/j.bone.2015.02.017_bb0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.3164526","article-title":"Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells","volume":"241","author":"Komm","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bone.2015.02.017_bb0210","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1073\/pnas.88.15.6613","article-title":"Avian osteoclasts as estrogen target cells","volume":"88","author":"Oursler","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2015.02.017_bb0215","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1248\/bpb.33.455","article-title":"Estrogenic effects of the herbal formula, menoprogen, in ovariectomized rats","volume":"33","author":"Ma","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bone.2015.02.017_bb0220","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/jrf.0.0890477","article-title":"Immunization of ovariectomized ewes against progesterone, oestrogen or cortisol to detect effects of adrenal steroids on reproduction","volume":"89","author":"Adams","year":"1990","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.bone.2015.02.017_bb0225","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tem.2005.01.004","article-title":"Transcription factor cross-talk: the estrogen receptor and NF-kappaB","volume":"16","author":"Kalaitzidis","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bone.2015.02.017_bb0230","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/onc.2008.300","article-title":"NF-kappaB signaling, liver disease and hepatoprotective agents","volume":"27","author":"Sun","year":"2008","journal-title":"Oncogene"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328215000629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328215000629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T20:26:10Z","timestamp":1537820770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328215000629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":46,"alternative-id":["S8756328215000629"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2015.02.017","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-\u03baB and PI3K\/Akt signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2015.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}