{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:51:57Z","timestamp":1789901517735,"version":"4.0.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["HEALTH-F4-2010-241504"],"award-info":[{"award-number":["HEALTH-F4-2010-241504"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI2009-10532"],"award-info":[{"award-number":["PSI2009-10532"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG041517"],"award-info":[{"award-number":["AG041517"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR047822"],"award-info":[{"award-number":["AR047822"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["083573\/Z\/07"],"award-info":[{"award-number":["083573\/Z\/07"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["089269\/Z\/09\/Z"],"award-info":[{"award-number":["089269\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["090532\/Z\/09\/Z"],"award-info":[{"award-number":["090532\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["092630"],"award-info":[{"award-number":["092630"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.bone.2015.08.013","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T06:54:50Z","timestamp":1439967290000},"page":"417-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Fine mapping of bone structure and strength QTLs in heterogeneous stock rat"],"prefix":"10.1016","volume":"81","author":[{"given":"Imranul","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Ca\u00f1ete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Mont-Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"L\u00f3pez-Aumatell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Mart\u00ednez-Membrives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sira","family":"D\u00edaz-Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Tobe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00e1ndez-Teruel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Stridh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Johannesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Baud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Econs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2015.08.013_bb0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2015.08.013_bb0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0140-6736(93)92555-8","article-title":"Bone density at various sites for prediction of hip fractures. The study of osteoporotic fractures research group","volume":"341","author":"Cummings","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2015.08.013_bb0015","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650081008","article-title":"Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures","volume":"8","author":"Faulkner","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF02106096","article-title":"Better discrimination of hip fracture using bone density, geometry and architecture","volume":"5","author":"Peacock","year":"1995","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2015.08.013_bb0025","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbmr.5650110414","article-title":"The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins","volume":"11","author":"Arden","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0030","first-page":"140","article-title":"Genetic influence on bone turnover in postmenopausal twins","volume":"81","author":"Garnero","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2015.08.013_bb0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/edrv.23.3.0464","article-title":"Genetics of osteoporosis","volume":"23","author":"Peacock","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bone.2015.08.013_bb0040","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/01.bor.0000166385.62851.92","article-title":"Genetic determinants of osteoporosis","volume":"17","author":"Ralston","year":"2005","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bone.2015.08.013_bb0045","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1359\/jbmr.080221","article-title":"Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats","volume":"23","author":"Alam","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bone.2007.11.004","article-title":"Genetic loci affecting bone structure and strength in inbred COP and DA rats","volume":"42","author":"Sun","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2015.08.013_bb0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2005.12.009","article-title":"Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength","volume":"39","author":"Alam","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2015.08.013_bb0060","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1359\/JBMR.050512","article-title":"Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats","volume":"20","author":"Alam","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1530-0277.1984.tb05706.x","article-title":"Development of the National Institutes of Health genetically heterogeneous rat stock","volume":"8","author":"Hansen","year":"1984","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00178778","article-title":"On the classification of regular systems of inbreeding","volume":"28","author":"Boucher","year":"1990","journal-title":"J. Math. Biol."},{"key":"10.1016\/j.bone.2015.08.013_bb0075","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1152\/physiolgenomics.00178.2009","article-title":"Fine-mapping a locus for glucose tolerance using heterogeneous stock rats","volume":"41","author":"Solberg Woods","year":"2010","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.bone.2015.08.013_bb0080","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1101\/gr.081497.108","article-title":"A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock","volume":"19","author":"Johannesson","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0085","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bone.2011.02.009","article-title":"Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility","volume":"48","author":"Alam","year":"2011","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.bone.2015.08.013_bb0090","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ng.2644","article-title":"Combined sequence-based and genetic mapping analysis of complex traits in outbred rats","volume":"45","author":"Baud","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2015.08.013_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2195","article-title":"High-resolution genome screen for bone mineral density in heterogeneous stock rat","author":"Alam","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0100","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1073\/pnas.230304397","article-title":"A method for fine mapping quantitative trait loci in outbred animal stocks","volume":"97","author":"Mott","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2015.08.013_bb0105","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1534\/genetics.107.080101","article-title":"Efficient control of population structure in model organism association mapping","volume":"178","author":"Kang","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.bone.2015.08.013_bb0110","series-title":"R: A Language and Environment for Statistical Computing","author":"R. Development Core Team","year":"2004"},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0115","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/genetics\/143.2.1013","article-title":"Confidence intervals in QTL mapping by bootstrapping","volume":"143","author":"Visscher","year":"1996","journal-title":"Genetics"},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0120","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<314::AID-DVG2>3.0.CO;2-9","article-title":"Multiple calvarial defects in lmx1b mutant mice","volume":"22","author":"Chen","year":"1998","journal-title":"Dev. Genet."},{"issue":"7","key":"10.1016\/j.bone.2015.08.013_bb0125","first-page":"937","article-title":"Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb","volume":"46","author":"Chen","year":"2002","journal-title":"Int. J. Dev. Biol."},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1440-169X.2012.01331.x","article-title":"Detection of genes regulated by Lmx1b during limb dorsalization","volume":"54","author":"Feenstra","year":"2012","journal-title":"Develop. Growth Differ."},{"issue":"44","key":"10.1016\/j.bone.2015.08.013_bb0135","doi-asserted-by":"crossref","first-page":"29658","DOI":"10.1074\/jbc.M800786200","article-title":"Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1","volume":"283","author":"Ravindran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2015.08.013_bb0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2014.02.015","article-title":"Is GSN significant for hip BMD in female Caucasians?","volume":"63","author":"Deng","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0145","doi-asserted-by":"crossref","first-page":"e30907","DOI":"10.1371\/journal.pone.0030907","article-title":"Identification of novel candidate oncogenes in chromosome region 17p11.2\u2013p12 in human osteosarcoma","volume":"7","author":"Both","year":"2012","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.bone.2015.08.013_bb0150","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/cncr.22595","article-title":"COPS3 amplification and clinical outcome in osteosarcoma","volume":"109","author":"Yan","year":"2007","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.bone.2015.08.013_bb0155","doi-asserted-by":"crossref","first-page":"E703","DOI":"10.1152\/ajpendo.00517.2012","article-title":"Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss","volume":"304","author":"Ke","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000357359","article-title":"Identification of nine new RAI1-truncating mutations in Smith-Magenis Syndrome patients without 17p11.2 deletions","volume":"5","author":"Dubourg","year":"2014","journal-title":"Mol. Syndromol."},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0165","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajhg.2010.07.011","article-title":"Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems","volume":"87","author":"Williams","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1359\/jbmr.080908","article-title":"An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association","volume":"24","author":"Farber","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1469-1809.2008.00490.x","article-title":"Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans","volume":"73","author":"Lee","year":"2009","journal-title":"Ann. Hum. Genet."},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0180","doi-asserted-by":"crossref","first-page":"e35979","DOI":"10.1371\/journal.pone.0035979","article-title":"Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice","volume":"7","author":"Bonar","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0185","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/jbmr.071002","article-title":"Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death","volume":"23","author":"McCall","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-4608(02)00627-1","article-title":"Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma","volume":"139","author":"van Dartel","year":"2002","journal-title":"Cancer Genet. Cytogenet."},{"issue":"11","key":"10.1016\/j.bone.2015.08.013_bb0195","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/sj.cdd.4401882","article-title":"Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL","volume":"13","author":"Huang","year":"2006","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.bone.2015.08.013_bb0200","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1128\/MCB.24.10.4329-4340.2004","article-title":"Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1","volume":"24","author":"Hyun","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.bone.2015.08.013_bb0205","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/hmg\/ddh102","article-title":"Huntingtin interacting protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts","volume":"13","author":"Oravecz-Wilson","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.bone.2015.08.013_bb0210","doi-asserted-by":"crossref","first-page":"e75638","DOI":"10.1371\/journal.pone.0075638","article-title":"Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development","volume":"8","author":"Panda","year":"2013","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0215","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1081\/ERC-200044174","article-title":"A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency","volume":"30","author":"Wudy","year":"2004","journal-title":"Endocr. Res."},{"key":"10.1016\/j.bone.2015.08.013_bb0220","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00335-004-2459-0","article-title":"Genome screen for bone mineral density phenotypes in Fischer 344 and Lewis rats","volume":"16","author":"Koller","year":"2005","journal-title":"Mamm. Genome"},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0225","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1086\/319518","article-title":"A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases","volume":"68","author":"Jawaheer","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.bone.2015.08.013_bb0230","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1210\/jc.2002-020474","article-title":"A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis","volume":"87","author":"Deng","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.bone.2015.08.013_bb0235","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1359\/jbmr.2002.17.9.1718","article-title":"Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study","volume":"17","author":"Karasik","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2015.08.013_bb0240","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1093\/hmg\/ddt675","article-title":"Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS\/GENOMOS consortium","volume":"23","author":"Moayyeri","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.bone.2015.08.013_bb0245","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1086\/302685","article-title":"Stratification analysis of an osteoarthritis genome screen-suggestive linkage to chromosomes 4, 6, and 16","volume":"65","author":"Loughlin","year":"1999","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0250","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1359\/jbmr.060806","article-title":"Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass","volume":"22","author":"Ioannidis","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2015.08.013_bb0255","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1086\/302569","article-title":"Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q","volume":"65","author":"Lepp\u00e4vuori","year":"1999","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0260","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1086\/510724","article-title":"Genomewide linkage scan for split-hand\/foot malformation with long-bone deficiency in a large Arab family identifies two novel susceptibility loci on chromosomes 1q42.2\u2013q43 and 6q14.1","volume":"80","author":"Naveed","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.bone.2015.08.013_bb0265","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1359\/jbmr.2001.16.6.985","article-title":"Genome screen for quantitative trait loci underlying normal variation in femoral structure","volume":"16","author":"Koller","year":"2001","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2015.08.013_bb0270","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1359\/jbmr.2003.18.6.1057","article-title":"Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19","volume":"18","author":"Koller","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2015.08.013_bb0275","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1210\/jc.2006-2607","article-title":"A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis","volume":"92","author":"Tang","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0280","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1673-8527(08)60095-8","article-title":"Bivariate whole-genome linkage scan for bone geometry and total body fat mass","volume":"36","author":"Lei","year":"2009","journal-title":"J. Genet. Genomics"},{"issue":"2","key":"10.1016\/j.bone.2015.08.013_bb0285","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00223-004-0088-y","article-title":"A second-stage genome scan for QTLs influencing BMD variation","volume":"75","author":"Huang","year":"2004","journal-title":"Calcif. Tissue Int."},{"issue":"9","key":"10.1016\/j.bone.2015.08.013_bb0290","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1359\/jbmr.080401","article-title":"Linkage screen for BMD phenotypes in male and female COP and DA rat strains","volume":"23","author":"Koller","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2015.08.013_bb0295","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/sj.ejhg.5201761","article-title":"A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13\u201316.1","volume":"15","author":"Thys","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"issue":"9","key":"10.1016\/j.bone.2015.08.013_bb0300","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1177\/0022034510370004","article-title":"Novel cleft susceptibility genes in chromosome 6q","volume":"89","author":"Letra","year":"2010","journal-title":"J. Dent. Res."},{"issue":"12","key":"10.1016\/j.bone.2015.08.013_bb0305","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1359\/jbmr.060812","article-title":"QTL with pleiotropic effects on serum levels of bone-specific alkaline phosphatase and osteocalcin maps to the baboon ortholog of human chromosome 6p23\u201321.3","volume":"21","author":"Havill","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0310","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1086\/510724","article-title":"Genome wide linkage scan for split-hand\/foot malformation with long-bone deficiency in a large Arab family identifies two novel susceptibility loci on chromosomes 1q42.2\u2013q43 and 6q14.1","volume":"80","author":"Naveed","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0315","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/geno.1998.5530","article-title":"The autosomal recessive Kenny-Caffey syndrome locus maps to chromosome 1q42\u2013q43","volume":"54","author":"Diaz","year":"1998","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0320","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cancergencyto.2004.03.007","article-title":"Amplification and overexpression of genes in 17p11.2~p12 in osteosarcoma","volume":"153","author":"van Dartel","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0325","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1534\/genetics.108.090407","article-title":"A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.)","volume":"180","author":"Sherwood","year":"2008","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.bone.2015.08.013_bb0330","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11914-014-0219-y","article-title":"Genetics of Paget's disease of bone","volume":"12","author":"Ralston","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.bone.2015.08.013_bb0335","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1359\/jbmr.071004","article-title":"Identification of a major locus for Paget's disease on chromosome 10p13 in families of British descent","volume":"23","author":"Lucas","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2015.08.013_bb0340","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1086\/323798","article-title":"Genomewide search in familial Paget disease of bone shows evidence of genetic heterogeneity with candidate loci on chromosomes 2q36, 10p13, and 5q35","volume":"69","author":"Hocking","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.bone.2015.08.013_bb0345","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/humu.20028","article-title":"Identification of a novel mutation in the coding region of the grey-lethal gene OSTM1 in human malignant infantile osteopetrosis","volume":"23","author":"Ram\u00edrez","year":"2004","journal-title":"Hum. Mutat."},{"issue":"5","key":"10.1016\/j.bone.2015.08.013_bb0350","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/ajmg.a.33826","article-title":"Craniometaphyseal dysplasia with severe craniofacial involvement shows homozygosity at 6q21\u201322.1 locus","volume":"155A","author":"Prontera","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"issue":"5","key":"10.1016\/j.bone.2015.08.013_bb0355","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejmg.2013.01.007","article-title":"A Chinese patient with KBG syndrome and a 9q31.2\u201333.1 microdeletion","volume":"56","author":"Xu","year":"2013","journal-title":"Eur. J. Med. Genet."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328215003245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328215003245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T21:20:07Z","timestamp":1668892807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328215003245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":71,"alternative-id":["S8756328215003245"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2015.08.013","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fine mapping of bone structure and strength QTLs in heterogeneous stock rat","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2015.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}