{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:23:12Z","timestamp":1790720592104,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Australian Government Department of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian National Health and Medical Research Council","award":["APP1000986"],"award-info":[{"award-number":["APP1000986"]}]}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.bone.2015.08.024","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T19:05:32Z","timestamp":1440788732000},"page":"675-682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["The effect of dose and type of proton pump inhibitor use on risk of fractures and osteoporosis treatment in older Australian women: A prospective cohort study"],"prefix":"10.1016","volume":"81","author":[{"given":"Mari\u00eblle M.C.","family":"van der Hoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Tett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar J.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette J.","family":"Dobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.E.E. (Geeske)","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2015.08.024_bb0005","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/pds.1972","article-title":"Prescribing of anti-osteoporotic therapies following the use of proton pump inhibitors in general practice","volume":"19","author":"McGowan","year":"2010","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.bone.2015.08.024_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1503\/cmaj.071330","article-title":"Use of proton pump inhibitors and risk of osteoporosis-related fractures","volume":"179","author":"Targownik","year":"2008","journal-title":"CMAJ"},{"key":"10.1016\/j.bone.2015.08.024_bb0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1756283X12437358","article-title":"Overutilization of proton-pump inhibitors: what the clinician needs to know","volume":"5","author":"Heidelbaugh","year":"2012","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.bone.2015.08.024_bb0020","series-title":"Differences in Utilisation of Gastroprotective Drugs Between 2001 and 2005 in Australia and Nova Scotia","author":"Tett","year":"2013"},{"key":"10.1016\/j.bone.2015.08.024_bb0025","author":"Australian Department of Health & Ageing"},{"key":"10.1016\/j.bone.2015.08.024_bb0030","author":"Food and Drug Administration"},{"key":"10.1016\/j.bone.2015.08.024_bb0035","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.bone.2010.12.015","article-title":"Meta-analysis: risk of fractures with acid-suppressing medication","volume":"48","author":"Kwok","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2015.08.024_bb0040","article-title":"Proton pump inhibitor and possible fracture risk","volume":"vol. 28, No 1","author":"Australian Department of Health & Ageing","year":"2009"},{"key":"10.1016\/j.bone.2015.08.024_bb0045","author":"U.S. Food and Drug Administration (FDA)"},{"key":"10.1016\/j.bone.2015.08.024_bb0050","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.maturitas.2014.05.019","article-title":"Use of proton pump inhibitors (PPI) and history of earlier fracture are independent risk factors for fracture in postmenopausal women. The WHILA study","volume":"78","author":"Moberg","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.bone.2015.08.024_bb0055","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1053\/j.gastro.2009.11.014","article-title":"Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss","volume":"138","author":"Targownik","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bone.2015.08.024_bb0060","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ajg.2012.200","article-title":"The Relationship Between Proton Pump Inhibitor Use and Longitudinal Change in Bone Mineral Density: a population-based from the Canadian multicentre osteoporosis study (CaMos)","volume":"107","author":"Targownik","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bone.2015.08.024_bb0065","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/archinternmed.2010.94","article-title":"Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative","volume":"170","author":"Gray","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bone.2015.08.024_bb0070","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-008-9170-1","article-title":"Acid-suppressive medications and risk of bone loss and fracture in older adults","volume":"83","author":"Yu","year":"2008","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2015.08.024_bb0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jbmr.2344","article-title":"Bone Mineral Density Changes Among Women Initiating Proton Pump Inhibitors or H2 Receptor Antagonists: A SWAN Cohort Study","volume":"30","author":"Solomon","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.024_bb0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bone.2013.09.014","article-title":"Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals","volume":"57","author":"Maggio","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2015.08.024_bb0085","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.metabol.2012.09.011","article-title":"Proton pump inhibitors have no measurable effect on calcium and bone metabolism in healthy young males: a prospective matched controlled study","volume":"62","author":"Sharara","year":"2013","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.bone.2015.08.024_bb0090","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1002\/jbmr.166","article-title":"Do proton pump inhibitors decrease calcium absorption?","volume":"25","author":"Hansen","year":"2010","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.024_bb0095","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1002\/jbmr.108","article-title":"Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial","volume":"25","author":"Wright","year":"2010","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.024_bb0100","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/ije\/dyi098","article-title":"Cohort profile: the Australian longitudinal study on women's health","volume":"34","author":"Lee","year":"2005","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bone.2015.08.024_bb0105","author":"Australian Department of Health & Ageing"},{"key":"10.1016\/j.bone.2015.08.024_bb0110","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/pds.1969","article-title":"Marked increase in proton pump inhibitors use in Australia","volume":"19","author":"Hollingworth","year":"2010","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.bone.2015.08.024_bb0115","author":"WHO Collaborating Centres for Drug Statistics Methodology"},{"key":"10.1016\/j.bone.2015.08.024_bb0120","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00198-012-2033-7","article-title":"Validity of self-reported osteoporosis in mid-age and older women","volume":"24","author":"Peeters","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2015.08.024_bb0125","series-title":"Australian Alcohol Guidelines: Health Risks and Benefits","author":"National Health and Medical Research Council","year":"2001"},{"key":"10.1016\/j.bone.2015.08.024_bb0130","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"10.1016\/j.bone.2015.08.024_bb0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1753-6405.2008.00305.x","article-title":"Reliability and validity of a modified self-administered version of the Active Australia physical activity survey in a sample of mid-age women","volume":"32","author":"Brown","year":"2008","journal-title":"Aust. N. Z. J. Public Health"},{"key":"10.1016\/j.bone.2015.08.024_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2036.1999.00022.x","article-title":"Review article: cytochrome P450 and the metabolism of proton pump inhibitors \u2014 emphasis on rabeprazole","volume":"13","author":"Ishizaki","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bone.2015.08.024_bb0145","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00198-012-2015-9","article-title":"Relationship between use of antidepressants and risk of fractures: a meta-analysis","volume":"24","author":"Rabenda","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2015.08.024_bb0150","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1302\/0301-620X.95B11.31158","article-title":"Effects of commonly used medications on bone tissue mineralisation in SaOS-2 human bone cell line: an in vitro study","volume":"95-B","author":"Salai","year":"2013","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.bone.2015.08.024_bb0155","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b5087","article-title":"Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes","volume":"340","author":"Levesque","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.bone.2015.08.024_bb0160","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/aje\/kwm324","article-title":"Immortal time bias in pharmacoepidemiology","volume":"167","author":"Suissa","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bone.2015.08.024_bb0165","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/jc.2004-1568","article-title":"Hip fracture in women without osteoporosis","volume":"90","author":"Wainwright","year":"2005","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bone.2015.08.024_bb0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00774-012-0406-9","article-title":"The effects of risedronate administered in combination with a proton pump inhibitor for the treatment of osteoporosis","volume":"31","author":"Itoh","year":"2013","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2015.08.024_bb0175","doi-asserted-by":"crossref","first-page":"iv9","DOI":"10.1093\/rheumatology\/ken180","article-title":"Advanced CT bone imaging in osteoporosis","volume":"47","author":"Genant","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.bone.2015.08.024_bb0180","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/jbmr.2279","article-title":"Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study","volume":"29","author":"Lewis","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2015.08.024_bb0185","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.annepidem.2014.01.004","article-title":"Proton-pump inhibitor use and hip fractures in men: a population-based case\u2013control study","volume":"24","author":"Adams","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.bone.2015.08.024_bb0190","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/phar.1410","article-title":"Study of the association between hip fracture and acid-suppressive drug use in a UK primary care setting","volume":"34","author":"Cea Soriano","year":"2014","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bone.2015.08.024_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00228-008-0576-5","article-title":"Relative potency of proton-pump inhibitors\u2014comparison of effects on intragastric pH","volume":"65","author":"Kirchheiner","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bone.2015.08.024_bb0200","first-page":"1","article-title":"Esomeprazole use is independently associated with significant reduction of BMD: 1-year prospective comparative safety study of four proton pump inhibitors","author":"Bahtiri","year":"2015","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2015.08.024_bb0205","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1001\/jama.2013.280490","article-title":"Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency","volume":"310","author":"Lam","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2015.08.024_bb0210","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/00365520902718929","article-title":"Coeliac disease-specific tissue transglutaminase autoantibodies are associated with osteoporosis and related fractures in middle-aged women","volume":"44","author":"Agardh","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bone.2015.08.024_bb0215","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11914-015-0273-0","article-title":"The role of B-vitamins in bone health and disease in older adults","volume":"13","author":"Bailey","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2015.08.024_bb0220","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0895-4356(96)00274-0","article-title":"Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients' self-reports and on determinants of inaccuracy","volume":"49","author":"Kriegsman","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.bone.2015.08.024_bb0225","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jclinepi.2014.09.019","article-title":"Diagnostic accuracy of self-reported arthritis in the general adult population is acceptable","volume":"68","author":"Peeters","year":"2015","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.bone.2015.08.024_bb0230","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00228-010-0942-y","article-title":"Primary-care prescribing of anti-osteoporotic-type medications following hospitalisation for fractures","volume":"67","author":"McGowan","year":"2011","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bone.2015.08.024_bb0235","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ajg.2012.444","article-title":"Guidelines for the diagnosis and management of gastroesophageal reflux disease","volume":"108","author":"Katz","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bone.2015.08.024_bb0240","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3109\/13880209.2014.892141","article-title":"Effects of calcitriol on bone mineral density in patients treated with esomeprazole","volume":"52","author":"Huang","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bone.2015.08.024_bb0245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00108-012-3231-2","article-title":"Long-term use of proton pump inhibitors: who needs prophylaxis?","volume":"54","author":"Scheurlen","year":"2013","journal-title":"Internist (Berl.)"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821500335X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821500335X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T19:24:07Z","timestamp":1537385047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632821500335X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":49,"alternative-id":["S875632821500335X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2015.08.024","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of dose and type of proton pump inhibitor use on risk of fractures and osteoporosis treatment in older Australian women: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2015.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}