{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:47Z","timestamp":1790192867447,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.bone.2016.01.005","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T05:15:24Z","timestamp":1452057324000},"page":"160-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load"],"prefix":"10.1016","volume":"84","author":[{"given":"Isabel","family":"Quir\u00f3s-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Rom\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alonso-Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barrio-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Carrillo-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Naves-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Jos\u00e9","family":"Corrales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Piedad","family":"Ruiz-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Benito","family":"Cannata-And\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Fern\u00e1ndez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2016.01.005_bb0005","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jbmr.5650110714","article-title":"Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro","volume":"11","author":"Almaden","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.01.005_bb0010","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.0000141775.67189.98","article-title":"Pathophysiology of vascular calcification in chronic kidney disease","volume":"95","author":"Moe","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2016.01.005_bb0015","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2007080854","article-title":"Mechanisms of vascular calcification in chronic kidney disease","volume":"19","author":"Moe","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2016.01.005_bb0020","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mad.2010.02.008","article-title":"A potential link between phosphate and aging\u2014lessons from Klotho-deficient mice","volume":"131","author":"Kuro-o","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bone.2016.01.005_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bone.2009.09.006","article-title":"High phosphorus diet induces vascular calcification, a related decrease in bone mass and changes in the aortic gene expression","volume":"46","author":"Roman-Garcia","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.01.005_bb0030","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/01.ATV.0000220441.42041.20","article-title":"Molecular mechanisms of vascular calcification: lessons learned from the aorta","volume":"26","author":"Shao","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bone.2016.01.005_bb0035","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.147.5.913","article-title":"Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy","volume":"147","author":"Sullivan","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2016.01.005_bb0040","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/ki.2011.26","article-title":"Phosphate and Klotho","author":"Kuro","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2016.01.005_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature04019","article-title":"Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation","volume":"437","author":"Varela","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bone.2016.01.005_bb0050","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1161\/CIRCRESAHA.111.300543","article-title":"Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells","volume":"112","author":"Liu","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2016.01.005_bb0055","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1161\/CIRCULATIONAHA.112.000571","article-title":"Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson\u2013Gilford progeria syndrome that is ameliorated on pyrophosphate treatment","volume":"127","author":"Villa-Bellosta","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2016.01.005_bb0060","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/gme.0b013e3181ce6874","article-title":"Differential effects of 17beta-estradiol and raloxifene on bone and lipid metabolism in rats with chronic kidney disease and estrogen insufficiency","volume":"17","author":"Naves-Diaz","year":"2010","journal-title":"Menopause"},{"key":"10.1016\/j.bone.2016.01.005_bb0065","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s002239900645","article-title":"Aluminum-induced osteogenesis in osteopenic rats with normal renal function","volume":"64","author":"Gomez-Alonso","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2016.01.005_bb0070","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hlca.19480310303","volume":"31","author":"Schwarzenbach","year":"1948","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.bone.2016.01.005_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ab.2004.02.002","article-title":"An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction","volume":"329","author":"Gregory","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bone.2016.01.005_bb0080","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/sj.cdd.4402197","article-title":"Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence","volume":"14","author":"Caron","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bone.2016.01.005_bb0085","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bone.2016.01.005_bb0090","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1210\/en.2011-1770","article-title":"Dual-specificity phosphatases are implicated in severe hyperplasia and lack of response to FGF23 of uremic parathyroid glands from rats","volume":"153","author":"Roman-Garcia","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2016.01.005_bb0095","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.009126","article-title":"HSV-1 Cgal + infection promotes quaking RNA binding protein production and induces nuclear-cytoplasmic shuttling of quaking I-5 isoform in human hepatoma cells","volume":"10","author":"Sanchez-Quiles","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bone.2016.01.005_bb0100","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.jprot.2012.01.009","article-title":"Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I\/III: characterization of DDX3X as a target of S-adenosylmethionine","volume":"75","author":"Schroder","year":"2012","journal-title":"J. Proteome"},{"key":"10.1016\/j.bone.2016.01.005_bb0105","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/hy1001.096358","article-title":"Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease","volume":"38","author":"Blacher","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.bone.2016.01.005_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021433","article-title":"Discordant gene expression signatures and related phenotypic differences in lamin A- and A\/C-related Hutchinson\u2013Gilford progeria syndrome (HGPS)","volume":"6","author":"Plasilova","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2016.01.005_bb0115","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.200904124","article-title":"Role of A-type lamins in signaling, transcription, and chromatin organization","volume":"187","author":"Andres","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2016.01.005_bb0120","doi-asserted-by":"crossref","first-page":"13049","DOI":"10.1073\/pnas.192460799","article-title":"Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect","volume":"99","author":"Bergo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2016.01.005_bb0125","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1161\/CIRCULATIONAHA.109.902056","article-title":"Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging","volume":"121","author":"Ragnauth","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2016.01.005_bb0130","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fj.12-218214","article-title":"The protein kinase Akt\/PKB regulates both prelamin A degradation and Lmna gene expression","volume":"27","author":"Bertacchini","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2016.01.005_bb0135","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1359\/jbmr.080902","article-title":"Inhibition of lamin A\/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis","volume":"24","author":"Rauner","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.01.005_bb0140","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1161\/ATVBAHA.110.209460","article-title":"Cardiovascular pathology in Hutchinson\u2013Gilford progeria: correlation with the vascular pathology of aging","volume":"30","author":"Olive","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bone.2016.01.005_bb0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1359\/jbmr.081010","article-title":"Effect of lamin A\/C knockdown on osteoblast differentiation and function","volume":"24","author":"Akter","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.01.005_bb0150","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1101\/gad.1364906","article-title":"Lamin A\/C and emerin are critical for skeletal muscle satellite cell differentiation","volume":"20","author":"Frock","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2016.01.005_bb0155","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/path.2999","article-title":"Nuclear lamins and laminopathies","volume":"226","author":"Worman","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.bone.2016.01.005_bb0160","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/emboj.2009.196","article-title":"Novel roles for A-type lamins in telomere biology and the DNA damage response pathway","volume":"28","author":"Gonzalez-Suarez","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2016.01.005_bb0165","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/cdd.2015.12","article-title":"Nesprin-2-dependent ERK1\/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing","volume":"22","author":"Warren","year":"2015","journal-title":"Cell Death Differ."},{"issue":"Pt 24","key":"10.1016\/j.bone.2016.01.005_bb0170","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1242\/jcs.112.24.4651","article-title":"Colocalization of intranuclear lamin foci with RNA splicing factors","volume":"112","author":"Jagatheesan","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2016.01.005_bb0175","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1242\/jcs.114.22.4001","article-title":"Distinct changes in intranuclear lamin A\/C organization during myoblast differentiation","volume":"114","author":"Muralikrishna","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2016.01.005_bb0180","article-title":"Decreased bone formation and osteopenia in lamin a\/c-deficient mice","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2016.01.005_bb0185","first-page":"1727","article-title":"STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice","volume":"118","author":"Ernst","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2016.01.005_bb0190","first-page":"1573","article-title":"A key pathogenic role for the STAT1\/T-bet signaling pathway in T-cell-mediated liver inflammation","volume":"38","author":"Siebler","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bone.2016.01.005_bb0195","doi-asserted-by":"crossref","first-page":"669","DOI":"10.5301\/jn.5000029","article-title":"Natural antioxidants and vascular calcification: a possible benefit","volume":"24","author":"Roman-Garcia","year":"2011","journal-title":"J. Nephrol."},{"key":"10.1016\/j.bone.2016.01.005_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.109.902056","article-title":"Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging","author":"Ragnauth","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2016.01.005_bb0205","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/ki.2011.18","article-title":"Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo","volume":"79","author":"Zhao","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2016.01.005_bb0210","doi-asserted-by":"crossref","first-page":"C126","DOI":"10.1152\/ajpcell.00329.2011","article-title":"Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress","volume":"303","author":"Muteliefu","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bone.2016.01.005_bb0215","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/hmg\/ddr327","article-title":"The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine","volume":"20","author":"Richards","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2016.01.005_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-1-4899-8032-8_19","article-title":"Nuclear lamins and oxidative stress in cell proliferation and longevity","volume":"773","author":"Shimi","year":"2014","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:13:00Z","timestamp":1654042380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328216000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":44,"alternative-id":["S8756328216000065"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2016.01.005","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2016.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}