{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:43:28Z","timestamp":1791110608879,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"am","delay-in-days":329,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01 AR52379"],"award-info":[{"award-number":["R01 AR52379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01 AR61821"],"award-info":[{"award-number":["R01 AR61821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"US Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81 XWH-17-1-0337"],"award-info":[{"award-number":["W81 XWH-17-1-0337"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004871","name":"Research Agreement with the Research Foundation of SUNY","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.bone.2016.02.005","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T13:07:27Z","timestamp":1454936847000},"page":"161-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse"],"prefix":"10.1016","volume":"87","author":[{"given":"Dongye","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-7794","authenticated-orcid":false,"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua Zhu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-8846","authenticated-orcid":false,"given":"Yi-Xian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2016.02.005_bb0005","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/beta-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0010","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","article-title":"Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis","volume":"24","author":"Li","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10103-011-0976-0","article-title":"Influence of creatine supplementation on bone quality in the ovariectomized rat model: an FT-Raman spectroscopy study","volume":"27","author":"de Souza","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.bone.2016.02.005_bb0020","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2147\/TCRM.S3552","article-title":"The use of calcium and vitamin D in the management of osteoporosis","volume":"4","author":"Sunyecz","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.bone.2016.02.005_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glt093","article-title":"Public health impact of osteoporosis","author":"Cauley","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bone.2016.02.005_bb0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11926-010-0097-y","article-title":"The societal burden of osteoporosis","volume":"12","author":"Becker","year":"2010","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bone.2016.02.005_bb0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0040","first-page":"435","article-title":"Osteoporosis \u2014 a current view of pharmacological prevention and treatment","volume":"7","author":"Das","year":"2013","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bone.2016.02.005_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s007740050090","article-title":"The response of bone to unloading","volume":"17","author":"Bikle","year":"1999","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0050","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1210\/jc.2010-0067","article-title":"Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss","volume":"95","author":"Gaudio","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00223-012-9610-9","article-title":"Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody","volume":"91","author":"Shahnazari","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2016.02.005_bb0060","first-page":"383","article-title":"Effects of a 120day period of bed-rest on bone mass and bone cell activities in man: attempts at countermeasure","volume":"2","author":"Vico","year":"1987","journal-title":"Bone Miner."},{"key":"10.1016\/j.bone.2016.02.005_bb0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2007-978693","article-title":"Immobilization-dependent bone collagen breakdown appears to increase with time: evidence for a lack of new bone equilibrium in response to reduced load during prolonged bed rest","volume":"31","author":"Fiore","year":"1999","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1098-3597(00)90001-2","article-title":"Epidemiology and pathogenesis of osteoporosis","volume":"2","author":"Raisz","year":"2000","journal-title":"Clin. Cornerstone"},{"key":"10.1016\/j.bone.2016.02.005_bb0075","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0749-3797(98)00085-3","article-title":"Physical activity interventions targeting older adults. A critical review and recommendations","volume":"15","author":"King","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.bone.2016.02.005_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0838.2003.00322.x","article-title":"Has exercise an antifracture efficacy in women?","volume":"14","author":"Karlsson","year":"2004","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.bone.2016.02.005_bb0085","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1139\/h06-051","article-title":"Mechanisms of bone remodeling during weight-bearing exercise","volume":"31","author":"Zernicke","year":"2006","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0090","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/gme.0b013e318148bbad","article-title":"The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague\u2013Dawley rats","volume":"15","author":"Tou","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.bone.2016.02.005_bb0095","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2012.06.100","article-title":"TNF-alpha mediates the stimulation of sclerostin expression in an estrogen-deficient condition","volume":"424","author":"Kim","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2016.02.005_bb0100","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2016.02.005_bb0105","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2016.02.005_bb0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00223-013-9749-z","article-title":"Involvement of WNT\/beta-catenin signaling in the treatment of osteoporosis","volume":"93","author":"Rossini","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2016.02.005_bb0115","doi-asserted-by":"crossref","first-page":"E1736","DOI":"10.1210\/jc.2012-1579","article-title":"Serum sclerostin increases in healthy adult men during bed rest","volume":"97","author":"Spatz","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0120","first-page":"263","article-title":"Sclerostin: a novel target for intervention in the treatment of osteoporosis","volume":"12","author":"Lewiecki","year":"2011","journal-title":"Discov. Med."},{"key":"10.1016\/j.bone.2016.02.005_bb0125","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3724\/SP.J.1005.2013.00939","article-title":"Expression and regulation of the SOST gene","volume":"35","author":"Qin","year":"2013","journal-title":"Yi Chuan"},{"key":"10.1016\/j.bone.2016.02.005_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062295","article-title":"Anti-sclerostin antibody inhibits internalization of sclerostin and sclerostin-mediated antagonism of Wnt\/LRP6 signaling","volume":"8","author":"van Dinther","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2016.02.005_bb0135","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0145","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2016.02.005_bb0150","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cytogfr.2005.02.005","article-title":"SOST\/sclerostin, an osteocyte-derived negative regulator of bone formation","volume":"16","author":"van Bezooijen","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bone.2016.02.005_bb0155","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bone.2010.09.009","article-title":"Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model","volume":"48","author":"Tian","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0160","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bone.2008.07.253","article-title":"The effects of frequency-dependent dynamic muscle stimulation on inhibition of trabecular bone loss in a disuse model","volume":"43","author":"Lam","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0165","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bone.2012.06.030","article-title":"Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model","volume":"51","author":"Hu","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bone.2015.04.002","article-title":"Sclerostin antibody treatment causes greater alveolar crest height and bone mass in an ovariectomized rat model of localized periodontitis","volume":"76","author":"Chen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bone.2014.07.031","article-title":"Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats","volume":"67","author":"Stolina","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0180","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5312\/wjo.v4.i3.124","article-title":"Biomechanical characteristics of bone in streptozotocin-induced diabetic rats: an in-vivo randomized controlled experimental study","volume":"4","author":"Korres","year":"2013","journal-title":"World J. Orthop."},{"key":"10.1016\/j.bone.2016.02.005_bb0185","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","article-title":"Basic biomechanical measurements of bone: a tutorial","volume":"14","author":"Turner","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0190","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.1807","article-title":"Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading","volume":"28","author":"Spatz","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0195","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00198-009-1047-2","article-title":"Assessing forearm fracture risk in postmenopausal women","volume":"21","author":"Melton","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2016.02.005_bb0200","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01495739708936692","article-title":"Quantification of bone microarchitecture with the structure model index","volume":"1","author":"Hildebrand","year":"1997","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"key":"10.1016\/j.bone.2016.02.005_bb0205","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/jbmr.182","article-title":"Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats","volume":"25","author":"Li","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.02.005_bb0210","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0504287","article-title":"Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells","volume":"77","author":"Janckila","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bone.2016.02.005_bb0215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-007-9091-4","article-title":"Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model","volume":"82","author":"Rissanen","year":"2008","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2016.02.005_bb0220","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/clinchem\/46.11.1751","article-title":"Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium","volume":"46","author":"Alatalo","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bone.2016.02.005_bb0225","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1210\/en.2011-0252","article-title":"Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats","volume":"152","author":"Li","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2016.02.005_bb0230","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7150\/ijms.11887","article-title":"Transient effect of 17beta-estradiol on osteoporosis in ovariectomized rats accompanied with unilateral disuse in the early phase","volume":"12","author":"Sun","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bone.2016.02.005_bb0235","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","article-title":"Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction","volume":"5","author":"Tatsumi","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0240","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass Ii","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2016.02.005_bb0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2741\/3673","article-title":"Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals","volume":"16","author":"Takahashi","year":"2011","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bone.2016.02.005_bb0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2016.02.005_bb0255","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20031454","article-title":"Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist","volume":"199","author":"van Bezooijen","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2016.02.005_bb0260","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1210\/en.2006-1372","article-title":"In vivo analysis of Wnt signaling in bone","volume":"148","author":"Glass","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2016.02.005_bb0265","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2007-0270","article-title":"Targeting the Wnt\/beta-catenin pathway to regulate bone formation in the adult skeleton","volume":"148","author":"Baron","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2016.02.005_bb0270","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1210\/jc.2009-2283","article-title":"Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women","volume":"95","author":"Mirza","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2016.02.005_bb0275","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2215\/CJN.06550810","article-title":"Sclerostin and Dickkopf-1 in renal osteodystrophy","volume":"6","author":"Cejka","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."}],"updated-by":[{"DOI":"10.1016\/j.bone.2016.05.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000}}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821630028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821630028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:39:38Z","timestamp":1757612378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632821630028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":55,"alternative-id":["S875632821630028X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2016.02.005","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.bone.2016.05.007","asserted-by":"object"}]},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2016.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}