{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:48:14Z","timestamp":1768070894676,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"am","delay-in-days":275,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Hearing Research Inc.","award":["NIH-NIDCR R01 DE019284"],"award-info":[{"award-number":["NIH-NIDCR R01 DE019284"]}]},{"name":"Hearing Research Inc.","award":["DOD PRORP OR130191"],"award-info":[{"award-number":["DOD PRORP OR130191"]}]},{"name":"Hearing Research Inc.","award":["NIH-NIAMS P30 AR066262-01"],"award-info":[{"award-number":["NIH-NIAMS P30 AR066262-01"]}]},{"name":"UNCF \u2014 Merck Postdoctoral Scholar Fellowship"},{"DOI":"10.13039\/100005193","name":"AAO-HNS CORE Resident Research Award","doi-asserted-by":"publisher","award":["NIH R03 DE016868"],"award-info":[{"award-number":["NIH R03 DE016868"]}],"id":[{"id":"10.13039\/100005193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008189","name":"Deafness Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bone.2016.04.010","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T21:45:00Z","timestamp":1460583900000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Parallel mechanisms suppress cochlear bone remodeling to protect hearing"],"prefix":"10.1016","volume":"89","author":[{"given":"Emmanuel J.","family":"J\u00e1uregui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Akil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Acevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith","family":"Hall-Glenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty S.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrishikesh A.","family":"Bale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Liebenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Lustig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Alliston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4248\/ijos.09019","article-title":"Osteocyte remodeling of the perilacunar and pericanalicular matrix","volume":"1","author":"Qing","year":"2009","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.bone.2016.04.010_bb0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bone.2008.09.017","article-title":"Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited","volume":"44","author":"Teti","year":"2009","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2016.04.010_bb0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00223-013-9774-y","article-title":"Osteocyte-driven bone remodeling","volume":"94","author":"Bellido","year":"2014","journal-title":"Calcif. Tissue Int."},{"issue":"12","key":"10.1016\/j.bone.2016.04.010_bb0020","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/jbmr.2003","article-title":"Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2","volume":"28","author":"Kogawa","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bone.2013.01.025","article-title":"Osteocytes remove and replace perilacunar mineral during reproductive cycles","volume":"54","author":"Wysolmerski","year":"2013","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2016.04.010_bb0030","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/jbmr.1646","article-title":"Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance","volume":"27","author":"Tang","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"October","key":"10.1016\/j.bone.2016.04.010_bb0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/bonekey.2012.229","article-title":"Osteocytic osteolysis: time for a second look?","volume":"1","author":"Wysolmerski","year":"2012","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.bone.2016.04.010_bb0045","series-title":"Untersurchungen uber Rachitis and Osteomalacia","author":"Recklinghausen","year":"1910"},{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bone.2013.01.025","article-title":"Osteocytes remove and replace perilacunar mineral during reproductive cycles","volume":"54","author":"Wysolmerski","year":"2014","journal-title":"Bone"},{"issue":"Pt 23","key":"10.1016\/j.bone.2016.04.010_bb0055","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1242\/jeb.202.23.3285","article-title":"The design of mineralised hard tissues for their mechanical functions","volume":"202","author":"Currey","year":"1999","journal-title":"J. Exp. Biol."},{"issue":"May","key":"10.1016\/j.bone.2016.04.010_bb0060","first-page":"1","article-title":"Tissue-specific calibration of extracellularmatrix material properties by transforming growth factor-b and Runx2 in bone is required for hearing","author":"Chang","year":"2010","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.bone.2016.04.010_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/000348940010900106","article-title":"Estimation of volume referent bone turnover in the otic capsule after sequential point labeling","volume":"109","author":"Frisch","year":"2000","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0070","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.mlg.0000191466.09210.9a","article-title":"Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss","volume":"116","author":"Zehnder","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bone.2016.04.010_bb0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nbd.2013.04.008","article-title":"Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss","volume":"56","author":"Kao","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.bone.2016.04.010_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1359\/jbmr.080812","article-title":"Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerin","volume":"24","author":"Kanzaki","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2016.04.010_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094989","article-title":"Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia","volume":"9","author":"Akil","year":"2014","journal-title":"PLoS ONE"},{"issue":"23","key":"10.1016\/j.bone.2016.04.010_bb0090","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1242\/dev.01461","article-title":"Altered endochondral bone development in matrix metalloproteinase 13-deficient mice","volume":"131","author":"Stickens","year":"2004","journal-title":"Development"},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2016.04.010_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0074-02761991000700002","article-title":"The use of the Picrosirius-polarization method for the study of the biopathology of collagen","volume":"86","author":"Montes","year":"1991","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"3\u20134","key":"10.1016\/j.bone.2016.04.010_bb0100","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10237-011-0325-z","article-title":"Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy","volume":"11","author":"Rezakhaniha","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"5","key":"10.1016\/j.bone.2016.04.010_bb0105","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jbmr.1567","article-title":"Demonstration of osteocytic perilacunar\/canalicular remodeling in mice during lactation","volume":"27","author":"Qing","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.04.010_bb0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bone.2013.12.008","article-title":"3D osteocyte lacunar morphometric properties and distributions in human femoral cortical bone using synchrotron radiation micro-CT images","volume":"60","author":"Dong","year":"2014","journal-title":"Bone"},{"issue":"1\u20132","key":"10.1016\/j.bone.2016.04.010_bb0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"Zheng","year":"1999","journal-title":"Hear. Res."},{"issue":"6","key":"10.1016\/j.bone.2016.04.010_bb0120","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C T method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"January","key":"10.1016\/j.bone.2016.04.010_bb0125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/01.mlg.0000150702.28451.35","article-title":"Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule","volume":"115","author":"Zehnder","year":"2005","journal-title":"Laryngoscope"},{"issue":"9 I","key":"10.1016\/j.bone.2016.04.010_bb0130","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/000348949110000913","article-title":"Remodeling patterns in the bony otic capsule of the dog","volume":"100","author":"Sorensen","year":"1991","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"12","key":"10.1016\/j.bone.2016.04.010_bb0135","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1177\/00220345770560122601","article-title":"Effects of hibernation on interradicular alveolar bone","volume":"56","author":"Haller","year":"1977","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2016.04.010_bb0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/jmor.1051670105","article-title":"The effects of cold-stress. Hibernation, and prolonged inactivity on bone dynamics in the golden hamster, Mesocricetus auratus","volume":"167","author":"Steinberg","year":"1981","journal-title":"J. Morphol."},{"issue":"3","key":"10.1016\/j.bone.2016.04.010_bb0145","first-page":"242","article-title":"The role of osteocytes in bone regulation: mineral homeostasis versus mechanoreception","volume":"2","author":"Cullinane","year":"2002","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"4","key":"10.1016\/j.bone.2016.04.010_bb0150","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0021-9290(79)90073-3","article-title":"Mechanical properties of bone tissues with greatly differing functions","volume":"12","author":"Currey","year":"1979","journal-title":"J. Biomech."},{"issue":"6","key":"10.1016\/j.bone.2016.04.010_bb0155","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI0215463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","author":"Yakar","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bone.2016.04.010_bb0160","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jbmr.1969","article-title":"Bone and skeletal muscle: neighbors with close ties","volume":"28","author":"DiGirolamo","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"MAY","key":"10.1016\/j.bone.2016.04.010_bb0165","first-page":"691","article-title":"Cancer-associated muscle weakness: what's bone got to do with it?","volume":"4","author":"Waning","year":"2015","journal-title":"Bonekey Rep."},{"issue":"2","key":"10.1016\/j.bone.2016.04.010_bb0170","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bone.2006.01.155","article-title":"Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin","volume":"39","author":"Kanzaki","year":"2006","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2016.04.010_bb0175","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bone.2008.01.030","article-title":"Osteocyte morphology in fibula and calvaria \u2014 is there a role for mechanosensing?","volume":"43","author":"Vatsa","year":"2008","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2016.04.010_bb0180","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1002\/jbmr.2309","article-title":"Structural and mechanical repair of diffuse damage in cortical bone in vivo","volume":"29","author":"Seref-Ferlengez","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2016.04.010_bb0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bone.2012.01.025","article-title":"Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations","volume":"50","author":"Kennedy","year":"2012","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216300989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216300989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:39:18Z","timestamp":1757612358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328216300989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":37,"alternative-id":["S8756328216300989"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2016.04.010","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parallel mechanisms suppress cochlear bone remodeling to protect hearing","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2016.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}