{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:26:13Z","timestamp":1789979173844,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"CDMRP","doi-asserted-by":"publisher","award":["W81XWH-13-2-0077"],"award-info":[{"award-number":["W81XWH-13-2-0077"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"CDMRP","doi-asserted-by":"publisher","award":["H81XWH-13-2-0076"],"award-info":[{"award-number":["H81XWH-13-2-0076"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bone.2016.06.014","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T07:58:47Z","timestamp":1467187127000},"page":"159-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Targeted stimulation of retinoic acid receptor-\u03b3 mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model"],"prefix":"10.1016","volume":"90","author":[{"given":"Gabriel J.","family":"Pavey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar T.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Tomasino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary L.","family":"Honnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danett K.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Loder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pacifici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bone.2016.06.014_bb0005","doi-asserted-by":"crossref","first-page":"689","DOI":"10.5435\/00124635-200911000-00003","article-title":"Heterotopic ossification following traumatic brain injury and spinal cord injury","volume":"17","author":"Cipriano","year":"2009","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.bone.2016.06.014_bb0010","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00003086-198808000-00011","article-title":"Clinical observations on fractures and heterotopic ossification in the spinal cord and traumatic brain injured populations","volume":"233","author":"Garland","year":"1988","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"3","key":"10.1016\/j.bone.2016.06.014_bb0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2106\/JBJS.F.00412","article-title":"Heterotopic ossification following traumatic and combat-related amputations. Prevalence, risk factors, and preliminary results of excision","volume":"89","author":"Potter","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5435\/00124635-200403000-00007","article-title":"Heterotopic ossification","volume":"12","author":"Kaplan","year":"2004","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.bone.2016.06.014_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003086-199801000-00007","article-title":"Characterization of bone morphogenetic protein 4 receptor in fibrodysplasia ossificans progressiva","volume":"346","author":"Lanchoney","year":"1998","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"3","key":"10.1016\/j.bone.2016.06.014_bb0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/BCR.0b013e3182957768","article-title":"Characterization of heterotopic ossification in burn patients","volume":"35","author":"Medina","year":"2014","journal-title":"J. Burn Care Res."},{"issue":"5","key":"10.1016\/j.bone.2016.06.014_bb0035","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/TA.0000000000000838","article-title":"Risk factors for the development of heterotopic ossification in seriously burned adults: A national institute on disability, independent living and rehabilitation research burn model system database analysis","volume":"79","author":"Levi","year":"2015","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.bone.2016.06.014_bb0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003086-198208000-00006","article-title":"Fractures and dislocations about the elbow in the head-injured adult","volume":"168","author":"Garland","year":"1982","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"7","key":"10.1016\/j.bone.2016.06.014_bb0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2106\/00004623-198062070-00012","article-title":"Periarticular heterotopic ossification in head-injured adults. Incidence and location","volume":"62","author":"Garland","year":"1980","journal-title":"J. Bone Joint Surg."},{"issue":"4","key":"10.1016\/j.bone.2016.06.014_bb0050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/BOT.0b013e3182a53130","article-title":"Reoperation after combat-related major lower extremity amputations","volume":"28","author":"Tintle","year":"2014","journal-title":"J. Orthop. Trauma"},{"issue":"5","key":"10.1016\/j.bone.2016.06.014_bb0055","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.H.00792","article-title":"Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors","volume":"91","author":"Forsberg","year":"2009","journal-title":"J. Bone Joint Surg."},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0060","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1097\/TA.0b013e3181e44cc7","article-title":"Comparison of development of heterotopic ossification in injured US and UK Armed Services personnel with combat-related amputations: preliminary findings and hypotheses regarding causality","volume":"69","author":"Brown","year":"2010","journal-title":"Journal of Trauma-Injury, Infection, and Critical Care"},{"issue":"9","key":"10.1016\/j.bone.2016.06.014_bb0065","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1007\/s11999-015-4272-3","article-title":"Effect of bioburden on heterotopic ossification formation in an established rat model","volume":"473","author":"Pavey","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"9","key":"10.1016\/j.bone.2016.06.014_bb0070","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1007\/s11999-015-4266-1","article-title":"What risk factors predict recurrence of heterotopic ossification after excision in combat-related amputations?","volume":"473","author":"Pavey","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0075","first-page":"54","article-title":"Heterotopic ossification in wartime wounds","volume":"19","author":"Forsberg","year":"2010","journal-title":"J. Surg. Orthop. Adv."},{"issue":"9","key":"10.1016\/j.bone.2016.06.014_bb0080","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1007\/s11999-015-4240-y","article-title":"Early Characterization of Blast-related Heterotopic Ossification in a Rat Model","volume":"479","author":"Qureshi","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bone.2013.01.002","article-title":"Early detection of burn induced heterotopic ossification using transcutaneous Raman spectroscopy","volume":"54","author":"Peterson","year":"2013","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0090","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bone.2013.05.016","article-title":"Ectopic bone formation in severely combat-injured orthopedic patients\u2014A hematopoietic niche","volume":"56","author":"Davis","year":"2013","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2016.06.014_bb0095","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2106\/JBJS.J.01417","article-title":"Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscle","volume":"93","author":"Davis","year":"2011","journal-title":"J. Bone Joint Surg. Am."},{"issue":"6","key":"10.1016\/j.bone.2016.06.014_bb0100","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/cb300655w","article-title":"Development of an ALK2-biased BMP type I receptor kinase inhibitor","volume":"8","author":"Mohedas","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"255","key":"10.1016\/j.bone.2016.06.014_bb0105","doi-asserted-by":"crossref","first-page":"255ra132","DOI":"10.1126\/scitranslmed.3008810","article-title":"Treatment of heterotopic ossification through remote ATP hydrolysis","volume":"6","author":"Peterson","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ydbio.2009.01.031","article-title":"Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse","volume":"328","author":"Williams","year":"2009","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200604150","article-title":"BMP action in skeletogenesis involves attenuation of retinoid signaling","volume":"174","author":"Hoffman","year":"2006","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0120","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0014-4827(80)90517-0","article-title":"Vitamin A inhibits chondrogenesis but not myogenesis","volume":"129","author":"Pacifici","year":"1980","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.bone.2016.06.014_bb0125","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nm.2334","article-title":"Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists","volume":"17","author":"Shimono","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jor.20985","article-title":"Inhibition of ectopic bone formation by a selective retinoic acid receptor \u03b1-agonist: A new therapy for heterotopic ossification?","volume":"28","author":"Shimono","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0135","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/dbio.1999.9207","article-title":"Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis","volume":"208","author":"Koyama","year":"1999","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.bone.2016.06.014_bb0140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1083\/jcb.200112029","article-title":"Requirement for RAR-mediated gene repression in skeletal progenitor differentiation","volume":"158","author":"Weston","year":"2002","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.bone.2016.06.014_bb0145","article-title":"The development of a rat model to investigate the formation of blast-related post-traumatic heterotopic ossification","volume":"97","author":"Polfer","year":"2015","journal-title":"The Bone and Joint Journal"},{"issue":"12","key":"10.1016\/j.bone.2016.06.014_bb0150","doi-asserted-by":"crossref","first-page":"a005058","DOI":"10.1101\/cshperspect.a005058","article-title":"Extracellular matrix degradation and remodeling in development and disease","volume":"3","author":"Lu","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bone.2016.06.014_bb0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0014-4827(78)90223-9","article-title":"Chondrogenesis and cell proliferation in limb bud cell cultures treated with cytosine arabinoside and vitamin A","volume":"112","author":"Hassell","year":"1978","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bone.2016.06.014_bb0160","first-page":"1","article-title":"Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds?","author":"Forsberg","year":"2014","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"12","key":"10.1016\/j.bone.2016.06.014_bb0165","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/BOT.0b013e3182724624","article-title":"Heterotopic ossification in orthopaedic trauma","volume":"26","author":"Nauth","year":"2012","journal-title":"J. Orthop. Trauma"},{"issue":"7","key":"10.1016\/j.bone.2016.06.014_bb0170","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/01.ASW.0000416006.55218.d0","article-title":"Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care","volume":"25","author":"Demidova-Rice","year":"2012","journal-title":"Adv. Skin Wound Care"},{"issue":"8","key":"10.1016\/j.bone.2016.06.014_bb0175","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/01.ASW.0000418541.31366.a3","article-title":"Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery","volume":"25","author":"Demidova-Rice","year":"2012","journal-title":"Adv. Skin Wound Care"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216301764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216301764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:39:24Z","timestamp":1757612364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328216301764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"alternative-id":["S8756328216301764"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2016.06.014","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted stimulation of retinoic acid receptor-\u03b3 mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2016.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}