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Chem."},{"key":"10.1016\/j.bone.2016.11.013_bb0415","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1021\/bi500409n","article-title":"Identification of cleavage sites leading to the shed form of the anti-aging protein klotho","volume":"53","author":"Chen","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.bone.2016.11.013_bb0420","doi-asserted-by":"crossref","first-page":"19796","DOI":"10.1073\/pnas.0709805104","article-title":"Insulin stimulates the cleavage and release of the extracellular domain of klotho by ADAM10 and ADAM17","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2016.11.013_bb0425","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.febslet.2009.09.009","article-title":"Klotho is a substrate for alpha-, beta- and gamma-secretase","volume":"583","author":"Bloch","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bone.2016.11.013_bb0430","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.febslet.2004.03.090","article-title":"Secreted klotho protein in sera and CSF: implication for post-translational cleavage in release of klotho protein from cell membrane","volume":"565","author":"Imura","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bone.2016.11.013_bb0435","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1681\/ASN.2014101030","article-title":"Renal production, uptake, and handling of circulating alphaKlotho","volume":"27","author":"Hu","year":"2016","journal-title":"J. Am. Soc. 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Lett."},{"key":"10.1016\/j.bone.2016.11.013_bb0460","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1471-2369-13-155","article-title":"Characteristics of urinary and serum soluble klotho protein in patients with different degrees of chronic kidney disease","volume":"13","author":"Akimoto","year":"2012","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bone.2016.11.013_bb0465","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/ki.2010.328","article-title":"Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective","volume":"78","author":"Hu","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2016.11.013_bb0470","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2016.11.013_bb0475","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/ndt\/gfu270","article-title":"Familial tumoral calcinosis: a valuable vehicle for discovery","volume":"29","author":"Moe","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2016.11.013_bb0480","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1158\/2159-8290.CD-13-0050","article-title":"Identification of targetable FGFR gene fusions in diverse cancers","volume":"3","author":"Wu","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bone.2016.11.013_bb0485","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1172\/JCI31330","article-title":"A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis","volume":"117","author":"Ichikawa","year":"2007","journal-title":"J. Clin. 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Med."},{"key":"10.1016\/j.bone.2016.11.013_bb0535","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ki.1980.85","article-title":"Renal toxicity of phosphate in rats","volume":"17","author":"Haut","year":"1980","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2016.11.013_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-1755.2004.00355.x","article-title":"The phosphatonin pathway: new insights in phosphate homeostasis","volume":"65","author":"Schiavi","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2016.11.013_bb0545","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00467-011-1843-8","article-title":"Human nephron number: implications for health and disease","volume":"26","author":"Bertram","year":"2011","journal-title":"Pediatr. 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