{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:52:52Z","timestamp":1785322372717,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.bone.2016.12.006","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T05:16:26Z","timestamp":1491196586000},"page":"68-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Osteoblast-specific deletion of Hrpt2\/Cdc73 results in high bone mass and increased bone turnover"],"prefix":"10.1016","volume":"98","author":[{"given":"Casey J.","family":"Droscha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra R.","family":"Diegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Ethen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis A.","family":"Burgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell J.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Maupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agni S.","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PengFei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin T.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2016.12.006_bb0005","first-page":"944","article-title":"Hereditary hyperparathyroidism-jaw tumor syndrome: The endocrine tumor gene HRPT2 maps to chromosome 1q21-q31","volume":"56","author":"Szabo","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2016.12.006_bb0010","doi-asserted-by":"crossref","unstructured":"Carpten, J. D. et al. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat. Genet. 32, 676\u2013680, doi:10.1038\/ng1048 (2002).","DOI":"10.1038\/ng1048"},{"key":"10.1016\/j.bone.2016.12.006_bb0015","first-page":"4204","article-title":"Autosomal dominant primary hyperparathyroidism and jaw tumor syndrome associated with renal hamartomas and cystic kidney disease: linkage to 1q21-q32 and loss of the wild type allele in renal hamartomas","volume":"81","author":"Teh","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2016.12.006_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2169\/internalmedicine.33.123","article-title":"Familial primary hyperparathyroidism complicated with Wilms' tumor","volume":"33","author":"Kakinuma","year":"1994","journal-title":"Intern. Med."},{"key":"10.1016\/j.bone.2016.12.006_bb0025","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jmg.40.9.657","article-title":"HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours","volume":"40","author":"Howell","year":"2003","journal-title":"J. Med. Genet."},{"issue":"1006\u20131012","key":"10.1016\/j.bone.2016.12.006_bb0030","article-title":"Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome","volume":"108","author":"Jackson","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.bone.2016.12.006_bb0035","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2016.12.006_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2796.2004.01421.x","article-title":"Uterine tumours are a phenotypic manifestation of the hyperparathyroidism-jaw tumour syndrome","volume":"257","author":"Bradley","year":"2005","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bone.2016.12.006_bb0045","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1590\/0004-2730000003381","article-title":"Bone disease in primary hyperparathyroidism","volume":"58","author":"Bandeira","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.bone.2016.12.006_bb0050","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1365-2796.2003.01168.x","article-title":"Hyperparathyroidism-jaw tumour syndrome","volume":"253","author":"Chen","year":"2003","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bone.2016.12.006_bb0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/qjmed\/94.4.213","article-title":"The hyperparathyroidism-jaw tumour syndrome in a Portuguese kindred","volume":"94","author":"Cavaco","year":"2001","journal-title":"QJM"},{"key":"10.1016\/j.bone.2016.12.006_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.joms.2014.09.008","article-title":"Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review","volume":"73","author":"Parfitt","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2016.12.006_bb0065","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2006.01.053","article-title":"Parafibromin\/Hyrax activates Wnt\/Wg target gene transcription by direct association with beta-catenin\/Armadillo","volume":"125","author":"Mosimann","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bone.2016.12.006_bb0070","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.1074\/jbc.M111.325647","article-title":"Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin","volume":"287","author":"Amrich","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2016.12.006_bb0075","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1128\/MCB.00654-07","article-title":"Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice","volume":"28","author":"Wang","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2016.12.006_bb0080","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bbagrm.2010.01.001","article-title":"The Paf1 complex: platform or player in RNA polymerase II transcription?","volume":"1799","author":"Jaehning","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bone.2016.12.006_bb0085","doi-asserted-by":"crossref","first-page":"34739","DOI":"10.1074\/jbc.C300269200","article-title":"The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p","volume":"278","author":"Wood","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2016.12.006_bb0090","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1097-2765(03)00091-1","article-title":"The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: Linking transcriptional elongation to histone methylation","volume":"11","author":"Krogan","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bone.2016.12.006_bb0095","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.cub.2005.07.028","article-title":"BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex","volume":"15","author":"Laribee","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bone.2016.12.006_bb0100","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cell.2015.07.042","article-title":"PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II","volume":"162","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bone.2016.12.006_bb0105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1097-2765(04)00257-6","article-title":"The Paf1 complex has functions independent of actively transcribing RNA polymerase II","volume":"14","author":"Mueller","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bone.2016.12.006_bb0110","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1128\/EC.00434-07","article-title":"Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II","volume":"7","author":"Nordick","year":"2008","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.bone.2016.12.006_bb0115","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1073\/pnas.0812023106","article-title":"The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3\u2032 mRNA processing factors","volume":"106","author":"Rozenblatt-Rosen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2016.12.006_bb0120","doi-asserted-by":"crossref","unstructured":"Penheiter, K. L., Washburn, T. M., Porter, S. E., Hoffman, M. G. & Jaehning, J. A. A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets. Mol Cell 20, 213\u2013223, doi:10.1016\/j.molcel.2005.08.023 (2005).","DOI":"10.1016\/j.molcel.2005.08.023"},{"key":"10.1016\/j.bone.2016.12.006_bb0125","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1038\/ncomms6433","article-title":"Cytoplasmic parafibromin\/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis","volume":"5","author":"Jo","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2016.12.006_bb0130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/mc.20591","article-title":"The tumor suppressor parafibromin is required for posttranscriptional processing of histone mRNA","volume":"49","author":"Farber","year":"2010","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bone.2016.12.006_bb0135","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1242\/dev.00491","article-title":"Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth","volume":"130","author":"Yu","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bone.2016.12.006_bb0140","doi-asserted-by":"crossref","first-page":"44005","DOI":"10.1074\/jbc.M208265200","article-title":"Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2016.12.006_bb0145","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.12.006_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063857","article-title":"Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing","volume":"8","author":"Burgers","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2016.12.006_bb0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.12.006_bb0160","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2011.08.020","article-title":"Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo","volume":"359","author":"Joeng","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2016.12.006_bb0165","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1359\/jbmr.1997.12.10.1570","article-title":"Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes","volume":"12","author":"Clemens","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.12.006_bb0170","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1359\/jbmr.070518","article-title":"Quantifying osteoblast and osteocyte apoptosis: challenges and rewards","volume":"22","author":"Jilka","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2016.12.006_bb0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.22203\/eCM.v006a05","article-title":"Bone microdamage and cell apoptosis","volume":"6","author":"Noble","year":"2003","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.bone.2016.12.006_bb0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.bone.2016.12.006_bb0185","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1128\/MCB.25.12.5052-5060.2005","article-title":"The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II","volume":"25","author":"Yart","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2016.12.006_bb0190","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1101\/gad.1292105","article-title":"The human PAF complex coordinates transcription with events downstream of RNA synthesis","volume":"19","author":"Zhu","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2016.12.006_bb0195","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/emboj\/21.7.1764","article-title":"The Paf1 complex physically and functionally associates with transcription elongation factors in vivo","volume":"21","author":"Squazzo","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2016.12.006_bb0200","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbagrm.2012.08.011","article-title":"The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states","volume":"1829","author":"Tomson","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bone.2016.12.006_bb0205","article-title":"PAF complex plays novel subunit-specific roles in alternative cleavage and polyadenylation","volume":"12","author":"Yang","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2016.12.006_bb0210","article-title":"Correction: PAF complex plays novel subunit-specific roles in alternative cleavage and polyadenylation","volume":"12","author":"Yang","year":"2016","journal-title":"PLoS Genet."},{"issue":"rs3","key":"10.1016\/j.bone.2016.12.006_bb0215","article-title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation","volume":"4","author":"Rigbolt","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bone.2016.12.006_bb0220","doi-asserted-by":"crossref","first-page":"30304","DOI":"10.1074\/jbc.M111.252981","article-title":"Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair","volume":"286","author":"Tatum","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2016.12.006_bb0225","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00223-002-1053-2","article-title":"Functional cooperativity between osteoblast transcription factors: evidence for the importance of subnuclear macromolecular complexes?","volume":"72","author":"Franceschi","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2016.12.006_bb0230","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jcb.10369","article-title":"Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways","volume":"88","author":"Franceschi","year":"2003","journal-title":"J. Cell. Biochem."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2016.12.006_bb0235","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/03008200390152188","article-title":"Multiple signaling pathways converge on the Cbfa1\/Runx2 transcription factor to regulate osteoblast differentiation","volume":"44","author":"Franceschi","year":"2003","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bone.2016.12.006_bb0240","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cell.2009.12.050","article-title":"The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII\/TFIIS","volume":"140","author":"Kim","year":"2010","journal-title":"Cell"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216303684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328216303684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T17:32:19Z","timestamp":1601832739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328216303684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":48,"alternative-id":["S8756328216303684"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2016.12.006","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteoblast-specific deletion of Hrpt2\/Cdc73 results in high bone mass and increased bone turnover","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2016.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}