{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:40:44Z","timestamp":1790419244970,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"am","delay-in-days":309,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-13-1-0113"],"award-info":[{"award-number":["W81XWH-13-1-0113"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.bone.2017.02.012","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T21:45:46Z","timestamp":1487799946000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair"],"prefix":"10.1016","volume":"98","author":[{"given":"Gurpreet S.","family":"Baht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puviindran","family":"Nadesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Silkstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Alman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0005","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0888-7543(87)90034-6","article-title":"Genetic analysis of NF1: identification of close flanking markers on chromosome 17","volume":"1","author":"Fain","year":"1987","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0010","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0888-7543(87)90035-8","article-title":"Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17","volume":"1","author":"Seizinger","year":"1987","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0015","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0888-7543(91)90017-9","article-title":"cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product","volume":"11","author":"Marchuk","year":"1991","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0020","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF01247353","article-title":"A highly informative CA\/GT repeat polymorphism in intron 38 of the human neurofibromatosis type 1 (NF1) gene","volume":"92","author":"Lazaro","year":"1993","journal-title":"Hum. Genet."},{"issue":"1","key":"10.1016\/j.bone.2017.02.012_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<1::AID-AJMG3>3.0.CO;2-8","article-title":"Epidemiology of neurofibromatosis type 1","volume":"89","author":"Friedman","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/(SICI)1096-8628(19960726)67:4<421::AID-AJMG20>3.0.CO;2-K","article-title":"Characterization of six mutations in exon 37 of neurofibromatosis type 1 gene","volume":"67","author":"Upadhyaya","year":"1996","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bone.2017.02.012_bb0035","series-title":"Publication No. 281. The Bannerstone Division of American Lectures in Dermatology","article-title":"A clinical, pathological, and genetic study of multiple neurofibromatosis","author":"Crowe","year":"1956"},{"issue":"12","key":"10.1016\/j.bone.2017.02.012_bb0040","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/bjo.53.12.793","article-title":"Optic glioma of childhood. Natural history and rationale for conservative management","volume":"53","author":"Hoyt","year":"1969","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0045","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0022-3476(05)83163-4","article-title":"Neurofibromatosis type 1: the cognitive phenotype","volume":"124","author":"Hofman","year":"1994","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.bone.2017.02.012_bb0050","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/(SICI)1096-8628(19990611)84:5<413::AID-AJMG5>3.0.CO;2-1","article-title":"Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1","volume":"84","author":"Stevenson","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0055","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2214\/ajr.130.4.615","article-title":"1977 Edward B. D. Neuhauser lecture: neurofibromatosis in children","volume":"130","author":"Holt","year":"1978","journal-title":"AJR Am. J. Roentgenol."},{"issue":"26","key":"10.1016\/j.bone.2017.02.012_bb0060","doi-asserted-by":"crossref","first-page":"E1659","DOI":"10.1097\/BRS.0b013e3182770aa2","article-title":"Posterior vertebral column resection for the treatment of dystrophic kyphosis associated with type-1 neurofibromatosis: a case report and review of the literature","volume":"37","author":"Stoker","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1016\/j.bone.2017.02.012_bb0065","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3171\/2012.11.SPINE12417","article-title":"Surgical correction of severe cervical kyphosis in patients with neurofibromatosis type 1","volume":"18","author":"Kawabata","year":"2013","journal-title":"J. Neurosurg. Spine"},{"issue":"2","key":"10.1016\/j.bone.2017.02.012_bb0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00264-015-3029-7","article-title":"Management of congenital pseudarthrosis of the tibia with the Ilizarov method in a paediatric population: influence of aetiological factors","volume":"40","author":"Borzunov","year":"2016","journal-title":"Int. Orthop."},{"issue":"6","key":"10.1016\/j.bone.2017.02.012_bb0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11832-010-0293-3","article-title":"Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia","volume":"4","author":"Birke","year":"2010","journal-title":"J. Child. Orthop."},{"issue":"8","key":"10.1016\/j.bone.2017.02.012_bb0080","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1302\/0301-620X.93B8.25940","article-title":"Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate","volume":"93","author":"Schindeler","year":"2011","journal-title":"J. Bone Joint Surg. (Br.)"},{"issue":"9","key":"10.1016\/j.bone.2017.02.012_bb0085","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00264-014-2361-7","article-title":"Effectiveness of recombinant human bone morphogenetic protein-7 in the management of congenital pseudoarthrosis of the tibia: a randomised controlled trial","volume":"38","author":"Das","year":"2014","journal-title":"Int. Orthop."},{"issue":"1","key":"10.1016\/j.bone.2017.02.012_bb0090","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jor.20481","article-title":"Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice","volume":"26","author":"Schindeler","year":"2008","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.02.012_bb0095","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(90)90024-9","article-title":"The neurofibromatosis type 1 gene encodes a protein related to GAP","volume":"62","author":"Xu","year":"1990","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bone.2017.02.012_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00432-012-1336-6","article-title":"Potential interactions of complementary and alternative medicine with cancer therapy in outpatients with gynecological cancer in a comprehensive cancer center","volume":"139","author":"Zeller","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bone.2017.02.012_bb0105","first-page":"30(9)","article-title":"Beta-catenin modulation in Neurofibromatosis type 1 bone repair-therapeutic implications","author":"Ghadakzadeh","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2017.02.012_bb0110","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1038\/ncomms8131","article-title":"Exposure to a youthful circulation rejuvenates bone repair through modulation of beta-catenin","volume":"6","author":"Baht","year":"2015","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bone.2017.02.012_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040249","article-title":"Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing","volume":"4","author":"Chen","year":"2007","journal-title":"PLoS Med."},{"issue":"29","key":"10.1016\/j.bone.2017.02.012_bb0120","doi-asserted-by":"crossref","first-page":"29ra30","DOI":"10.1126\/scitranslmed.3000231","article-title":"Wnt proteins promote bone regeneration","volume":"2","author":"Minear","year":"2010","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.bone.2017.02.012_bb0125","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/jbmr.29","article-title":"rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair","volume":"25","author":"Minear","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.02.012_bb0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4055\/cios.2011.3.3.230","article-title":"Disturbed osteoblastic differentiation of fibrous hamartoma cell from congenital pseudarthrosis of the tibia associated with neurofibromatosis type I","volume":"3","author":"Lee","year":"2011","journal-title":"Clin. Orthop. Surg."},{"issue":"2","key":"10.1016\/j.bone.2017.02.012_bb0135","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/1078-0432.CCR-13-0780","article-title":"The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis","volume":"20","author":"Luscan","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bone.2017.02.012_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037940","article-title":"A high throughput screen identifies Nefopam as targeting cell proliferation in beta-catenin driven neoplastic and reactive fibroproliferative disorders","volume":"7","author":"Poon","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bone.2017.02.012_bb0145","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0150","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jor.22562","article-title":"Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation","volume":"32","author":"Baht","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2017.02.012_bb0155","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201500190RR","article-title":"beta-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications","author":"Ghadakzadeh","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2017.02.012_bb0160","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/978-1-61779-415-5_29","article-title":"Quantitative X-ray imaging of rodent bone by Faxitron","volume":"816","author":"Bassett","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.bone.2017.02.012_bb0165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/biores.2014.0017","article-title":"High resolution X-ray: a reliable approach for quantifying osteoporosis in a rodent model","volume":"3","author":"Velasco","year":"2014","journal-title":"Biores. Open Access"},{"issue":"2","key":"10.1016\/j.bone.2017.02.012_bb0170","first-page":"85","article-title":"Cell culture studies on neurofibromatosis (von Recklinghausen). VI. No increased stimulation of cell proliferation by sera from neurofibromatosis patients","volume":"1","author":"Binder","year":"1988","journal-title":"Neurofibromatosis"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217300571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217300571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:39:44Z","timestamp":1757612384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217300571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":34,"alternative-id":["S8756328217300571"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.02.012","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}