{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:39:36Z","timestamp":1792701576103,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15K10439"],"award-info":[{"award-number":["15K10439"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bone.2017.05.016","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T09:02:06Z","timestamp":1502355726000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis"],"prefix":"10.1016","volume":"105","author":[{"given":"Yusuke","family":"Osawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusaku","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Fujio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisei","family":"Ohkawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinji","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2017.05.016_bb0005","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1002\/ajmg.a.32485","article-title":"The population based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US","volume":"146","author":"Waller","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"issue":"9582","key":"10.1016\/j.bone.2017.05.016_bb0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0140-6736(07)61090-3","volume":"370","author":"Horton","year":"2007","journal-title":"Achondroplasia. Lancet."},{"key":"10.1016\/j.bone.2017.05.016_bb0015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","article-title":"Fibroblast growth factor receptor 3 is a negative regulator of bone growth","volume":"84","author":"Deng","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.05.016_bb0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/ped.12890","article-title":"Low bone mineral density in achondroplasia and hypochondroplasia","volume":"58","author":"Matsushita","year":"2016","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.bone.2017.05.016_bb0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10067-012-2126-x","article-title":"Assessment of osteoporotic alterations in achondroplastic patients: a case series","volume":"32","author":"Arita","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.bone.2017.05.016_bb0030","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/hmg\/ddp590","article-title":"Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis","volume":"19","author":"Su","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2017.05.016_bb0035","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1210\/en.2003-0158","volume":"144","author":"Nakajima","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2017.05.016_bb0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nm971","article-title":"Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway","volume":"10","author":"Yasoda","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2017.05.016_bb0045","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ajhg.2012.10.014","article-title":"Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia","volume":"91","author":"Lorget","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2017.05.016_bb0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00003086-199001000-00011","article-title":"Problems, obstacles, and complications of limb lengthening by the Ilizarov technique","volume":"250","author":"Paley","year":"1990","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003086-198910000-00007","article-title":"Leg lengthening. A review of 30years","volume":"247","author":"Moseley","year":"1989","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0060","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF00636172","article-title":"Limb lengthening and three-dimensional deformity corrections: a retrospective clinical study","volume":"109","author":"Korzinek","year":"1990","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.bone.2017.05.016_bb0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/17453674.2014.899856","article-title":"The etiology of short stature affects the clinical outcome of lower limb lengthening using external fixation. A systematic review of 18 trials involving 547 patients","volume":"85","author":"Kim","year":"2014","journal-title":"Acta Orthop."},{"key":"10.1016\/j.bone.2017.05.016_bb0070","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1302\/0301-620X.70B4.3403595","article-title":"Bone lengthening in rabbits by callus distraction. The role of periosteum and endosteum","volume":"70","author":"Kojimoto","year":"1988","journal-title":"J. Bone Joint Surg. (Br.)"},{"key":"10.1016\/j.bone.2017.05.016_bb0075","first-page":"273","article-title":"The mechanical behavior and morphological structure of callus in experimental callotasis","volume":"4","author":"Ohyama","year":"1994","journal-title":"Biomed. Mater. Eng."},{"key":"10.1016\/j.bone.2017.05.016_bb0080","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/17453679408995494","article-title":"Early bone matrix formation during distraction. A biochemical study in sheep","volume":"65","author":"Kallio","year":"1994","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.bone.2017.05.016_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00003086-198902000-00029","article-title":"The tension-stress effect on the genesis and growth of tissues: part II. The influence of the rate and frequency of distraction","volume":"239","author":"Ilizarov","year":"1989","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2106\/00004623-200201000-00013","article-title":"Structural stages in the development of the long bones and epiphyses: a study in the New Zealand white rabbit","volume":"84","author":"Rivas","year":"2002","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2017.05.016_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01241398-198801000-00018","article-title":"Current techniques of limb lengthening","volume":"8","author":"Paley","year":"1988","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.bone.2017.05.016_bb0100","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1242\/dev.125.24.4977","article-title":"Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor3","volume":"125","author":"Naski","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.05.016_bb0105","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bone.2011.06.024","article-title":"Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors","volume":"49","author":"Fujio","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.05.016_bb0110","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jor.21501","article-title":"Inhibin A enhances bone formation during distraction osteogenesis","volume":"30","author":"Perrien","year":"2012","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jor.22527","article-title":"Cisplatin inhibits bone healing during distraction osteogenesis","volume":"32","author":"Stine","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056790","article-title":"The effect of heparan sulfate application on bone formation during distraction osteogenesis","volume":"8","author":"Gdalevitch","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.05.016_bb0125","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0278-2391(03)00672-4","article-title":"Ultrasound: assessment of the distraction osteogenesis wound in patients undergoing mandibular lengthening","volume":"61","author":"Troulis","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2017.05.016_bb0130","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.ebiom.2015.11.024","article-title":"Lansoprazole upregulates polyubiquitination of the TNF receptor-associated factor 6 and facilitates Runx2-mediated osteoblastogenesis","volume":"2","author":"Mishima","year":"2015","journal-title":"EBioMedicine."},{"key":"10.1016\/j.bone.2017.05.016_bb0135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/02656736.2014.988662","article-title":"In vivo heat-stimulus-triggered osteogenesis","volume":"31","author":"Ikuta","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.bone.2017.05.016_bb0140","doi-asserted-by":"crossref","first-page":"730105","DOI":"10.1155\/2015\/730105","article-title":"A comparison of the process of remodeling of hydroxyapatite\/poly-d\/l-lactide and beta-tricalcium phosphate in a loading site","volume":"2015","author":"Akagi","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bone.2017.05.016_bb0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00005131-200302000-00006","article-title":"Histomorphometry of distraction osteogenesis during experimental tibial lengthening","volume":"17","author":"Fink","year":"2003","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.bone.2017.05.016_bb0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00264-002-0391-z","article-title":"Distraction osteogenesis by Ilizarov and unilateral external fixators in a canine model","volume":"27","author":"Kusec","year":"2003","journal-title":"Int. Orthop."},{"key":"10.1016\/j.bone.2017.05.016_bb0160","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s002239900625","article-title":"The role of chondrocytes in intramembranous and endochondral ossification during distraction osteogenesis in the rabbit","volume":"64","author":"Li","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2017.05.016_bb0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11751-010-0083-y","article-title":"Bone lengthening osteogenesis, a combination of intramembranous and endochondral ossification: an experimental study in sheep","volume":"5","author":"Forriol","year":"2010","journal-title":"Strategies Trauma Limb Reconstr."},{"key":"10.1016\/j.bone.2017.05.016_bb0170","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1302\/0301-620X.79B5.0790824","article-title":"Three modes of ossification during distraction osteogenesis in the rat","volume":"79","author":"Yasui","year":"1997","journal-title":"J. Bone Joint Surg. (Br.)"},{"key":"10.1016\/j.bone.2017.05.016_bb0175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/hmg\/ddn339","article-title":"FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway","volume":"18","author":"Matsushita","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2017.05.016_bb0180","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/jbmr.2839","article-title":"Deletion of FGFR3 in osteoclast lineage cells results in increased bone mass in mice by inhibiting osteoclastic bone resorption","volume":"31","author":"Su","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0185","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2017.05.016_bb0190","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1002\/jcp.24083","article-title":"Role of FGFs\/FGFRs in skeletal development and bone regeneration","volume":"227","author":"Du","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2017.05.016_bb0195","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0736-0266(02)00017-7","article-title":"A model for intramembranous ossification during fracture healing","volume":"20","author":"Thompson","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2017.05.016_bb0200","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbrc.2008.08.165","article-title":"Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation","volume":"376","author":"Su","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2017.05.016_bb0205","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/en.2014-1914","article-title":"Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene","volume":"156","author":"Matsushita","year":"2015","journal-title":"Endocrinology"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217301825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217301825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T22:05:59Z","timestamp":1658700359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217301825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":41,"alternative-id":["S8756328217301825"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.05.016","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}