{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:58:40Z","timestamp":1791007120133,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"International Fibrodysplasia Ossificans Progressiva Association (IFOPA)"},{"name":"Center for Research in FOP and Related Disorders"},{"name":"Ian Cali Endowment for FOP Research"},{"DOI":"10.13039\/100013182","name":"Whitney Weldon Endowment for FOP Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013182","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Isaac and Rose Nassau Professorship of Orthopaedic Molecular Medicine"},{"name":"Ian Cali Distinguished Clinician-Scientist"},{"name":"Robert and Arlene Kogod Professorship in Geriatric Medicine"},{"name":"Radiant Hope Foundation"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR001860"],"award-info":[{"award-number":["UL1 TR001860"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of California Davis School of Medicine"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bone.2017.06.009","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T01:46:50Z","timestamp":1497404810000},"page":"124-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Joint-specific risk of impaired function in fibrodysplasia ossificans progressiva (FOP)"],"prefix":"10.1016","volume":"109","author":[{"given":"Robert J.","family":"Pignolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blythe P.","family":"Durbin-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Rocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick S.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bone.2017.06.009_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/ejhg.2014.274","article-title":"Clinical utility gene card for: Fibrodysplasia ossificans progressiva","volume":"23","author":"Bravenboer","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bone.2017.06.009_bb0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.berh.2007.11.007","article-title":"Fibrodysplasia ossificans progressiva","volume":"22","author":"Kaplan","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bone.2017.06.009_bb0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1750-1172-6-80","article-title":"Fibrodysplasia ossificans progressiva: clinical and genetic aspects","volume":"6","author":"Pignolo","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"issue":"Suppl. 2","key":"10.1016\/j.bone.2017.06.009_bb0020","first-page":"437","article-title":"Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons","volume":"10","author":"Pignolo","year":"2013","journal-title":"Pediatr. Endocrinol. Rev."},{"issue":"5","key":"10.1016\/j.bone.2017.06.009_bb0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.bone.2017.06.009_bb0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00774-008-0879-8","article-title":"Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)","volume":"26","author":"Kaplan","year":"2008","journal-title":"J. Bone Miner. Metab."},{"issue":"3","key":"10.1016\/j.bone.2017.06.009_bb0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/humu.20868","article-title":"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1","volume":"30","author":"Kaplan","year":"2009","journal-title":"Hum. Mutat."},{"issue":"2","key":"10.1016\/j.bone.2017.06.009_bb0040","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11914-015-0258-z","article-title":"The immunological contribution to heterotopic ossification disorders","volume":"13","author":"Convente","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2017.06.009_bb0045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2015.12.013","article-title":"Granting immunity to FOP and catching heterotopic ossification in the act","volume":"49","author":"Kaplan","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.bone.2017.06.009_bb0050","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/jbmr.2848","article-title":"Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling","volume":"31","author":"Wang","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2017.06.009_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1302\/0301-620X.64B1.7068725","article-title":"Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients","volume":"64","author":"Connor","year":"1982","journal-title":"J. Bone Joint Surg. Br."},{"issue":"3","key":"10.1016\/j.bone.2017.06.009_bb0060","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2106\/JBJS.I.00705","article-title":"Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva","volume":"92","author":"Kaplan","year":"2010","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2017.06.009_bb0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-199404000-00038","article-title":"Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva","volume":"301","author":"Rocke","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.06.009_bb0070","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jbmr.2728","article-title":"The natural history of flare-ups in Fibrodysplasia Ossificans Progressiva (FOP): A comprehensive global assessment","volume":"31","author":"Pignolo","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"282","key":"10.1016\/j.bone.2017.06.009_bb0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.bone.2017.06.009_bb0080","series-title":"The Natural Duration of Cancer Reports on Public Health and Medical Subjects","first-page":"1","author":"Greenwood","year":"1926"},{"key":"10.1016\/j.bone.2017.06.009_bb0085","author":"Rebora"},{"issue":"2","key":"10.1016\/j.bone.2017.06.009_bb0095","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2106\/00004623-199302000-00008","article-title":"The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients","volume":"75","author":"Cohen","year":"1993","journal-title":"J. Bone Joint Surg. Am."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T13:10:51Z","timestamp":1659100251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217302053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":18,"alternative-id":["S8756328217302053"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.06.009","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Joint-specific risk of impaired function in fibrodysplasia ossificans progressiva (FOP)","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}