{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:26:27Z","timestamp":1789979187746,"version":"4.0.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bone.2017.06.011","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T12:16:45Z","timestamp":1497701805000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva"],"prefix":"10.1016","volume":"109","author":[{"given":"Dana M.","family":"Alessi Wolken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Idone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Hatsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-8942","authenticated-orcid":false,"given":"Aris N.","family":"Economides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"303","key":"10.1016\/j.bone.2017.06.011_bb0005","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"50","key":"10.1016\/j.bone.2017.06.011_bb0010","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1073\/pnas.1510540112","article-title":"Neofunction of ACVR1 in fibrodysplasia ossificans progressiva","volume":"112","author":"Hino","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"366","key":"10.1016\/j.bone.2017.06.011_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf1090","article-title":"Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification","volume":"8","author":"Dey","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/BMM:3:3-4:183","article-title":"The phenotype of fibrodysplasia ossificans progressiva","volume":"3","author":"Kaplan","year":"2005","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2017.06.011_bb0025","series-title":"Bone and Development","first-page":"233","article-title":"Fibrodysplasia ossificans progressiva: developmental implications of a novel metamorphogene","author":"Kaplan","year":"2010"},{"issue":"2","key":"10.1016\/j.bone.2017.06.011_bb0030","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bone.2013.09.002","article-title":"The phenotype and genotype of fibrodysplasia ossificans progressiva in China: a report of 72 cases","volume":"57","author":"Zhang","year":"2013","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000365770","article-title":"Fibrodysplasia ossificans progressiva: clinical course, genetic mutations and genotype-phenotype correlation","volume":"5","author":"Huning","year":"2014","journal-title":"Mol. Syndr."},{"issue":"10","key":"10.1016\/j.bone.2017.06.011_bb0040","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/ajmg.a.37205","article-title":"Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): a report of two patients","volume":"167A","author":"Kaplan","year":"2015","journal-title":"Am. J. Med. Genet. A"},{"issue":"11","key":"10.1016\/j.bone.2017.06.011_bb0045","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00431-010-1232-5","article-title":"Fibrodysplasia ossificans progressiva (FOP): watch the great toes!","volume":"169","author":"Kartal-Kaess","year":"2010","journal-title":"Eur. J. Pediatr."},{"issue":"1","key":"10.1016\/j.bone.2017.06.011_bb0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1302\/0301-620X.64B1.7068725","article-title":"Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients","volume":"64","author":"Connor","year":"1982","journal-title":"J. Bone Joint Surg. Br."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0055","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jbmr.2728","article-title":"The natural history of flare-ups in fibrodysplasia ossificans progressiva (FOP): a comprehensive global assessment","volume":"31","author":"Pignolo","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/BMM:3:3-4:189","article-title":"Immunological features of fibrodysplasia ossificans progressiva and the dysregulated BMP4 pathway","volume":"3","author":"Kaplan","year":"2005","journal-title":"Clin. Rev. Bone Miner. Metab."},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0065","doi-asserted-by":"crossref","first-page":"e654","DOI":"10.1542\/peds.2005-0469","article-title":"Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva","volume":"116","author":"Kitterman","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.bone.2017.06.011_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003086-199801000-00005","article-title":"Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva","volume":"346","author":"Gannon","year":"1998","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"8","key":"10.1016\/j.bone.2017.06.011_bb0075","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1053\/hupa.2001.26464","article-title":"Mast cell involvement in fibrodysplasia ossificans progressiva","volume":"32","author":"Gannon","year":"2001","journal-title":"Hum. Pathol."},{"issue":"12","key":"10.1016\/j.bone.2017.06.011_bb0080","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.2106\/00004623-200312000-00010","article-title":"In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification","volume":"85-A","author":"Glaser","year":"2003","journal-title":"J. Bone Joint Surg. Am."},{"issue":"2","key":"10.1016\/j.bone.2017.06.011_bb0085","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2106\/JBJS.F.00472","article-title":"Hematopoietic stem-cell contribution to ectopic skeletogenesis","volume":"89","author":"Kaplan","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"issue":"8","key":"10.1016\/j.bone.2017.06.011_bb0090","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/jbmr.1637","article-title":"An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva","volume":"27","author":"Chakkalakal","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0095","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"issue":"44","key":"10.1016\/j.bone.2017.06.011_bb0100","doi-asserted-by":"crossref","first-page":"36990","DOI":"10.1074\/jbc.M112.365932","article-title":"Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva","volume":"287","author":"Chaikuad","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/humu.20868","article-title":"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1","volume":"30","author":"Kaplan","year":"2009","journal-title":"Hum. Mutat."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005005","article-title":"Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients","volume":"4","author":"Petrie","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0115","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bone.2010.10.164","article-title":"A novel ACVR1 mutation in the glycine\/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date","volume":"48","author":"Gregson","year":"2011","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.bone.2017.06.011_bb0120","first-page":"3462","article-title":"The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization","volume":"119","author":"Shen","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bone.2017.06.011_bb0125","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1359\/jbmr.091110","article-title":"ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation","volume":"25","author":"Dinther","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2017.06.011_bb0130","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/nm.2252","article-title":"Conversion of vascular endothelial cells into multipotent stem-like cells","volume":"16","author":"Medici","year":"2010","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.071030","article-title":"Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP)","volume":"23","author":"Billings","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0140","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/stem.1633","article-title":"Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification","volume":"32","author":"Culbert","year":"2014","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0145","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nbt811","article-title":"A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse","volume":"21","author":"Schnutgen","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bone.2017.06.011_bb0150","series-title":"Gene Knockout Protocols","first-page":"365","article-title":"Creation and use of a Cre recombinase transgenic database","author":"Nagy","year":"2009"},{"issue":"9","key":"10.1016\/j.bone.2017.06.011_bb0155","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/jbmr.2820","article-title":"Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1(R206H) fibrodysplasia ossificans progressiva (FOP) mutation","volume":"31","author":"Chakkalakal","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0160","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains","volume":"237","author":"Feil","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bone.2017.06.011_bb0165","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gng012","article-title":"Rapid generation of inducible mouse mutants","volume":"31","author":"Seibler","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"51","key":"10.1016\/j.bone.2017.06.011_bb0170","doi-asserted-by":"crossref","first-page":"53126","DOI":"10.1074\/jbc.M408090200","article-title":"Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system","volume":"279","author":"del Re","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.bone.2017.06.011_bb0175","doi-asserted-by":"crossref","first-page":"21037","DOI":"10.1074\/jbc.M110.114959","article-title":"Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb","volume":"285","author":"Sako","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2017.06.011_bb0180","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1210\/me.2008-0290","article-title":"Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators","volume":"22","author":"Souza","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bone.2017.06.011_bb0185","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-12-385961-7.00013-5","article-title":"The regulation and functions of activin and follistatin in inflammation and immunity","volume":"85","author":"Hedger","year":"2011","journal-title":"Vitam. Horm."},{"issue":"1\u20132","key":"10.1016\/j.bone.2017.06.011_bb0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2011.10.009","article-title":"The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair","volume":"359","author":"de Kretser","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.bone.2017.06.011_bb0195","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(91)90549-E","article-title":"Expression cloning of an activin receptor, a predicted transmembrane serine kinase","volume":"65","author":"Mathews","year":"1991","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bone.2017.06.011_bb0200","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0092-8674(93)90488-C","article-title":"Identification of human activin and TGF\u03b2 type I receptors that form heteromeric kinase complexes with type II receptors","volume":"75","author":"Attisano","year":"1993","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.bone.2017.06.011_bb0205","doi-asserted-by":"crossref","first-page":"11242","DOI":"10.1073\/pnas.90.23.11242","article-title":"Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor","volume":"90","author":"Tsuchida","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"40","key":"10.1016\/j.bone.2017.06.011_bb0210","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.273.40.25628","article-title":"Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2","volume":"273","author":"Macias-Silva","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2017.06.011_bb0215","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021881","article-title":"Activins and inhibins: roles in development, physiology, and disease","volume":"8","author":"Namwanje","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2017.06.011_bb0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12964-015-0104-z","article-title":"Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B","volume":"13","author":"Olsen","year":"2015","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bone.2017.06.011_bb0225","first-page":"238","article-title":"Radiographic and scintigraphic features of modeling and remodeling in the heterotopic skeleton of patients who have fibrodysplasia ossificans progressiva","volume":"304","author":"Kaplan","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2017.06.011_bb0230","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00003086-199411000-00024","article-title":"Traumatic fractures of heterotopic bone in patients who have fibrodysplasia ossificans progressiva. A report of 2 cases","volume":"308","author":"Einhorn","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.bone.2017.06.011_bb0235","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1634\/stemcells.2008-0576","article-title":"Dysregulation of local stem\/progenitor cells as a common cellular mechanism for heterotopic ossification","volume":"27","author":"Kan","year":"2009","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0240","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2106\/JBJS.H.01177","article-title":"Identification of progenitor cells that contribute to heterotopic skeletogenesis","volume":"91","author":"Lounev","year":"2009","journal-title":"J. Bone Joint Surg. Am."},{"issue":"5","key":"10.1016\/j.bone.2017.06.011_bb0245","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/jbmr.1562","article-title":"Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification","volume":"27","author":"Wosczyna","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2017.06.011_bb0250","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/dvg.20201","article-title":"Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2","volume":"44","author":"Fukuda","year":"2006","journal-title":"Genesis"},{"issue":"10","key":"10.1016\/j.bone.2017.06.011_bb0255","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/j.1460-2075.1995.tb07214.x","article-title":"GS domain mutations that constitutively activate T beta RI, the downstream signaling component in the TGF-beta receptor complex","volume":"14","author":"Wieser","year":"1995","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.bone.2017.06.011_bb0260","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1128\/MCB.01595-12","article-title":"Constitutively active ALK2 receptor mutants require type II receptor cooperation","volume":"33","author":"Bagarova","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.bone.2017.06.011_bb0265","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","article-title":"BMP type I receptor inhibition reduces heterotopic [corrected] ossification","volume":"14","author":"Yu","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2017.06.011_bb0270","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cytogfr.2015.12.007","article-title":"Common mutations in ALK2\/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders","volume":"27","author":"Pacifici","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"issue":"8","key":"10.1016\/j.bone.2017.06.011_bb0275","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJM199608223350804","article-title":"Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva","volume":"335","author":"Shafritz","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2017.06.011_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymthe.2017.01.008","article-title":"Strategic targeting of multiple BMP receptors prevents trauma-induced heterotopic ossification","author":"Agarwal","year":"2017","journal-title":"Mol. Ther."},{"issue":"9","key":"10.1016\/j.bone.2017.06.011_bb0285","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrrheum.2010.122","article-title":"Inherited human diseases of heterotopic bone formation","volume":"6","author":"Shore","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"29","key":"10.1016\/j.bone.2017.06.011_bb0290","doi-asserted-by":"crossref","first-page":"22542","DOI":"10.1074\/jbc.M109.094557","article-title":"Molecular consequences of the ACVR1R206H mutation of fibrodysplasia ossificans progressiva","volume":"285","author":"Song","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2\u20134","key":"10.1016\/j.bone.2017.06.011_bb0295","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000324230","article-title":"In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP","volume":"194","author":"Groppe","year":"2011","journal-title":"Cells Tissues Organs"},{"issue":"1 Supplement","key":"10.1016\/j.bone.2017.06.011_bb0300","first-page":"856","article-title":"Activities of dysregulated ALK2 receptor kinases provide insight Into the protein structural-functional basis of Fibrodysplasia Ossificans Progressiva","volume":"30","author":"Groppe","year":"2016","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0305","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/BMM:3:3-4:205","article-title":"Three pairs of monozygotic twins with fibrodysplasia ossificans progressiva","volume":"3","author":"Hebela","year":"2005","journal-title":"Clin. Rev. Bone Miner. Metab."},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0310","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/tera.1420070310","article-title":"Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid","volume":"7","author":"Kochhar","year":"1973","journal-title":"Teratology"},{"issue":"1","key":"10.1016\/j.bone.2017.06.011_bb0315","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00304671","article-title":"Production of congenital limb defects with retinoic acid: phenomenological evidence of progressive differentiation during limb morphogenesis","volume":"161","author":"Kwasigroch","year":"1980","journal-title":"Anat. Embryol."},{"issue":"4","key":"10.1016\/j.bone.2017.06.011_bb0320","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nm.2334","article-title":"Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-[gamma] agonists","volume":"17","author":"Shimono","year":"2011","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.bone.2017.06.011_bb0325","first-page":"1243","article-title":"Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema","volume":"10","author":"Hind","year":"2009","journal-title":"Curr. Opin. Investig. Drugs"},{"issue":"20","key":"10.1016\/j.bone.2017.06.011_bb0330","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89805","article-title":"mTOR inhibition and BMP signaling act synergistically to reduce muscle fibrosis and improve myofiber regeneration","volume":"1","author":"Agarwal","year":"2016","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.bone.2017.06.011_bb0335","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1073\/pnas.1515397113","article-title":"Inhibition of Hif1alpha prevents both trauma-induced and genetic heterotopic ossification","volume":"113","author":"Agarwal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bone.2017.06.011_bb0340","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1016\/j.bmcl.2013.03.113","volume":"23","author":"Engers","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.bone.2017.06.011_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062721","article-title":"A new class of small molecule inhibitor of BMP signaling","volume":"8","author":"Sanvitale","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bone.2017.06.011_bb0350","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/cb300655w","article-title":"Development of an ALK2-biased BMP type I receptor kinase inhibitor","volume":"8","author":"Mohedas","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"19","key":"10.1016\/j.bone.2017.06.011_bb0355","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1021\/jm501177w","article-title":"Structure\u2013activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants","volume":"57","author":"Mohedas","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bone.2017.06.011_bb0360","series-title":"Methods and Compositions for the Treatment or Prevention of Abnormal Bone Formation in a Soft Tissue","author":"Yu","year":"2016"},{"issue":"7","key":"10.1016\/j.bone.2017.06.011_bb0365","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/gt.2011.152","article-title":"Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting","volume":"19","author":"Kaplan","year":"2012","journal-title":"Gene Ther."},{"issue":"7","key":"10.1016\/j.bone.2017.06.011_bb0370","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/gt.2011.193","article-title":"Disease-causing allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva","volume":"19","author":"Takahashi","year":"2012","journal-title":"Gene Ther."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T20:49:27Z","timestamp":1719262167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217302107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":74,"alternative-id":["S8756328217302107"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.06.011","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}