{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:04:49Z","timestamp":1762459489965,"version":"3.44.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.bone.2017.07.010","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T15:31:10Z","timestamp":1499873470000},"page":"188-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats"],"prefix":"10.1016","volume":"103","author":[{"given":"Laura C.","family":"Ortinau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca K.","family":"Dirkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Scott","family":"Rector","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"author":"Federation","key":"10.1016\/j.bone.2017.07.010_bb0005"},{"key":"10.1016\/j.bone.2017.07.010_bb0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2017.07.010_bb0015","first-page":"S3","article-title":"The global burden of diabetes and its complications: an emerging pandemic","volume":"17","author":"van Dieren","year":"2010","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.bone.2017.07.010_bb0020","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.2337\/dc17-S006","volume":"40","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/aje\/kwm106","article-title":"Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture","volume":"166","author":"Janghorbani","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bone.2017.07.010_bb0030","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/er.2012-1042","article-title":"The impact of diabetes and diabetes medications on bone health","volume":"36","author":"Gilbert","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bone.2017.07.010_bb0035","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1210\/jc.2009-2638","article-title":"Thiazolidinediones and fractures: evidence from translating research into action for diabetes","volume":"95","author":"Bilik","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0040","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/jc.2006-0614","article-title":"Risk of fracture in women with type 2 diabetes: the Women's Health Initiative Observational Study","volume":"91","author":"Bonds","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0045","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.2337\/dc10-0067","article-title":"Diabetes and risk of hip fracture in the Singapore Chinese Health Study","volume":"33","author":"Koh","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0050","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1210\/jc.2016-2569","article-title":"Longer duration of diabetes strongly impacts fracture risk assessment: the Manitoba BMD cohort","volume":"101","author":"Majumdar","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0055","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/BOT.0b013e318274da8b","article-title":"Physiological challenges of bone repair","volume":"26","author":"Borrelli","year":"2012","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.bone.2017.07.010_bb0060","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2337\/dc07-2270","article-title":"Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from a Diabetes Outcome Progression Trial (ADOPT)","volume":"31","author":"Kahn","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S2213-8587(14)70227-X","article-title":"Possible adverse effects of SGLT2 inhibitors on bone","volume":"3","author":"Taylor","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bone.2017.07.010_bb0070","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2016-3237","article-title":"Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial","author":"Viscoli","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0075","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/jbmr.86","article-title":"Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS)","volume":"25","author":"Cauley","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jbmr.2106","article-title":"In vivo assessment of bone quality in postmenopausal women with type 2 diabetes","volume":"29","author":"Farr","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bone.2015.07.027","article-title":"Determinants of bone strength and quality in diabetes mellitus in humans","volume":"82","author":"Farr","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0090","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1210\/jc.2010-0226","article-title":"High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus","volume":"95","author":"Burghardt","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0095","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00198-014-2927-7","article-title":"Defects in cortical microarchitecture among African-American women with type 2 diabetes","volume":"26","author":"Yu","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0105","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1038\/boneres.2016.1","article-title":"Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions","volume":"4","author":"Rubin","year":"2016","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0110","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2016-1437","article-title":"Advanced glycation endproducts and bone material strength in type 2 diabetes","author":"Furst","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bone.2015.07.028","article-title":"Effect of type 2 diabetes-related non-enzymatic glycation on bone biomechanical properties","volume":"82","author":"Karim","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11914-014-0202-7","article-title":"Diabetes, collagen, and bone quality","volume":"12","author":"Saito","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2017.07.010_bb0125","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","article-title":"Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus","volume":"21","author":"Saito","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0130","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00198-014-2938-4","article-title":"Association between non-enzymatic glycation, resorption, and microdamage in human tibial cortices","volume":"26","author":"Ural","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0135","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diab.44.7.775","article-title":"Bone loss and bone turnover in diabetes","volume":"44","author":"Krakauer","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2017.07.010_bb0140","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1210\/jc.2012-1546","article-title":"Circulating osteogenic precursor cells in type 2 diabetes mellitus","volume":"97","author":"Manavalan","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0145","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1359\/JBMR.041219","article-title":"Diabetes and bone loss at the hip in older black and white adults","volume":"20","author":"Schwartz","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00441-014-1857-1","article-title":"Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice","volume":"357","author":"de Oliveira","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0155","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jnutbio.2009.10.002","article-title":"High fat diet-induced animal model of age-associated obesity and osteoporosis","volume":"21","author":"Halade","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bone.2017.07.010_bb0160","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bone.2017.07.010_bb0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00223-015-9954-z","article-title":"High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment","volume":"96","author":"Shu","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0170","doi-asserted-by":"crossref","first-page":"E1220","DOI":"10.1152\/ajpendo.00378.2011","article-title":"Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function","volume":"301","author":"Hamann","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11745-010-3397-0","article-title":"Expression of genes associated with bone resorption is increased and bone formation is decreased in mice fed a high-fat diet","volume":"45","author":"Xiao","year":"2010","journal-title":"Lipids"},{"key":"10.1016\/j.bone.2017.07.010_bb0180","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1210\/en.2014-1427","article-title":"Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats","volume":"156","author":"Chen","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2017.07.010_bb0185","doi-asserted-by":"crossref","first-page":"M1","DOI":"10.1530\/JOE-14-0224","article-title":"Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice","volume":"223","author":"Turner","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2017.07.010_bb0190","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2017.07.010_bb0195","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.1803","article-title":"Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus","volume":"28","author":"Hamann","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0200","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/jc.2011-2186","article-title":"Circulating levels of sclerostin are increased in patients with type 2 diabetes mellitus","volume":"97","author":"Garcia-Martin","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0205","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1210\/jc.2012-1901","article-title":"Sclerostin levels associated with inhibition of the Wnt\/beta-catenin signaling and reduced bone turnover in type 2 diabetes mellitus","volume":"97","author":"Gaudio","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0210","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1210\/jc.2011-2958","article-title":"Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes","volume":"97","author":"Gennari","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0215","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.2337\/dc17-S007","volume":"40","author":"Lifestyle Management","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0220","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00198-011-1656-4","article-title":"Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered","volume":"23","author":"Moustafa","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0225","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0230","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bone.2015.04.036","article-title":"Role of IGF-I signaling in muscle bone interactions","volume":"80","author":"Bikle","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0235","article-title":"Control of bone anabolism in response to mechanical loading and PTH by distinct mechanisms downstream of the PTH receptor","author":"Delgado-Calle","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0240","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/dc12-1188","article-title":"High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study","volume":"36","author":"Oei","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0245","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.metabol.2015.04.004","article-title":"Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running","volume":"64","author":"Hinton","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.bone.2017.07.010_bb0250","series-title":"American Society for Nutrition Annual Meeting, Experimental Biology","article-title":"Exercise or caloric restriction reduces bone resorption and improves cortical bone strength in hyperphagic OLETF Rats","author":"Ortinau","year":"2016"},{"key":"10.1016\/j.bone.2017.07.010_bb0255","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/diab.41.11.1422","article-title":"Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain","volume":"41","author":"Kawano","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2017.07.010_bb0260","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnut.2016.00021","article-title":"Obesity in the Otsuka Long Evans Tokushima Fatty Rat: mechanisms and discoveries","volume":"3","author":"Bi","year":"2016","journal-title":"Front Nutr."},{"key":"10.1016\/j.bone.2017.07.010_bb0265","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/jbmr.2210","article-title":"A review of rodent models of type 2 diabetic skeletal fragility","volume":"29","author":"Fajardo","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0270","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1113\/jphysiol.2009.172601","article-title":"Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats","volume":"587","author":"Laye","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.bone.2017.07.010_bb0275","doi-asserted-by":"crossref","first-page":"E1179","DOI":"10.1152\/ajpendo.00703.2009","article-title":"Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats","volume":"298","author":"Rector","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0280","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF02012553","article-title":"Rate of normal longitudinal bone growth in the rat","volume":"10","author":"Hansson","year":"1972","journal-title":"Calcif. Tissue Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0285","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S8756-3282(02)00983-3","article-title":"Time course of epiphyseal growth plate fusion in rat tibiae","volume":"32","author":"Martin","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0290","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1113\/JP272235","article-title":"Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis","volume":"594","author":"Linden","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.bone.2017.07.010_bb0295","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00587471","article-title":"Effects of training on VO2 max and VO2 during two running intensities in rats","volume":"386","author":"Patch","year":"1980","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bone.2017.07.010_bb0300","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1249\/MSS.0000000000000430","article-title":"Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training","volume":"47","author":"Linden","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2017.07.010_bb0305","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2009.11.030","article-title":"Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model","volume":"52","author":"Rector","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bone.2017.07.010_bb0310","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-007-9091-4","article-title":"Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model","volume":"82","author":"Rissanen","year":"2008","journal-title":"Calcif. Tissue Int."},{"article-title":"Research ASfBaM, bone and skeletal muscle interactions: protocols","year":"2012","series-title":"Bone and Skeletal Muscle Interactions Pre-Meeting Workshop: Techniques in Bone and Muscle Biology","key":"10.1016\/j.bone.2017.07.010_bb0315"},{"key":"10.1016\/j.bone.2017.07.010_bb0320","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.bone.2010.08.023","article-title":"BoneJ: free and extensible bone image analysis in ImageJ","volume":"47","author":"Doube","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0325","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-8981(67)90167-2","article-title":"Determination of hydroxyproline","volume":"18","author":"Stegemann","year":"1967","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bone.2017.07.010_bb0330","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bone.2006.12.056","article-title":"Effects of non-enzymatic glycation on cancellous bone fragility","volume":"40","author":"Tang","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0335","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bone.2016.02.007","article-title":"Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression","volume":"86","author":"Kelly","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0340","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/jbmr.2539","article-title":"Establishing biomechanical mechanisms in mouse models: practical guidelines for systematically evaluating phenotypic changes in the diaphyses of long bones","volume":"30","author":"Jepsen","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0345","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0095-4543(05)70130-5","article-title":"The natural history of type 2 diabetes. Implications for clinical practice","volume":"26","author":"Ramlo-Halsted","year":"1999","journal-title":"Prim. Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0350","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2337\/dc09-0264","article-title":"Excessive loss of skeletal muscle mass in older adults with type 2 diabetes","volume":"32","author":"Park","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2017.07.010_bb0355","series-title":"Experimental Biology","article-title":"Bone geometry and trabecular and cortical microarchitecture are altered by type 2 diabetes, but not insulin resistance, in the hyperphagic OLETF rat","author":"Dirkes","year":"2016"},{"key":"10.1016\/j.bone.2017.07.010_bb0360","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/dom.12786","article-title":"Sitagliptin and risk of fractures in type 2 diabetes: results from the TECOS trial","volume":"19","author":"Josse","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0365","article-title":"Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: a population-based study","author":"Nilsson","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0370","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00198-015-3258-z","article-title":"Bone histomorphometry in diabetes mellitus","volume":"26","author":"Moreira","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0375","doi-asserted-by":"crossref","first-page":"1615735","DOI":"10.1155\/2016\/1615735","article-title":"Fracture risk in type 2 diabetes: current perspectives and gender differences","volume":"2016","author":"Russo","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bone.2017.07.010_bb0380","first-page":"59","article-title":"Physical activity and bone health","volume":"111","author":"Carter","year":"2014","journal-title":"Mo. Med."},{"key":"10.1016\/j.bone.2017.07.010_bb0385","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.bioeng.8.061505.095721","article-title":"Biomechanical and molecular regulation of bone remodeling","volume":"8","author":"Robling","year":"2006","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.bone.2017.07.010_bb0390","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1139\/o05-163","article-title":"Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages","volume":"84","author":"Gopalakrishnan","year":"2006","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.bone.2017.07.010_bb0395","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S8756-3282(00)00426-9","article-title":"Glucose-induced inhibition of in vitro bone mineralization","volume":"28","author":"Balint","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0400","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bone.2015.07.012","article-title":"Bone's responses to mechanical loading are impaired in type 1 diabetes","volume":"81","author":"Parajuli","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0405","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00223-007-9101-6","article-title":"Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model","volume":"82","author":"Rissanen","year":"2008","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062172","article-title":"Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level","volume":"8","author":"Schulte","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl. 2","key":"10.1016\/j.bone.2017.07.010_bb0415","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/8756-3282(92)90196-4","article-title":"Implications of architecture for the pathogenesis and prevention of vertebral fracture","volume":"13","author":"Parfitt","year":"1992","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0420","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s007740050052","article-title":"Bone loss in a rat model of non-insulin-dependent diabetes mellitus, the OLETF (Otsuka Long-Evans Tokushima fatty strain) rat","volume":"16","author":"Omi","year":"1998","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0425","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11914-006-0002-9","article-title":"Bone geometry and skeletal fragility","volume":"4","author":"Bouxsein","year":"2006","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2017.07.010_bb0430","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00223-009-9273-3","article-title":"Physical exercise improves properties of bone and its collagen network in growing and maturing mice","volume":"85","author":"Isaksson","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2017.07.010_bb0435","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bone.2015.07.030","article-title":"Exercise increases pyridinoline cross-linking and counters the mechanical effects of concurrent lathyrogenic treatment","volume":"81","author":"McNerny","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0440","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exger.2015.01.048","article-title":"Effect of in vivo loading on bone composition varies with animal age","volume":"63","author":"Aido","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2017.07.010_bb0445","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1210\/jc.2010-0720","article-title":"Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women","volume":"95","author":"Drake","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0450","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.00092.2013","article-title":"Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity","volume":"305","author":"Lau","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.07.010_bb0455","doi-asserted-by":"crossref","first-page":"E478","DOI":"10.1073\/pnas.1409857112","article-title":"Osteocytes mediate the anabolic actions of canonical Wnt\/beta-catenin signaling in bone","volume":"112","author":"Tu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2017.07.010_bb0460","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.matbio.2016.02.010","article-title":"PTH signaling mediates perilacunar remodeling during exercise","volume":"52\u201354","author":"Gardinier","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bone.2017.07.010_bb0465","first-page":"E318","article-title":"Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation","volume":"268","author":"Lean","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bone.2017.07.010_bb0470","first-page":"E937","article-title":"Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus","volume":"270","author":"Lean","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bone.2017.07.010_bb0475","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/jbmr.2714","article-title":"PTH promotes bone anabolism by stimulating aerobic glycolysis via IGF signaling","volume":"30","author":"Esen","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0480","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/bonekey.2012.60","article-title":"The skeletal muscle secretome: an emerging player in muscle-bone crosstalk","volume":"1","author":"Hamrick","year":"2012","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.bone.2017.07.010_bb0485","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bone.2015.03.019","article-title":"In vivo mechanical loading rapidly activates beta-catenin signaling in osteocytes through a prostaglandin mediated mechanism","volume":"76","author":"Lara-Castillo","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.07.010_bb0490","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jbmr.2064","article-title":"Deletion of a single beta-catenin allele in osteocytes abolishes the bone anabolic response to loading","volume":"29","author":"Javaheri","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0495","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(00)81558-5","article-title":"Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass","volume":"100","author":"Ducy","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.07.010_bb0500","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/oby.2007.608","article-title":"High-fat diets: modeling the metabolic disorders of human obesity in rodents","volume":"15","author":"Buettner","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bone.2017.07.010_bb0505","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1359\/JBMR.050523","article-title":"Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathways","volume":"20","author":"Baldock","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0510","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/jbmr.1786","article-title":"Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone","volume":"28","author":"Wong","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.07.010_bb0515","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.physbeh.2007.11.035","article-title":"Unraveling the obesity of OLETF rats","volume":"94","author":"Moran","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bone.2017.07.010_bb0520","first-page":"R254","article-title":"A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats","volume":"281","author":"Bi","year":"2001","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.bone.2017.07.010_bb0525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fendo.2017.00047","article-title":"Cholecystokinin-from local gut hormone to ubiquitous messenger","volume":"8","author":"Rehfeld","year":"2017","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2017.07.010_bb0530","doi-asserted-by":"crossref","first-page":"0590","DOI":"10.1098\/rsif.2015.0590","article-title":"Predicting cortical bone adaptation to axial loading in the mouse tibia","volume":"12","author":"Pereira","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.bone.2017.07.010_bb0535","first-page":"20140786","article-title":"Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle","volume":"281","author":"Vickerton","year":"2014","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.bone.2017.07.010_bb0540","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","article-title":"Osteocytes, mechanosensing and Wnt signaling","volume":"42","author":"Bonewald","year":"2008","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217302363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:42:49Z","timestamp":1757612569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217302363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":108,"alternative-id":["S8756328217302363"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.07.010","relation":{},"ISSN":["8756-3282"],"issn-type":[{"type":"print","value":"8756-3282"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}