{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:57Z","timestamp":1790834457873,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Foundation - Flanders","award":["G.0A72.13"],"award-info":[{"award-number":["G.0A72.13"]}]},{"name":"Research Foundation - Flanders","award":["G.0964.14"],"award-info":[{"award-number":["G.0964.14"]}]},{"name":"Research Foundation - Flanders","award":["G.0A42.16"],"award-info":[{"award-number":["G.0A42.16"]}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["3M120209"],"award-info":[{"award-number":["3M120209"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bone.2017.08.022","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T23:46:01Z","timestamp":1503791161000},"page":"50-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["The skeletal vascular system \u2013 Breathing life into bone tissue"],"prefix":"10.1016","volume":"115","author":[{"given":"Steve","family":"Stegen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2017.08.022_bb0005","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.08.022_bb0010","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1242\/dev.136861","article-title":"Blood vessel formation and function in bone","volume":"143","author":"Sivaraj","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0015","doi-asserted-by":"crossref","first-page":"a008334","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2017.08.022_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","article-title":"Bone development","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.022_bb0025","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2017.08.022_bb0030","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","article-title":"Recent advances in craniofacial morphogenesis","volume":"235","author":"Chai","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bone.2017.08.022_bb0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ncb3476","article-title":"Cell-matrix signals specify bone endothelial cells during developmental osteogenesis","volume":"19","author":"Langen","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bone.2017.08.022_bb0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.08.022_bb0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature13034","article-title":"Direct measurement of local oxygen concentration in the bone marrow of live animals","volume":"508","author":"Spencer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.08.022_bb0050","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1073\/pnas.1324290111","article-title":"Up-regulation of glycolytic metabolism is required for HIF1alpha-driven bone formation","volume":"111","author":"Regan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2017.08.022_bb0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate haematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.08.022_bb0060","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev-cellbio-111315-124936","article-title":"Regulation of hematopoiesis and osteogenesis by blood vessel-derived signals","volume":"32","author":"Ramasamy","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2017.08.022_bb0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/dvdy.24463","article-title":"Vascular endothelial growth factor control mechanisms in skeletal growth and repair","volume":"246","author":"Hu","year":"2017","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bone.2017.08.022_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2017.08.022_bb0075","doi-asserted-by":"crossref","first-page":"a006569","DOI":"10.1101\/cshperspect.a006569","article-title":"VEGF and Notch in tip and stalk cell selection","volume":"3","author":"Blanco","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bone.2017.08.022_bb0080","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrrheum.2012.36","article-title":"Hypoxia-driven pathways in bone development, regeneration and disease","volume":"8","author":"Maes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2017.08.022_bb0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.08.022_bb0090","first-page":"213","article-title":"Signaling circuitry in vascular morphogenesis","volume":"17","author":"Warren","year":"2010","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bone.2017.08.022_bb0095","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1242\/dev.139253","article-title":"Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology","volume":"143","author":"Ben Shoham","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0100","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1242\/dev.117952","article-title":"Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development","volume":"142","author":"Duan","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0105","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1074\/jbc.M111.288472","article-title":"Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts","volume":"287","author":"Tang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2017.08.022_bb0110","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1242\/dev.127.7.1445","article-title":"Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state","volume":"127","author":"Haigh","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0115","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA is necessary for chondrocyte survival during bone development","volume":"131","author":"Zelzer","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0120","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jbmr.1487","article-title":"VEGF-independent cell-autonomous functions of HIF-1alpha regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival","volume":"27","author":"Maes","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.08.022_bb0125","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0925-4773(01)00428-2","article-title":"Tissue specific regulation of VEGF expression during bone development requires Cbfa1\/Runx2","volume":"106","author":"Zelzer","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bone.2017.08.022_bb0130","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/emboj.2009.361","article-title":"Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones","volume":"29","author":"Maes","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2017.08.022_bb0135","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0925-4773(01)00601-3","article-title":"Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188","volume":"111","author":"Maes","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bone.2017.08.022_bb0140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI200419383","article-title":"Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival","volume":"113","author":"Maes","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2017.08.022_bb0145","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13146","article-title":"Endothelial Notch activity promotes angiogenesis and osteogenesis in bone","volume":"507","author":"Ramasamy","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.08.022_bb0150","doi-asserted-by":"crossref","first-page":"13601","DOI":"10.1038\/ncomms13601","article-title":"Blood flow controls bone vascular function and osteogenesis","volume":"7","author":"Ramasamy","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2017.08.022_bb0155","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2017.08.022_bb0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/emboj.2012.308","article-title":"Identification of a clonally expanding haematopoietic compartment in bone marrow","volume":"32","author":"Wang","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2017.08.022_bb0165","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81169-1","article-title":"MMP-9\/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes","volume":"93","author":"Vu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.08.022_bb0170","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1242\/dmm.004226","article-title":"Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation","volume":"3","author":"Ortega","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bone.2017.08.022_bb0175","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.190.2.293","article-title":"Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption","volume":"190","author":"Niida","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2017.08.022_bb0180","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1182\/blood-2014-09-570192","article-title":"Making sense of hematopoietic stem cell niches","volume":"125","author":"Boulais","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bone.2017.08.022_bb0185","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.08.022_bb0190","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1172\/JCI31581","article-title":"The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2017.08.022_bb0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2012.01.051","article-title":"The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO","volume":"149","author":"Rankin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.08.022_bb0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2016.01.002","article-title":"HIF-1alpha promotes glutamine-mediated redox homeostasis and glycogen-dependent bioenergetics to support postimplantation bone cell survival","volume":"23","author":"Stegen","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2017.08.022_bb0205","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bone.2016.03.014","article-title":"Adequate hypoxia inducible factor 1alpha signaling is indispensable for bone regeneration","volume":"87","author":"Stegen","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.022_bb0210","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1101\/gad.255000.114","article-title":"Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin","volume":"29","author":"Wu","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2017.08.022_bb0215","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1038\/ncomms13885","article-title":"Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone","volume":"7","author":"Huang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2017.08.022_bb0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/aja.1001740203","article-title":"Perivascular cells in cartilage canals of the developing mouse epiphysis","volume":"174","author":"Cole","year":"1985","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.bone.2017.08.022_bb0225","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2106\/00004623-200201000-00013","article-title":"Structural stages in the development of the long bones and epiphyses: a study in the New Zealand white rabbit","volume":"84-A","author":"Rivas","year":"2002","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2017.08.022_bb0230","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2017.08.022_bb0235","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1073\/pnas.060037197","article-title":"Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I","volume":"97","author":"Zhou","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2017.08.022_bb0240","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Bone quality\u2014the material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2017.08.022_bb0245","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1359\/jbmr.1997.12.2.283","article-title":"Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures","volume":"12","author":"Vogt","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.08.022_bb0250","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1359\/jbmr.070415","article-title":"Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats","volume":"22","author":"Prisby","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.08.022_bb0255","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/8756-3282(87)90015-9","article-title":"Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study","volume":"8","author":"Burkhardt","year":"1987","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.022_bb0260","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm.3668","article-title":"PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2017.08.022_bb0265","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12013-013-9780-8","article-title":"Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity","volume":"69","author":"Liu","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bone.2017.08.022_bb0270","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/nrdp.2015.19","article-title":"Type 2 diabetes mellitus","volume":"1","author":"DeFronzo","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bone.2017.08.022_bb0275","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/aje\/kwm106","article-title":"Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture","volume":"166","author":"Janghorbani","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bone.2017.08.022_bb0280","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/JOE-14-0514","article-title":"Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat","volume":"225","author":"Stabley","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2017.08.022_bb0285","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jcb.10435","article-title":"Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation","volume":"88","author":"Gerstenfeld","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2017.08.022_bb0290","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00003086-200009000-00033","article-title":"Is human fracture hematoma inherently angiogenic?","author":"Street","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2017.08.022_bb0295","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: the cellular picture","volume":"19","author":"Schindeler","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2017.08.022_bb0300","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/physrev.00022.2016","article-title":"Bone cell bioenergetics and skeletal energy homeostasis","volume":"97","author":"Riddle","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2017.08.022_bb0305","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2017.08.022_bb0310","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00402-008-0777-5","article-title":"The systemic angiogenic response during bone healing","volume":"129","author":"Weiss","year":"2009","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.bone.2017.08.022_bb0315","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bone.2003.12.024","article-title":"Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair","volume":"34","author":"Komatsu","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.022_bb0320","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1073\/pnas.0708474105","article-title":"Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration","volume":"105","author":"Wan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2017.08.022_bb0325","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/jor.20886","article-title":"Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice","volume":"27","author":"Shen","year":"2009","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.bone.2017.08.022_bb0330","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2014.09.017","article-title":"Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration","volume":"70","author":"Stegen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.022_bb0335","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1242\/dev.00559","article-title":"Altered fracture repair in the absence of MMP9","volume":"130","author":"Colnot","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.08.022_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001150","article-title":"Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration","volume":"2","author":"Behonick","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.08.022_bb0345","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/dmm.006304","article-title":"Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2","volume":"4","author":"Lieu","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bone.2017.08.022_bb0350","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/sj.gt.3302943","article-title":"Recombinant AAV-mediated VEGF gene therapy induces mandibular condylar growth","volume":"14","author":"Rabie","year":"2007","journal-title":"Gene Ther."},{"key":"10.1016\/j.bone.2017.08.022_bb0355","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1089\/ten.tea.2008.0214","article-title":"The dose of growth factors influences the synergistic effect of vascular endothelial growth factor on bone morphogenetic protein 4-induced ectopic bone formation","volume":"15","author":"Li","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bone.2017.08.022_bb0360","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrd2761","article-title":"Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease","volume":"8","author":"Fraisl","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bone.2017.08.022_bb0365","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2015.12.024","article-title":"Targeting the hypoxic response in bone tissue engineering: a balance between supply and consumption to improve bone regeneration","volume":"432","author":"Stiers","year":"2016","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:30:51Z","timestamp":1659385851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217303174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":73,"alternative-id":["S8756328217303174"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.022","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The skeletal vascular system \u2013 Breathing life into bone tissue","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}