{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:23:32Z","timestamp":1791566612000,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016787","name":"Penn Center for Musculoskeletal Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007928","name":"Perelman School of Medicine, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AR41916"],"award-info":[{"award-number":["R01-AR41916"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-AR050950"],"award-info":[{"award-number":["P30-AR050950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bone.2017.08.023","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T02:01:02Z","timestamp":1503712862000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)"],"prefix":"10.1016","volume":"109","author":[{"given":"Tracy A.","family":"Brennan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter M.","family":"Lindborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Bergbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick S.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Pignolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bone.2017.08.023_bb0005","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.4049\/jimmunol.1103366","article-title":"Stem cell factor programs the mast cell activation phenotype","volume":"188","author":"Ito","year":"2012","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bone.2017.08.023_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bone.2017.08.023_bb0015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ajpath.2015.07.025","article-title":"The mast cell-IgE paradox: from homeostasis to anaphylaxis","volume":"186","author":"Galli","year":"2016","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.bone.2017.08.023_bb0020","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","article-title":"Immunomodulatory mast cells: negative, as well as positive, regulators of immunity","volume":"8","author":"Galli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bone.2017.08.023_bb0025","first-page":"535","article-title":"Antigen-induced, IgE-mediated degranulation of cloned immature mast cells derived from normal mice","volume":"126","author":"Dvorak","year":"1987","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.bone.2017.08.023_bb0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0008-8749(87)90068-2","article-title":"Morphologic mast cell cycles","volume":"105","author":"Dvorak","year":"1987","journal-title":"Cell. Immunol."},{"issue":"8","key":"10.1016\/j.bone.2017.08.023_bb0035","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1053\/hupa.2001.26464","article-title":"Mast cell involvement in fibrodysplasia ossificans progressiva","volume":"32","author":"Gannon","year":"2001","journal-title":"Hum. Pathol."},{"issue":"4","key":"10.1016\/j.bone.2017.08.023_bb0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/dvg.20201","article-title":"Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2","volume":"44","author":"Fukuda","year":"2006","journal-title":"Genesis"},{"issue":"12","key":"10.1016\/j.bone.2017.08.023_bb0045","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","article-title":"BMP type I receptor inhibition reduces heterotopic [corrected] ossification","volume":"14","author":"Yu","year":"2008","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.bone.2017.08.023_bb0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/089686080402400513","article-title":"Ossification of the peritoneal membrane","volume":"24","author":"Di Paolo","year":"2004","journal-title":"Perit. Dial. Int."},{"issue":"11","key":"10.1016\/j.bone.2017.08.023_bb0055","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","article-title":"Bone formation and inflammation in cardiac valves","volume":"103","author":"Mohler","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2017.08.023_bb0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-12-800267-4.00006-7","article-title":"Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing","volume":"122","author":"Douaiher","year":"2014","journal-title":"Adv. Immunol."},{"issue":"4","key":"10.1016\/j.bone.2017.08.023_bb0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/wound.2012.0414","article-title":"A snapshot of direct cell-cell communications in wound healing and scarring","volume":"2","author":"Ehrlich","year":"2013","journal-title":"Adv. Wound Care"},{"issue":"5","key":"10.1016\/j.bone.2017.08.023_bb0070","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biomaterials.2013.10.068","article-title":"The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan","volume":"35","author":"Farrugia","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bone.2017.08.023_bb0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11882-012-0322-z","article-title":"Mast cell activation syndrome: a review","volume":"13","author":"Frieri","year":"2013","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.bone.2017.08.023_bb0080","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fimmu.2012.00120","article-title":"Mast cell: an emerging partner in immune interaction","volume":"3","author":"Gri","year":"2012","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bone.2017.08.023_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2013.09.018","article-title":"A focus on mast cells and pain","volume":"264","author":"Heron","year":"2013","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.bone.2017.08.023_bb0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molimm.2014.02.020","article-title":"Mast cells as targets for immunotherapy of solid tumors","volume":"63","author":"Oldford","year":"2015","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.bone.2017.08.023_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2012.07.007","article-title":"Widespread immunological functions of mast cells: fact or fiction?","volume":"37","author":"Rodewald","year":"2012","journal-title":"Immunity"},{"issue":"33","key":"10.1016\/j.bone.2017.08.023_bb0100","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1016\/j.biomaterials.2011.07.084","article-title":"The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials","volume":"32","author":"Thevenot","year":"2011","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bone.2017.08.023_bb0105","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1182\/blood-2013-04-498105","article-title":"Mast cell activation contributes to sickle cell pathobiology and pain in mice","volume":"122","author":"Vincent","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bone.2017.08.023_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00011-013-0690-4","article-title":"Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification","volume":"63","author":"Kan","year":"2014","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.bone.2017.08.023_bb0115","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1124\/jpet.107.132795","article-title":"Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons","volume":"324","author":"Bucelli","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.bone.2017.08.023_bb0120","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1002\/jcb.23259","article-title":"Substance P signaling mediates BMP-dependent heterotopic ossification","volume":"112","author":"Kan","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.bone.2017.08.023_bb0125","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/jcb.23225","article-title":"Sensory nerve induced inflammation contributes to heterotopic ossification","volume":"112","author":"Salisbury","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.bone.2017.08.023_bb0130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i4.30","article-title":"Heterotopic ossification has some nerve","volume":"20","author":"Salisbury","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"2","key":"10.1016\/j.bone.2017.08.023_bb0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"O'Connor","year":"2004","journal-title":"J. Cell. Physiol."},{"issue":"18","key":"10.1016\/j.bone.2017.08.023_bb0140","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1097\/QAD.0b013e3283405c33","article-title":"Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals","volume":"24","author":"Manak","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.bone.2017.08.023_bb0145","first-page":"1","article-title":"The medical management of fibrodysplasia ossificans progressiva","volume":"4","author":"Kaplan","year":"2011","journal-title":"Clin. Proc. Intl. Clin. Consort FOP"},{"issue":"4","key":"10.1016\/j.bone.2017.08.023_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2125.1986.tb02905.x","article-title":"The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration","volume":"22","author":"Neale","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bone.2017.08.023_bb0155","first-page":"126","article-title":"Expanded uses of cromolyn","volume":"47","author":"Podolsky","year":"1981","journal-title":"Ann. Allergy"},{"issue":"7","key":"10.1016\/j.bone.2017.08.023_bb0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.2042-7158.1972.tb09051.x","article-title":"The fate of (14C)disodium cromoglycate in man","volume":"24","author":"Walker","year":"1972","journal-title":"J. Pharm. Pharmacol."},{"issue":"8","key":"10.1016\/j.bone.2017.08.023_bb0165","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1136\/ard.2004.029835","article-title":"Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis","volume":"64","author":"Juurikivi","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"20","key":"10.1016\/j.bone.2017.08.023_bb0170","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1056\/NEJMoa1613125","article-title":"KIT inhibition by imatinib in patients with severe refractory asthma","volume":"376","author":"Cahill","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bone.2017.08.023_bb0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11420-013-9335-y","article-title":"Use of imatinib in the prevention of heterotopic ossification","volume":"9","author":"Werner","year":"2013","journal-title":"HSS J."},{"issue":"9","key":"10.1016\/j.bone.2017.08.023_bb0180","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/jbmr.2848","article-title":"Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling","volume":"31","author":"Wang","year":"2016","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:12:35Z","timestamp":1778940755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217303198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":36,"alternative-id":["S8756328217303198"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.023","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}