{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:41:48Z","timestamp":1790743308362,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bone.2017.08.026","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T00:31:20Z","timestamp":1504312280000},"page":"163-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism"],"prefix":"10.1016","volume":"105","author":[{"given":"Xiaodong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longchuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Asuncion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Grisanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ya","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Tian","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Villasenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Stolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Charles","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Ominsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua Zhu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2017.08.026_bb0005","series-title":"Bone Histomorphometry","author":"Axelrod","year":"1994"},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2017.08.026_bb0010","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.2215\/CJN.04151206","article-title":"Normal bone anatomy and physiology","volume":"3","author":"Clarke","year":"2008","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0015","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1182\/blood-2004-06-2480","article-title":"Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche","volume":"105","author":"Taichman","year":"2005","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0020","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tem.2009.02.001","article-title":"Bone as an endocrine organ","volume":"20","author":"Fukumoto","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.08.026_bb0025","series-title":"Primer on the Metabolic Bone Disease s and Disorders of Mineral Metabolism","article-title":"Bone Remodeling","author":"Mundy","year":"1999"},{"issue":"3","key":"10.1016\/j.bone.2017.08.026_bb0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00357770","article-title":"The mode of progression of subperiosteal resorption in the hyperparathyroidism of chronic renal failure","volume":"10","author":"Meema","year":"1983","journal-title":"Skelet. Radiol."},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1148\/126.1.67","article-title":"A roentgenologic study of cortical bone resorption in chronic renal failure","volume":"126","author":"Meema","year":"1978","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.bone.2017.08.026_bb0040","first-page":"650","article-title":"Intracortical tunnels: an early sign of hyperparathyroidism in chronic uremia under periodic hemodialysis","volume":"69","author":"Meneghello","year":"1983","journal-title":"La Radiologia medica"},{"issue":"8","key":"10.1016\/j.bone.2017.08.026_bb0045","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"4 Suppl 3","key":"10.1016\/j.bone.2017.08.026_bb0050","first-page":"S1","volume":"42","author":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","year":"2003","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"issue":"11","key":"10.1016\/j.bone.2017.08.026_bb0055","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2017.08.026_bb0060","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/ki.2008.264","article-title":"Chronic kidney disease and bone fracture: a growing concern","volume":"74","author":"Nickolas","year":"2008","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2017.08.026_bb0065","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jbmr.309","article-title":"Renal osteodystrophy in the first decade of the new millennium: analysis of 630 bone biopsies in black and white patients","volume":"26","author":"Malluche","year":"2011","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5414\/CNP69269","article-title":"An assessment of cinacalcet HCl effects on bone histology in dialysis patients with secondary hyperparathyroidism","volume":"69","author":"Malluche","year":"2008","journal-title":"Clin. Nephrol."},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0075","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ki.2014.349","article-title":"Bone histomorphometry before and after long-term treatment with cinacalcet in dialysis patients with secondary hyperparathyroidism","volume":"87","author":"Behets","year":"2015","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0080","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2165\/00003088-200948050-00002","article-title":"Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride","volume":"48","author":"Padhi","year":"2009","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1542-4758.2009.00397.x","article-title":"Assessment of adherence to cinacalcet by prescription refill rates in hemodialysis patients","volume":"14","author":"Gincherman","year":"2010","journal-title":"Hemodialysis international. International Symposium on Home Hemodialysis"},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/jpet.113.204834","article-title":"Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients","volume":"346","author":"Walter","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0095","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1124\/mol.115.098392","article-title":"Critical cysteine residues in both the calcium-sensing receptor and the allosteric activator AMG 416 underlie the mechanism of action","volume":"88","author":"Alexander","year":"2015","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ndt\/gft417","article-title":"Velcalcetide (AMG 416), a novel peptide agonist of the calcium-sensing receptor, reduces serum parathyroid hormone and FGF23 levels in healthy male subjects","volume":"29","author":"Martin","year":"2014","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ki.2013.289","article-title":"AMG 416 (velcalcetide) is a novel peptide for the treatment of secondary hyperparathyroidism in a single-dose study in hemodialysis patients","volume":"85","author":"Martin","year":"2014","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0110","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1185\/03007995.2015.1031731","article-title":"A randomized, double-blind, phase 2 study evaluating the safety and efficacy of AMG 416 for the treatment of secondary hyperparathyroidism in hemodialysis patients","volume":"31","author":"Bell","year":"2015","journal-title":"Curr. Med. Res. Opin."},{"issue":"15","key":"10.1016\/j.bone.2017.08.026_bb0115","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJMoa031633","article-title":"Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis","volume":"350","author":"Block","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01137964","article-title":"Surgically induced uremia in rats. I: effect on bone strength and metabolism","volume":"13","author":"Jablonski","year":"1993","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.bone.2017.08.026_bb0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S8756-3282(98)00098-2","article-title":"Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency","volume":"23","author":"Miller","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.08.026_bb0130","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.bone.2017.08.026_bb0135","article-title":"Etelcalcetide, a novel calcimimetic, prevents vascular calcification in a rat model of renal insufficiency with secondary hyperparathyroidism","author":"Yu","year":"2016","journal-title":"AJP Renal Physiology"},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0140","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0145","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1359\/JBMR.040404","article-title":"Continuous parathyroid hormone induces cortical porosity in the rat: effects on bone turnover and mechanical properties","volume":"19","author":"Lotinun","year":"2004","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0150","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.1523-1755.1998.00782.x","article-title":"NPS R-568 halts or reverses osteitis fibrosa in uremic rats","volume":"53","author":"Wada","year":"1998","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2017.08.026_bb0155","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ndt\/gfh829","article-title":"Effects of cinacalcet on bone mineral density in patients with secondary hyperparathyroidism","volume":"20","author":"Lien","year":"2005","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0160","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1523-1755.2005.00596.x","article-title":"Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism","volume":"68","author":"Cunningham","year":"2005","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0165","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF00311432","article-title":"Evaluation of bone loss and the serum markers of bone metabolism in patients with hyperparathyroidism","volume":"25","author":"Katagiri","year":"1995","journal-title":"Surg. Today"},{"issue":"5","key":"10.1016\/j.bone.2017.08.026_bb0170","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s11255-011-0050-7","article-title":"Cinacalcet lowers FGF-23 level together with bone metabolism in hemodialyzed patients with secondary hyperparathyroidism","volume":"44","author":"Hryszko","year":"2012","journal-title":"Int. Urol. Nephrol."},{"issue":"6","key":"10.1016\/j.bone.2017.08.026_bb0175","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2215\/CJN.03270314","article-title":"Effect of Cinacalcet and vitamin D analogs on fibroblast growth factor-23 during the treatment of secondary hyperparathyroidism","volume":"10","author":"Sprague","year":"2015","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCULATIONAHA.114.013876","article-title":"Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: the evaluation of Cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial","volume":"132","author":"Moe","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0185","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/ndt\/gfr384","article-title":"Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism","volume":"27","author":"Koizumi","year":"2012","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0190","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00360.2010","article-title":"PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"Lavi-Moshayoff","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0195","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1681\/ASN.2011101006","article-title":"Calcium deficiency reduces circulating levels of FGF23","volume":"23","author":"Rodriguez-Ortiz","year":"2012","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0200","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1172\/JCI61405","article-title":"FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality","volume":"122","author":"Shalhoub","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0205","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","author":"Nemeth","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.bone.2017.08.026_bb0210","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1523-1755.2005.67103.x","article-title":"Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism","volume":"67","author":"Colloton","year":"2005","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2017.08.026_bb0215","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/ndt\/gfr589","article-title":"Cinacalcet HCl prevents development of parathyroid gland hyperplasia and reverses established parathyroid gland hyperplasia in a rodent model of CKD","volume":"27","author":"Miller","year":"2012","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"issue":"1","key":"10.1016\/j.bone.2017.08.026_bb0220","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","article-title":"Extracellular calcium sensing and extracellular calcium signaling","volume":"81","author":"Brown","year":"2001","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.bone.2017.08.026_bb0225","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/ndt\/gfm177","article-title":"Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies","volume":"22","author":"Drueke","year":"2007","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0230","first-page":"289","article-title":"The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism","volume":"17","author":"Chattopadhyay","year":"1996","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.bone.2017.08.026_bb0235","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng1295-389","article-title":"A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism","volume":"11","author":"Ho","year":"1995","journal-title":"Nat. Genet."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T06:07:28Z","timestamp":1539151648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217303216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":47,"alternative-id":["S8756328217303216"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.026","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}