{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:53:49Z","timestamp":1780556029285,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence","award":["MOHW106-TDU-B-212-113004"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113004"]}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academia Sinica Taiwan Biobank","award":["BM10501010037"],"award-info":[{"award-number":["BM10501010037"]}]},{"name":"Stroke Clinical Trial Consortium","award":["MOST 105-2325-B-039-003"],"award-info":[{"award-number":["MOST 105-2325-B-039-003"]}]},{"name":"Tseng-Lien Lin Foundation"},{"name":"Taiwan Brain Disease Foundation"},{"name":"China Medical University Hospital Cancer Research Center of Excellence","award":["MOHW105-TDU-B-212-134003"],"award-info":[{"award-number":["MOHW105-TDU-B-212-134003"]}]}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bone.2017.10.016","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T16:02:22Z","timestamp":1508342542000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Risk of fracture in transfusion-na\u00efve thalassemia population: A nationwide population-based retrospective cohort study"],"prefix":"10.1016","volume":"106","author":[{"given":"Yu-Guang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey-En","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hao","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9813","key":"10.1016\/j.bone.2017.10.016_bb0005","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0140-6736(11)60283-3","article-title":"Thalassaemia","volume":"379","author":"Higgs","year":"2012","journal-title":"Lancet"},{"issue":"20","key":"10.1016\/j.bone.2017.10.016_bb0010","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMra1404415","article-title":"The alpha-thalassemias","volume":"371","author":"Piel","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bone.2017.10.016_bb0015","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3324\/haematol.2012.066845","article-title":"Non-transfusion-dependent thalassemias","volume":"98","author":"Musallam","year":"2013","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.bone.2017.10.016_bb0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bone.2010.10.173","article-title":"Bone disease and skeletal complications in patients with beta thalassemia major","volume":"48","author":"Haidar","year":"2011","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2017.10.016_bb0025","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1359\/jbmr.080505","article-title":"Bone disease in thalassemia: a frequent and still unresolved problem","volume":"24","author":"Vogiatzi","year":"2009","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2017.10.016_bb0030","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bone.2005.10.001","article-title":"Prevalence of fractures among the Thalassemia syndromes in North America","volume":"38","author":"Vogiatzi","year":"2006","journal-title":"Bone"},{"issue":"13","key":"10.1016\/j.bone.2017.10.016_bb0035","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000700","article-title":"Risk of erectile dysfunction in transfusion-naive thalassemia men: a nationwide population-based retrospective cohort study","volume":"94","author":"Chen","year":"2015","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.bone.2017.10.016_bb0040","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejim.2015.02.001","article-title":"Risk of coronary artery disease in transfusion-naive thalassemia populations: a nationwide population-based retrospective cohort study","volume":"26","author":"Chen","year":"2015","journal-title":"Eur. J. Intern. Med."},{"issue":"6","key":"10.1016\/j.bone.2017.10.016_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021404","article-title":"Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bone.2017.10.016_bb0050","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1253\/circj.CJ-14-1227","article-title":"Hormone therapy and risk of venous thromboembolism among postmenopausal women in Taiwan - a 10-year nationwide population-based study","volume":"79","author":"Lee","year":"2015","journal-title":"Circ. J."},{"issue":"7","key":"10.1016\/j.bone.2017.10.016_bb0055","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00198-012-2260-y","article-title":"Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures","volume":"24","author":"Wong","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"11","key":"10.1016\/j.bone.2017.10.016_bb0060","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/jbmr.2266","article-title":"Thalassemia bone disease: a 19-year longitudinal analysis","volume":"29","author":"Wong","year":"2014","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2017.10.016_bb0065","first-page":"5","article-title":"Molecular study and prenatal diagnosis of alpha- and beta-thalassemias in Chinese","volume":"97","author":"Ko","year":"1998","journal-title":"J. Formos. Med. Assoc."},{"issue":"3","key":"10.1016\/j.bone.2017.10.016_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bcmd.2013.04.007","article-title":"Distribution of thalassemias and associated hemoglobinopathies identified by prenatal diagnosis in Taiwan","volume":"51","author":"Peng","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"issue":"3","key":"10.1016\/j.bone.2017.10.016_bb0075","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/03630269.2011.572524","article-title":"Molecular lesion frequency of hemoglobin gene disorders in Taiwan","volume":"35","author":"Liu","year":"2011","journal-title":"Hemoglobin"},{"issue":"2","key":"10.1016\/j.bone.2017.10.016_bb0080","first-page":"167","article-title":"Osteoporosis in thalassemia major: an update and the I-CET 2013 recommendations for surveillance and treatment","volume":"11","author":"De Sanctis","year":"2013","journal-title":"Pediatr. Endocrinol. Rev."},{"issue":"6","key":"10.1016\/j.bone.2017.10.016_bb0085","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/8756-3282(95)00117-V","article-title":"Bone minerals in beta-thalassemia minor","volume":"16","author":"Kalef-Ezra","year":"1995","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.bone.2017.10.016_bb0090","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1046\/j.1532-5415.2002.50313.x","article-title":"Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated?","volume":"50","author":"Chaves","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"issue":"2","key":"10.1016\/j.bone.2017.10.016_bb0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0002-9343(03)00263-8","article-title":"Anemia and decline in physical performance among older persons","volume":"115","author":"Penninx","year":"2003","journal-title":"Am. J. Med."},{"issue":"4","key":"10.1016\/j.bone.2017.10.016_bb0100","first-page":"211","article-title":"Bone and maxillofacial abnormalities in thalassemia: a review of the literature","volume":"22","author":"Di Matteo","year":"2008","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"10","key":"10.1016\/j.bone.2017.10.016_bb0105","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00198-009-1131-7","article-title":"Anemia and the risk of non-vertebral fractures: the Tromso Study","volume":"21","author":"Jorgensen","year":"2010","journal-title":"Osteoporos. Int."},{"issue":"13","key":"10.1016\/j.bone.2017.10.016_bb0110","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/archinte.166.13.1380","article-title":"Low testosterone levels and the risk of anemia in older men and women","volume":"166","author":"Ferrucci","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.bone.2017.10.016_bb0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1359\/jbmr.060110","article-title":"Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden","volume":"21","author":"Mellstrom","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.10.016_bb0120","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2147\/CIA.S115472","article-title":"A concise review of testosterone and bone health","volume":"11","author":"Mohamad","year":"2016","journal-title":"Clin. Interv. Aging"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217303824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T06:10:14Z","timestamp":1539151814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217303824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":24,"alternative-id":["S8756328217303824"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.10.016","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of fracture in transfusion-na\u00efve thalassemia population: A nationwide population-based retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}