{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:15:00Z","timestamp":1789877700928,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bone.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T19:16:02Z","timestamp":1510686962000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Adults with cystic fibrosis have deficits in bone structure and strength at the distal tibia despite similar size and measuring standard and relative sites"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-1088","authenticated-orcid":false,"given":"Kyle K.","family":"Nishiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kepley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rosete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Edward","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"DiMango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bone.2017.11.006_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jcf.2009.04.001","article-title":"An overview of international literature from cystic fibrosis registries: 1. Mortality and survival studies in cystic fibrosis","volume":"8","author":"Buzzetti","year":"2009","journal-title":"J. Cyst. Fibros."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0010","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1210\/jc.2004-1629","article-title":"Guide to bone health and disease in cystic fibrosis","volume":"90","author":"Aris","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.bone.2017.11.006_bb0015","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1164\/rccm.201009-1478CI","article-title":"Managing cystic fibrosis: strategies that increase life expectancy and improve quality of life","volume":"183","author":"Cohen-Cymberknoh","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0020","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7326\/0003-4819-128-3-199802010-00004","article-title":"Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis","volume":"128","author":"Aris","year":"1998","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.bone.2017.11.006_bb0025","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-3476(94)70194-6","article-title":"Kyphosis and fractures in children and young adults with cystic fibrosis","volume":"125","author":"Henderson","year":"1994","journal-title":"J. Pediatr."},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0022-3476(79)80346-7","article-title":"Reduced serum 25-hydroxyvitamin D concentration and disordered mineral metabolism in patients with cystic fibrosis","volume":"94","author":"Hahn","year":"1979","journal-title":"J. Pediatr."},{"issue":"6","key":"10.1016\/j.bone.2017.11.006_bb0035","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archpedi.1979.02130060072016","article-title":"Demineralization in cystic fibrosis detected by direct photon absorptiometry","volume":"133","author":"Mischler","year":"1979","journal-title":"Am. J. Dis. Child."},{"issue":"6 Pt 1","key":"10.1016\/j.bone.2017.11.006_bb0040","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1164\/ajrccm.157.6.9712089","article-title":"Bone mass and vitamin D deficiency in adults with advanced cystic fibrosis lung disease","volume":"157","author":"Donovan","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.bone.2017.11.006_bb0045","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jcf.2015.01.011","article-title":"Trends in bone mineral density in young adults with cystic fibrosis over a 15year period","volume":"14","author":"Putman","year":"2015","journal-title":"J. Cyst. Fibros."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/adc.81.3.235","article-title":"Bone mineral status in 134 patients with cystic fibrosis","volume":"81","author":"Laursen","year":"1999","journal-title":"Arch. Dis. Child."},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00223-006-0117-0","article-title":"Quantitative ultrasound in adults with cystic fibrosis: correlation with bone mineral density and risk of vertebral fractures","volume":"80","author":"Rossini","year":"2007","journal-title":"Calcif. Tissue Int."},{"issue":"2","key":"10.1016\/j.bone.2017.11.006_bb0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1378\/chest.130.2.539","article-title":"Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density","volume":"130","author":"Stephenson","year":"2006","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.bone.2017.11.006_bb0065","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1164\/rccm.200206-578OC","article-title":"Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis","volume":"166","author":"Elkin","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.bone.2017.11.006_bb0070","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00198-003-1388-1","article-title":"Abnormalities of the PTH-vitamin D axis and bone turnover markers in children, adolescents and adults with cystic fibrosis: comparison with healthy controls","volume":"14","author":"Greer","year":"2003","journal-title":"Osteoporos. Int."},{"issue":"12","key":"10.1016\/j.bone.2017.11.006_bb0075","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.bone.2017.11.006_bb0080","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.medengphy.2006.11.002","article-title":"Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality","volume":"29","author":"MacNeil","year":"2007","journal-title":"Med. Eng. Phys."},{"issue":"4","key":"10.1016\/j.bone.2017.11.006_bb0085","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1359\/jbmr.091020","article-title":"Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study","volume":"25","author":"Nishiyama","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.bone.2017.11.006_bb0090","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1210\/jc.2014-1982","article-title":"Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis","volume":"99","author":"Putman","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jbmr.171","article-title":"Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study","volume":"26","author":"Macdonald","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2017.11.006_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11914-013-0142-7","article-title":"Clinical imaging of bone microarchitecture with HR-pQCT","volume":"11","author":"Nishiyama","year":"2013","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2017.11.006_bb0105","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/THC-1998-65-606","article-title":"In vivo high resolution 3D-QCT of the human forearm","volume":"6","author":"Laib","year":"1998","journal-title":"Technol. Health Care"},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S8756-3282(98)00159-8","article-title":"Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-micrometer-resolution microcomputed tomography","volume":"24","author":"Laib","year":"1999","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","article-title":"A new method for the model-independent assessment of thickness in three-dimensional images","volume":"185","author":"Hildebrand","year":"1997","journal-title":"J. Microsc."},{"issue":"4","key":"10.1016\/j.bone.2017.11.006_bb0120","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","article-title":"Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss","volume":"72","author":"Parfitt","year":"1983","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2017.11.006_bb0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bone.2007.07.007","article-title":"Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis","volume":"41","author":"Buie","year":"2007","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.bone.2017.11.006_bb0130","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1210\/jc.2014-1041","article-title":"Teriparatide increases strength of the peripheral skeleton in premenopausal women with idiopathic osteoporosis: a pilot HR-pQCT study","volume":"99","author":"Nishiyama","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0135","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bone.2010.05.034","article-title":"Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT","volume":"47","author":"Burghardt","year":"2010","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2017.11.006_bb0140","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s00198-016-3557-z","article-title":"Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis","volume":"27","author":"Putman","year":"2016","journal-title":"Osteoporos. Int."},{"issue":"7","key":"10.1016\/j.bone.2017.11.006_bb0145","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/jbmr.50","article-title":"Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis","volume":"25","author":"Liu","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2017.11.006_bb0150","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1359\/jbmr.060716","article-title":"Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone","volume":"21","author":"Liu","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.bone.2017.11.006_bb0155","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/jbmr.420","article-title":"Individual trabecula segmentation (ITS)-based morphological analysis of microscale images of human tibial trabecular bone at limited spatial resolution","volume":"26","author":"Liu","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2017.11.006_bb0160","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/1350-4533(95)91884-J","article-title":"Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures","volume":"17","author":"M\u00fcller","year":"1995","journal-title":"Med. Eng. Phys."},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0165","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0021-9290(95)80008-5","article-title":"A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models","volume":"28","author":"Van Rietbergen","year":"1995","journal-title":"J. Biomech."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0170","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1359\/jbmr.071108","article-title":"Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women","volume":"23","author":"Boutroy","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2017.11.006_bb0175","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.bone.2008.01.017","article-title":"Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method","volume":"42","author":"MacNeil","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.11.006_bb0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bone.2014.03.043","article-title":"Assessment of the healing process in distal radius fractures by high resolution peripheral quantitative computed tomography","volume":"64","author":"de Jong","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.11.006_bb0185","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2016-3459","article-title":"Accrual of bone mass in children and adolescents with cystic fibrosis","author":"Sharma","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2017.11.006_bb0190","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00198-008-0646-7","article-title":"Well-nourished cystic fibrosis patients have normal mineral density, but reduced cortical thickness at the forearm","volume":"20","author":"Louis","year":"2009","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.bone.2017.11.006_bb0195","doi-asserted-by":"crossref","first-page":"L9","DOI":"10.1210\/jc.2014-4143","article-title":"Response letter to the editor","volume":"100","author":"Putman","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.11.006_bb0200","series-title":"Comparability of HR-pQCT Bone Quality Measures Improved by Scanning Anatomically Standardized Regions","first-page":"S436","author":"Bonaretti","year":"2014"},{"issue":"8","key":"10.1016\/j.bone.2017.11.006_bb0205","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00198-006-0110-5","article-title":"Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation","volume":"17","author":"Ashe","year":"2006","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bone.2017.11.006_bb0210","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.carj.2010.04.011","article-title":"Reproducibility of peripheral quantitative computed tomography measurements at the radius and tibia in healthy pre- and postmenopausal women","volume":"62","author":"Szabo","year":"2011","journal-title":"Can. Assoc. Radiol. J."},{"issue":"10","key":"10.1016\/j.bone.2017.11.006_bb0215","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/jbmr.111","article-title":"Bone density, geometry, microstructure and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women","volume":"25","author":"Liu","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.006_bb0220","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bone.2016.02.016","article-title":"High-resolution peripheral quantitative computed tomography (HR-pQCT) can assess microstructural and biomechanical properties of both human distal radius and tibia: ex vivo computational and experimental validations","volume":"86","author":"Zhou","year":"2016","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217304258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217304258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:46:25Z","timestamp":1750985185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217304258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":44,"alternative-id":["S8756328217304258"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.11.006","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adults with cystic fibrosis have deficits in bone structure and strength at the distal tibia despite similar size and measuring standard and relative sites","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}