{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:34:42Z","timestamp":1767893682786,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011781","name":"Shriners Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shriners of North America","award":["8022"],"award-info":[{"award-number":["8022"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-137102"],"award-info":[{"award-number":["MOP-137102"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bone.2017.11.013","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T07:46:01Z","timestamp":1511423161000},"page":"131-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice"],"prefix":"10.1016","volume":"107","author":[{"given":"Frank","family":"Rauch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqing","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Lamplugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Hekmatnejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Gaumond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Penney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yojiro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Moffatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2017.11.013_bb0005","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2017.11.013_bb0010","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1007\/s00198-016-3709-1","article-title":"DNA sequence analysis in 598 individuals with a clinical diagnosis of osteogenesis imperfecta: diagnostic yield and mutation spectrum","volume":"27","author":"Bardai","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2017.11.013_bb0015","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrendo.2011.81","article-title":"New perspectives on osteogenesis imperfecta","volume":"7","author":"Forlino","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bone.2017.11.013_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/jmedgenet-2012-101307","article-title":"Osteogenesis imperfecta type V: marked phenotypic variability despite the presence of the IFITM5 c.-14C>T mutation in all patients","volume":"50","author":"Rauch","year":"2013","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bone.2017.11.013_bb0025","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1359\/jbmr.2000.15.9.1650","article-title":"Type V osteogenesis imperfecta: a new form of brittle bone disease","volume":"15","author":"Glorieux","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0030","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/jbmr.3180","article-title":"Hypermineralization and high osteocyte lacunar density in osteogenesis imperfecta type V bone indicate exuberant primary bone formation","volume":"32","author":"Blouin","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ajhg.2012.06.005","article-title":"A single recurrent mutation in the 5\u2032-UTR of IFITM5 causes osteogenesis imperfecta type V","volume":"91","author":"Cho","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2017.11.013_bb0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajhg.2012.06.011","article-title":"A mutation in the 5\u2032-UTR of IFITM5 creates an in-frame start codon and causes autosomal-dominant osteogenesis imperfecta type V with hyperplastic callus","volume":"91","author":"Semler","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2017.11.013_bb0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MCD.0b013e32836032f0","article-title":"Genotype-phenotype study in type V osteogenesis imperfecta","volume":"22","author":"Balasubramanian","year":"2013","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.bone.2017.11.013_bb0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/PGE-14079","article-title":"The recurrent causal mutation for osteogenesis imperfecta type V occurs at a highly methylated CpG dinucleotide within the IFITM5 gene","volume":"3","author":"Corradi","year":"2014","journal-title":"J. Pediatr. Genet."},{"issue":"5","key":"10.1016\/j.bone.2017.11.013_bb0055","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/ajmg.a.36409","article-title":"Two mutations in IFITM5 causing distinct forms of osteogenesis imperfecta","volume":"164A","author":"Guillen-Navarro","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bone.2017.11.013_bb0060","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/jbmr.1891","article-title":"Phenotypic variability of osteogenesis imperfecta type V caused by an IFITM5 mutation","volume":"28","author":"Shapiro","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0065","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/ajmg.a.36025","article-title":"A recurrent mutation in the 5\u2032-UTR of IFITM5 causes osteogenesis imperfecta type V","volume":"161","author":"Takagi","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bone.2017.11.013_bb0070","article-title":"Phenotype and genotype analysis of Chinese patients with osteogenesis imperfecta type V","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.11.013_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2474-15-107","article-title":"The IFITM5 mutation c.-14C>T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V","volume":"15","author":"Lazarus","year":"2014","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2017.11.013_bb0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000439506","article-title":"Clinical and molecular characterization of osteogenesis imperfecta type V","volume":"6","author":"Brizola","year":"2015","journal-title":"Mol. Syndromol."},{"key":"10.1016\/j.bone.2017.11.013_bb0085","first-page":"37","article-title":"Phenotypic variability in individuals with type V Osteogenesis Imperfecta with identical IFITM5 mutations","volume":"1","author":"Fitzgerald","year":"2013","journal-title":"J. Rare. Disord."},{"key":"10.1016\/j.bone.2017.11.013_bb0090","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/jbmr.2243","article-title":"Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination","volume":"29","author":"Patoine","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0095","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1210\/jc.2014-3082","article-title":"Type V OI primary osteoblasts display increased mineralization despite decreased COL1A1 expression","volume":"100","author":"Reich","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.11.013_bb0100","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1359\/jbmr.080412","article-title":"Bril: a novel bone-specific modulator of mineralization","volume":"23","author":"Moffatt","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.22203\/eCM.v022a05","article-title":"Ameloblastin is not implicated in bone remodelling and repair","volume":"22","author":"Kuroda","year":"2011","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2017.11.013_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084201","article-title":"Comparative gene-expression analysis of the dental follicle and periodontal ligament in humans","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.11.013_bb0115","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1074\/jbc.M113.457010","article-title":"Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation","volume":"288","author":"Kasaai","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2017.11.013_bb0120","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2407-14-559","article-title":"DeltaNp63alpha enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2","volume":"14","author":"Ram Kumar","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2017.11.013_bb0125","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jbm.a.31240","article-title":"Phenotype and gene expression pattern of osteoblast-like cells cultured on polystyrene and hydroxyapatite with pre-adsorbed type-I collagen","volume":"83","author":"Hanagata","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bone.2017.11.013_bb0130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00774-010-0221-0","article-title":"Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice","volume":"29","author":"Hanagata","year":"2011","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2017.11.013_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184568","article-title":"The osteogenic cell surface marker BRIL\/IFITM5 is dispensable for bone development and homeostasis in mice","volume":"12","author":"Patoine","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.11.013_bb0140","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bone.2017.11.013_bb0145","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jbmr.2363","article-title":"A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation","volume":"30","author":"Lietman","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-59745-549-7_1","article-title":"Methodologies for staining and visualisation of beta-galactosidase in mouse embryos and tissues","volume":"411","author":"Loughna","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bone.2017.11.013_bb0155","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2144\/02321st02","article-title":"Visualization of whole-mount skeletal expression patterns of LacZ reporters using a tissue clearing protocol","volume":"32","author":"Kawaguchi","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.bone.2017.11.013_bb0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S","volume":"22","author":"Mcleod","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.bone.2017.11.013_bb0165","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bone.2017.11.013_bb0170","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/dvdy.21960","article-title":"Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development","volume":"238","author":"Lee","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bone.2017.11.013_bb0175","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jcb.21465","article-title":"Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia","volume":"103","author":"Moffatt","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"Pt 1","key":"10.1016\/j.bone.2017.11.013_bb0180","first-page":"175","article-title":"The timing of ossification of the limb bones, and growth rates of various long bones of the fore and hind limbs of the prenatal and early postnatal laboratory mouse","volume":"186","author":"Patton","year":"1995","journal-title":"J. Anat."},{"key":"10.1016\/j.bone.2017.11.013_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.11.013_bb0190","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1242\/dev.02480","article-title":"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors","volume":"133","author":"Rodda","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.bone.2017.11.013_bb0195","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81169-1","article-title":"MMP-9\/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes","volume":"93","author":"Vu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bone.2017.11.013_bb0200","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/stem.1107","article-title":"Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy","volume":"30","author":"Gioia","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2017.11.013_bb0205","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tem.2009.12.004","article-title":"Prostaglandins in bone: bad cop, good cop?","volume":"21","author":"Blackwell","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2017.11.013_bb0210","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bone.2006.04.006","article-title":"Alteration of femoral bone morphology and density in COX-2\u2212\/\u2212 mice","volume":"39","author":"Robertson","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.11.013_bb0215","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1172\/JCI0215681","article-title":"Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair","volume":"109","author":"Zhang","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2017.11.013_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120164","article-title":"Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice","volume":"10","author":"Choudhary","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2017.11.013_bb0225","first-page":"517","article-title":"Fracture healing and lipid mediators","volume":"3","author":"O'Connor","year":"2014","journal-title":"Bonekey. Rep."},{"key":"10.1016\/j.bone.2017.11.013_bb0230","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/humu.22111","article-title":"Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis","volume":"33","author":"Diggle","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bone.2017.11.013_bb0235","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/humu.22042","article-title":"Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing","volume":"33","author":"Seifert","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bone.2017.11.013_bb0240","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0022-3476(80)80282-4","article-title":"Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease","volume":"97","author":"Ueda","year":"1980","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bone.2017.11.013_bb0245","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1359\/jbmr.070418","article-title":"Natural history of hyperplastic callus formation in osteogenesis imperfecta type V","volume":"22","author":"Cheung","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2017.11.013_bb0250","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00256-007-0441-0","article-title":"Hyperplastic callus formation in osteogenesis imperfecta type V: follow-up of three generations over ten years","volume":"37","author":"Cheung","year":"2008","journal-title":"Skelet. Radiol."},{"key":"10.1016\/j.bone.2017.11.013_bb0255","first-page":"780959","article-title":"Swellings over the limbs as the earliest feature in a patient with Osteogenesis Imperfecta type V","volume":"2014","author":"Al","year":"2014","journal-title":"Case Rep. Orthop."},{"key":"10.1016\/j.bone.2017.11.013_bb0260","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bone.2009.08.061","article-title":"Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells","volume":"46","author":"Celil Aydemir","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2017.11.013_bb0265","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2011.04.136","article-title":"Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes","volume":"409","author":"Hanagata","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2017.11.013_bb0270","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0952-3278(96)90055-1","article-title":"Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)","volume":"54","author":"Orlicky","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bone.2017.11.013_bb0275","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/14728222.2017.1279146","article-title":"The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases","volume":"21","author":"Rodriguez-Calvo","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bone.2017.11.013_bb0280","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.1128\/MCB.17.10.5946","article-title":"Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells","volume":"17","author":"Philips","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2017.11.013_bb0285","doi-asserted-by":"crossref","first-page":"53167","DOI":"10.1074\/jbc.M405677200","article-title":"Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts","volume":"279","author":"Pirih","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2017.11.013_bb0290","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1210\/me.2003-0247","article-title":"Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts","volume":"18","author":"Lammi","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bone.2017.11.013_bb0295","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2005.04.132","article-title":"Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo","volume":"332","author":"Pirih","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2017.11.013_bb0300","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-291X(03)00931-8","article-title":"Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts","volume":"306","author":"Pirih","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2017.11.013_bb0305","first-page":"7617048","article-title":"NURR1 downregulation favors osteoblastic differentiation of MSCs","volume":"2017","author":"Di","year":"2017","journal-title":"Stem Cells Int."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217304325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328217304325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T06:12:19Z","timestamp":1539151939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328217304325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":61,"alternative-id":["S8756328217304325"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2017.11.013","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2017.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}