{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:05:01Z","timestamp":1787065501788,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bone.2018.01.004","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T14:22:36Z","timestamp":1515680556000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers"],"prefix":"10.1016","volume":"108","author":[{"given":"Lauriane","family":"Chambard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Ollier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Duboeuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Carlier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Brevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Szulc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Pialat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Wegrzyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Clezardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille B.","family":"Confavreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2018.01.004_bb0005","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bone.2018.01.004_bb0010","doi-asserted-by":"crossref","first-page":"iii27","DOI":"10.1093\/annonc\/mdu199","article-title":"Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Reck","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0015","first-page":"576","article-title":"Epidemiology and treatment costs of bone metastases from lung cancer: a French prospective, observational, multicenter study (GFPC 0601)","volume":"6","author":"Decroisette","year":"2011","journal-title":"J. Thorac. Oncol. Off. Publ. Int. Assoc. Stud. Lung Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0020","first-page":"580","article-title":"Mutational profiling of bone metastases from lung adenocarcinoma: results of a prospective study (POUMOS-TEC)","volume":"3","author":"Confavreux","year":"2014","journal-title":"Bone Key Rep."},{"key":"10.1016\/j.bone.2018.01.004_bb0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.lungcan.2013.03.001","article-title":"Major changes in lung cancer over the last ten years in France: the KBP-CPHG studies","volume":"81","author":"Locher","year":"2013","journal-title":"Lung Cancer Amst. Neth."},{"key":"10.1016\/j.bone.2018.01.004_bb0030","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.lungcan.2012.05.094","article-title":"Prognostic factors for non-small cell lung cancer with bone metastasis at the time of diagnosis","volume":"77","author":"Bae","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0035","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0040","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.3961","article-title":"Excess TGF-\u03b2 mediates muscle weakness associated with bone metastases in mice","volume":"21","author":"Waning","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2018.01.004_bb0045","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrc.2016.44","article-title":"Bone metastasis: the importance of the neighbourhood","volume":"16","author":"Croucher","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0050","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1200\/JCO.2005.06.091","article-title":"Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid","volume":"23","author":"Coleman","year":"2005","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ctrv.2008.05.001","article-title":"Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions","volume":"34","author":"Coleman","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bone.2018.01.004_bb0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/cncr.23529","article-title":"Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid","volume":"113","author":"Lipton","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbo.2017.09.001","article-title":"The role of biomarkers in the management of bone-homing malignancies","volume":"9","author":"D'Oronzo","year":"2017","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2018.01.004_bb0075","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1158\/0008-5472.CAN-06-3369","article-title":"Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas","volume":"67","author":"Yamabuki","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2018.01.004_bb0080","first-page":"629","article-title":"Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma, Virchows arch. Int","volume":"454","author":"Darlavoix","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.bone.2018.01.004_bb0085","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bbrc.2013.12.076","article-title":"Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation","volume":"443","author":"Chu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2018.01.004_bb0090","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1074\/jbc.R400025200","article-title":"C-reactive protein","volume":"279","author":"Black","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2018.01.004_bb0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s13244-015-0414-0","article-title":"Imaging body composition in cancer patients: visceral obesity, sarcopenia and sarcopenic obesity may impact on clinical outcome","volume":"6","author":"Yip","year":"2015","journal-title":"Insights Imaging"},{"key":"10.1016\/j.bone.2018.01.004_bb0100","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0105","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","article-title":"Epidemiology of sarcopenia among the elderly in New Mexico","volume":"147","author":"Baumgartner","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bone.2018.01.004_bb0110","series-title":"A Language and Environment for Statistical Computing","isbn-type":"print","author":"Team, R. Developement Core. R","year":"2013","ISBN":"https:\/\/id.crossref.org\/isbn\/3900051070"},{"key":"10.1016\/j.bone.2018.01.004_bb0115","author":"Therneau"},{"key":"10.1016\/j.bone.2018.01.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-416","article-title":"Inaugural bone metastases in non-small cell lung cancer: a specific prognostic entity?","volume":"14","author":"Deberne","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0125","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/cncr.24813","article-title":"Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB\/IV nonsmall cell lung cancer","volume":"116","author":"Janjigian","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcp042806","article-title":"Hypercalcemia associated with cancer","volume":"352","author":"Stewart","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2018.01.004_bb0135","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1200\/JCO.1995.13.5.1221","article-title":"Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European lung cancer working party","volume":"13","author":"Paesmans","year":"1995","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0140","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0145","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00198-010-1462-4","article-title":"Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis","volume":"22","author":"Confavreux","year":"2011","journal-title":"Osteoporos Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found USA"},{"key":"10.1016\/j.bone.2018.01.004_bb0150","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2018.01.004_bb0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: a systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.bone.2018.01.004_bb0160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1746-1596-9-52","article-title":"Serum level of DKK-1 and its prognostic potential in non-small cell lung cancer","volume":"9","author":"Dong","year":"2014","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.bone.2018.01.004_bb0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3233\/CBM-2012-00295","article-title":"Promoter methylation of Wnt antagonist DKK1 gene and prognostic value in Korean patients with non-small cell lung cancers","volume":"12","author":"Na","year":"2012","journal-title":"Cancer Biomark. Sect. Dis. Markers"},{"key":"10.1016\/j.bone.2018.01.004_bb0170","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2015.3654","article-title":"Differential expression of Dickkopf-1 among non-small cell lung cancer cells","author":"Xiang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bone.2018.01.004_bb0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2013.11.038","article-title":"Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and \u03b3-radiation sensitivity","volume":"443","author":"Kim","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2018.01.004_bb0180","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cncr.27730","article-title":"Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas","volume":"119","author":"Johnson","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0185","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.bjc.6602258","article-title":"The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis","volume":"92","author":"Mascaux","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0190","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcsm.12059","article-title":"Pathophysiology of anorexia in the cancer cachexia syndrome","volume":"6","author":"Ezeoke","year":"2015","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2018.01.004_bb0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jcsm.12156","article-title":"Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer","volume":"8","author":"Molfino","year":"2017","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2018.01.004_bb0200","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nn.4574","article-title":"Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus","volume":"20","author":"Campos","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bone.2018.01.004_bb0205","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/bjc.2013.525","article-title":"Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia","volume":"109","author":"Ihnatko","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0210","article-title":"Management of Anorexia-Cachexia in late stage lung cancer patients","volume":"14","author":"Del Ferraro","year":"2012","journal-title":"J. Hosp. Palliat. Nurs. JHPN Off. J. Hosp. Palliat. Nurses Assoc."},{"key":"10.1016\/j.bone.2018.01.004_bb0215","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1158\/1078-0432.CCR-09-1525","article-title":"Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer","volume":"15","author":"Tan","year":"2009","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.bone.2018.01.004_bb0220","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.bone.2018.01.004_bb0225","article-title":"Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer","author":"Go","year":"2015","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer."},{"key":"10.1016\/j.bone.2018.01.004_bb0230","first-page":"326","article-title":"Prognostic significance of C-reactive protein and smoking in patients with advanced non-small cell lung cancer treated with first-line palliative chemotherapy","volume":"4","author":"Koch","year":"2009","journal-title":"J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer."},{"key":"10.1016\/j.bone.2018.01.004_bb0235","first-page":"3098","article-title":"Prognostic significance of the neutrophil to lymphocyte ratio in patients with non-small cell lung cancer: a systemic review and meta-analysis","volume":"8","author":"Peng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bone.2018.01.004_bb0240","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-13-158","article-title":"Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review","volume":"13","author":"Jafri","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2018.01.004_bb0245","first-page":"87","article-title":"Cachexia index in advanced non-small-cell lung cancer patients","volume":"9","author":"Jafri","year":"2015","journal-title":"Clin. Med. Insights Oncologia"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218300048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218300048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:38:58Z","timestamp":1762659538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328218300048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":49,"alternative-id":["S8756328218300048"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2018.01.004","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2018.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}