{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:54:33Z","timestamp":1792205673795,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","thebonejournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bone.2018.02.008","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T13:52:53Z","timestamp":1519998773000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Marrow adiposity and bone: Review of clinical implications"],"prefix":"10.1016","volume":"118","author":[{"given":"Julien","family":"Paccou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Penel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cortet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Hardouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2018.02.008_bb0005","first-page":"39","article-title":"Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development","volume":"17","author":"Migliaccio","year":"2014","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.bone.2018.02.008_bb0010","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/nutrit\/nux046","article-title":"Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis","volume":"75","author":"Dolan","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bone.2018.02.008_bb0015","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.amjmed.2011.06.013","article-title":"Obesity is not protective against fracture in postmenopausal women: GLOW","volume":"124","author":"Compston","year":"2011","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bone.2018.02.008_bb0020","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jbmr.3085","article-title":"Total and visceral adiposity are associated with prevalent vertebral fracture in women but not men at age 62years: the Newcastle thousand families study","volume":"32","author":"Hind","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jbmr.2017","article-title":"A meta-analysis of the association of fracture risk and body mass index in women","volume":"29","author":"Johansson","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0030","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3945\/an.117.015545","article-title":"Abdominal obesity and risk of hip fracture: a systematic review and meta-analysis of prospective studies","volume":"8","author":"Sadeghi","year":"2017","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bone.2018.02.008_bb0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-8587(14)70007-5","article-title":"The bone\u2013fat interface: basic and clinical implications of marrow adiposity","volume":"3","author":"Devlin","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bone.2018.02.008_bb0040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.metabol.2016.11.013","article-title":"Mechanisms of marrow adiposity and its implications for skeletal health","volume":"67","author":"Veldhuis-Vlug","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.bone.2018.02.008_bb0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tem.2016.03.016","article-title":"Marrow adipose tissue: trimming the fat","volume":"27","author":"Scheller","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0050","article-title":"Quantitative MRI and spectroscopy of bone marrow","author":"Karampinos","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0055","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/jmri.22489","article-title":"Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis","volume":"33","author":"Li","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0060","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1210\/jc.2010-1922","article-title":"Bone marrow fat is inversely related to cortical bone in young and old subjects","volume":"96","author":"Wren","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0065","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00198-006-0285-9","article-title":"MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women","volume":"18","author":"Shen","year":"2007","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.02.008_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jmri.22757","article-title":"Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?","volume":"35","author":"Baum","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0075","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1210\/jc.2011-2605","article-title":"Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study","volume":"97","author":"Shen","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0080","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jbspin.2014.02.013","article-title":"Bone marrow fat","volume":"81","author":"Hardouin","year":"2014","journal-title":"J. Bone Spine."},{"key":"10.1016\/j.bone.2018.02.008_bb0085","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1210\/jc.2015-2338","article-title":"The role of bone marrow fat in skeletal health: usefulness and perspectives for clinicians","volume":"100","author":"Paccou","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0090","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s003300050547","article-title":"Magnetic resonance imaging of normal bone marrow","volume":"8","author":"Vande Berg","year":"1998","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.bone.2018.02.008_bb0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00003086-197110000-00021","article-title":"Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies","volume":"80","author":"Meunier","year":"1971","journal-title":"Clin. Orthop."},{"key":"10.1016\/j.bone.2018.02.008_bb0100","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiology.217.2.r00nv20527","article-title":"Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry","volume":"217","author":"Wehrli","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2018.02.008_bb0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/1522-2586(200102)13:2<263::AID-JMRI1038>3.0.CO;2-M","article-title":"Age- and sex-specific differences in the 1H-spectrum of vertebral bone marrow","volume":"13","author":"Kugel","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jmri.23619","article-title":"Bone marrow fat content in the elderly: a reversal of sex difference seen in younger subjects","volume":"36","author":"Griffith","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/298675","article-title":"Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat","volume":"2013","author":"Shen","year":"2013","journal-title":"J. Obes."},{"key":"10.1016\/j.bone.2018.02.008_bb0120","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1148\/radiol.2363041425","article-title":"Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy","volume":"236","author":"Griffith","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2018.02.008_bb0125","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jmri.20367","article-title":"Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study","volume":"22","author":"Yeung","year":"2005","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0130","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s00330-010-2054-6","article-title":"Prediction of bone loss in elderly female subjects by MR perfusion imaging and spectroscopy","volume":"21","author":"Griffith","year":"2011","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.bone.2018.02.008_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bone.2017.03.048","article-title":"Bone marrow perfusion measured with dynamic contrast enhanced magnetic resonance imaging is correlated to body mass index in adults","volume":"99","author":"Budzik","year":"2017","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2018.02.008_bb0140","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/jbmr.1950","article-title":"Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0145","article-title":"Measuring marrow density and area using peripheral quantitative computed tomography at the tibia: Precision in young and older adults and individuals with spinal cord injury","author":"Gibbs","year":"2017","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bone.2018.02.008_bb0150","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/ejcn.2012.35","article-title":"MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults","volume":"66","author":"Shen","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2018.02.008_bb0155","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.crad.2009.12.011","article-title":"Evaluation of MR spectroscopy and diffusion-weighted MRI in detecting bone marrow changes in postmenopausal women with osteoporosis","volume":"65","author":"Tang","year":"2010","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.bone.2018.02.008_bb0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1011513223894","article-title":"Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis","volume":"2","author":"Justesen","year":"2001","journal-title":"Biogerontology"},{"key":"10.1016\/j.bone.2018.02.008_bb0165","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/jcp.55.9.693","article-title":"Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis","volume":"55","author":"Verma","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bone.2018.02.008_bb0170","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1210\/jc.2012-3949","article-title":"Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults","volume":"98","author":"Schwartz","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/oby.2010.106","article-title":"Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women","volume":"19","author":"Bredella","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.bone.2018.02.008_bb0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bone.2017.02.001","article-title":"Osteoporotic fractures in men (MrOS) research group. Vertebral bone marrow fat, bone mineral density and diabetes: the osteoporotic fractures in men (MrOS) study","volume":"97","author":"Sheu","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0185","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1210\/jc.2012-2246","article-title":"Determinants of bone microarchitecture and mechanical properties in obese men","volume":"97","author":"Bredella","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0190","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2214\/ajr.183.6.01831761","article-title":"Bone marrow fat and bone mineral density on proton MR spectroscopy and dual-energy X-ray absorptiometry: their ratio as a new indicator of bone weakening","volume":"183","author":"Schellinger","year":"2004","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.bone.2018.02.008_bb0195","first-page":"1620","article-title":"Value of vertebral proton MR spectroscopy in determining bone weakness","volume":"22","author":"Schellinger","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.bone.2018.02.008_bb0200","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1210\/jc.2012-1477","article-title":"Increased marrow adiposity in premenopausal women with idiopathic osteoporosis","volume":"97","author":"Cohen","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0205","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1210\/jc.2012-3949","article-title":"Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults","volume":"98","author":"Schwartz","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0210","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2017.08.014","article-title":"Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS) 1H NMR spectroscopy","volume":"105","author":"Li","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0215","article-title":"Bone marrow fat contributes to insulin sensitivity and adiponectin secretion in premenopausal women","author":"Ermetici","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.bone.2018.02.008_bb0220","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bone.2016.12.018","article-title":"Marrow adipose tissue composition in adults with morbid obesity","volume":"97","author":"Yu","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.3212","article-title":"Bone marrow fat changes after gastric bypass surgery are associated with loss of bone mass","author":"Kim","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0230","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/ijo.2008.170","article-title":"Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults","volume":"32","author":"Di Iorgi","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bone.2018.02.008_bb0235","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1210\/jc.2004-1805","article-title":"Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study","volume":"90","author":"Ensrud","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0240","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2007-1473","article-title":"Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial","volume":"93","author":"Villareal","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0245","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/oby.2011.40","article-title":"Impact of intra- and extra-osseous soft tissue composition on changes in bone mineral density with weight loss and regain","volume":"19","author":"Bosy-Westphal","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.bone.2018.02.008_bb0250","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/jmri.24908","article-title":"MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women","volume":"42","author":"Cordes","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bone.2018.02.008_bb0255","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1007\/s00198-012-1919-8","article-title":"Predictive factors of change in BMD at 1 and 2 years in women with anorexia nervosa: a study of 146 cases","volume":"23","author":"Legroux-G\u00e9rot","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.02.008_bb0260","unstructured":"Legroux-G\u00e9rot I, Vignau J, Viltart O, Hardouin P, Chauveau C, Cortet B. Adipokines and bone status in a cohort of anorexic patients. Under revision for Joint Bone Spine (ref: BONSOI-D-17-00330R1)."},{"key":"10.1016\/j.bone.2018.02.008_bb0265","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/jc.2008-2532","article-title":"Increased bone marrow fat in anorexia nervosa","volume":"94","author":"Bredella","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0270","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2014.06.014","article-title":"Marrow fat composition in anorexia nervosa","volume":"66","author":"Bredella","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0275","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/jbmr.1640","article-title":"Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa","volume":"27","author":"Fazeli","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0280","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002087","article-title":"Fracture risk after bariatric surgery: a 12-year nationwide cohort study","volume":"94","author":"Lu","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.bone.2018.02.008_bb0285","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e5085","article-title":"Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study","volume":"345","author":"Lalmohamed","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.bone.2018.02.008_bb0290","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/jbmr.3101","article-title":"Fracture risk after bariatric surgery: roux-en-Y gastric bypass versus adjustable gastric banding","volume":"32","author":"Yu","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0295","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bone.2015.01.010","article-title":"Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: a pilot study","volume":"74","author":"Schafer","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0300","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bone.2016.11.014","article-title":"Effects of Roux-en-Y gastric bypass and sleeve gastrectomy on bone mineral density and marrow adipose tissue","volume":"95","author":"Bredella","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0305","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1359\/jbmr.080323","article-title":"Fracture risk in type 2 diabetes: update of a population-based study","volume":"23","author":"Melton","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0310","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1210\/jcem.86.1.7139","article-title":"Older women with diabetes have an increased risk of fracture: a prospective study","volume":"86","author":"Schwartz","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0315","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00125-014-3289-6","article-title":"Fracture risk in diabetic elderly men: the MrOS study","volume":"57","author":"Napoli","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.bone.2018.02.008_bb0320","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00198-008-0574-6","article-title":"Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women","volume":"19","author":"Syed","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.02.008_bb0325","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s00198-010-1353-8","article-title":"Effects of risedronate on bone marrow adipocytes in postmenopausal women","volume":"22","author":"Duque","year":"2011","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found Osteoporos. Natl. Osteoporos. Found USA"},{"key":"10.1016\/j.bone.2018.02.008_bb0330","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1210\/jc.2013-1172","article-title":"Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study","volume":"98","author":"Cohen","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0335","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/13697137.2015.1126576","article-title":"Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy","volume":"19","author":"Yang","year":"2016","journal-title":"Climacteric"},{"key":"10.1016\/j.bone.2018.02.008_bb0340","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1210\/jc.2012-3748","article-title":"Differential effects of exercise on tibial shaft marrow density in young female athletes","volume":"98","author":"Rantalainen","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0345","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2014.03.044","article-title":"Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise","volume":"64","author":"Styner","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0350","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1056\/NEJMoa066224","article-title":"Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy","volume":"355","author":"Kahn","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2018.02.008_bb0355","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/en.2003-0746","article-title":"Bone is a target for the antidiabetic compound rosiglitazone","volume":"145","author":"Rzonca","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2018.02.008_bb0360","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bone.2012.11.002","article-title":"Marrow adiposity recovery after early zoledronic acid treatment of glucocorticoid-induced bone loss in rabbits assessed by magnetic resonance spectroscopy","volume":"52","author":"Li","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.02.008_bb0365","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1359\/jbmr.090802","article-title":"Concentration of adipogenic and proinflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women","volume":"25","author":"Pino","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.02.008_bb0370","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cmet.2014.06.003","article-title":"Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction","volume":"20","author":"Cawthorn","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2018.02.008_bb0375","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/21623945.2016.1149269","article-title":"Inside out: bone marrow adipose tissue as a source of circulating adiponectin","volume":"5","author":"Scheller","year":"2016","journal-title":"Adipocyte."},{"key":"10.1016\/j.bone.2018.02.008_bb0380","doi-asserted-by":"crossref","first-page":"E2584","DOI":"10.1210\/jc.2013-4493","article-title":"Circulating Sclerostin associated with vertebral bone marrow fat in older men but not women","volume":"99","author":"Ma","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821830067X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632821830067X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:15:52Z","timestamp":1543234552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632821830067X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":76,"alternative-id":["S875632821830067X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2018.02.008","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Marrow adiposity and bone: Review of clinical implications","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2018.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}