{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:36:00Z","timestamp":1767922560553,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81573104"],"award-info":[{"award-number":["81573104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81773372"],"award-info":[{"award-number":["81773372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81172610"],"award-info":[{"award-number":["81172610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bone.2018.03.026","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T12:36:27Z","timestamp":1523363787000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease"],"prefix":"10.1016","volume":"120","author":[{"given":"RuiPeng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RongQiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YongMin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenYan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuanYuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoLi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiFeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoYan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunLing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2018.03.026_bb0005","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","article-title":"Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease","volume":"22","author":"Guo","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2018.03.026_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1471-2474-14-209","article-title":"The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease","volume":"14","author":"Han","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2018.03.026_bb0015","first-page":"259","article-title":"Monitoring the state of Kaschin-Beck disease: analysis of national surveillance data and prediction of future prevalence trends","volume":"26","author":"Liu","year":"2011","journal-title":"Chin. J. Ctrl. Endem. Dis."},{"key":"10.1016\/j.bone.2018.03.026_bb0020","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.324_1378","article-title":"A medical mystery in middle China","volume":"324","author":"Stone","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bone.2018.03.026_bb0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.joca.2010.02.004","article-title":"Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease","volume":"18","author":"Xiong","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2018.03.026_bb0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2011.02.040","article-title":"Medical geology of arsenic, selenium and thallium in China","volume":"421-422","author":"Li","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bone.2018.03.026_bb0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12011-012-9469-7","article-title":"T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province","volume":"150","author":"Sun","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bone.2018.03.026_bb0040","first-page":"238","article-title":"Research advance on relation between humic acid and chondrocyte injuries","volume":"36","author":"Ying","year":"2007","journal-title":"J. Hyg. Res."},{"key":"10.1016\/j.bone.2018.03.026_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-013-9686-8","article-title":"Selenium: a protective factor for Kaschin-Beck disease in Qing-Tibet Plateau","volume":"153","author":"Zhao","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bone.2018.03.026_bb0050","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10653-010-9366-y","article-title":"Environmental selenium in the Kaschin-Beck disease area, Tibetan Plateau, China","volume":"33","author":"Zhang","year":"2011","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.bone.2018.03.026_bb0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bone.2010.09.015","article-title":"Kashin-Beck disease and Sayiwak disease in China: prevalence and a comparison of the clinical manifestations, familial aggregation, and heritability","volume":"48","author":"Lu","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.03.026_bb0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2018.03.026_bb0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12263-013-0377-z","article-title":"The effects of interactions between selenium and zinc serum concentration and SEP15 and SLC30A3 gene polymorphisms on memory scores in a population of mature and elderly adults","volume":"9","author":"da Rocha","year":"2014","journal-title":"Genes Nutr."},{"key":"10.1016\/j.bone.2018.03.026_bb0070","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1158\/1940-6207.CAPR-09-0216","article-title":"A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival","volume":"3","author":"Penney","year":"2010","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.bone.2018.03.026_bb0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12263-010-0176-8","article-title":"Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer","volume":"5","author":"Sutherland","year":"2010","journal-title":"Genes Nutr."},{"key":"10.1016\/j.bone.2018.03.026_bb0080","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1158\/1055-9965.EPI-10-0364","article-title":"Effects of selenium status and polymorphisms in Selenoprotein genes on prostate cancer risk in a prospective study of European men","volume":"19","author":"Steinbrecher","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bone.2018.03.026_bb0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00394-008-0696-9","article-title":"Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism","volume":"47","author":"Jablonska","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.bone.2018.03.026_bb0090","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2011.02.042","article-title":"Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain[J]","volume":"1385","author":"Taqi","year":"2011","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.bone.2018.03.026_bb0095","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1017\/S0007114516000362","article-title":"Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis[J]","volume":"115","author":"Dai","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bone.2018.03.026_bb0100","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1038\/sj.onc.1207683","article-title":"Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype","volume":"23","author":"Apostolou","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2018.03.026_bb0105","doi-asserted-by":"crossref","first-page":"35540","DOI":"10.1074\/jbc.M004014200","article-title":"Structure-expression relationships of the 15-kDa selenoprotein gene - possible role of the protein in cancer etiology","volume":"275","author":"Kumaraswamy","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2018.03.026_bb0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1158\/1940-6207.CAPR-10-0072","article-title":"Is prostate cancer prevention with selenium all in the genes?","volume":"3","author":"Platz","year":"2010","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"1","key":"10.1016\/j.bone.2018.03.026_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yexcr.2016.04.014","article-title":"TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species [J]","volume":"344","author":"Yan","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bone.2018.03.026_bb0125","doi-asserted-by":"crossref","first-page":"33203","DOI":"10.1074\/jbc.M111.259218","article-title":"Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice","volume":"286","author":"Kasaikina","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218301455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218301455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T21:41:12Z","timestamp":1565300472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328218301455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":24,"alternative-id":["S8756328218301455"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2018.03.026","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2018.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}