{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:09:03Z","timestamp":1792382943684,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bone.2018.05.030","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T03:58:58Z","timestamp":1527652738000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"special_numbering":"C","title":["Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes"],"prefix":"10.1016","volume":"114","author":[{"given":"Lamya","family":"Karim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Moulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Van Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Velie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-0778","authenticated-orcid":false,"given":"Fatemeh","family":"Malekipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Abdeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Ayres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-7414","authenticated-orcid":false,"given":"Mary L.","family":"Bouxsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2018.05.030_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bone.2008.03.017","article-title":"Diabetes and fragility fractures - a burgeoning epidemic?","volume":"43","author":"Epstein","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0010","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00223-003-0023-7","article-title":"Diabetes mellitus: does it affect bone?","volume":"73","author":"Schwartz","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2018.05.030_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11914-007-0025-x","article-title":"Diabetes, fracture, and bone fragility","volume":"5","author":"Schwartz","year":"2007","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2018.05.030_bb0020","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1001\/jama.2011.715","article-title":"Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes","volume":"305","author":"Schwartz","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2018.05.030_bb0025","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1359\/jbmr.091004","article-title":"Obesity and fractures in postmenopausal women","volume":"25","author":"Premaor","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0030","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/ageing\/afr145","article-title":"Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam","volume":"41","author":"Pijpers","year":"2012","journal-title":"Age Ageing"},{"key":"10.1016\/j.bone.2018.05.030_bb0035","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1210\/jc.2010-0226","article-title":"High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus","volume":"95","author":"Burghardt","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.05.030_bb0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/acr.20602","article-title":"Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls","volume":"64","author":"Pritchard","year":"2012","journal-title":"Arthritis Care Res."},{"issue":"2","key":"10.1016\/j.bone.2018.05.030_bb0045","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type-2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(98)00119-5","article-title":"Mechanisms of maturation and ageing of collagen","volume":"106","author":"Bailey","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bone.2018.05.030_bb0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S8756-3282(97)00279-2","article-title":"Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance","volume":"22","author":"Knott","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2009.09.003","article-title":"Non-enzymatic glycation alters microdamage formation in human cancellous bone","volume":"46","author":"Tang","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0065","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2818.2001.00783.x","article-title":"Accumulation of in-vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone","volume":"201","author":"Zioupos","year":"2001","journal-title":"J. Microsc."},{"key":"10.1016\/j.bone.2018.05.030_bb0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S8756-3282(98)00103-3","article-title":"Influence of microdamage on fracture toughness of the human femur and tibia","volume":"23","author":"Norman","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0075","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bone.2006.12.056","article-title":"Effects of non-enzymatic glycation on cancellous bone fragility","volume":"40","author":"Tang","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S8756-3282(00)00434-8","article-title":"Influence of nonenzymatic glycation on biomechanical properties of cortical bone","volume":"28","author":"Vashishth","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0085","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/jor.20337","article-title":"Age-related factors affecting the postyield energy dissipation of human cortical bone","volume":"25","author":"Nyman","year":"2007","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035047","article-title":"Heterogeneous glycation of cancellous bone and its association with bone quality and fragility","volume":"7","author":"Karim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2018.05.030_bb0095","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/jor.21275","article-title":"Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone","volume":"29","author":"Follet","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0100","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1210\/jc.2007-1270","article-title":"Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes","volume":"93","author":"Yamamoto","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.05.030_bb0105","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/jc.2008-2498","article-title":"Pentosidine and increased fracture risk in older adults with type 2 diabetes","volume":"94","author":"Schwartz","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.05.030_bb0110","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1682\/JRRD.2010.09.0186","article-title":"Arthroplasty in veterans: analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes","volume":"48","author":"Oren","year":"2011","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.bone.2018.05.030_bb0115","doi-asserted-by":"crossref","first-page":"11654","DOI":"10.1016\/S0021-9258(18)99007-1","article-title":"Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo","volume":"266","author":"Dyer","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2018.05.030_bb0120","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.bone.2006.06.016","article-title":"Influence of bone volume fraction and architecture on computed large-deformation failure mechanisms in human trabecular bone","volume":"39","author":"Bevill","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.107.2.247","article-title":"Studies on the formation of collagen. I. Properties and fractionation of neutral salt extracts of normal guinea pig connective tissue","volume":"107","author":"Gross","year":"1958","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2018.05.030_bb0130","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00198-014-2927-7","article-title":"Defects in cortical microarchitecture among African-American women with type 2 diabetes","volume":"26","author":"Yu","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.05.030_bb0135","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0140","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/EJE-15-0860","article-title":"Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease","volume":"174","author":"Shanbhogue","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bone.2018.05.030_bb0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jbmr.3240","article-title":"Diabetes and deficits in cortical bone density, microarchitecture, and bone size: Framingham HR-pQCT study","volume":"33","author":"Samelson","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0150","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jbmr.3057","article-title":"Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: a population-based study","volume":"32","author":"Nilsson","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0155","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bone.2017.01.037","article-title":"Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity","volume":"97","author":"Osima","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0160","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00198-011-1595-0","article-title":"Bone structure and turnover in type 2 diabetes mellitus","volume":"23","author":"Shu","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.05.030_bb0165","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00198-014-2988-7","article-title":"Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures","volume":"26","author":"Heilmeier","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.05.030_bb0170","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bone.2012.12.015","article-title":"Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing","volume":"53","author":"Gallant","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0175","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1210\/en.2014-1041","article-title":"Early-onset type 2 diabetes impairs skeletal acquisition in the male TALLYHO\/JngJ mouse","volume":"155","author":"Devlin","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2018.05.030_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.3393","article-title":"Contributions of material properties and structure to increased bone fragility for a given bone mass in the UCD-T2DM rat model of type 2 diabetes","author":"Acevedo","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0185","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jbmr.2106","article-title":"In vivo assessment of bone quality in postmenopausal women with type 2 diabetes","volume":"29","author":"Farr","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2018.05.030_bb0190","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1210\/jc.2016-1437","article-title":"Advanced glycation endproducts and bone material strength in type 2 diabetes","volume":"101","author":"Furst","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2018.05.030_bb0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2015.03.021","article-title":"Comparison of cyclic and impact-based reference point indentation measurements in human cadaveric tibia bone","volume":"106","author":"Karim","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0200","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jmbbm.2017.06.036","article-title":"The inferomedial femoral neck is compromised by age but not disease: fracture toughness and the multifactorial mechanisms comprising reference point microindentation","volume":"75","author":"Jenkins","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bone.2018.05.030_bb0205","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1007\/s00198-013-2319-4","article-title":"Differences in non-enzymatic glycation and collagen cross-links between human cortical and cancellous bone","volume":"24","author":"Karim","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2018.05.030_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bone.2015.07.028","article-title":"Effect of type 2 diabetes-related non-enzymatic glycation on bone biomechanical properties","volume":"82","author":"Karim","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0215","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11914-007-0004-2","article-title":"The role of the collagen matrix in skeletal fragility","volume":"5","author":"Vashishth","year":"2007","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2018.05.030_bb0220","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1138\/20090390","article-title":"Advanced glycation end-products and bone fractures","volume":"6","author":"Vashishth","year":"2009","journal-title":"IBMS Bonekey"},{"key":"10.1016\/j.bone.2018.05.030_bb0225","first-page":"14","article-title":"A comparison of collagen crosslink content in bone specimens from elective Total hip arthroplasty patients with and without type 2 diabetes","volume":"2","author":"Pritchard","year":"2016","journal-title":"J. Bone Rep. Recomm."},{"key":"10.1016\/j.bone.2018.05.030_bb0230","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bone.2013.01.032","article-title":"Bone mineralization is elevated and less heterogeneous in adults with type 2 diabetes and osteoarthritis compared to controls with osteoarthritis alone","volume":"54","author":"Pritchard","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(01)00697-4","article-title":"Age-related changes in the collagen network and toughness of bone","volume":"31","author":"Wang","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bone.2018.05.030_bb0240","doi-asserted-by":"crossref","first-page":"956","DOI":"10.2106\/00004623-197557070-00013","article-title":"Contribution of collagen and mineral to the elastic-plastic properties of bone","volume":"57","author":"Burstein","year":"1975","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2018.05.030_bb0245","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1196\/annals.1333.082","article-title":"Advanced glycation end products and bone loss during aging","volume":"1043","author":"Odetti","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bone.2018.05.030_bb0250","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/ard.61.2.145","article-title":"Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis","volume":"61","author":"Arokoski","year":"2002","journal-title":"Ann. Rheum. Dis."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218302205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218302205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:39:35Z","timestamp":1762659575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328218302205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":50,"alternative-id":["S8756328218302205"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2018.05.030","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2018.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}