{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:34:35Z","timestamp":1777293275636,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-DE24000"],"award-info":[{"award-number":["R01-DE24000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bone.2018.10.023","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T15:11:07Z","timestamp":1540480267000},"page":"176-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis"],"prefix":"10.1016","volume":"122","author":[{"given":"Yan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-9431","authenticated-orcid":false,"given":"Xue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy C.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydnee","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretel","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita","family":"Bellido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-396X","authenticated-orcid":false,"given":"Jill A.","family":"Helms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bone.2018.10.023_bb0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/ar.22455","article-title":"Modeling the human mandible under masticatory loads: which input variables are important?","volume":"295","author":"Groning","year":"2012","journal-title":"Anat. Rec."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0010","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1469-7580.2006.00540.x","article-title":"Where tendons and ligaments meet bone: attachment sites (\u2018entheses\u2019) in relation to exercise and\/or mechanical load","volume":"208","author":"Benjamin","year":"2006","journal-title":"J. Anat."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0015","first-page":"35","article-title":"The development and morphogenesis of the tendon-to-bone insertion - what development can teach us about healing","volume":"10","author":"Thomopoulos","year":"2010","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0022034515626102","article-title":"Mechanoresponsive properties of the periodontal ligament","volume":"95","author":"Huang","year":"2016","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.bone.2018.10.023_bb0025","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jre.12477","article-title":"The intricate anatomy of the periodontal ligament and its development: lessons for periodontal regeneration","volume":"52","author":"de Jong","year":"2017","journal-title":"J. Periodontal Res."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/dev.116228","article-title":"Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone","volume":"142","author":"Takimoto","year":"2015","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.bone.2018.10.023_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.joms.2014.07.016","article-title":"Management of ankylosed maxillary canine with single-tooth osteotomy in conjunction with orthognathic surgery","volume":"72","author":"Rodrigues","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0040","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/SCS.0000000000000737","article-title":"New surgical technique and distraction osteogenesis for ankylosed dental movement","volume":"25","author":"Agabiti","year":"2014","journal-title":"J. Craniofac. Surg."},{"issue":"2","key":"10.1016\/j.bone.2018.10.023_bb0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajodo.2013.04.025","article-title":"Timely relocation of subapically impacted maxillary canines and replacement of an ankylosed mandibular molar are the keys to eruption disturbances in a prepubertal patient","volume":"145","author":"Shi","year":"2014","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0050","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ajodo.2010.06.029","article-title":"Treatment of ankylosed maxillary central incisors by segmental osteotomy with autogenous bone graft","volume":"141","author":"You","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/jcpe.12508","article-title":"Mineralized periodontia in extinct relatives of mammals shed light on the evolutionary history of mineral homeostasis in periodontal tissue maintenance","volume":"43","author":"LeBlanc","year":"2016","journal-title":"J. Clin. Periodontol."},{"issue":"5","key":"10.1016\/j.bone.2018.10.023_bb0060","doi-asserted-by":"crossref","first-page":"E478","DOI":"10.1073\/pnas.1409857112","article-title":"Osteocytes mediate the anabolic actions of canonical Wnt\/beta-catenin signaling in bone","volume":"112","author":"Tu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.bone.2018.10.023_bb0065","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1210\/en.2014-1046","article-title":"Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes","volume":"155","author":"Ben-awadh","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bone.2004.03.006","article-title":"Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene","volume":"35","author":"Kalajzic","year":"2004","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0075","first-page":"289","article-title":"Demonstration of all connective tissue elements in a single section; pentachrome stains","volume":"60","author":"Movat","year":"1955","journal-title":"A.M.A. Arch. Pathol."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0080","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2006.10.027","article-title":"Effect of mechanical stimuli on skeletal regeneration around implants","volume":"40","author":"Leucht","year":"2007","journal-title":"Bone"},{"issue":"29","key":"10.1016\/j.bone.2018.10.023_bb0085","doi-asserted-by":"crossref","first-page":"29ra30","DOI":"10.1126\/scitranslmed.3000231","article-title":"Wnt proteins promote bone regeneration","volume":"2","author":"Minear","year":"2010","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0090","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/00220345990780030401","article-title":"Attrition, eruption, and the periodontium","volume":"78","author":"Newman","year":"1999","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2018.10.023_bb0095","series-title":"Colyer's Variations and Diseases of the Teeth of Animals","year":"1990"},{"issue":"942","key":"10.1016\/j.bone.2018.10.023_bb0100","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1098\/rspb.1959.0053","article-title":"The distribution of mitoses and cells in the tissues bounded by the socket wall of the rabbit mandibular incisor","volume":"151","author":"Ness","year":"1959","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"issue":"7","key":"10.1016\/j.bone.2018.10.023_bb0105","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/ar.22712","article-title":"Relationship between cell proliferation and eruption rate in the rat incisor","volume":"296","author":"Gomes","year":"2013","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.bone.2018.10.023_bb0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/00220345420210020901","article-title":"Tooth eruption: the axial movement of continuously growing teeth","volume":"21","author":"Sicher","year":"1942","journal-title":"J. Dent. Res."},{"issue":"9","key":"10.1016\/j.bone.2018.10.023_bb0115","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2013.137","article-title":"Osteopetrosis: genetics, treatment and new insights into osteoclast function","volume":"9","author":"Sobacchi","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"issue":"11","key":"10.1016\/j.bone.2018.10.023_bb0120","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0003-9969(94)90083-3","article-title":"Dental abnormalities in the osteopetrotic rat mutation microphthalmia blanc","volume":"39","author":"Cielinski","year":"1994","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bone.2018.10.023_bb0125","doi-asserted-by":"crossref","first-page":"19971","DOI":"10.1038\/srep19971","article-title":"ClC-7 deficiency impairs tooth development and eruption","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bone.2018.10.023_bb0130","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1177\/0022034515608828","article-title":"Root and eruption defects in c-Fos mice are driven by loss of osteoclasts","volume":"94","author":"Alfaqeeh","year":"2015","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0135","first-page":"462","article-title":"The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice","volume":"7","author":"Kesterson","year":"1993","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00303077","article-title":"Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4","volume":"277","author":"Hirota","year":"1994","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ijos.2014.62","article-title":"Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis","volume":"7","author":"Zweifler","year":"2015","journal-title":"Int. J. Oral Sci."},{"issue":"10","key":"10.1016\/j.bone.2018.10.023_bb0150","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.archoralbio.2012.07.005","article-title":"Quantitative determination of matrix Gla protein (MGP) and BMP-2 during the osteogenic differentiation of human periodontal ligament cells","volume":"57","author":"Li","year":"2012","journal-title":"Arch. Oral Biol."},{"issue":"2","key":"10.1016\/j.bone.2018.10.023_bb0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1902\/jop.2006.050057","article-title":"Bone sialoprotein gene transfer to periodontal ligament cells may not be sufficient to promote mineralization in vitro or in vivo","volume":"77","author":"Hakki","year":"2006","journal-title":"J. Periodontol."},{"issue":"5477","key":"10.1016\/j.bone.2018.10.023_bb0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.289.5477.265","article-title":"Role of the mouse ank gene in control of tissue calcification and arthritis","volume":"289","author":"Ho","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bone.2018.10.023_bb0165","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.archoralbio.2009.02.011","article-title":"Structure and mechanical properties of Ank\/Ank mutant mouse dental tissues\u2013an animal model for studying periodontal regeneration","volume":"54","author":"Fong","year":"2009","journal-title":"Arch. Oral Biol."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ydbio.2009.07.015","article-title":"Wnt\/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development","volume":"334","author":"Chen","year":"2009","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ydbio.2007.10.016","article-title":"Wnt\/beta-catenin signaling directs multiple stages of tooth morphogenesis","volume":"313","author":"Liu","year":"2008","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0180","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5115\/acb.2012.45.3.193","article-title":"Col1a1-cre mediated activation of beta-catenin leads to aberrant dento-alveolar complex formation","volume":"45","author":"Kim","year":"2012","journal-title":"Anat. Cell Biol."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0185","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajodo.2014.05.027","article-title":"Downregulation of Wnt causes root resorption","volume":"146","author":"Lim","year":"2014","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0190","doi-asserted-by":"crossref","first-page":"228","DOI":"10.7150\/ijbs.5476","article-title":"Disruption of Wnt\/beta-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth","volume":"9","author":"Zhang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.bone.2018.10.023_bb0195","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1902\/jop.2014.140286","article-title":"Alveolar bone turnover and periodontal ligament width are controlled by Wnt","volume":"86","author":"Lim","year":"2015","journal-title":"J. Periodontol."},{"issue":"5","key":"10.1016\/j.bone.2018.10.023_bb0200","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/0022034514528211","article-title":"Primary cilia integrate hedgehog and Wnt signaling during tooth development","volume":"93","author":"Liu","year":"2014","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0205","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1038\/s41598-017-08607-5","article-title":"A reciprocal interaction between beta-catenin and osterix in cementogenesis","volume":"7","author":"Choi","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bone.2018.10.023_bb0210","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jre.12018","article-title":"Excessive Wnt\/beta-catenin signaling disturbs tooth-root formation","volume":"48","author":"Bae","year":"2013","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.bone.2018.10.023_bb0215","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2018.10.023_bb0220","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"5\u20136","key":"10.1016\/j.bone.2018.10.023_bb0225","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1387\/ijdb.11669371","article-title":"The developmental biology of cementum","volume":"45","author":"Diekwisch","year":"2001","journal-title":"Int. J. Dev. Biol."},{"issue":"9","key":"10.1016\/j.bone.2018.10.023_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074697","article-title":"Periodontal ligament, cementum, and alveolar bone in the oldest herbivorous tetrapods, and their evolutionary significance","volume":"8","author":"LeBlanc","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2018.10.023_bb0235","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1525-142X.2009.00327.x","article-title":"The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium","volume":"11","author":"Luan","year":"2009","journal-title":"Evol. Dev."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218304034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328218304034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:47:24Z","timestamp":1775252844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328218304034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":47,"alternative-id":["S8756328218304034"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2018.10.023","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2018.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}