{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:14:17Z","timestamp":1793294057316,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K20674"],"award-info":[{"award-number":["16K20674"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bone.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T19:14:53Z","timestamp":1549394093000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Advanced glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-8497","authenticated-orcid":false,"given":"Eijiro","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Kido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Naruishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Yumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00795-015-0099-y","article-title":"The osteocyte plays multiple roles in bone remodeling and mineral homeostasis","volume":"48","author":"Chen","year":"2015","journal-title":"Med. Mol. Morphol."},{"issue":"9","key":"10.1016\/j.bone.2019.02.001_bb0010","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00198-010-1194-5","article-title":"Osteocyte: the unrecognized side of bone tissue","volume":"21","author":"Rochefort","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.02.001_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2018.02.028","article-title":"Targeted inhibition of sclerostin for post-menopausal osteoporosis therapy: a critical assessment of the mechanism of action","volume":"826","author":"Bhattacharyya","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11154-015-9311-6","article-title":"Sclerostin and skeletal health","volume":"16","author":"Sharifi","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"10","key":"10.1016\/j.bone.2019.02.001_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025900","article-title":"Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway","volume":"6","author":"Wijenayaka","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bone.2019.02.001_bb0030","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.3437105","article-title":"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease","volume":"15","author":"Loots","year":"2005","journal-title":"Genome Res."},{"issue":"16","key":"10.1016\/j.bone.2019.02.001_bb0035","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal woman with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"19","key":"10.1016\/j.bone.2019.02.001_bb0040","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2106\/JBJS.M.01096","article-title":"A review of osteocyte function and the emerging importance of sclerostin","volume":"96","author":"Compton","year":"2014","journal-title":"J. Bone Joint Surg. Am."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/jc.2011-2186","article-title":"Circulating levels of sclerostin are increased in patients with type 2 diabetes mellitus","volume":"97","author":"Garcia-Martin","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0050","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/jc.2016-2371","article-title":"High sclerostin and dickkop-1 (Dkk1) serum levels in children adolescents with type 1 diabetes mellitus","volume":"102","author":"Faienza","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.bone.2019.02.001_bb0055","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1210\/jc.2013-2143","article-title":"Elevated sclerostin levels are associated with vertebral fractures in patients with type 2 diabetes mellitus","volume":"98","author":"Yamamoto","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2019.02.001_bb0060","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/503754","article-title":"Periodontal disease: linking the primary inflammation to bone loss","volume":"2013","author":"Di Benedetto","year":"2013","journal-title":"Clin. Dev. Immunol."},{"issue":"10","key":"10.1016\/j.bone.2019.02.001_bb0065","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00011-009-0041-7","article-title":"Epigenetics and periodontal disease: future perspectives","volume":"58","author":"Gomez","year":"2009","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bone.2019.02.001_bb0070","first-page":"587279","article-title":"Mixed red-complex bacterial infection in periodontitis","volume":"2103","author":"Suzuki","year":"2013","journal-title":"Int. J. Dent. Clin."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0757.2009.00333.x","article-title":"Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis","volume":"54","author":"Jain","year":"2010","journal-title":"Periodontol. 2000"},{"issue":"6","key":"10.1016\/j.bone.2019.02.001_bb0080","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1128\/IAI.67.6.2841-2846.1999","article-title":"Inhibition of osteoblastic cell differentiation by lipopolysaccharide extract from Porphyromonas gingivalis","volume":"67","author":"Kadono","year":"1999","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.bone.2019.02.001_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0722.2008.00535.x","article-title":"Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: consequences for bone repair during periodontal disease","volume":"116","author":"Roberts","year":"2008","journal-title":"Eur. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2012.02579.x","article-title":"Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen","volume":"333","author":"Bostanci","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"issue":"9499","key":"10.1016\/j.bone.2019.02.001_bb0095","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal disease","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0100","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal disease. The sixth complication of diabetes mellitus","volume":"16","author":"L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2019.02.001_bb0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0757.2006.00193.x","article-title":"Diabetes mellitus and periodontal disease","volume":"44","author":"Mealey","year":"2007","journal-title":"Periodontol. 2000"},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0110","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1210\/jc.2007-1817","article-title":"The role of advanced glycation end products in progression and complications of diabetes","volume":"93","author":"Goh","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jphs.2017.07.005","article-title":"The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets","volume":"134","author":"Morioka","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bone.2019.02.001_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13098-017-0278-1","article-title":"The impact of type 2 diabetes on bone metabolism","volume":"9","author":"Sanches","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"issue":"6","key":"10.1016\/j.bone.2019.02.001_bb0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11914-016-0332-1","article-title":"Advanced glycation end products, diabetes, and bone strength","volume":"14","author":"Yamamoto","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.bone.2019.02.001_bb0130","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jre.12007","article-title":"Gingival advanced glycation end-products in diabetes mellitus-associated chronic periodontitis: an immunohistochemical study","volume":"48","author":"Zizzi","year":"2013","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/prd.12089","article-title":"Local inflammatory reactions in patients with diabetes and periodontitis","volume":"69","author":"Sonneschein","year":"2015","journal-title":"Periodontol. 2000"},{"issue":"12","key":"10.1016\/j.bone.2019.02.001_bb0140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1055\/s-2007-991157","article-title":"The combination of high glucose and advanced glycation end-products (AGEs) inhibits the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced increase in the receptor for AGEs","volume":"39","author":"Ogawa","year":"2007","journal-title":"Horm. Metab. Res."},{"issue":"3","key":"10.1016\/j.bone.2019.02.001_bb0145","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jre.12310","article-title":"Inhibitory effects of advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide on the expression of osteoblastic markers of rat bone marrow cells in culture","volume":"51","author":"Sakamoto","year":"2016","journal-title":"J. Periodontal Res."},{"issue":"6","key":"10.1016\/j.bone.2019.02.001_bb0150","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jcpe.12245","article-title":"Involvement of the Wnt-\u03b2-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis","volume":"41","author":"Napimoga","year":"2014","journal-title":"J. Clin. Periodontol."},{"issue":"12","key":"10.1016\/j.bone.2019.02.001_bb0155","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1902\/jop.2015.150270","article-title":"Gingival crevicular fluid levels of sclerostin, osteoprotegerin, and receptor activator of nuclear factor-\u03baB ligand in periodontitis","volume":"86","author":"Balli","year":"2015","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0160","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00223-012-9641-2","article-title":"Advanced glycation end products (AGEs), but not high glucose, inhibit the osteoblastic differentiation of mouse stromal ST2 cells through the suppression of osterix expression, and inhibit cell growth and increasing cell apoptosis","volume":"91","author":"Okazaki","year":"2012","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0021-9258(18)71242-8","article-title":"The quantitative histochemistry of brain. II Enzyme measurements","volume":"207","author":"Lowry","year":"1954","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0170","first-page":"49","article-title":"Negative effects of chronic inflammatory periodontal disease on diabetes mellitus","volume":"2","author":"Nishimura","year":"2000","journal-title":"J. Int. Acad. Periodontol."},{"issue":"6","key":"10.1016\/j.bone.2019.02.001_bb0175","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/154405910408300610","article-title":"The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study","volume":"83","author":"Saito","year":"2004","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jdiacomp.2005.05.006","article-title":"Periodontal status of diabetics compared with nondiabetics: a meta-analysis","volume":"20","author":"Khader","year":"2006","journal-title":"J. Diabetes Complicat."},{"issue":"7","key":"10.1016\/j.bone.2019.02.001_bb0185","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1902\/jop.2009.080669","article-title":"Advanced glycation end products inhibit the expression of collagen type I and III by human gingival fibroblasts","volume":"80","author":"Ren","year":"2009","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0190","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1902\/jop.2011.100754","article-title":"Matrix metalloproteinase-1 of gingival fibroblasts influenced by advanced glycation end products (AGEs) and their association with receptor for AGEs and nuclear factor-\u03baB in gingival connective tissue","volume":"83","author":"Yu","year":"2012","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0195","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbrc.2015.02.091","article-title":"Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells","volume":"461","author":"Tanaka","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0200","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00223-017-0243-x","article-title":"Advanced glycation end product 3 (AGE3) increase apoptosis and the expression of sclerostin by stimulating TGF-\u03b2 expression and secretion in osteocyte-like MLO-Y4-A2 cells","volume":"100","author":"Notsu","year":"2017","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.bone.2019.02.001_bb0205","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1902\/jop.2015.150083","article-title":"Osteocytic sclerostin expression in alveolar bone in rats with diabetes mellitus and ligature-induced periodontitis","volume":"86","author":"Kim","year":"2015","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bone.2019.02.001_bb0210","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.intimp.2017.09.004","article-title":"Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1\/2, P38 and STAT3 signaling pathways","volume":"52","author":"Chen","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.bone.2019.02.001_bb0215","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jre.12518","article-title":"Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts","volume":"53","author":"Nonaka","year":"2018","journal-title":"J. Periodontal Res."},{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0220","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.archoralbio.2013.11.008","article-title":"Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells","volume":"59","author":"Kato","year":"2014","journal-title":"Arch. Oral Biol."},{"issue":"5","key":"10.1016\/j.bone.2019.02.001_bb0225","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1600-0765.2010.01286.x","article-title":"Expression of periodontal interleukin-6 protein is increased across patients with neither periodontal disease nor diabetes, patients with periodontal disease alone and patients with both disease","volume":"45","author":"Ross","year":"2010","journal-title":"J. Periodontal Res."},{"issue":"5","key":"10.1016\/j.bone.2019.02.001_bb0230","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.1002253","article-title":"Septic shock is associated with receptor for advanced glycation end products ligation of LPS","volume":"186","author":"Yamamoto","year":"2011","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bone.2019.02.001_bb0235","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.atherosclerosis.2010.07.011","article-title":"Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells","volume":"212","author":"Pollreisz","year":"2010","journal-title":"Atherosclerosis"},{"issue":"33","key":"10.1016\/j.bone.2019.02.001_bb0240","doi-asserted-by":"crossref","first-page":"20147","DOI":"10.1074\/jbc.M115.655787","article-title":"Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (Receptor Activator of NF-\u03baB Ligand) through activation of toll-like receptor 2 in osteoblasts","volume":"290","author":"Kassem","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.bone.2019.02.001_bb0245","doi-asserted-by":"crossref","first-page":"24159","DOI":"10.1074\/jbc.M110.198085","article-title":"TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappa B","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2019.02.001_bb0250","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cellimm.2011.06.014","article-title":"Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity","volume":"271","author":"Lei","year":"2011","journal-title":"Cell. Immunol."},{"issue":"8","key":"10.1016\/j.bone.2019.02.001_bb0255","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1359\/jbmr.090305","article-title":"Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNF alpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts","volume":"24","author":"Vincent","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"47","key":"10.1016\/j.bone.2019.02.001_bb0260","doi-asserted-by":"crossref","first-page":"28189","DOI":"10.1074\/jbc.M115.669499","volume":"290","author":"Meng","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0265","first-page":"650","article-title":"Advanced glycation end products affect growth and function of osteoblasts","volume":"29","author":"Franke","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bone.2019.02.001_bb0270","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gene.2004.06.044","article-title":"Wnt signaling in osteoblasts and bone disease","volume":"341","author":"Westendorf","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.bone.2019.02.001_bb0275","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes and osteoclasts","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res."},{"issue":"Pt A","key":"10.1016\/j.bone.2019.02.001_bb0280","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biocel.2016.05.015","article-title":"The role of the Wnt\/\u03b2-catenin signaling pathway in formation and maintenance of bone and teeth","volume":"77","author":"Duan","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.bone.2019.02.001_bb0285","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.1803","article-title":"Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus","volume":"28","author":"Hamann","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"23","key":"10.1016\/j.bone.2019.02.001_bb0290","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.bone.2019.02.001_bb0295","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1002\/art.37697","article-title":"Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model","volume":"64","author":"Liu","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.bone.2019.02.001_bb0300","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20031454","article-title":"Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist","volume":"199","author":"van Bezooijen","year":"2004","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bone.2019.02.001_bb0305","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/jb\/mvv124","article-title":"Regulation of bone metabolism by Wnt signals","volume":"159","author":"Kobayashi","year":"2016","journal-title":"J. Biochem."},{"issue":"11","key":"10.1016\/j.bone.2019.02.001_bb0310","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1002\/jcb.26011","article-title":"Wnt\/b-catenin signaling activates expression of the bone-related transcription factor RUNX2 in select human osteocarcome cell types","volume":"118","author":"Vega","year":"2017","journal-title":"J. Cell. Biochem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219300419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219300419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T12:27:13Z","timestamp":1662899233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328219300419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":62,"alternative-id":["S8756328219300419"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2019.02.001","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}