{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:50:41Z","timestamp":1786985441520,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"am","delay-in-days":282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32DK108554"],"award-info":[{"award-number":["F32DK108554"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.bone.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T02:35:28Z","timestamp":1556850928000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u03bcCT in a rat model of CKD"],"prefix":"10.1016","volume":"125","author":[{"given":"Erin M.B.","family":"McNerny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy T.","family":"Buening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad W.","family":"Aref","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-9004","authenticated-orcid":false,"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2019.05.002_bb0005","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00198-012-2133-4","article-title":"Alterations of bone microstructure and strength in end-stage renal failure","volume":"24","author":"Trombetti","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0010","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.2009121208","article-title":"Bone mass and microarchitecture in CKD patients with fracture","volume":"21","author":"Nickolas","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2019.05.002_bb0015","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","volume":"28","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1525-139X.2012.01096.x","article-title":"Determination of bone architecture and strength in men and women with stage 5 chronic kidney disease","volume":"25","author":"West","year":"2012","journal-title":"Semin. Dial."},{"key":"10.1016\/j.bone.2019.05.002_bb0025","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jbmr.2167","article-title":"Cortical porosity identifies women with osteopenia at increased risk for forearm fractures","volume":"29","author":"Bala","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0035","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/jbmr.1934","article-title":"Fracture risk and height: an association partly accounted for by cortical porosity of relatively thinner cortices","volume":"28","author":"Bj\u00f8rnerem","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0040","doi-asserted-by":"crossref","first-page":"ii27","DOI":"10.1093\/ageing\/afl081","article-title":"The role of cortical bone and its microstructure in bone strength","volume":"35","author":"Augat","year":"2006","journal-title":"Age Ageing"},{"key":"10.1016\/j.bone.2019.05.002_bb0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s40620-017-0424-8","volume":"30","year":"2017","journal-title":"J. Nephrol."},{"key":"10.1016\/j.bone.2019.05.002_bb0050","doi-asserted-by":"crossref","unstructured":"Bacchetta J, Boutroy S, Juillard L et al. Bone imaging and chronic kidney disease: will high-resolution peripheral tomography improve bone evaluation and therapeutic management? J. Ren. Nutr. [Internet] 2009; 19: 44\u201349. Available from: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051227608004561.","DOI":"10.1053\/j.jrn.2008.10.023"},{"key":"10.1016\/j.bone.2019.05.002_bb0055","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1053\/j.ajkd.2013.12.016","volume":"63","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bone.2019.05.002_bb0060","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/01.mnh.0000447014.36475.58","volume":"23","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bone.2019.05.002_bb0065","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00198-011-1781-0","article-title":"Fracture risk assessment in patients with chronic kidney disease","volume":"23","author":"Jamal","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0070","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.2215\/CJN.09711010","article-title":"Bone microarchitecture in hemodialysis patients assessed by HR-pQCT","volume":"6","author":"Cejka","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2019.05.002_bb0075","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11914-015-0262-3","article-title":"Bone imaging and fracture risk assessment in kidney disease","volume":"13","author":"Jamal","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2019.05.002_bb0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11914-013-0140-9","article-title":"High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group","volume":"11","author":"Cheung","year":"2013","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2019.05.002_bb0085","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0036-1592430","article-title":"Radiation exposure in bone densitometry","volume":"20","author":"Solomou","year":"2016","journal-title":"Semin. Musculoskelet. Radiol."},{"key":"10.1016\/j.bone.2019.05.002_bb0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11914-013-0142-7","article-title":"Clinical imaging of bone microarchitecture with HR-pQCT","volume":"11","author":"Nishiyama","year":"2013","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2019.05.002_bb0095","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bone.2010.10.007","article-title":"In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging","volume":"48","author":"Schulte","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.05.002_bb0100","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/bonekey.2014.59","article-title":"Quantitative analysis of bone and soft tissue by micro-computed tomography: applications to ex vivo and in vivo studies","volume":"3","author":"Campbell","year":"2014","journal-title":"BoneKEy reports"},{"key":"10.1016\/j.bone.2019.05.002_bb0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ymeth.2009.08.007","article-title":"Application of micro-CT in small animal imaging","volume":"50","author":"Schambach","year":"2010","journal-title":"Methods"},{"key":"10.1016\/j.bone.2019.05.002_bb0110","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0167-7799(02)02004-8","article-title":"Micro-CT in small animal and specimen imaging","volume":"20","author":"Holdsworth","year":"2002","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bone.2019.05.002_bb0115","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0120","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bone.2006.04.017","article-title":"Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography","volume":"39","author":"Boyd","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.05.002_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bone.2003.08.012","article-title":"Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data","volume":"34","author":"Waarsing","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.05.002_bb0130","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1359\/jbmr.2003.18.9.1622","article-title":"Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography","volume":"18","author":"David","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0135","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00198-009-0882-5","article-title":"Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT","volume":"20","author":"Brouwers","year":"2009","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0140","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/jbmr.2089","article-title":"A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD","volume":"29","author":"Moe","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jbmr.2372","article-title":"Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy","volume":"30","author":"Moe","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ki.2015.315","article-title":"Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease","volume":"89","author":"Newman","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0155","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1093\/ndt\/gfp078","article-title":"R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)","volume":"24","author":"Moe","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2019.05.002_bb0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bone.2010.04.600","article-title":"Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure","volume":"47","author":"Nikolov","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.05.002_bb0165","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.kint.2016.06.019","article-title":"Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease","volume":"90","author":"Cejka","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0170","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2369-15-69","article-title":"Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5\/6 nephrectomy and adenine models","volume":"15","author":"Ferrari","year":"2014","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bone.2019.05.002_bb0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2485\/jhtb.20.79","article-title":"Assessment of trabecular bone architecture and intrinsic properties of cortical bone tissue in a mouse model of chronic kidney disease","volume":"20","author":"Kadokawa","year":"2011","journal-title":"J. Hard Tissue Biol."},{"key":"10.1016\/j.bone.2019.05.002_bb0180","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder","volume":"75","author":"Moe","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0185","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/jbmr.485","article-title":"The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat","volume":"26","author":"Moe","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.05.002_bb0190","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.bone.2019.05.002_bb0195","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTestPackage: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.bone.2019.05.002_bb0200","author":"Lenth"},{"key":"10.1016\/j.bone.2019.05.002_bb0205","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00198-014-2978-9","article-title":"Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease","volume":"26","author":"Allen","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.05.002_bb0210","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00198-012-2103-x","article-title":"Skeletal effects of zoledronic acid in an animal model of chronic kidney disease","volume":"24","author":"Allen","year":"2013","journal-title":"Osteoporos. Int."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219301668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219301668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:12:51Z","timestamp":1778940771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328219301668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":42,"alternative-id":["S8756328219301668"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2019.05.002","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u03bcCT in a rat model of CKD","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}