{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:29:51Z","timestamp":1785716991882,"version":"3.56.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["R01 AR050211"],"award-info":[{"award-number":["R01 AR050211"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["P30 AR057235"],"award-info":[{"award-number":["P30 AR057235"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["P30 AR074992"],"award-info":[{"award-number":["P30 AR074992"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"NIBIB","doi-asserted-by":"publisher","award":["T32 EB018266"],"award-info":[{"award-number":["T32 EB018266"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"NCRR","doi-asserted-by":"publisher","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.bone.2019.07.022","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T15:56:30Z","timestamp":1564415790000},"page":"577-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice"],"prefix":"10.1016","volume":"127","author":[{"given":"Brandon A.","family":"Coates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan G.","family":"Buettmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Gontarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2019.07.022_bb0005","unstructured":"W.-C. Pollak, Andrew N. Sylvia I., Fracture trends, in: United States Bone and Joint Initiative: The Burden of Musculoskeletal Diseases in the United States (BMUS), Third edition, 2014, Rosemont, IL, n.d. http:\/\/www.boneandjointburden.org\/ (accessed November 13, 2018)."},{"key":"10.1016\/j.bone.2019.07.022_bb0010","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2016.2775","article-title":"Epidemiology of fracture nonunion in 18 human bones","volume":"151","author":"Zura","year":"2016","journal-title":"JAMA Surg."},{"key":"10.1016\/j.bone.2019.07.022_bb0015","doi-asserted-by":"crossref","unstructured":"M.S. Gaston, A.H.R.W. Simpson, Inhibition of fracture healing, J. Bone Joint Surg.. British Volume. 89-B (2007) 1553\u20131560. doi:https:\/\/doi.org\/10.1302\/0301-620X.89B12.19671.","DOI":"10.1302\/0301-620X.89B12.19671"},{"key":"10.1016\/j.bone.2019.07.022_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.csm.2005.08.010","article-title":"The pathophysiology of stress fractures","volume":"25","author":"Pepper","year":"2006","journal-title":"Clin. Sports Med."},{"key":"10.1016\/j.bone.2019.07.022_bb0025","unstructured":"S.J. Warden, D.B. Burr, P.D. Brukner, Stress Fractures: Pathophysiology, Epidemiology, and Risk Factors, (n.d.) 7."},{"key":"10.1016\/j.bone.2019.07.022_bb0030","series-title":"Musculoskeletal Fatigue and Stress Fractures","first-page":"161","article-title":"Bone fatigue and remodeling in the devlopment of stress fractures","author":"Schaffler","year":"2000"},{"key":"10.1016\/j.bone.2019.07.022_bb0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0278-5919(05)70016-8","article-title":"Epidemiology and site specificity of stress fractures","volume":"16","author":"Bennell","year":"1997","journal-title":"Clin. Sports Med."},{"key":"10.1016\/j.bone.2019.07.022_bb0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jor.1100020115","article-title":"Production of a standard closed fracture in laboratory animal bone","volume":"2","author":"Bonnarens","year":"1984","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0045","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0736-0266(02)00017-7","article-title":"A model for intramembranous ossification during fracture healing","volume":"20","author":"Thompson","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0050","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jcb.10435","article-title":"Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation","volume":"88","author":"Gerstenfeld","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2019.07.022_bb0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"Marsell","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.bone.2019.07.022_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jor.23652","article-title":"Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferation: fracture healing in aged mice","author":"Hebb","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0065","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.3892\/mmr.2017.7198","article-title":"Time-series expression profile analysis of fracture healing in young and old mice","volume":"16","author":"Yuan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bone.2019.07.022_bb0070","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/jbmr.486","article-title":"The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation","volume":"26","author":"Grimes","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0075","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bone.2005.09.015","article-title":"Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair","volume":"38","author":"Rundle","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.injury.2011.10.031","article-title":"Differential gene expression analysis in fracture callus of patients with regular and failed bone healing","volume":"43","author":"Zimmermann","year":"2012","journal-title":"Injury"},{"key":"10.1016\/j.bone.2019.07.022_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bone.2018.04.017","article-title":"Healing of fractures in osteoporotic bones in mice treated with bisphosphonates - a transcriptome analysis","volume":"112","author":"Hauser","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029328","article-title":"Differential gene expression from microarray analysis distinguishes woven and lamellar bone formation in the rat ulna following mechanical loading","volume":"6","author":"McKenzie","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2019.07.022_bb0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s001980050222","article-title":"Age- and gender-specific rate of fractures in Australia: a population-based study","volume":"10","author":"Sanders","year":"1999","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2019.07.022_bb0100","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2019.07.022_bb0105","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bone.2015.09.003","article-title":"Bmp2 conditional knockout in osteoblasts and endothelial cells does not impair bone formation after injury or mechanical loading in adult mice","volume":"81","author":"McBride-Gagyi","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0110","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.bone.2010.02.030","article-title":"Healing of non-displaced fractures produced by fatigue loading of the mouse ulna","volume":"46","author":"Martinez","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bone.2017.07.017","article-title":"Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice","volume":"103","author":"Liu","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0120","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bone.2019.07.022_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0620-6","article-title":"Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy","volume":"16","author":"Angelova","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.bone.2019.07.022_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003150","article-title":"Systems genetic analysis of osteoblast-lineage cells","volume":"8","author":"Calabrese","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2019.07.022_bb0140","first-page":"85","article-title":"Gene expression in osteoblastic cells","volume":"1","author":"Rodan","year":"1991","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.bone.2019.07.022_bb0145","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1172\/JCI45913","article-title":"OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice","volume":"121","author":"Barrow","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2019.07.022_bb0150","doi-asserted-by":"crossref","first-page":"14637","DOI":"10.1074\/jbc.M807598200","article-title":"Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis","volume":"284","author":"Irie","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2019.07.022_bb0155","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.joen.2006.02.003","article-title":"Quantitative analysis of osteoclast-specific gene markers stimulated by lipopolysaccharide","volume":"32","author":"Jiang","year":"2006","journal-title":"J. Endod."},{"key":"10.1016\/j.bone.2019.07.022_bb0160","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jcp.21331","article-title":"Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation","volume":"215","author":"Yang","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2019.07.022_bb0165","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1359\/jbmr.2003.18.4.599","article-title":"Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics","volume":"18","author":"Zaidi","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024887","article-title":"Analysis of VEGF-a regulated gene expression in endothelial cells to identify genes linked to angiogenesis","volume":"6","author":"Rivera","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2019.07.022_bb0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36187","article-title":"Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells","volume":"7","author":"Sabbagh","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.bone.2019.07.022_bb0180","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2010.04.006","article-title":"Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation","volume":"462","author":"Dehne","year":"2010","journal-title":"Gene"},{"key":"10.1016\/j.bone.2019.07.022_bb0185","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1159\/000438550","article-title":"Characterization of chondrogenic gene expression and cartilage phenotype differentiation in human breast adipose-derived stem cells promoted by ginsenoside Rg1 in vitro","volume":"37","author":"Xu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bone.2019.07.022_bb0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ydbio.2007.03.518","article-title":"Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton","volume":"306","author":"Yu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2019.07.022_bb0195","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/jbmr.2451","article-title":"Disruption of Scube2 impairs endochondral bone formation","volume":"30","author":"Lin","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0200","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bone.2017.07.018","article-title":"Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice","volume":"103","author":"Withers","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0205","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bone.2009.06.010","article-title":"Identification of differentially expressed genes between osteoblasts and osteocytes","volume":"45","author":"Paic","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0210","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jbmr.509","article-title":"Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes","volume":"26","author":"Bond","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0215","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0022034516678203","article-title":"The role of Pannexin 3 in bone biology","volume":"96","author":"Ishikawa","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0220","series-title":"Overexpression of C1q\/Tumor Necrosis Factor\u2013related Protein-3 Promotes Phosphate-induced Vascular Smooth Muscle Cell Calcification Both In Vivo and In Vitro, Arteriosclerosis, Thrombosis, and Vascular Biology","first-page":"1002","volume":"34","author":"Zhou","year":"2014"},{"key":"10.1016\/j.bone.2019.07.022_bb0225","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/1471-2164-8-458","article-title":"Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis","volume":"8","author":"Coussens","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bone.2019.07.022_bb0230","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bone.2008.09.010","article-title":"Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair","volume":"44","author":"Wohl","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0235","doi-asserted-by":"crossref","first-page":"19465","DOI":"10.1074\/jbc.274.27.19465","article-title":"Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling","volume":"274","author":"Fedi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2019.07.022_bb0240","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2019.07.022_bb0245","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bone.2010.09.026","article-title":"CXC receptor knockout mice: characterization of skeletal features and membranous bone healing in the adult mouse","volume":"48","author":"Bischoff","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0250","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bone.2019.07.022_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.68.1.1","article-title":"CXC chemokines in angiogenesis","volume":"68","author":"Belperio","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bone.2019.07.022_bb0260","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jor.21367","article-title":"Effects of Interleukin-6 ablation on fracture healing in mice","volume":"29","author":"Wallace","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0265","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bone.2007.07.022","article-title":"Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice","volume":"41","author":"Yang","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0270","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1359\/jbmr.2002.17.6.963","article-title":"Cyclo-oxygenase 2 function is essential for bone fracture healing","volume":"17","author":"Simon","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0275","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0736-0266(03)00003-2","article-title":"Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs","volume":"21","author":"Gerstenfeld","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0280","doi-asserted-by":"crossref","first-page":"49011","DOI":"10.1074\/jbc.M207804200","article-title":"Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice","volume":"277","author":"Takeuchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2019.07.022_bb0285","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/jid.2013.164","article-title":"Local arginase 1 activity is required for cutaneous wound healing","volume":"133","author":"Campbell","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bone.2019.07.022_bb0290","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1359\/jbmr.2001.16.6.1004","article-title":"Expression of osteoprotegerin, receptor activator of NF-\u03baB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing","volume":"16","author":"Kon","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0295","first-page":"416","article-title":"Interleukin-1 and bone metabolism: a review","volume":"64","author":"Tatakis","year":"1993","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bone.2019.07.022_bb0300","article-title":"Alteration of blood clot structures by interleukin-1 beta in association with bone defects healing","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2019.07.022_bb0305","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.4049\/jimmunol.166.12.7128","article-title":"An essential role of the NF-B\/toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells","volume":"166","author":"Li","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.bone.2019.07.022_bb0310","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.immuni.2011.02.016","article-title":"Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands","volume":"34","author":"Shi","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.bone.2019.07.022_bb0315","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jor.22203","article-title":"Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna","volume":"31","author":"Kidd","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0320","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1172\/JCI0215681","article-title":"Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair","volume":"109","author":"Zhang","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bone.2019.07.022_bb0325","doi-asserted-by":"crossref","first-page":"152","DOI":"10.22203\/eCM.v032a10","article-title":"The crucial role of neutrophil granulocytes in bone fracture healing","volume":"32","author":"Kovtun","year":"2016","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2019.07.022_bb0330","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bone.2015.10.019","article-title":"Macrophages in bone fracture healing: their essential role in endochondral ossification","volume":"106","author":"Schlundt","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0335","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bone.2016.09.018","article-title":"Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade","volume":"93","author":"Levy","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0340","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s12026-016-8868-9","article-title":"Immunological characterization of the early human fracture hematoma","volume":"64","author":"Hoff","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10928","article-title":"IL-17-producing \u03b3\u03b4 T cells enhance bone regeneration","volume":"7","author":"Ono","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2019.07.022_bb0350","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jbmr.185","article-title":"Fracture healing is accelerated in the absence of the adaptive immune system","volume":"26","author":"Toben","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0355","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bone.2016.02.007","article-title":"Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression","volume":"86","author":"Kelly","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0360","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000491742","article-title":"IL-8 enhances therapeutic effects of BMSCs on bone regeneration via CXCR2-mediated PI3k\/Akt signaling pathway","volume":"48","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bone.2019.07.022_bb0365","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2012.00088","article-title":"A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?","volume":"3","author":"McGonnell","year":"2012","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2019.07.022_bb0370","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s12013-014-0378-6","article-title":"AKT pathway affects bone regeneration in nonunion treated with umbilical cord-derived mesenchymal stem cells","volume":"71","author":"Qu","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bone.2019.07.022_bb0375","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bone.2016.11.020","article-title":"Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation","volume":"95","author":"Scanlon","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2019.07.022_bb0380","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1113\/jphysiol.2014.271940","article-title":"Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration: bioelectric networks as epi-genetic controls of growth and form","volume":"592","author":"Levin","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.bone.2019.07.022_bb0385","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mod.2017.06.001","article-title":"Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration","volume":"146","author":"Franklin","year":"2017","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bone.2019.07.022_bb0390","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1359\/jbmr.0301213","article-title":"Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease","volume":"19","author":"Valverde","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2019.07.022_bb0395","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.13474","article-title":"The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts","volume":"57","author":"Petty","year":"2016","journal-title":"Epilepsia."},{"key":"10.1016\/j.bone.2019.07.022_bb0400","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10006-010-0237-6","article-title":"Adverse effects of the amlodipine on bone healing of the mandibular fracture: an experimental study in rats","volume":"15","author":"Moraes","year":"2011","journal-title":"Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2019.07.022_bb0405","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.2147\/DDDT.S80778","article-title":"The effects of amlodipine and platelet rich plasma on bone healing in rats","author":"Atalay","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bone.2019.07.022_bb0410","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jns5.12071","article-title":"Painful neuropathies: the emerging role of sodium channelopathies","volume":"19","author":"Brouwer","year":"2014","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.bone.2019.07.022_bb0415","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4161\/chan.4.6.12869","article-title":"Calcium channel functions in pain processing","volume":"4","author":"Park","year":"2010","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.bone.2019.07.022_bb0420","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tins.2013.12.002","article-title":"Opening paths to novel analgesics: the role of potassium channels in chronic pain","volume":"37","author":"Tsantoulas","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bone.2019.07.022_bb0425","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2013.11.011","article-title":"Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input","volume":"251","author":"Tsantoulas","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bone.2019.07.022_bb0430","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1523\/JNEUROSCI.0604-07.2007","article-title":"Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity","volume":"27","author":"Chien","year":"2007","journal-title":"J. Neurosci."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219302960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219302960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T17:06:21Z","timestamp":1695056781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328219302960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":86,"alternative-id":["S8756328219302960"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2019.07.022","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2019.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}