{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:08:55Z","timestamp":1778944135115,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004206","name":"Osaka University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002714","name":"Albert-Ludwigs-Universit\u00e4t Freiburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2372\/1"],"award-info":[{"award-number":["FOR2372\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["OR218"],"award-info":[{"award-number":["OR218"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2372\/6"],"award-info":[{"award-number":["FOR2372\/6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.bone.2019.07.031","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T02:39:58Z","timestamp":1564540798000},"page":"592-601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva"],"prefix":"10.1016","volume":"127","author":[{"given":"Julia K.","family":"Ebner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele M.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evi","family":"Kostenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Siegert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-0436","authenticated-orcid":false,"given":"Klaus","family":"Aktories","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim H.C.","family":"Orth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bone.2019.07.031_bb0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bone.2019.07.031_bb0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.berh.2007.11.007","article-title":"Fibrodysplasia ossificans progressiva","volume":"22","author":"Kaplan","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.bone.2019.07.031_bb0015","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1242\/dmm.010280","article-title":"Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis","volume":"5","author":"Kaplan","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bone.2019.07.031_bb0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1385\/BMM:3:3-4:213","article-title":"Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva","volume":"3","author":"Kaplan","year":"2005","journal-title":"Clinical Reviews in Bone and Mineral Metabolism"},{"issue":"303","key":"10.1016\/j.bone.2019.07.031_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"50","key":"10.1016\/j.bone.2019.07.031_bb0030","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1073\/pnas.1510540112","article-title":"Neofunction of ACVR1 in fibrodysplasia ossificans progressiva","volume":"112","author":"Hino","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2019.07.031_bb0035","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bone.2010.10.164","article-title":"A novel ACVR1 mutation in the glycine\/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date","volume":"48","author":"Gregson","year":"2011","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2019.07.031_bb0040","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/humu.20868","article-title":"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1","volume":"30","author":"Kaplan","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bone.2019.07.031_bb0045","first-page":"1","article-title":"Pasteurella multocida: diseases and pathogenesis","volume":"361","author":"Wilkie","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"11","key":"10.1016\/j.bone.2019.07.031_bb0050","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2460\/ajvr.1988.49.11.1844","article-title":"Induction of nasal turbinate atrophy in germ-free pigs, using Pasteurella multocida as well as bacterium-free crude and purified dermonecrotic toxin of P multocida","volume":"49","author":"Kamp","year":"1988","journal-title":"Am. J. Vet. Res."},{"issue":"1","key":"10.1016\/j.bone.2019.07.031_bb0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1099\/00221287-136-1-81","article-title":"Cloning of the toxin gene from Pasteurella multocida and its role in atrophic rhinitis","volume":"136","author":"Lax","year":"1990","journal-title":"J. Gen. Microbiol."},{"issue":"17","key":"10.1016\/j.bone.2019.07.031_bb0060","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1073\/pnas.0900160106","article-title":"Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation","volume":"106","author":"Orth","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bone.2019.07.031_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/toxins2020205","article-title":"Pasteurella multocida toxin activates various heterotrimeric G proteins by deamidation","volume":"2","author":"Orth","year":"2010","journal-title":"Toxins (Basel)"},{"issue":"2","key":"10.1016\/j.bone.2019.07.031_bb0070","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1096\/fj.12-213900","article-title":"Substrate specificity of Pasteurella multocida toxin for \u03b1 subunits of heterotrimeric G proteins","volume":"27","author":"Orth","year":"2013","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bone.2019.07.031_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003385","article-title":"Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G\u03b1(q\/11)--p63RhoGEF--RhoA axis","volume":"9","author":"Siegert","year":"2013","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.bone.2019.07.031_bb0080","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02190-14","article-title":"Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin","volume":"5","author":"Strack","year":"2014","journal-title":"MBio"},{"issue":"267","key":"10.1016\/j.bone.2019.07.031_bb0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00003086-199106000-00001","article-title":"The possible significance of hexosephosphoric esters in ossification (reprinted from Biochem J, Vol 17, Pg 286, 1923)","author":"Robison","year":"1991","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"5639","key":"10.1016\/j.bone.2019.07.031_bb0090","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/270725a0","article-title":"Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle","volume":"270","author":"Yaffe","year":"1977","journal-title":"Nature"},{"issue":"4727","key":"10.1016\/j.bone.2019.07.031_bb0095","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.2414846","article-title":"Plasticity of the differentiated state","volume":"230","author":"Blau","year":"1985","journal-title":"Science"},{"issue":"6 Pt 1","key":"10.1016\/j.bone.2019.07.031_bb0100","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","article-title":"Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage","volume":"127","author":"Katagiri","year":"1994","journal-title":"J. Cell Biol."},{"issue":"15","key":"10.1016\/j.bone.2019.07.031_bb0105","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1111\/j.1742-4658.2011.08197.x","article-title":"Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated \u03b1 subunit of the heterotrimeric GTPase Gq","volume":"278","author":"Kamitani","year":"2011","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.bone.2019.07.031_bb0110","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1096\/fj.12-213900","article-title":"Substrate specificity of Pasteurella multocida toxin for \u03b1 subunits of heterotrimeric G proteins","volume":"27","author":"Orth","year":"2013","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bone.2019.07.031_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003385","article-title":"Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G\u03b1q\/11-p63RhoGEF-RhoA axis","volume":"9","author":"Siegert","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bone.2019.07.031_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res."},{"issue":"16","key":"10.1016\/j.bone.2019.07.031_bb0125","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1101\/gad.12.16.2445","article-title":"Smads and early developmental signaling by the TGF\u03b2 superfamily","volume":"12","author":"Whitman","year":"1998","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.bone.2019.07.031_bb0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1385\/BMM:3:3-4:243","article-title":"Treatment considerations for the management of fibrodysplasia ossificans progressiva","volume":"3","author":"Glaser","year":"2005","journal-title":"Clinical Reviews in Bone and Mineral Metabolism"},{"issue":"49","key":"10.1016\/j.bone.2019.07.031_bb0135","doi-asserted-by":"crossref","first-page":"35757","DOI":"10.1074\/jbc.M611902200","article-title":"Continuous activation of G\u03b1q in osteoblasts results in osteopenia through impaired osteoblast differentiation","volume":"282","author":"Ogata","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bone.2019.07.031_bb0140","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.bbamcr.2012.05.018","article-title":"PKC signaling inhibits osteogenic differentiation through the regulation of Msx2 function","volume":"1823","author":"Jeong","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.bone.2019.07.031_bb0145","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bone.2010.09.238","article-title":"PKC\u03b1 suppresses osteoblastic differentiation","volume":"48","author":"Nakura","year":"2011","journal-title":"Bone"},{"issue":"49","key":"10.1016\/j.bone.2019.07.031_bb0150","doi-asserted-by":"crossref","first-page":"50773","DOI":"10.1074\/jbc.M404145200","article-title":"Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2","volume":"279","author":"Kim","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2019.07.031_bb0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"44","key":"10.1016\/j.bone.2019.07.031_bb0160","doi-asserted-by":"crossref","first-page":"36701","DOI":"10.1074\/jbc.M507203200","article-title":"Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12\/13","volume":"280","author":"Orth","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2019.07.031_bb0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"Ramakers","year":"2003","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.bone.2019.07.031_bb0170","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/cmb.2012.0279","article-title":"A new method for quantitative real-time polymerase chain reaction data analysis","volume":"20","author":"Rao","year":"2013","journal-title":"J. Comput. Biol."},{"issue":"6","key":"10.1016\/j.bone.2019.07.031_bb0175","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1128\/IAI.69.6.3628-3634.2001","article-title":"Biological activity of a C-terminal fragment of Pasteurella multocida toxin","volume":"69","author":"Busch","year":"2001","journal-title":"Infect. Immun."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219303059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219303059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:14:08Z","timestamp":1778940848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328219303059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":35,"alternative-id":["S8756328219303059"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2019.07.031","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2019.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}